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DTSTART;TZID=Europe/Paris:20250206T190000
DTEND;TZID=Europe/Paris:20250206T213000
DTSTAMP:20260425T011958
CREATED:20250115T091647Z
LAST-MODIFIED:20250115T091647Z
UID:26597-1738868400-1738877400@www.ijm.fr
SUMMARY:Dance conference: Move your science
DESCRIPTION:Dance conference: MOVE YOUR SCIENCE\nThursday\, February 6\, 7pm | Hall Buffon\, Institut Jacques Monod\nFree with registration\nCollective creation with doctoral students Kenza Alaoui Sossé\, Amandine Albizzati\, Mariam Bougma\, Stéphanie Brunot\, Mert Can\, Johanna Exenberger\, Audrey Gosset\, Capucine Gros\, Emile Le Lièvre and Joséphine Schelle \nChoreography and dance/science research: Cosetta Graffione and Namiko Gahier-Ogawa \nScientific coordination and dance/science research: Mélina Heuzé\, teacher-researcher \nSince September\, ten doctoral students from all disciplines at Université Paris Cité have been working with choreographers Cosetta Graffione and Namiko Gahier-Ogawa and teacher-researcher Mélina Heuzé to share their scientific project in a spirit of mediation with the general public.\nIn a dialogue between art and science\, the public will be able to experience the scientific principles of their thesis work through dance sequences that bring out the poetry of the body. \nThis four-part dance conference will be followed by a discussion with the audience over a friendly drink.
URL:https://www.ijm.fr/event/dance-conference-move-your-science/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/heuze-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250207T114500
DTEND;TZID=Europe/Paris:20250207T130000
DTSTAMP:20260425T011958
CREATED:20241219T104206Z
LAST-MODIFIED:20241219T104206Z
UID:26252-1738928700-1738933200@www.ijm.fr
SUMMARY:Institut Jacques Monod lecture - Sophie G. Martin
DESCRIPTION:On Friday\, February 7th 2025\, Sophie G. Martin (Department of Molecular and Cellular Biology\, University of Geneva\, Switzerland) will present an Institut Jacques Monod lecture on the theme: \nSignaling and actin focus architecture for cell-cell fusion \n  \nAbstract: \nSexual reproduction is ubiquitous amongst eukaryotes. This requires alternation of cell-cell (gamete) fusion and genome reduction through meiosis. My lab has been using the yeast sexual reproduction pathway to study how cells polarize to find a mate and mount a fusion reaction. In the fission yeast Schizosaccharomyces pombe\, sexual reproduction occurs between P and M cells\, which communicate through pheromone-GPCR-MAPK signaling\, driving the formation of cell pairs. Transition from gametes to zygote involves local cell wall digestion at the point of gamete contact\, while preserving cell integrity. We have shown that cell-cell fusion requires the actin fusion focus\, an aster-like assembly of linear actin filaments assembled by the formin Fus1\, which concentrates both signaling molecules and secretory vesicles carrying cell wall digestion enyzmes. I will present our recent work on the molecular mechanisms of formation of the actin fusion focus\, which require both formation of a formin biomolecular condensate and cytoskeletal focusing through formin-myosin feedback. I will also describe our progress in understanding the roles of local MAPK and PAK signaling for cells to pierce their cell wall once and only once.
URL:https://www.ijm.fr/event/institut-jacques-monod-lecture-sophie-g-martin/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/WP-IJM-Lectures-Sophie-Martin-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250211T114500
DTEND;TZID=Europe/Paris:20250211T130000
DTSTAMP:20260425T011959
CREATED:20241223T131853Z
LAST-MODIFIED:20241223T131853Z
UID:26288-1739274300-1739278800@www.ijm.fr
SUMMARY:Institut Jacques Monod  lectures- Richard Benton
DESCRIPTION:On Tuesday\, February 11th\, Richard Benton (Center for Integrative Genomics\, University of Lausanne) will present an Institut Jacques Monod lectures on the theme: \nFatal chemosensation\, and how insects fight back \n  \nAbstract: \nInsecticide resistance is a widespread challenge for the management of vectors transmitting pathogens and agricultural pests\, requiring a better understanding of the genetic mechanisms underlying the evolution of resistance. Drosophila sechellia is a compelling model for such studies as it naturally evolved resistance to octanoic acid\, an abundant chemical of its noni fruit host that is toxic for other insects\, including close relatives D. simulans and D. melanogaster. We have used a multi-pronged strategy to identify genes contributing to octanoic acid resistance. We began by experimentally-evolving D. simulans strains with higher tolerance to octanoic acid and determined the resulting genetic architecture. To identify specific candidate genes\, we integrated this analysis with a genome-wide association study of octanoic acid resistance in D. simulans and a genome-wide CRISPR selection screen upon octanoic acid exposure in D. melanogaster S2R+ cultured cells. We identified four candidates\, with diverse predicted molecular and expression properties\, and validated their relevance using genetic analyses in D. melanogaster. Two of these genes displayed an increased expression in the experimentally-evolved strains\, paralleling their higher levels of expression in D. sechellia. Our results suggest an adaptive role of these genes in shaping toxin resistance both under laboratory conditions and during D. sechellia’s evolutionary history.
