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X-WR-CALDESC:Events for Institut Jacques Monod
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DTSTART;TZID=Europe/Paris:20250404T114500
DTEND;TZID=Europe/Paris:20250404T130000
DTSTAMP:20260424T215109
CREATED:20250324T145408Z
LAST-MODIFIED:20250324T145408Z
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SUMMARY:Institut Jacques Monod Seminar - Lionel Christiaen
DESCRIPTION:Invited by the Minc Lab\, Lionel Christiaen (Michael Sars Centre\, University of Bergen\, Bergen\, Norway) will present an Institut Jacques Monod Seminar on the theme: \nRegulation of deterministic development \nAbstract: \nChristiaen’s research aims at understanding how tissue-specific regulatory programs and cell-cell communication coordinate cellular behavior in the context of animal development\, regeneration and evolution. His laboratory focuses on mesodermal lineages that produce both heart and head muscles\, using the ascidian Ciona as model. His laboratory has contributed seminal findings in developmental and evolutionary biology\, identifying key processes contributing to human congenital disorders. The Ciona model provides a unique opportunity to study the regulation of chordate development at single cell resolution\, thanks to a highly deterministic (“hard-wired”) mode of embryogenesis. However\, recent attempts to uncover the impact of varying temperatures in a changing world are beginning to reveal regulative mechanisms of thermal adaptation.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-lionel-christiaen/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/Bandeau-web-seminar-Lionel-Christiaen-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250408T114500
DTEND;TZID=Europe/Paris:20250408T130000
DTSTAMP:20260424T215110
CREATED:20250326T143945Z
LAST-MODIFIED:20250326T143945Z
UID:27705-1744112700-1744117200@www.ijm.fr
SUMMARY:Seminar - Suzette Lust
DESCRIPTION:Invited by the Institut Jacques Monod\, Suzette Lust (Postdoctoral researcher in Danijela Matic Vignjevic’s team – Cell migration and invasion Laboratory at Institut Curie) will present a seminar on the theme: \nUnderstanding the role of interstitial flow in vascular smooth muscle cell phenotype in the context of aortic aneurysms \n  \nThis seminar is part of the Paris Postdocs Seminars series. \nAbstract: \nAortic aneurysms are abnormal enlargements of blood vessel diameter caused by aberrant extra-cellular matrix (ECM) remodelling. As the tissue dilates\, it loses its mechanical integrity\, exposing patients to risk of highly fatal aortic dissections or ruptures. This is mediated in part by phenotypic switching and or apoptosis of the intima-resident vascular smooth muscles (VSMCs). What drives this pathology is not well understood\, particularly in the case of aneurysms in Bicuspid Aortic Valve disease (BAV) patients\, a congenital condition characterised by the malformation of the aortic valve resulting in only 2 leaflets. Improvements in imaging techniques have now allowed pathological blood flow patterns to be correlated to aneurysm morphology and indeed there is increasing evidence that mechanotransduction from flow may be a driver of aneurysm development. Blood flow imparts mechanical forces to cells through stretching and frictional shear forces and we are focused here on the interstitial flow driven into the wall by differential pressure gradients within the aorta. \nWe hypothesise that interstitial flow plays a crucial role in regulating VSMC phenotype and ECM interactions and that this may be used to correlate disrupted flow patterns seen in BAV patients to the morphology changes in their aortas. \nTo test this hypothesis\, we created a reductionist in-vitro model culturing VSMCs in 3D under interstitial flow. We combined a synthetic PEG based ECM mimicking hydrogel with primary cultures of VSCMs with a microfluidics setup. \nWe showed hydrogels doctored with degradable bioactive peptides could be broken down by exogenous and cell derived MMPs. We measured hydrogel permeability using 2 separate techniques which confirmed the material to have a low permeability compared to other standard hydrogels\, on the order of 10−16 m2. Furthermore\, we characterised mass transport of solutes within hydrogels and were able to demonstrate a negligible impact of changing polymer solid content on diffusivity in hydrogels of up to 5% weight/volume for molecules up to 40 kDa in size. Via production of MMPs\, VSMCs break down the hydrogel and importantly by day 7 of culture\, we detected newly synthesised fibronectin\, collagen 1 and 4 proteins. We stimulated encapsulated cells with interstitial flows demonstrating that cells align to the flow direction. Finally\, we performed RNA sequencing on 3 human patient samples comparing standard culture conditions\, non-flow stimulated encapsulated cells and interstitial-flow stimulated cells. The data set reveals significant upregulation of genes in multiple pathways associated with cyclic AMP production\, which plays a crucial role in regulating VSMC contractility and calcium signalling and hence phenotype. The data suggests that this is mediated via activation of G-protein receptors leading to increased expression of adenylyl cyclase but this remains to be confirmed. \nIn conclusion\, we developed a novel in-vitro platform to study the impact of interstitial flow on VSMC behaviour. Our data suggests that interstitial flow may play a regulating role in determining VSMC phenotype with potential consequences for matrix remodelling in disease.
