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X-WR-CALNAME:Institut Jacques Monod
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X-WR-CALDESC:Events for Institut Jacques Monod
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DTSTART;TZID=Europe/Paris:20250711T114500
DTEND;TZID=Europe/Paris:20250711T130000
DTSTAMP:20250612T114114Z
CREATED:20250612T114114Z
LAST-MODIFIED:20250612T114114Z
UID:28409-1752234300-1752238800@www.ijm.fr
SUMMARY:Institut Jacques Monod Lecture - Gijsje Koenderink
DESCRIPTION:On July 11th\, Gijsje Koenderink (Department of Bionanoscience\, Kavli Institute of Nanoscience Delft\, Delft University of Technology) will present an Institut Jacques Monod lecture on the theme: \nHow cytoskeletal crosstalk makes cells strong \nAbstract: \nOur bodies are built up of cells and tissues with unique physical properties. Cells and tissues are dynamic but also need to withstand large mechanical loads. This paradoxical mechanical behavior is governed by fibrous protein scaffolds known as the cytoskeleton and the extracellular matrix. Fibrous networks have many advantageous mechanical properties: fibers can form space-filling elastic networks at low volume fractions and they reversibly stress-stiffen\, which provides protection from damage. However\, it is still poorly understood how biopolymer networks can combine these features with the ability to dynamically adapt their structure and mechanics. In this seminar I will focus on the cytoskeleton: how can the cytoskeleton combine mechanical strength with the ability to dynamically adapt its structure and mechanics? I will summarize our recent insights in this question obtained via quantitative measurements on living cells coupled with experiments on cell-free model systems. I will focus on the role of mechanical crosstalk between the actin\, intermediate filament\, and septin cytoskeletal networkds\, three key determinants of cell mechanics. These three filamentous systems contribute different structural and dynamical properties\, but their activities are closely coordinated. I will show that combining cell and cell-free assays allows us to dissect the collaborative and individual roles of the cytoskeletal systems. Our findings may eventually be interesting to guide the search for selective anticancer drugs\, since cancer cells often overexpress specific intermediate filaments or septins leading to abnormal mechanical behaviors.
URL:https://www.ijm.fr/event/institut-jacques-monod-lecture-gijsje-koenderink/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/06/bandeau-IJM-Lectures-Gijsje-Koenderink-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250708T114500
DTEND;TZID=Europe/Paris:20250708T130000
DTSTAMP:20250603T131610Z
CREATED:20250603T131610Z
LAST-MODIFIED:20250603T131610Z
UID:28329-1751975100-1751979600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Adèle Marston
DESCRIPTION:Invited by the Wassmann lab\, Professor Adele L. Marston (Centre for Cell Biology\, University of Edinburgh) will present an Institut Jacques Monod seminar on the theme: \nFunctional organisation of pericentromeres in mitosis and meiosis \nAbstract: \nOur overall goal is to understand how cells inherit the correct number of chromosomes during mitosis and meiosis. Deviations in chromosome number\, called aneuploidy\, are a hallmark of cancer and cause birth defects\, miscarriages and infertility. Mitosis generates genetically identical daughter cells by evenly segregating the sister chromatids. Meiosis partitions half the genome into gametes through two consecutive segregation events: homologs segregate in meiosis-I\, followed by sister chromatids in meiosis-II. Meiosis is especially error-prone: around 1% of human sperm and up to 30% of oocytes are aneuploid. To discover molecular mechanisms\, we exploit the tractability of yeast\, combined with work in frog\, mouse and human oocytes. Our approach is guided by the research question\, leading to the employment and development of a wide range of cell biological\, genomic\, proteomic and biochemical assays. Our group discovered unanticipated roles for pericentromeres\, discrete chromosomal domains flanking centromeres\, and specialised functions for kinetochores in orienting chromosomes to ensure accurate segregation. In my seminar I will discuss our recent work revealing how pericentromere organization directs accurate chromosome segregation in mitosis and meiosis\, in both yeast and oocytes.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-adele-marston/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/06/Bandeau-web-seminar-Adele-Marston-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250707T080000
