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DTSTART;TZID=Europe/Paris:20240605T114500
DTEND;TZID=Europe/Paris:20240605T130000
DTSTAMP:20260425T163558
CREATED:20240530T133336Z
LAST-MODIFIED:20240530T133336Z
UID:19204-1717587900-1717592400@www.ijm.fr
SUMMARY:IJM Seminar – Roland Leborgne – 05/07/24
DESCRIPTION:Invited by the Guichet Lab\, Roland Leborgne (Institut de Génétique et Développement de rennes) will present an Institut Jacques Monod on the theme: \nInvestigation the Role of Cadherin and Integrin during Epithelial Cell Rearrangements \n  \nAbstract: \nEpithelia are robust tissues whose mechanical cohesion requires the formation of cell-cell adhesive contacts supported by adherens junctions (AJs)\, mainly composed of E-Cadherin clusters stabilized by actomyosin filaments. The mechanical sealing properties of epithelia are constantly challenged by cell-cell rearrangements that occur during delamination\, intercalation and cell division. During these events\, E-Cadherin contacts are dismantled\, yet neighbor exchange occurs without the tissue tearing apart. The interplay between actomyosin contractility and the remodelling of AJs are proposed to be sufficient to mechanically support these multicellular rearrangements. However\, and unexpectedly\, we discovered that during cell intercalation and cytokinesis in the Drosophila pupal epithelium\, focal adhesions (FAs) containing alpha-\, beta-integrin receptors and Talin\, are transiently assembled at sites of AJ remodeling. AJs and FAs are two main adhesive structures that ensure the formation of robust mechanical contacts enabling the transmission of cytoskeletal force to support changes in cell and tissue shape. Using state-of-the-art genetic\, super-resolution imaging and biophysical approaches\, we propose to study the assembly of FAs\, their connection to actomyosin force generation and their functions during cytokinesis and cell intercalation in invertebrate and vertebrates model systems. Our working hypothesis is that the cleavage furrow ingression at cytokinesis and the junction shrinkage during cell intercalation cause a shear stress that triggers the local dismantling of AJs and\, concomitantly\, the assembly of FAs\, in the plane of AJs. This multidisciplinary proposal will provide a comprehensive understanding of the cooperation and interdependence between cadherin and integrin-mediated intercellular adhesion required to ensure tissue tensional homeostasis. \n  \nThe seminar will take place on Friday\, July 5th at 11.45 am in room François Jacob (15 rue Hélène Brion 75013 Paris)
URL:https://www.ijm.fr/event/ijm-seminar-roland-leborgne-05-07-24/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
CATEGORIES:IJM Seminar
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/05/WP-seminaire-IJM_Roland-Leborgne-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240607T114500
DTEND;TZID=Europe/Paris:20240607T130000
DTSTAMP:20260425T163558
CREATED:20240531T114046Z
LAST-MODIFIED:20240531T114046Z
UID:19235-1717760700-1717765200@www.ijm.fr
SUMMARY:IJM Seminar – Nick Irwin
DESCRIPTION:Invited by the Duharcourt lab\, Nick Irwin (Gregor Mendel Institute\, Vienna BioCenter) will present an Institut Jacques Monod Seminar on the theme: \nSelf-assembling viral histones unravel early nucleosome evolution \n  \nAbstract: \nThe nucleosome is a defining feature of eukarytoes that plays a central role in the coordination and regulation of the genome. Accordingly\, understanding the origin of the nucleosome is essential for interpreting how eukaryotes evolved from prokaryotic ancestors. The strong conservation of the nucleosome and its histone constituents makes reconstructing nucleosome evolution challenging\, but divergent histone homologues found in large double stranded DNA viruses could provide a new perspective for interpreting the evolution of this complex. By surveying viral diversity\, we identified hundreds of viral histones with unique protein architectures\, including histone quadruplets which comprise the four core histones linked in series. These viral histones branch phylogenetically between Archaea and eukaryotes and display intermediate structural and functional characteristics\, self-assembling into eukaryotic-like nucleosomes that stack into archaeal-like oligomers. Finally\, we demonstrate how histone linkage can facilitate nucleosome assembly\, permitting the formation of animal nucleosomes in the bacterium Escherichia coli. I will discuss how these data can help us understand not only the origin of viral histones\, but lead to an empirically based hypothesis for the origin of the nucleosome.
