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X-ORIGINAL-URL:https://www.ijm.fr/?lang=en
X-WR-CALDESC:Events for Institut Jacques Monod
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TZID:Europe/Paris
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241009T093000
DTEND;TZID=Europe/Paris:20241009T103000
DTSTAMP:20260425T092446
CREATED:20240930T132744Z
LAST-MODIFIED:20240930T132744Z
UID:25032-1728466200-1728469800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on October 9th at the Institut Jacques Monod. \nDuring this meeting\, \n\nArya Krishnan (PhD student\, Janke’s team\, Institute Curie) will present “Tubulin Code: Generating recognition patterns to selectively direct Microtubule-Associated Proteins »\nArtem Fokin (post-doc\, Gautreau’s team\, Ecole Polytechnique) will present “Identification of Novel Coordinators of Collective Cell Migration »
URL:https://www.ijm.fr/event/cytoskeleton-club/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/20241009-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241011T114500
DTEND;TZID=Europe/Paris:20241011T130000
DTSTAMP:20260425T092446
CREATED:20240909T092859Z
LAST-MODIFIED:20240909T092859Z
UID:24024-1728647100-1728651600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Peter Bieling
DESCRIPTION:Invited by the Romet-Lemonne/Jégou Lab\, Peter Bieling (Max Planck Institute of Molecular Physiology\, Dortmund) présentera un séminaire de l’Institut Jacques Monod sur le thème : \nThe end in sight – an in-depth perspective on actin filament dynamics \n  \nAbstract: \nAll eukaryotic cells actively establish and change their shape through a spatially diversified actin cytoskeleton. The ends of actin filaments have emerged as important regulatory sites\, to which a diverse set of regulators bind to control cytoskeleton dynamics. Recently\, we have overcome the biophysical challenges associated with generating uniform populations of short actin filaments. This paved the way for the structural characterization of filament ends not only on their own\, but also in complex with small molecule drugs and actin end-binding proteins. First\, this allowed us to identify the mechanism underlying the biochemical aging of actin subunits after their incorporation into the filament.  Second\, it enabled us to understand at the molecular level how a diversity of regulatory factors controls the speed of subunit addition and loss at the end of actin filaments. \n 
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-peter-bieling/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/Bandeau-web-seminar-Peter-Bieling-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241011T140000
DTEND;TZID=Europe/Paris:20241011T170000
DTSTAMP:20260425T092446
CREATED:20240930T085857Z
LAST-MODIFIED:20240930T085857Z
UID:25020-1728655200-1728666000@www.ijm.fr
SUMMARY:Thesis defense - Louis Laurent
DESCRIPTION:Louis LAURENT (Borghi Lab) will defend his thesis: \nMechanisms of cell density sensitivity in an epithelium by focal adhesions \n  \nThe defens will be held on Friday\, October 11\, 2024 at 2pm in the François Jacob room at the Institut Jacques Monod.(15 rue Hélène Brion\, 75013\, Paris). \nThe defense will be conducted in French.
