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X-WR-CALNAME:Institut Jacques Monod
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X-WR-CALDESC:Events for Institut Jacques Monod
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DTSTART;TZID=Europe/Paris:20250603T114500
DTEND;TZID=Europe/Paris:20250603T130000
DTSTAMP:20260424T181955
CREATED:20250520T130321Z
LAST-MODIFIED:20250520T130321Z
UID:28205-1748951100-1748955600@www.ijm.fr
SUMMARY:Seminar - Irene Basili
DESCRIPTION:Invited by the Institut Jacques Monod\, Irene Basili will present a seminar on the theme: \nAMBRA1 controls the Sonic Hedgehog signaling pathway and SHH-medulloblastoma \nAbstract: \nAMBRA1 (Autophagy and Beclin 1 Regulator 1) is primarily recognized as a tumor suppressor\, however its role as a tumor promoter has garnered increasing attention. Here\, leveraging clinical data of an international multi-omic medulloblastoma (MB) cohort\, we identified that elevated AMBRA1 protein levels\, independently of its mRNA expression\, correlate with poor prognosis in the Sonic Hedgehog subgroup (MBSHH) compared to other MB variants. Mechanistically\, AMBRA1 enhances SHH signaling by stabilizing GLI1\, the pathway’s final effector\, via inhibition of its βTrCP-mediated degradation. Additionally\, AMBRA1 protein stability is modulated by the REN E3 ubiquitin ligase\, a tumor suppressor gene lost in MBSHH. Inhibition of AMBRA1 blocks MBSHH growth in murine and patient-derived pre-clinical models\, highlighting its therapeutic potential. Moreover\, combining AMBRA1 knockdown with FDA-approved SHH inhibitors enhances antitumor efficacy. These findings identify the AMBRA1/βTrCP/REN axis as a key regulatory mechanism in SHH signaling and discover an unrecognized function of AMBRA1 in MBSHH\, providing actionable insights for innovative targeted therapies. \nThis seminar is part of the Paris Postdoc seminar series.
URL:https://www.ijm.fr/event/seminar-irene-basili/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/20250603-Irene-Basili-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250606T114500
DTEND;TZID=Europe/Paris:20250606T130000
DTSTAMP:20260424T181955
CREATED:20250513T093808Z
LAST-MODIFIED:20250513T094229Z
UID:28088-1749210300-1749214800@www.ijm.fr
SUMMARY:Institut Jacques Monod seminar - Aydan Karslioglu
DESCRIPTION:Invited by the Greenberg Lab and the Epigenetic & cell fate\, Aydan Karslioglu (Group Leader\, Max Planck Institute for Molecular Genetics) will present an Institut Jacques Monod seminar on the theme: \nAdjusting the timing of mammalian development \nAbstract: \nOur lab focuses on mechanisms regulating stem cell state transitions and fate commitment. Specifically\, we study how cells communicate signals from their surroundings to the gene expression machinery\, especially in the context of cell fate decisions in development and disease. To delineate principles of stemness\, we use in vitro and in vivo models and probe molecular processes critical for the emergence\, maintenance\, and resolution of stem states in physiological and adverse conditions.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-aydan-karslioglu/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/Bandeau-web-seminar-Aydan-Karslioglu-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250613T114500
DTEND;TZID=Europe/Paris:20250613T130000
DTSTAMP:20260424T181955
CREATED:20250515T085936Z
LAST-MODIFIED:20250515T101058Z
UID:28136-1749815100-1749819600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Frank Maixner et Sabry Sarhan
DESCRIPTION:Invited by the Grange/Geigl\, Frank Maixner and Sabry Sarhan (Eurac Research – Institute for Mummy Studies\, Bolzano\, Italy) will present an Institut Jacques Monod seminar on theme: \nGenome wide data of a Penicillium roqueforti strain from Iron Age Austria: the oldest molecular evidence for fermented blue cheese. \nAbstract: \nThe application of metagenomic analysis on dated ancient human specimens opens a window into the past that enables scientists to address unique evolutionary research questions. Paleofeces are an important source of information to study the evolution of dietary habits and human health. The UNESCO World Heritage region of Hallstatt-Dachstein/Salzkammergut is one of Europe’s oldest cultural and industrial landscapes; its underground salt mines dating back at least to the 14th century BC are one of the few archaeological sites where paleofeces are well preserved. Here we subjected human paleofeces dated from the Bronze Age to early Modern Times to an in-depth microscopic\, metagenomic and proteomic analysis. This allowed us to reconstruct the diet of the former population and gain insights into their ancient gut microbiome composition. Dietary survey identified a highly fibrous\, carbohydrate-rich diet supplemented with proteins from broad beans and occasionally with fruits\, nuts\, or animal food. Linked to these traditional dietary habits all ancient miners up to the early Modern times have gut microbiome structures akin to modern non-Westernized individuals which may indicate a shift in the gut community composition of modern Westernized populations due to quite recent dietary and lifestyle changes. When we extended our microbial survey to fungi present in the paleofeces\, we observed in one of the Iron Age samples a high abundance of Penicillium roqueforti DNA. Genome-wide analysis placed the ancient P. roqueforti strain into the current non-Roquefort blue cheese diversity next to modern variants from different parts of the Alps (e.g. Termignon). Our findings present the earliest molecular evidence for blue cheese consumption during Iron Age Europe\, which opens a new opportunity to better understand the domestication history of blue cheese fermentation.