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DTSTART;TZID=Europe/Paris:20260302T114500
DTEND;TZID=Europe/Paris:20260302T130000
DTSTAMP:20260418T021809
CREATED:20260210T093507Z
LAST-MODIFIED:20260210T093507Z
UID:32128-1772451900-1772456400@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Catherine H. Freudenreich
DESCRIPTION:Invited par l’équipe Palancade\, Catherine H. Freudenreich (Professor of Biology\, School of Arts & Sciences\, Tufts University\, Medford\, MA\, USA) will present an Institut Jacques Monod seminar on the theme: \nReplication and repair of structure-forming repeats: role of repositioning to the nuclear periphery \nAbstract: \nAll cells encounter replication barriers upon genome duplication and must overcome those barriers to survive. Many repeat sequences can form alternative DNA structures that interfere with replication and repair. This can lead to disease-causing repeat expansions. Alternatively\, breaks within structure-forming repeats cause chromosome deletions and rearrangements\, which are common in cancer cells undergoing replication stress. One strategy that cells use to overcome some types of replication barriers or difficult-to-repair lesions is repositioning to the nuclear periphery. I will describe research from my lab on how structure-forming DNA repeats are replicated and repaired and the role of relocation to the nuclear pore in these processes. Recent results on the mechanisms used to move damaged chromosomes to the nuclear pore and the role of this pathway in protecting genome instability will be covered.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-catherine-h-freudenreich-2/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2026/02/Bandeau-web-seminar-Catherine-H.-Freudenreich-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260303T114500
DTEND;TZID=Europe/Paris:20260303T130000
DTSTAMP:20260418T021809
CREATED:20260223T110320Z
LAST-MODIFIED:20260223T110320Z
UID:32292-1772538300-1772542800@www.ijm.fr
SUMMARY:Paris Postdoc Seminar - Katie Pelletier
DESCRIPTION:Katie Pelletier (postdoc at the Institut de Biologie de l’École Normale Supérieure (IBENS)) will present a Paris Postdoc Seminar on the theme: \nChanging developmental signal has an effect on developmental bias: Wnt mutation modifies phenotypic co-variation patterns for cell fates in the nematode vulva \nAbstract: \nWhile mutation is mostly random at the DNA level\, realized co-variation between traits following random perturbation can be strongly biased along some directions of phenotypic space. Development is often invoked as an explanation as to why some combinations of trait values are more probable to co-occur than others. However\, studies that modify the accessible phenotypic space though a manipulation of development are lacking. We use variation in cell fate of nematode vulva precursor cells to ask if reduction of morphogen signal is sufficient to change the co-variation pattern of these cells. Previous work in the lab has demonstrated that in Caenorhabditis\, the most posterior cell\, P3.p\, is sensitive to random genetic perturbations while the fate of the next most anterior cell\, P4.p\, is not (Picao-Osorio et al 2025). Posteriorly expressed Wnt signal\, encoded by two genes\, egl-20 and cwn-1\, is important for promoting the divided cell fate in Pn.p cells in C. elegans. We reduced the Wnt signal dose using a cwn-1 deletion and assayed the accessible phenotypic space of this mutant. The large-effect cwn-1 mutation results in a shift in the phenotypically accessible space\, as P4.p becomes sensitive to random mutation\, in contrast to P3.p being sensitive in the wild-type line. This is a direct example of how changes to a developmental signal can modify the realized co-variation of traits following perturbations.
