Cycle cellulaire et développement

 

 

L’équipe Cycle Cellulaire et Développement vise à acquérir de nouvelles connaissances pour décrypter la façon dont les cellules se divisent afin de mieux comprendre les mécanismes du cancer, une maladie résultant d’une division cellulaire incontrôlée.

 

Responsable : Lionel Pintard

Directeur de Recherche CNRS

+33 (0)157278089

lionel.pintard(at)ijm.fr

@LabPintard

https://sites.google.com/site/pintardlab/

 

 

RECHERCHEMEMBRESPUBLISNEWS

 

Thèmes et Axes de recherche :

 

Biologie quantitative et modélisation , Développement et évolution , Dynamique cellulaire et signalisation , Dynamique du génome et des chromosomes, Pathologies moléculaires et cellulaires

 

Sélection de publications :

 

Tavernier, N., Thomas, Y., Vigneron, S., Maisonneuve, P., Orlicky, S., Mader, P., Regmi, S. G., Van Hove, L., Levinson, N. M., Gasmi-Seabrook, G., Joly, N., Poteau, M., Velez-Aguilera, G., Gavet, O., Castro, A., Dasso, M., Lorca, T., Sicheri, F.*, and Pintard, L.* (2021). Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry. Nat Commun 12, 1899. doi: 10.1038/s41467-021-21922-w.

https://www.nature.com/articles/s41467-021-21922-w

 

G. Velez-Aguilera, S. Nkombo Nkoula, B. Ossareh-Nazari, J. Link, D. Paouneskou, L. Van Hove, N. Joly, J. M. Verbavatz, V. Jantsch and L. Pintard. (2020). The Polo-like kinase (PLK-1) promotes the merger of the parental genome into a single nucleus by triggering lamina disassembly. eLife, Oct 8;9:e59510. doi: 10.7554/eLife.59510

https://elifesciences.org/articles/59510

 

Joly, N., Beaumale, E., Van Hove, L., Martino, L., and Pintard, L. (2020). Phosphorylation of the microtubule-severing AAA+ enzyme Katanin regulates C. elegans embryo development. J Cell Biol 219

https://rupress.org/jcb/article/219/6/e201912037/151781/Phosphorylation-of-the-microtubule-severing-AAA

 

Pintard, L., and Bowerman, B. (2019). Mitotic Cell Division in Caenorhabditis elegans. Genetics 211, 35-73.

https://www.genetics.org/content/genetics/211/1/35.full.pdf

 

Pintard, L., and Archambault, V. (2018). A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key. Open Biol 8,

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180114

 

Vigneron, S., Sundermann, L., Labbé, J. C., Pintard, L., Radulescu, O., Castro, A., and Lorca, T. (2018). Cyclin A-cdk1-Dependent Phosphorylation of Bora Is the Triggering Factor Promoting Mitotic Entry. Dev Cell 45, 637-650.e7.

https://www.cell.com/action/showPdf?pii=S1534-5807%2818%2930362-9

 

Dickinson, D. J., Schwager, F., Pintard, L., Gotta, M., and Goldstein, B. (2017). A Single-Cell Biochemistry Approach Reveals PAR Complex Dynamics during Cell Polarization. Dev Cell 42, 416-434.e11.

https://www.cell.com/action/showPdf?pii=S1534-5807%2817%2930600-7

 

Martino, L., Morchoisne-Bolhy, S., Cheerambathur, D. K., Van Hove, L., Dumont, J., Joly, N., Desai, A., Doye, V., and Pintard, L. (2017). Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans. Dev Cell 43, 157-171.e7.

https://www.cell.com/action/showPdf?pii=S1534-5807%2817%2930772-4

 

Cirillo, L., Thomas, Y., Pintard, L., and Gotta, M. (2016). BORA-dependent PLK1 regulation: A new weapon for cancer therapy. Mol Cell Oncol 3, e1199265.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176151/pdf/kccy-15-23-1249544.pdf

 

Joly, N., Martino, L., Gigant, E., Dumont, J., and Pintard, L. (2016). Microtubule-severing activity of the AAA+ ATPase Katanin is essential for female meiotic spindle assembly. Development 143, 3604-3614.

https://dev.biologists.org/content/develop/143/19/3604.full.pdf

 

Ossareh-Nazari, B., Katsiarimpa, A., Merlet, J., and Pintard, L. (2016). RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans. G3 (Bethesda) 6, 3431-3442.

https://www.g3journal.org/content/ggg/6/10/3431.full.pdf

 

Thomas, Y., Cirillo, L., Panbianco, C., Martino, L., Tavernier, N., Schwager, F., Van Hove, L., Joly, N., Santamaria, A., Pintard, L., and Gotta, M. (2016). Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells. Cell Rep 15, 510-518.

https://www.cell.com/action/showPdf?pii=S2211-1247%2816%2930320-5

 

Tavernier, N., Noatynska, A., Panbianco, C., Martino, L., Van Hove, L., Schwager, F., Léger, T., Gotta, M., and Pintard, L. (2015). Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos. J Cell Biol 208, 661-669.

https://rupress.org/jcb/article/208/6/661/38083/Cdk1-phosphorylates-SPAT-1-Bora-to-trigger-PLK-1