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-frank-maixner-et-sabry-sarhan/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/Bandeau-web-seminar-Frank-Maixner-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250618T093000
DTEND;TZID=Europe/Paris:20250618T110000
DTSTAMP:20260424T181955
CREATED:20250610T115259Z
LAST-MODIFIED:20250610T115259Z
UID:28379-1750239000-1750244400@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The las Cytoskeleton club meeting of the 2024-2025 season will take place on Wednesday June 18th. \nDuring this meeting: \n– Julie Homsen (Phd student\, A. Echard’s lab\, Institut Pasteur) will talk about «  GPRC5A is a potential component of the abscission checkpoint preventing premature chromatin bridge breakage »  \n– Baptiste Vauleon (PhD student\, M. Piel’s lab\, Institut Curie/IPPG) will talk about : «  Mechanical polarity of the cortex and single cell morphogenesis ». 
URL:https://www.ijm.fr/event/cytoskeleton-club-8/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/06/20250618-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250620T114500
DTEND;TZID=Europe/Paris:20250620T130000
DTSTAMP:20260424T181955
CREATED:20250513T094631Z
LAST-MODIFIED:20250513T094631Z
UID:28095-1750419900-1750424400@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Carlos Estella
DESCRIPTION:Invited by the Konstantinides Lab\, Carlos Estella (Laboratory of stress response and morphogenesis. Centro de Biología Molecular CSIC-UAM\, Madrid\, Spain) will present an Institut Jacques Monod seminar on the theme: \nA cross talk between p53 and the cell cycle regulates apoptotic induction and tumor formation in Drosophila \nAbstract: \nCell division is essential for tissue regeneration and organismal survival. However\, errors in this process can lead to uncontrolled cell proliferation and cancer. The tumor suppressor gene p53 plays a critical role in maintaining genomic integrity by coordinating cellular responses to stress\, such as DNA damage. These responses include cell cycle arrest\, DNA repair\, senescence\, or apoptosis. Importantly\, how these responses are precisely coordinated to maintain tissue homeostasis remains poorly understood. \nTo address this challenge\, simple genetic models are needed to study the precise regulation of cellular responses triggered by p53 and its role in tumorigenesis. To simplify the study of p53’s functions\, we use Drosophila melanogaster\, which has a single p53 homolog. Drosophila serves as a powerful genetic model due to its highly conserved pathways and sophisticated genetic tools. Notably\, approximately 85% of human cancer-related genes have orthologs in flies. In this seminar I´ll discuss recent work from our laboratory that demonstrated how the cellular context and proliferative status of a cell significantly impact p53’s ability to regulate the various responses triggered by DNA damage. In addition\, I´ll present the tumorigenic potential of p53 when its apoptotic role is inhibited. We find that cells with chronic p53 activity that have inhibited its apoptotic potential acquire a persistent activity of the JNK pathway\, which drives them into a senescent-like status and induce the non-autonomous overgrowth of the surrounding tissue. These results lead us to propose a model in which cell cycle progression and p53 pro-apoptotic activity are molecularly connected to coordinate the appropriate response after DNA damage.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-carlos-estella/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/Bandeau-web-seminar-Carlos-Estella-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250623T090000
DTEND;TZID=Europe/Paris:20250623T180000
DTSTAMP:20260424T181955
CREATED:20250520T084255Z
LAST-MODIFIED:20250520T084255Z
UID:28194-1750669200-1750701600@www.ijm.fr
SUMMARY:VIP & DIF 2025
DESCRIPTION:Registration for the VIP & DIF Day #5 is open !  \nWhere: Institut Jacques Monod (Amphi  Buffon – 15 rue Hélène Brion – 75013 Paris)\nWhen: Monday 23rd of June 2025. \nThis year\, we will have the pleasure to welcome the two following keynote speakers: \n\n    Maria-Cristina Gambetta\, from University of Lausanne\n\n\n    Alper Akay\, from University of East Anglia\n\nSubmit your Poster or Short Talk abstracts.\nhttps://sites.google.com/view/vipdif/registration-2025 \nParticipation is free but registration is mandatory for everyone.\nDeadline for registration is the 1st of June 2025.
URL:https://www.ijm.fr/event/vip-dif-2025/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/web-image-bandeau-scaled.jpg
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