URL:https://www.ijm.fr/event/ijm-seminar-nick-irwin/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
CATEGORIES:IJM Seminar
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/05/WP-IJM-seminars_Nick-Irwin-scaled.jpg
ORGANIZER;CN="Institut Jacques Monod - Duharcourt Lab":MAILTO:sandra.duharcourt@ijm.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240614T114500
DTEND;TZID=Europe/Paris:20240614T130000
DTSTAMP:20260425T163558
CREATED:20240531T115734Z
LAST-MODIFIED:20240531T115734Z
UID:19246-1718365500-1718370000@www.ijm.fr
SUMMARY:IJM Seminar – Olivia de Roure
DESCRIPTION:Invited by the Ladoux/Mège\, Olivia Du Roure (Laboratoire PMMH ESPCI Paris PSL) will present an Institut Jacques Monod Seminar on the theme: \nDynamics and mechanics of the cortex of living cells \nAbstract: \nThe cell cortex is a contractile actin meshwork located below the plasma membrane\, which determines cell shape and is instrumental for cell mechanics\, migration and division. Because the cortical thickness is below optical resolution\, it has been generally considered as a thin uniform elastic and contractile layer. Using two mutually attracted magnetic beads\, one inside the cell and the other in the extracellular medium\, the cortex of live cells can be pinched to probe its physical properties. Accurate and time resolved measure of the thickness of cell cortex revealed a new picture of this structure as highly dynamic\, harboring large fluctuations in its third dimension due to actomyosin contractility. We propose that this cortex dynamics plays an essential role in the fast shape changing capacity of highly contractile cells that use amoeboid-like migration. Cortex mechanics is currently studied\, showing interesting non linear behavior that seems to be linked to myosin II motors activity.
URL:https://www.ijm.fr/event/ijm-seminar-olivia-de-roure/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
CATEGORIES:IJM Seminar
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/05/WP-seminaire-IJM_Olivia-Du-Roure-scaled.jpg
ORGANIZER;CN="Institut Jacques Monod - Beno%C3%AEt Ladoux":MAILTO:benoit.ladoux@ijm.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240618T114500
DTEND;TZID=Europe/Paris:20240618T130000
DTSTAMP:20260425T163558
CREATED:20240531T095436Z
LAST-MODIFIED:20240531T095436Z
UID:19226-1718711100-1718715600@www.ijm.fr
SUMMARY:IJM Seminar – Matthias Peter
DESCRIPTION:On June\, Tuesday 18th\, the Labex WHO AM I? invites Professor Matthias Peter (Institute of Biochemistry\, ETH Zurich) to present an IJM Seminar on the theme: \nUbiquitin tails \n  \nAbstract: \nWe are interested in the function of E3-ubiquitin ligases orchestrating diverse cellular processes. For many years\, we characterized the regulation and function of Cullin-RING E3 ligases (CRLs)\, which comprise the largest family of RING-based E3 ubiquitin ligases and catalyze approximately 20% of all ubiquitination reactions leading to proteasomal degradation. In this exposé\, I will first summarize our recent attempts to understand specific functions of CUL4B-complexes\, which are associated with X-linked intellectual disability (XLID). If time (and you..) permit/s\, I will then discuss human CTLH/GID (hGID) E3 ligase complexes\, which regulate G1 progression\, mainly through their substrate-receptors Gid4 and Gid7/Wdr26. Using biochemical and cellular assays\, we identified cognate hGID substrates involved in cell cycle progression\, cell migration and metabolism.