DTEND;TZID=Europe/Paris:20250707T140000
DTSTAMP:20250623T134032Z
CREATED:20250623T134032Z
LAST-MODIFIED:20250623T134032Z
UID:28488-1751875200-1751896800@www.ijm.fr
SUMMARY:PhD thesis defense - Safia El Jailani
DESCRIPTION:Safia El Jailani (Wassmann Lab) will defense her PhD thesis on Monday\, July 7th: \nMechanisms ensuring tight control of cohesin cleavage to prevent aneuploidies in oocytes \n  \nThe defense will take place in English in the Alan Turing amphitheater (Bâtiment Sophie Germain) Place Aurélie Nemours\, 75013 Paris). \nThe jury will be composed of: \n\nJulien Dumont\nMarie-Hélène Verlhac\nAdele Marston\nAnthi Karaiskou\nAndreas Boland
URL:https://www.ijm.fr/event/phd-thesis-defense-safia-el-jailani/?lang=en
LOCATION:Amphithéâtre Alan Turing – Bâtiment Sophie Germain\, 8 place Aurélie Nemours\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/06/These-bandeau-Safia-El-Jailani-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250706
DTEND;VALUE=DATE:20250713
DTSTAMP:20250403T140159Z
CREATED:20250121T110058Z
LAST-MODIFIED:20250403T140159Z
UID:26710-1751760000-1752364799@www.ijm.fr
SUMMARY:Mechanobiology Conference III 2025
DESCRIPTION:The conference “Mechanobiology Conference III: From Fundamental Research to Applications” that will be held at the conference center in ICISE Quy Nhon\, central Vietnam on July 06-12\, 2025. Three members of the IJM team\, Benoit Ladoux\, René-Marc Mége and Wang Xi\, are part of the Organizing Committee. \nPlease visit the website or check out the flyer for more information. \nThe registration and abstract submission is now open. Students and postdocs are strongly encouraged to submit their work for oral or poster contributions. A limited number of travel grants for students and postdocs will be considered upon request. \nSome important dates are: \n\n30 April: Deadline for abstract submission.\n23 May: Deadline for early bird registration.\n06 June: Deadline for standard registration.\n\nThe conference will focus on the latest advances in mechanobiology\, with topics including\, but not limited to: \n\n Cell/Molecular signaling\n Disease Development and Biomedical applications\n Morphogenesis and multicellular processes\n Biomaterials/Bioengineering\n Single-cell migration\n Theoretical biophysics\n\nIf you have any further questions\, please do not hesitate to contact: \n\nAdministrative and logistic information: Thao Do\, rencontres.vietnam@gmail.com\nScientific program:  Wang Xi\, wang.xi@ijm.fr and Carles Blanch carles.blanch-mercader@curie.fr
URL:https://www.ijm.fr/event/mechanobiology-conference-iii-2025/?lang=en
LOCATION:ICISE Quy Nhon\, Vietnam\, 7 Đại lộ Khoa học\, khu vực 2\,\, Quy Nhơn\, Bình Định\,\, Viet Nam
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/vietnam-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250623T090000
DTEND;TZID=Europe/Paris:20250623T180000
DTSTAMP:20250520T084255Z
CREATED:20250520T084255Z
LAST-MODIFIED:20250520T084255Z
UID:28194-1750669200-1750701600@www.ijm.fr
SUMMARY:VIP & DIF 2025
DESCRIPTION:Registration for the VIP & DIF Day #5 is open !  \nWhere: Institut Jacques Monod (Amphi  Buffon – 15 rue Hélène Brion – 75013 Paris)\nWhen: Monday 23rd of June 2025. \nThis year\, we will have the pleasure to welcome the two following keynote speakers: \n\n    Maria-Cristina Gambetta\, from University of Lausanne\n\n\n    Alper Akay\, from University of East Anglia\n\nSubmit your Poster or Short Talk abstracts.\nhttps://sites.google.com/view/vipdif/registration-2025 \nParticipation is free but registration is mandatory for everyone.\nDeadline for registration is the 1st of June 2025.