URL:https://www.ijm.fr/event/seminar-suzette-lust/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250408-Suzette-Lust-web-scaled.jpg
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20250409
DTEND;VALUE=DATE:20250412
DTSTAMP:20260424T215110
CREATED:20241209T104027Z
LAST-MODIFIED:20241209T104027Z
UID:26072-1744156800-1744415999@www.ijm.fr
SUMMARY:Paris - Munich Epigenetics Workshop & Symposium 2025
DESCRIPTION:The second edition of the Paris-Munich Epigenetics meeting will be held from 9 to 11 April 2025 in the Buffon amphitheater. Attendance is free of charge but registration is mandatory. \nPlease visit the website to find out more about the program and to register. \nThe Paris-Munich Epigenetics Worshop & Symposium has two parts: \n\nthe SYMPOSIUM\, open for all students and researchers in the Paris/Munich communities and beyond\na WORKSHOP for selected doctoral or postdoctoral researchers that are new to the field of Epigenetics\n\nThe WORKSHOP takes place on April 9 prior to the symposium\, and is open for selected early stage doctoral and postdoctoral researchers new to the field of Epigenetics. The workshop focussed on the core concepts of cutting-edge Epigenetics research\, taught by senior academic experts\, as well as career orientation and communication skills\, presented by alumna and professionals in the field. Workshop participants will have the opportunity to network and exchange\, with discussions during the workshop\, as well as with featured short talks and posters during the symposium. \n  \nThe SYMPOSIUM takes place from April 9-11\, 2025  and is open for all interested students and scientists from the Paris and Munich communities and beyond. During the Symposium renowned speakers from the two communities present their latest insights into Epigenetics in sessions on chromatin environment\, organization\, remodelling and reprogramming. Short talks and poster presentations from early career (doctoral and postdoctoral) researchers will be selected from the submitted abstracts. \n  \nThe deadline for both abstract submissions and workshop applications is January 15\, 2025.
URL:https://www.ijm.fr/event/paris-munich-epigenetics-workshop-symposium-2025/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/bandeau-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250409T093000
DTEND;TZID=Europe/Paris:20250409T110000
DTSTAMP:20260424T215110
CREATED:20250331T094740Z
LAST-MODIFIED:20250331T094740Z
UID:27738-1744191000-1744196400@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\,9th at the Institut Pasteur: \n\nIngrid Billault-Chaumartin (post-doc\,  Romet-Lemonne/Jegou team\, IJM) will present “How similar is actin assembly between distant species ? »\nNicolas Joly ( Researcher \,  Pintard tema\, IJM)  will present “Mechanistic Insights into Katanin Activation: Coupling Microtubule Binding with ATP Hydrolysis
URL:https://www.ijm.fr/event/cytoskeleton-club-6/?lang=en
LOCATION:Institut Pasteur\, 28 rue du dr roux\, 75015 Paris\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250319bandeau-1-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250411T114500
DTEND;TZID=Europe/Paris:20250411T130000
DTSTAMP:20260424T215110
CREATED:20250313T131823Z
LAST-MODIFIED:20250313T135245Z
UID:27626-1744371900-1744376400@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Marion Silies
DESCRIPTION:Invited by the Konstantinides Lab\, Dr. Marion Silies (Johannes-Gutenberg-University Mainz\, Germany) will present an Institut Jacques Monod seminar on the theme: \nHeterogeneity of connectivity and function in the fly visual system \nAbstract: \nVisual systems are considered homogeneous structures where repeating visual units contain the same circuit motifs that fulfil the same functional role\, leading to translation invariance. However\, our recent work\, analyzing full fly brain connectomes\, revealed remarkable heterogeneity\, even within anatomically and genetically identifiable cell types. I will describe this heterogeneity in synaptic connectivity\, and address where it arises developmentally. Furthermore\, I will discuss how heterogeneous circuit motifs can lead to degeneracy of neuronal function\, and thus to both\, reliablility and flexiblity of neuronal information processing in the visual system.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-marion-silies/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/Bandeau-web-seminar-Marion-Silies-scaled.jpg
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