URL:https://www.ijm.fr/event/ijm-seminar-matthias-peter/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
CATEGORIES:IJM Seminar
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/05/WP-seminaire-IJM_Matthias-Peter-scaled.jpg
ORGANIZER;CN="Labex WHO AM I?":MAILTO:lionel.pintard@ijm.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240619T180000
DTEND;TZID=Europe/Paris:20240619T193000
DTSTAMP:20260425T163558
CREATED:20240531T120202Z
LAST-MODIFIED:20240531T120202Z
UID:19251-1718820000-1718825400@www.ijm.fr
SUMMARY:LSC Lecture – Lera Boroditsky
DESCRIPTION:Life\, Structure and Cognition 2024 – A multitude of times\n  \nAs part of the “Life Structure and Cognition 2024 : A multitude of times” meeting\,  Lera Boroditsky (University of California\, San Diego)\, Professor of sciences cognition will present the conference « How languages and cultures construct time » on June\, 19th at 6pm in Buffon amphitheater. \n  \n“How do we think about time? On the one hand\, time is abstract: we cannot smell time\, we cannot taste time\, we cannot see it or touch it with our hands. On the other hand\, time forms the very fabric of our experience; we can’t experience anything outside of time. So how do we construct our understanding of this fundamental domain? And how do we even go beyond and invent fanciful notions like time-travel? I will show how languages and cultures allow us to build complex representations of time that go way beyond what we can experience. Because languages differ\, humans around the world think about time in remarkably different ways\, with culturally-based notions of time deeply embedded in the organization of our brains.” \n  \nThe lecture is free\, but registration is mandatory by June 2nd\, 2024 at : https://www.eventbrite.com/e/life-structure-and-cognition-2024-lera-boroditsky-tickets-894263926477 \n  \nThe 2024 edition of the LSC Meeting\, “A Multitude of Times\,” will focus on time and its declinations within social\, biological\, and physical systems. The scope of this in-person 4 day-long meeting is to bring together scientists from the LSC Committee with invited experts and the IHES scientists to present the latest progress in understanding time as a multifaceted concept and its many implications on different aspects of life. The idea is to fuel discussions\, brainstorm\, and explore alternative paths toward understanding how the multitude of ways we can conceive time contribute together to the richness of Biology and Cognitive processes. \nMore informations about the meeting: https://indico.math.cnrs.fr/event/11509/overview \n  \nSpeakers:\nLera Boroditsky\, Relationships between mind\, world and language (UC San Diego\, US)\nJulien d’Huy\, Evolution and spreading of myths (Collège de France\, FR)\nMargarete Diaz Cuadros\, Species-specific developmental rates (Massachusetts General Hospital & Harvard University\, US)\nLeon Peshkin\, Aging clocks (Harvard Medical School\, US)\nJoe Thornton\, Molecular mechanisms of evolution (University of Chicago\, US)\nWarrick Roseboom\, Time perception\, perceived causality\, and memory (University of Sussex\, UK) \nOrganization: \n\nYves Barral\, ETH Zurich\nEugene Koonin\, NIH\nMikhail Gromov\, IHES/Univ. Paris-Saclay & NYU\nNicolas Minc\, Univ. Paris Cité/CNRS\nPierre-Yves Oudeyer\, INRIA Bordeaux\nBob Penner\, IHES/Univ. Paris-Saclay & UCLA\nYukiko Yamashita\, MIT\n\nExecutive organization: Grazia Gonella\, ETH Zurich\ncontact: lsc@biol.ethz.ch
URL:https://www.ijm.fr/event/lsc-lecture-lera-boroditsky/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/05/image-bandeau-WP-scaled.jpg
ORGANIZER;CN="ETH Zurich & IHES":MAILTO:lsc@biol.ethz.ch
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240620T150000
DTEND;TZID=Europe/Paris:20240620T160000
DTSTAMP:20260425T163558
CREATED:20240612T141441Z
LAST-MODIFIED:20240612T141441Z
UID:19399-1718895600-1718899200@www.ijm.fr
SUMMARY:IJM Seminar - Vincent Laudet
DESCRIPTION:Invited by the Courtier\, Vincent Laudet (Eco-Evo-Devo Unit\, Okinawa Institute of Science and Technology\, Japan / Institute of Cellular and Organismic Biology\, Academia Sinica\, Taiwan. CNRS IRL 2028 “Eco-Evo-Devo of Coral Reef Fish Life Cycle” (EARLY) ) will present an Institut Jacques Monod Seminar on the theme: \nClownfishes: New models for Eco-Evo-Devo \n  \nAbstract: \nClownfishes are becoming relevant marine models in developmental biology and evolutionary sciences. A large amount of knowledge has been gathered on these iconic fish by ecological labs that have characterized their ecology\, diversity\, pigmentation\, behavior and complex interactions. We are now scrutinizing the molecular and developmental basis of all these features. In my labs we are developing the clownfish Amphiprion ocellaris as an experimental laboratory model and we benefit also from the presence of 6 different species of anemonefishes around Okinawa. Clownfish are suitable as a functional lab models on which experimental approaches can be performed. Because they live in highly structured social group in sea anemone\, they allow tackling a series of scientific questions such as the formation and functions of pigment patterns\, the social control of growth\, sex change or the molecular basis of symbiosis. But clownfish are also allowed to analyze larval recruitment\, local adaptation and the effect of climate change and pollution on the reef ecosystem. I will present these models mainly focusing on their life history strategy and how hormones control their plastic response to environment. \nMore generally what we are doing on clownfish can also be done with other coral reef fish or marine organisms living in Okinawa. This is why to promote exchange and collaboration between OIST and CNRS units we have set up an “International Research Laboratory” called EARLY (“An Eco-Evo-Devo perspective on corAl Reef fishes Life cYcle.”) that is a flexible and reactive platform to promote collaborations.