URL:https://www.ijm.fr/event/vip-dif-2025/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/web-image-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250620T114500
DTEND;TZID=Europe/Paris:20250620T130000
DTSTAMP:20250513T094631Z
CREATED:20250513T094631Z
LAST-MODIFIED:20250513T094631Z
UID:28095-1750419900-1750424400@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Carlos Estella
DESCRIPTION:Invited by the Konstantinides Lab\, Carlos Estella (Laboratory of stress response and morphogenesis. Centro de Biología Molecular CSIC-UAM\, Madrid\, Spain) will present an Institut Jacques Monod seminar on the theme: \nA cross talk between p53 and the cell cycle regulates apoptotic induction and tumor formation in Drosophila \nAbstract: \nCell division is essential for tissue regeneration and organismal survival. However\, errors in this process can lead to uncontrolled cell proliferation and cancer. The tumor suppressor gene p53 plays a critical role in maintaining genomic integrity by coordinating cellular responses to stress\, such as DNA damage. These responses include cell cycle arrest\, DNA repair\, senescence\, or apoptosis. Importantly\, how these responses are precisely coordinated to maintain tissue homeostasis remains poorly understood. \nTo address this challenge\, simple genetic models are needed to study the precise regulation of cellular responses triggered by p53 and its role in tumorigenesis. To simplify the study of p53’s functions\, we use Drosophila melanogaster\, which has a single p53 homolog. Drosophila serves as a powerful genetic model due to its highly conserved pathways and sophisticated genetic tools. Notably\, approximately 85% of human cancer-related genes have orthologs in flies. In this seminar I´ll discuss recent work from our laboratory that demonstrated how the cellular context and proliferative status of a cell significantly impact p53’s ability to regulate the various responses triggered by DNA damage. In addition\, I´ll present the tumorigenic potential of p53 when its apoptotic role is inhibited. We find that cells with chronic p53 activity that have inhibited its apoptotic potential acquire a persistent activity of the JNK pathway\, which drives them into a senescent-like status and induce the non-autonomous overgrowth of the surrounding tissue. These results lead us to propose a model in which cell cycle progression and p53 pro-apoptotic activity are molecularly connected to coordinate the appropriate response after DNA damage.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-carlos-estella/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/Bandeau-web-seminar-Carlos-Estella-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250618T093000
DTEND;TZID=Europe/Paris:20250618T110000
DTSTAMP:20250610T115259Z
CREATED:20250610T115259Z
LAST-MODIFIED:20250610T115259Z
UID:28379-1750239000-1750244400@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The las Cytoskeleton club meeting of the 2024-2025 season will take place on Wednesday June 18th. \nDuring this meeting: \n– Julie Homsen (Phd student\, A. Echard’s lab\, Institut Pasteur) will talk about «  GPRC5A is a potential component of the abscission checkpoint preventing premature chromatin bridge breakage »  \n– Baptiste Vauleon (PhD student\, M. Piel’s lab\, Institut Curie/IPPG) will talk about : «  Mechanical polarity of the cortex and single cell morphogenesis ». 
URL:https://www.ijm.fr/event/cytoskeleton-club-8/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/06/20250618-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250613T114500
DTEND;TZID=Europe/Paris:20250613T130000
DTSTAMP:20250515T101058Z
CREATED:20250515T085936Z
LAST-MODIFIED:20250515T101058Z
UID:28136-1749815100-1749819600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Frank Maixner et Sabry Sarhan
DESCRIPTION:Invited by the Grange/Geigl\, Frank Maixner and Sabry Sarhan (Eurac Research – Institute for Mummy Studies\, Bolzano\, Italy) will present an Institut Jacques Monod seminar on theme: \nGenome wide data of a Penicillium roqueforti strain from Iron Age Austria: the oldest molecular evidence for fermented blue cheese. \nAbstract: \nThe application of metagenomic analysis on dated ancient human specimens opens a window into the past that enables scientists to address unique evolutionary research questions. Paleofeces are an important source of information to study the evolution of dietary habits and human health. The UNESCO World Heritage region of Hallstatt-Dachstein/Salzkammergut is one of Europe’s oldest cultural and