URL:https://www.ijm.fr/event/institut-jacques-monod-lectures-richard-benton/?lang=en
LOCATION:Bâtiment Condorcet Amphithéâtre Pierre Gilles de Gennes\, 4 rue Elsa Morante\, Paris\, Sélectionner un État :\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/WP-IJM-Lectures-Richard-Benton-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250212T140000
DTEND;TZID=Europe/Paris:20250212T150000
DTSTAMP:20260425T011959
CREATED:20250127T140538Z
LAST-MODIFIED:20250127T140538Z
UID:26833-1739368800-1739372400@www.ijm.fr
SUMMARY:Seminar - Felix Ruhnow
DESCRIPTION:Invited by the Centre for Genomic Regulation\, Felix Ruhnow will present a seminar on the theme: \nNuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends \n  \nAbstract: \nNuclear mitotic apparatus protein (NuMA) is indispensable for the mitotic functions of the major microtubule minus-end directed motor cytoplasmic dynein 1. NuMA and dynein are both essential for correct spindle pole organization. How these proteins cooperate to gather microtubule minus ends at spindle poles remains unclear. Here we use microscopy-based in vitro reconstitutions to demonstrate that NuMA is a dynein adaptor\, activating processive dynein motility together with dynein’s cofactors dynactin and Lissencephaly-1 (Lis1). Additionally\, we find that NuMA binds and stabilizes microtubule minus ends\, allowing dynein/dynactin/NuMA. to transport microtubule minus ends as cargo to other minus ends. We further show that the microtubule-nucleating γ-tubulin ring complex (γTuRC) hinders NuMA binding and that NuMA can only cap minus ends of γTuRC-nucleated microtubules after γTuRC release. These results provide new mechanistic insight into how dynein\, dynactin\, NuMA\, Lis1 together with γTuRC and uncapping proteins cooperate to organize spindle poles in cells.
URL:https://www.ijm.fr/event/seminar-felix-ruhnow/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/Bandeau-web-seminar-2-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250214T114500
DTEND;TZID=Europe/Paris:20250214T130000
DTSTAMP:20260425T011959
CREATED:20241217T133040Z
LAST-MODIFIED:20241217T133040Z
UID:26236-1739533500-1739538000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Peter Andolfatto
DESCRIPTION:Invited by the Courtier\, Peter Andolfatto (Professor\, Dept. of Biological Sciences\, Columbia University) will present an Institut Jacques Monod seminar on the theme: \nThe evolution of toxin-resistant Na+\,K+-ATPases: new insights from frogs and fireflies  \n  \nWe study the process of adaptive evolution through the lens of repeated adaptation of many distantly species to a similar selection pressure (i.e. “parallel evolution”). Over the past decade\, we have explored patterns of adaptation in the context of animals that have specialized in eating plants\, or other animals\, that contain toxic cardiotonic steroids (CTS). CTS are toxic to animals because they inhibit sodium-potassium ATPase\, a key enzyme in animals needed in everything from maintaining cell homeostasis\, muscle contraction to neuron activity. Here I review our most recent work combining comparative molecular evolution\, molecular and biochemical assays and in vivo engineering of Drosophila to deduce the rules governing the adaptive evolution of CTS resistance in animals. Together\, our results have interesting implications for how epistasis and pleiotropy both limit the rate of adaptive protein evolution and increase its predictability.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-peter-andolfatto/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/Bandeau-web-seminar-Peter-Andolfatto-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250219T093000
DTEND;TZID=Europe/Paris:20250219T110000
DTSTAMP:20260425T011959
CREATED:20250205T110041Z
LAST-MODIFIED:20250205T110041Z
UID:27113-1739957400-1739962800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\, February 19th: \n\nRayane Dibsy (post-doc\, A. Echard’s Lab\, Institut Pasteur présentera  «  The proteasome promotes cytokinetic abscission by relieving Aurora B kinase-mediated inhibition of ESCRT-III turnover. »\nJonathan Fouchard ( Researcher\, Laboratoire de Biologie du Développement\, IBPS) présentera ‘Three-dimensional cell shape\, focal adhesions and vimentin during spreading’
URL:https://www.ijm.fr/event/cytoskeleton-club-4/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/02/20250219bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250224T114500