URL:https://www.ijm.fr/event/thesis-defense-louis-laurent/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/These-bandeau-Louis-LAURENT-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241018T114500
DTEND;TZID=Europe/Paris:20241018T130000
DTSTAMP:20260425T092446
CREATED:20240903T120506Z
LAST-MODIFIED:20240903T120506Z
UID:23814-1729251900-1729256400@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Till Bartke
DESCRIPTION:Invited by the Duharcourt Lab\, Till Bartke (Institute of Functional Epigenetics – Helmholtz Zentrum München) will present an Institut Jacques Monod Seminars on the theme: \nDecoding chromatin states by proteomic profiling of modification-dependent nucleosome readers \n  \nAbstract: \nDNA and histone modifications combine into characteristic patterns that demarcate functional regions of the genome. While many “readers” of individual modifications have been described\, how composite modification signatures\, histone variants\, and inter-nucleosomal linkers are interpreted by the epigenetic machinery is still an open question. To obtain a comprehensive understanding of how chromatin readers decode complex chromatin states we have created a library of around 80 modified di-nucleosomes representing promoter\, enhancer\, and heterochromatin states using chemical biology approaches. We have used these di-nucleosomes in SILAC and label-free nucleosome affinity purifications to profile the interactions of ~2000 nuclear proteins with the different modification states by quantitative proteomics. Systematic quantification of their binding to the differently modified di-nucleosomes using tailored computational analysis methods has enabled us to predict modification features recognised by several hundred chromatin readers and to identify networks of co-regulated proteins\, thereby allowing us to describe complex chromatin modification read-outs at a large scale. Apart from highly distinctive binding responses to different modification features\, we find that many factors recognise multiple features and that nucleosomal modifications and linker DNA operate largely independently in recruiting proteins to chromatin. To make the data easily accessible\, we have developed the interactive online resource MARCS (the ‘Modification Atlas of Regulation by Chromatin States’) which provides computational tools to analyse and visualise the data. Our results bridge the gap between chromatin states and chromatin readers\, and through MARCS we provide a valuable information source to the community to further advance the discovery of fundamental principles of genome regulation. \n  \nBiosketch – Till Bartke \nTill Bartke is the Deputy Director of the Institute of Functional Epigenetics (IFE) at Helmholtz Munich (Germany). He has a long-standing interest in the epigenetic regulation of chromatin by chemical modifications of histone proteins and the DNA. After completing his PhD at the Max Planck Institute of Biochemistry in Martinsried (Germany) under the supervision of Stefan Jentsch and postdoctoral research with Tony Kouzarides at the Gurdon Institute at the University of Cambridge (UK)\, Till established his own group at the MRC Laboratory of Medical Sciences\, Imperial College London (UK). He joined the IFE as Deputy Director in April 2017. Till’s research combines chemical biology\, quantitative proteomics\, genomics\, and computational approaches to investigate the cellular functions of readers of complex epigenetic modification signatures at molecular and systems-wide scales. \n 
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-till-bartke/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/Bandeau-web-seminar-Till-Bartke-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241018T140000
DTEND;TZID=Europe/Paris:20241018T170000
DTSTAMP:20260425T092446
CREATED:20240923T125438Z
LAST-MODIFIED:20240923T125726Z
UID:24175-1729260000-1729270800@www.ijm.fr
SUMMARY:Thesis defense - Lina-Marie Briu
DESCRIPTION:Lina-Marie BRIU (Cadoret Lab) will defend her thesis: \nMolecular functions of PARylation on the dynamics of DNA Replication \nThis will take place on Friday\, October 18th\, at 2PM in the François Jacob room of the Institute Jacques Monod (15 rue Hélène Brion\, 75013\, Paris). \nThe defense will be held in French. The jury will be composed of: \n\nFrançoise DANTZER\, DR\, Université de Strasbourg\, Rapportrice\nFilippo ROSSELLI\, DR\, Université Paris-Saclay\, Rapporteur\nPatricia KANNOUCHE\, DR\, Université Paris-Saclay\, Examinatrice\nCyril RIBEYRE\, CR-HDR\, Université de Montpellier\, Examinateur\nSébastien HUET\, Professeur\, Université de Rennes\, Examinateur\nJean-Charles CADORET\, Professeur\, Université Paris-Cité\, Directeur de thèse
URL:https://www.ijm.fr/event/thesis-defense-lina-marie-briu/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/These-bandeau-Lina-Marie-BRIU-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241022T114500
DTEND;TZID=Europe/Paris:20241022T130000
DTSTAMP:20260425T092447
CREATED:20240930T091132Z
LAST-MODIFIED:20240930T091132Z
UID:25027-1729597500-1729602000@www.ijm.fr
SUMMARY:Paris Postdoc Seminars - Alexandre Garneau
DESCRIPTION:Invited by the Institut Jacques Monod\, Alexandre Garneau (Université Paris Cité\, INSERM U1151\, Institut Necker-Enfants Malades\, Paris\, France) will present an Paris Postdoc Seminars on the theme: \nImpact of the AKT2E17K gain-of-function mutation in mouse models \n  \nAbstract \nAlexandre obtained a PhD in Physical activity sciences from Université de Montréal (Canada) in 2022. During his doctoral studies under the cosupervision of cardiovascular physiologist Julie L. Lavoie (CHUM Research Center) and nephrologist Dr. Paul Isenring (L’Hôtel-Dieu de Québec Research Center)\, he investigated the cardiovascular and metabolic phenotype displayed by a mouse model of neuropathy which was knocked out for the ion transporter KCC3. He also conducted an internship at Vanderbilt University (Nashville\, USA) under the supervision of Prof. Eric Delpire in order to characterize a corresponding gain-of-function mouse model. \nAlexandre joined Dr. Guillaume Canaud’s team in April 2022 as a postdoctoral researcher to study the role of AKT2 in metabolic and cellular physiology. His interest is focused particularly on the implication of AKT2 in energy metabolism and cell survival. He will present his data obtained using systemic and tissue-specific inducible mouse models expressing a gain-of-function variant found in humans.