industrial landscapes; its underground salt mines dating back at least to the 14th century BC are one of the few archaeological sites where paleofeces are well preserved. Here we subjected human paleofeces dated from the Bronze Age to early Modern Times to an in-depth microscopic\, metagenomic and proteomic analysis. This allowed us to reconstruct the diet of the former population and gain insights into their ancient gut microbiome composition. Dietary survey identified a highly fibrous\, carbohydrate-rich diet supplemented with proteins from broad beans and occasionally with fruits\, nuts\, or animal food. Linked to these traditional dietary habits all ancient miners up to the early Modern times have gut microbiome structures akin to modern non-Westernized individuals which may indicate a shift in the gut community composition of modern Westernized populations due to quite recent dietary and lifestyle changes. When we extended our microbial survey to fungi present in the paleofeces\, we observed in one of the Iron Age samples a high abundance of Penicillium roqueforti DNA. Genome-wide analysis placed the ancient P. roqueforti strain into the current non-Roquefort blue cheese diversity next to modern variants from different parts of the Alps (e.g. Termignon). Our findings present the earliest molecular evidence for blue cheese consumption during Iron Age Europe\, which opens a new opportunity to better understand the domestication history of blue cheese fermentation.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-frank-maixner-et-sabry-sarhan/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/Bandeau-web-seminar-Frank-Maixner-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250606T114500
DTEND;TZID=Europe/Paris:20250606T130000
DTSTAMP:20250513T094229Z
CREATED:20250513T093808Z
LAST-MODIFIED:20250513T094229Z
UID:28088-1749210300-1749214800@www.ijm.fr
SUMMARY:Institut Jacques Monod seminar - Aydan Karslioglu
DESCRIPTION:Invited by the Greenberg Lab and the Epigenetic & cell fate\, Aydan Karslioglu (Group Leader\, Max Planck Institute for Molecular Genetics) will present an Institut Jacques Monod seminar on the theme: \nAdjusting the timing of mammalian development \nAbstract: \nOur lab focuses on mechanisms regulating stem cell state transitions and fate commitment. Specifically\, we study how cells communicate signals from their surroundings to the gene expression machinery\, especially in the context of cell fate decisions in development and disease. To delineate principles of stemness\, we use in vitro and in vivo models and probe molecular processes critical for the emergence\, maintenance\, and resolution of stem states in physiological and adverse conditions.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-aydan-karslioglu/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/Bandeau-web-seminar-Aydan-Karslioglu-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250603T114500
DTEND;TZID=Europe/Paris:20250603T130000
DTSTAMP:20250520T130321Z
CREATED:20250520T130321Z
LAST-MODIFIED:20250520T130321Z
UID:28205-1748951100-1748955600@www.ijm.fr
SUMMARY:Seminar - Irene Basili
DESCRIPTION:Invited by the Institut Jacques Monod\, Irene Basili will present a seminar on the theme: \nAMBRA1 controls the Sonic Hedgehog signaling pathway and SHH-medulloblastoma \nAbstract: \nAMBRA1 (Autophagy and Beclin 1 Regulator 1) is primarily recognized as a tumor suppressor\, however its role as a tumor promoter has garnered increasing attention. Here\, leveraging clinical data of an international multi-omic medulloblastoma (MB) cohort\, we identified that elevated AMBRA1 protein levels\, independently of its mRNA expression\, correlate with poor prognosis in the Sonic Hedgehog subgroup (MBSHH) compared to other MB variants. Mechanistically\, AMBRA1 enhances SHH signaling by stabilizing GLI1\, the pathway’s final effector\, via inhibition of its βTrCP-mediated degradation. Additionally\, AMBRA1 protein stability is modulated by the REN E3 ubiquitin ligase\, a tumor suppressor gene lost in MBSHH. Inhibition of AMBRA1 blocks MBSHH growth in murine and patient-derived pre-clinical models\, highlighting its therapeutic potential. Moreover\, combining AMBRA1 knockdown with FDA-approved SHH inhibitors enhances antitumor efficacy. These findings identify the AMBRA1/βTrCP/REN axis as a key regulatory mechanism in SHH signaling and discover an unrecognized function of AMBRA1 in MBSHH\, providing actionable insights for innovative targeted therapies. \nThis seminar is part of the Paris Postdoc seminar series.