DTEND;TZID=Europe/Paris:20250224T130000
DTSTAMP:20260425T011959
CREATED:20250128T140351Z
LAST-MODIFIED:20250214T094643Z
UID:26858-1740397500-1740402000@www.ijm.fr
SUMMARY:[Cancelled] Institut Jacques Monod Seminars - Marla Sokolowski
DESCRIPTION:This seminar is cancelled.\n  \nInvited by the par l’équipe Courtier\, Marla Sokolowski (Department of Ecology and Evolutionary Biology\, University of Toronto) will present an Institut Jacques Monod Seminar on the theme: \nThe foraging gene: will that be for here or to go? \nAbstract: \nThe Drosophila melanogaster foraging (for) gene\, with its rover and sitter larval foraging variants\, is an established behaviour genetics model. Orthologues of the foraging gene also modulate the individual and social behaviour of a wide range of species including the regulation of behaviour in eusocial insects. In Drosophila\, foraging modifies the expression of multiple traits\, including feeding and foraging\, stress tolerance\, sleep\, metabolism\, dispersal\, escape responses\, social behaviour\, and learning and memory. From a social context perspective\, Drosophila foraging affects larval clustering during foraging under high larval densities\, adult social behaviour and social networks\, and social learning. We wondered how foraging accomplishes its behavioural pleiotropy at the molecular level. We found that D. melanogaster foraging has a complex modular genomic structure with four promoters\, 21 transcripts\, and eight protein isoforms. The four promoter modules are differentially regulated during development and in a timescale\, tissue\, and cell-type dependent manner. Two examples illustrate these findings: the epigenetic regulation of the adult rover-sitter foraging-related phenotypes by G9a\, a histone methyltransferase\, and the regulation of differences in the latency of rover compared to sitter larval escape responses to noxious stimuli such as parasitoid wasps. Our work provides a nuanced picture of the molecular basis of foraging’s pleiotropy.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-marla-sokolowski/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/Bandeau-web-seminar-Marla-Sokolowski-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250225T114500
DTEND;TZID=Europe/Paris:20250225T130000
DTSTAMP:20260425T011959
CREATED:20250123T141141Z
LAST-MODIFIED:20250123T141141Z
UID:26792-1740483900-1740488400@www.ijm.fr
SUMMARY:Paris Postdoc Seminar - Nathaniel Henneman
DESCRIPTION:Invited by the Institut Jacques Monod\, Nathaniel Henneman (team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM)) will present a Paris Postdoc Seminar on the theme: \nNuclear functions of nutrient sensing signaling for metabolic adaptation \n  \nIntroduction & abstract: \nI am a Postdoc in the team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM). I graduated from Bates College (USA) in 2016\, majoring in Biology. I then spent two years working on retinal degeneration at Emory University before obtaining my master’s degree at University of Paris Descartes in 2019 and defended my PhD in December 2023. \nOne of the key questions I am to address in my work is how cellular metabolism\, gene expression and transcription\, are all coordinated. Energy stress in fasting is managed by activating autophagy and promoting the transcriptional remodeling of metabolism. Cytosolic nutrient sensors coordinate extracellular nutrient availability with intracellular metabolic processes to allow for cell survival. Class 3 PI3K is a highly conserved nutrient sensor known to regulate autophagy and endocytosis in response to varying nutrient conditions. It’s direct role in transcription\, however\, was only suggested in few studies in yeast and plants. However\, we believe there is a nuclear pool of class 3 PI3K that directly regulates gene expression for metabolic adaptation. My work aims to address this unmet burden in the field. We find that nuclear class 3 PI3K regulates the transcriptional response to nutrient stress by controlling RNA Polymerase II\, the Set1/COMPASS methyltransferase\, and nuclear methionine to SAM flux. I aim to understand how these players are needed for our fasting adaptation and how these mechanisms could affect our metabolic resilience.
URL:https://www.ijm.fr/event/paris-postdoc-seminar-nathaniel-henneman/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/20250225-Nathaniel-Hennman-web-scaled.jpg
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