URL:https://www.ijm.fr/event/paris-postdoc-seminars-alexandre-garneau/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/20241022-Alexander-Garneau-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241022T160000
DTEND;TZID=Europe/Paris:20241022T173000
DTSTAMP:20260425T092447
CREATED:20240923T134507Z
LAST-MODIFIED:20240923T134507Z
UID:24183-1729612800-1729618200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Kelly G. Ten Hagen
DESCRIPTION:Invited by the Courtier Lab\, Kelly G. Ten Hagen (Senior Investigator and Chief\, Developmental Glycobiology Section\, Associate Scientific Director for Diversity\, Equity\, Inclusion and Accessibility\, National Institute of Dental and Craniofacial Research\, National Institutes of Health\, USA) présentera un Séminaire de l’Institut Jacques Monod sur le thème : \nMucins and O-glycosylation in Health and Disease \n  \nAbstract: \nMucins are evolutionarily conserved transmembrane and extracellular matrix molecules that mediate cell communication and signaling events\, and also serve as a protective barrier on the external surface of cells.  Many of the unique functional properties of mucins are due to the abundant O-linked glycans present. Defects in mucin-type O-linked glycosylation are responsible for a number of diseases and are also associated with tumor progression and metastasis; HDL-cholesterol and triglyceride levels; congenital defects; and bone mineral density alterations.  Our research investigates the role of this conserved protein modification in normal organ development and function to gain a mechanistic understanding of how alterations in O-glycosylation and mucin biosynthesis contribute to disease susceptibility and progression.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-kelly-g-ten-hagen/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/Bandeau-web-seminar-Kelly-Hagen-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241025T114500
DTEND;TZID=Europe/Paris:20241025T130000
DTSTAMP:20260425T092447
CREATED:20240924T073417Z
LAST-MODIFIED:20240924T073417Z
UID:24188-1729856700-1729861200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Joël Lemière
DESCRIPTION:Invited by the Romet-Lemonne / Jégou Lab\, Joël Lemière (Assistant Researcher in the Department of Cell and Tissue Biology at UCSF\, San Francisco\, USA) will present an Institut Jacques Monod Seminars on the theme: \nOsmotic control of nuclear size and the N/C ratio in fission yeast \nAbstract: \nThe size of the nucleus scales robustly with cell size so that the nuclear-to-cell volume ratio (N/C ratio) is typically maintained as a constant in many cell types. Previous studies show that the N/C ratio is not determined merely by the amount of DNA but is influenced by nuclear envelope transport and mechanics. We recently developed a quantitative model for nuclear size control based upon a balance of colloid osmotic pressures in the nucleoplasm and cytoplasm. This model posits that the N/C ratio is determined by the numbers of macromolecules in the nucleoplasm and cytoplasm as well as the nuclear envelope membrane tension. \nIn the fission yeast S. pombe\, the nucleus behaves as an ideal osmometer whose volume is primarily dictated by osmotic forces\, with no detectable contribution of membrane tension. Thus\, we predict that the key determinants of nuclear size in fission yeast are simply the numbers of macromolecules in the nucleoplasm and cytoplasm. Here\, to test this model\, we quantified the effects of massive overexpression (~10^7molecules) of exogenous proteins targeted to either the nucleus or the cytoplasm. In both cases\, the resulting N/C ratio quantitatively aligned with our model’s prediction. We have thus developed a tunable system for altering the N/C ratio by overexpression of a single exogenous protein. These data provide critical quantitative support for the osmotic model for nuclear size control.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-joel-lemiere/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/Bandeau-web-seminar-Joel-Lemiere-scaled.jpg
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