URL:https://www.ijm.fr/event/seminar-irene-basili/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/20250603-Irene-Basili-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250523T140000
DTEND;TZID=Europe/Paris:20250523T170000
DTSTAMP:20250429T132943Z
CREATED:20250429T132943Z
LAST-MODIFIED:20250429T132943Z
UID:27977-1748008800-1748019600@www.ijm.fr
SUMMARY:Authorization to supervise research (HDR) - Isabelle Becam
DESCRIPTION:Isabelle Becam (Conduit Lab) will defend his Authorization to supervise research (HDR): \n“Hétérogénéité dans la formation des microtubules et son rôle fonctionnel dans les cellules” \n  \nThe defense will take place on Friday\, May 23 in François Jacob room. \nThe jury will be composed of: \n\nAgnès Audibert\, Rapporteur\nGisela d’Angelo\, Rapporteur\nVeronique Marthiens\, Rapporteur\nAlexandre Baffet\, Examinateur\nCarsten Janke\, Examinateur
URL:https://www.ijm.fr/event/authorization-to-supervise-research-hdr-isabelle-becam/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/04/HDR-bandeau-Isabelle-Becam-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250523T114500
DTEND;TZID=Europe/Paris:20250523T130000
DTSTAMP:20250415T085222Z
CREATED:20250415T085222Z
LAST-MODIFIED:20250415T085222Z
UID:27840-1748000700-1748005200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Frédéric Pincet
DESCRIPTION:Invited by the Romet-Lemonne/Jégou\, Frédéric Pincet (CNRS/ENS-PLS\, Paris) will present an Institut Jacques Monod seminar on the theme: \nThe Dual Role of Golgins in Maintaining Golgi Structure and Mediating Vesicle Traffic \n  \nAbstract: \nThe architecture of the Golgi apparatus is remarkably complex. In mammalian cells\, it is composed of stacks of disk-shaped membrane compartments that are laterally connected to form a ribbon-like structure. These stacks are polarized along the cis-to-trans axis and are embedded within a dense protein matrix\, whose primary components belong to the Golgin protein family. This refined organization is transiently lost during mitosis\, when the Golgi apparatus disperses into small vesicular and tubular remnants. However\, during telophase\, these remnants rapidly reassemble within minutes\, restoring the original architecture and cisternal composition. Even during interphase\, the integrity of the Golgi architecture is continuously challenged by dynamic processes\, including intensive vesicular trafficking both within the Golgi and with neighboring compartments\, as well as by cisternal maturation. As a result\, the Golgi apparatus presents a seemingly paradoxical combination of dynamic plasticity and structural robustness. In this seminar\, I will propose that Golgins act as key regulators balancing this duality. Golgins can function both as vesicle tethers\, facilitating trafficking\, and as structural scaffolds\, promoting the spontaneous organization of the Golgi matrix. We tested this hypothesis using a combination of in vitro biophysical and biochemical assays\, as well as super-resolution imaging of Golgin localization. Our results show that Golgins can self-assemble into two-dimensional condensates exhibiting a hierarchical set of interactions correlated with Golgi organization. Simultaneously\, Golgins and their condensates are capable of specifically tethering vesicles\, thus maintaining efficient vesicular trafficking within the matrix.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-frederic-pincet/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/04/Bandeau-web-seminar-Frederic-Pincet-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250522T150000
DTEND;TZID=Europe/Paris:20250522T160000
DTSTAMP:20250417T095621Z
CREATED:20250417T095621Z
LAST-MODIFIED:20250417T095621Z
UID:27854-1747926000-1747929600@www.ijm.fr
SUMMARY:Seminar - Daehan Lee
DESCRIPTION:Invited by the Courtier lab and the Konstantinides Lab\, Daehan Lee (Department of Biological Sciences\, College of Natural Sciences\, Sungkyunkwan University\nSuwon 16419\, Republic of Korea) will present a seminar on the theme: \nEcological Transitions Across Scales: Rewiring Sense\, Losing Sex\, Dodging Death\, and Becoming Complex \nAbstract: \nEcological transitions—changes in the physical\, chemical\, or biotic environment experienced by organisms—can have profound effects on developmental\, physiological\, and evolutionary trajectories. In this seminar\, I will examine how ecological shifts across multiple scales drive remodeling of biological systems\, from gene regulatory networks to life history strategies. Using a set of diverse model organisms\, I will present evidence for ecological transitions as catalysts of evolutionary change: sensory system reorganization during host specialization in Drosophila sechellia; the evolutionary loss of sexual reproduction under laboratory conditions in Caenorhabditis elegans; stage-specific aging and regeneration linked to ecological niches in the life cycle of jellyfish; and the emergence of multicellularity in choanoflagellates in response to environmental and social cues. Together\, these studies illustrate how ecological context shapes the evolution of complexity\, modulates developmental plasticity\, and alters fundamental features of animal biology.