URL:https://www.ijm.fr/event/ijm-seminar-vincent-laudet/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
CATEGORIES:IJM Seminar
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/06/WP-IJM-seminars_Vincent-Laudet-scaled.jpg
ORGANIZER;CN="IJM Courtier":MAILTO:virginie.courtier@ijm.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240621T114500
DTEND;TZID=Europe/Paris:20240621T130000
DTSTAMP:20260425T163558
CREATED:20240531T113732Z
LAST-MODIFIED:20240531T113732Z
UID:19232-1718970300-1718974800@www.ijm.fr
SUMMARY:IJM Seminar – Ezzat El-Sherif
DESCRIPTION:Invited by the Konstantinides\, Ezzat El-Sherif (School of Integrative Biological and Chemical Sciences\, University of Texas Rio Grande Valley\, Edinburg\, Texas\, US) will present an Institut Jacques Monod Seminar on the theme: \nHow enhancers translate time into space during development \n  \nAbstract: \nIn embryonic development\, is time more important or space? Conventionally\, the answer would be: Both! However\, recent studies on various embryonic tissues emphasize the primacy of time\, showing that spatial gene expressions often stem from converting temporal gene sequences\, both periodic and non-periodic\, into spatial patterns. This phenomenon has been proposed (by my work and others’) to result from the modulation of embryonic timing by morphogen gradients. Yet\, the specific molecular mechanisms through which morphogen gradients modulate developmental timing remain unknown. In our work\, we used the Anterior-Posterior patterning of the short-germ beetle Tribolium as a model to explore how developmental timing is modulated at the enhancer level. We first developed a predictive system to identify Tribolium enhancers\, using time- and tissue-specific ATAC-seq. We then developed a live enhancer reporter system utilizing MS2 tagging. This methodology allowed us to discover several Tribolium enhancers and to investigate the spatiotemporal dynamics of select enhancers in live embryos. Our findings suggest a model in which embryonic timing is regulated by a balance between two types of enhancers: ‘dynamic enhancers\,’ which prompt rapid changes in gene expression\, and ‘static enhancers\,’ which contribute to the stabilization of gene expression patterns.
URL:https://www.ijm.fr/event/ijm-seminar-ezzat-el-sherif/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
CATEGORIES:IJM Seminar
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/05/WP-IJM-seminars_Ezzat-El-Sherif-scaled.jpg
ORGANIZER;CN="Institut Jacques Monod - Konstantinides Lab":MAILTO:nikos.konstantinides@ijm.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240628T114500
DTEND;TZID=Europe/Paris:20240628T130000
DTSTAMP:20260425T163558
CREATED:20240531T094931Z
LAST-MODIFIED:20240625T094519Z
UID:19220-1719575100-1719579600@www.ijm.fr
SUMMARY:[Cancelled] IJM Seminar – Gaëlle Legube
DESCRIPTION:The seminar is cancelled\nInvited by par the Duharcourt\, Gaëlle Legube (CBI\, Toulouse) will present an Institut Jacques Monod seminar on the theme: \nChromosome and chromatin dynamics at DNA double strand breaks \n  \nAbstract: \nDNA double-strand breaks (DSBs) are highly toxic lesions that are rapidly repaired by two main pathways\, namely Homologous Recombination (HR) and Non Homologous End Joining (NHEJ). Using a cell line\, called DIvA (for DSB Inducible via AsiSI)\, where multiples breaks are induced at annotated positions\, combined with genome-wide\, high throughput sequencing based techniques (ChIP-seq\, HiC…) we investigate the contribution of chromatin and chromosome conformation in the response to DSB. I will present our recent work\, on the contribution of chromatin and Topologically Associating Domains (TADs) during DSB repair. More specifically we recently demonstrated the role of cohesin-mediated loop extrusion in establishing gammaH2AX on an entire TAD in cis to DSBs. We now provide evidence that when established\, gammaH2AX “tagged” TAD further self-segregate in the nucleus\, forming a novel DSB-induced chromatin compartment (the “D” compartment) that contributes to the activation of the DNA damage response
URL:https://www.ijm.fr/event/ijm-seminar-gaelle-legube/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/05/WP-IJM-seminars_Gaelle-Legube-scaled.jpg
ORGANIZER;CN="Institut Jacques Monod - Duharcourt Lab":MAILTO:sandra.duharcourt@ijm.fr
END:VEVENT
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