URL:https://www.ijm.fr/event/paris-postdoc-seminar-katie-pelletier/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2026/02/20260217-Katie-Pelletier-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260318T093000
DTEND;TZID=Europe/Paris:20260318T110000
DTSTAMP:20260418T021809
CREATED:20260309T094907Z
LAST-MODIFIED:20260309T094907Z
UID:32423-1773826200-1773831600@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next cytoskeleton club meeting will take place on Vednesday\, 18th March \n\nEtienne Pinard\, (PhD student (Robin Team)\, CADMO – Cortical Actomyosin Dynamics in Development and Morphogenesis\, Institute for Biology Paris-Seine will present “Dynamics of cortical actomyosin and ATP availability in the C. elegans early embryo”\nNicolas Joly\, (Pintard team\, Institut Jacques Monod) will present “Molecular Mechanisms of Katanin Activation: Coupling Microtubule Binding to ATP Hydrolysis”
URL:https://www.ijm.fr/event/cytoskeleton-club-13/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2026/03/20260318-bandeau.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260320T114500
DTEND;TZID=Europe/Paris:20260320T130000
DTSTAMP:20260418T021809
CREATED:20260210T105210Z
LAST-MODIFIED:20260210T110557Z
UID:32137-1774007100-1774011600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Pablo Meyer Rojas
DESCRIPTION:Invited by the Minc Lab\, Pablo Meyer Rojas\, Manager of Biological Analytics and Modeling group and Senior Research Scientist IBM Research USA\, will present an Institut Jacques Monod seminar on the theme: \nPre-training DNA language models to make them understand Biology \nAbstract: \nLarge language models (LLMs) trained on text demonstrated remarkable results on natural language processing (NLP) tasks. These models have been adapted to decipher the language of DNA\, where sequences of nucleotides act as “words” that encode genomic functions. However\, the human genome differs fundamentally from natural language\, as it lacks clearly defined words or a consistent grammar. DNA language models (DNALMs) such as EVO or DNABERT\, have achieved a high level of performance on genome-related biological tasks using DNA sequences as input.  Deep learning (DL) models trained for specific tasks such as Alpha-Genome or the ones developed through the DREAM crowdsourcing challenges often surpass DNALMs. However\, neither DNALMs nor DL models have explanations for how they encode the biological functions they are good at predicting. To address this problem\, we pre-train foundation models that effectively integrate sequence variations\, in particular Single Nucleotide Polymorphisms (SNPs)\, as they underlie important biological functions and disease. We show that integrating this and other biological knowledge into the pre-training of DNALMs brings better and interpretable performance of the models.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-pablo-meyer-rojas/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2026/02/Bandeau-web-seminar-Pablo-Meyer-Rojas-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260323T140000
DTEND;TZID=Europe/Paris:20260323T150000
DTSTAMP:20260418T021809
CREATED:20260309T100100Z
LAST-MODIFIED:20260309T100100Z
UID:32413-1774274400-1774278000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Erin L. Barnhart
DESCRIPTION:Invited by the Konstantinides\, Erin L. Barnhart (Department of Biological Sciences\, Columbia University) will present an Institut Jacques Monod seminar on the theme: \nOrganelle dynamics and neuronal form and function \nAbstract: \nNeurons are signal processors: individual units that receive\, process\, and transmit signals within a circuit. Neurons are also cells: dynamic\, self-organizing systems in which constituent elements (e.g. organelles) turn over on time scales substantially shorter than the lifetime of the neuron. In my group\, we aim to understand\, first\, how neurons maintain mitochondrial homeostasis; second\, how deficits in mitochondrial homeostasis affect neuronal form and function; and third\, how mitochondria and the endoplasmic reticulum tune specific neuronal computations in vivo. In this talk\, I will discuss our ongoing efforts to develop a comprehensive\, quantitative model linking mitochondrial homeostasis to neuronal morphology in Drosophila. I will also discuss how deficits in mitochondrial dynamics — motility\, fission\, and fusion — affect neuronal development\, as well as neuronal function in adult flies.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-erin-l-barnhart/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2026/03/Bandeau-web-seminar-Erin-L.-Barnhart.jpg
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20260326
DTEND;VALUE=DATE:20260328
DTSTAMP:20260418T021809
CREATED:20251127T151006Z
LAST-MODIFIED:20251127T151006Z
UID:31016-1774483200-1774655999@www.ijm.fr
SUMMARY:2nd meeting of France-BioImaging Mechanobiology Working Group
DESCRIPTION:The second meeting of the FBI Mechanobiology WG will take place on the 26 and 27 of March 2026 at the Institut de Biologie Paris Seine and the Institut Jacques Monod in Paris. \nThe programme will include a seminar by Kate Miroshnikova (NIDDK/NIH\, Bethesda USA and Max Planck Institute for Molecular Biomedicine\, Münster\, Germany)\, presentations by participants and practical mechanobiology workshops (a choice of 4 workshops from a dozen: optical tweezers\, micro/nano-fabrication\, microfluidics\, AFM\, micropipette aspiration\, mechanical confinement\, force measurements\, etc…). \n\nPreliminary program:\nDay 1 – 26/03/2026\, Paris 5e (IBPS / Curie / IPGG) \n\nMorning : scientific presentations\, small group discussion\nAfternoon : 2 sessions of practical workshops on real set-ups in participating labs (Paris 5e)\n\nDay 2 – 27/03/2026\, Paris 13e (IJM / MSC / LIED) \n\nMorning : scientific presentations\, poster session\nAfternoon : 2 sessions of practical workshops on real set-ups in participating labs (Paris 13e)\n\n\nInfos & registration:\nRegistration is free\, but places are limited and priority will be given to contributors whose abstracts have been selected. \nRestration link : here
URL:https://www.ijm.fr/event/2nd-meeting-of-france-bioimaging-mechanobiology-working-group/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/11/web-image-bandeau-scaled.jpg
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