URL:https://www.ijm.fr/event/seminar-daehan-lee/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/04/Bandeau-web-seminar-Daehan-Lee-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250514T093000
DTEND;TZID=Europe/Paris:20250514T110000
DTSTAMP:20250512T123230Z
CREATED:20250512T123230Z
LAST-MODIFIED:20250512T123230Z
UID:28082-1747215000-1747220400@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next cytoskeleton club meeting will take place on Wednesday\, May 14th at th Institut Jacques Monod: \n\nSandra Carvalho (PhD student \, A. Guichet’s Lab\, Institut Jacques Monod) will talk about:  “How do actin pulses at tricellular AJs provide forces for 3D cell intercalation ?” \nDaniel Plura (PhD student\, F. Robin’s  Lab\,  IBPS) will talk about: “Adaptability of the actomyosin network during C.elegans embryo development”
URL:https://www.ijm.fr/event/cytoskeleton-club-7/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/20250514-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250505T140000
DTEND;TZID=Europe/Paris:20250505T150000
DTSTAMP:20250429T084034Z
CREATED:20250429T084034Z
LAST-MODIFIED:20250429T084034Z
UID:27972-1746453600-1746457200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Sumin Jang
DESCRIPTION:Invited by the Ribes/Nedelec Lab\, Sumin Jang (Department of Pathology and Cell biology\, Columbia University\, New York\, USA) will present an Institut Jacques Monod seminar on the theme : \nHuman-specific progenitors extend and expand neurogenesis in the spinal cord \n  \nHer research explores the evolution of developmental programs and their implications for the increasing complexity of the human nervous system. \nShe combines single-cell omics with mouse and human organoids\, to investigate these questions. \n  \nSelection of publications: \nIndependent control of neurogenesis and dorsoventral patterning by NKX2-2 Jang S\, Abarinov E\, Dobkin J\, Wichterle H. bioRxiv [Preprint]. 2024 Oct 13:2024.10.13.618113. doi: 10.1101/2024.10.13.618113. PMID: 39415990 Free PMC article. Preprint \nA human-specific progenitor sub-domain extends neurogenesis and increases motor neuron production Jang S\, Gumnit E\, Wichterle H.Nat Neurosci. 2024 Oct;27(10):1945-1953. doi: 10.1038/s41593-024-01739-8. Epub 2024 Aug 29.PMID: 39210067 \nTranscriptional dynamics of murine motor neuron maturation in vivo and in vitro. Patel T\, Hammelman J\, Aziz S\, Jang S\, Closser M\, Michaels TL\, Blum JA\, Gifford DK\, Wichterle H.Nat Commun. 2022 Sep 15;13(1):5427. doi: 10.1038/s41467-022-33022-4.PMID: 36109497Free PMC article. \nAn expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity. Closser M\, Guo Y\, Wang P\, Patel T\, Jang S\, Hammelman J\, De Nooij JC\, Kopunova R\, Mazzoni EO\, Ruan Y\, Gifford DK\, Wichterle H.Neuron. 2022 Jan 5;110(1):70-85.e6. doi: 10.1016/j.neuron.2021.10.014. Epub 2021 Nov 1.PMID: 34727520Free PMC article.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-sumin-jang/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/04/Bandeau-web-seminar-Sumin-Jang-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250411T114500
DTEND;TZID=Europe/Paris:20250411T130000
DTSTAMP:20250313T135245Z
CREATED:20250313T131823Z
LAST-MODIFIED:20250313T135245Z
UID:27626-1744371900-1744376400@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Marion Silies
DESCRIPTION:Invited by the Konstantinides Lab\, Dr. Marion Silies (Johannes-Gutenberg-University Mainz\, Germany) will present an Institut Jacques Monod seminar on the theme: \nHeterogeneity of connectivity and function in the fly visual system \nAbstract: \nVisual systems are considered homogeneous structures where repeating visual units contain the same circuit motifs that fulfil the same functional role\, leading to translation invariance. However\, our recent work\, analyzing full fly brain connectomes\, revealed remarkable heterogeneity\, even within anatomically and genetically identifiable cell types. I will describe this heterogeneity in synaptic connectivity\, and address where it arises developmentally. Furthermore\, I will discuss how heterogeneous circuit motifs can lead to degeneracy of neuronal function\, and thus to both\, reliablility and flexiblity of neuronal information processing in the visual system.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-marion-silies/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/Bandeau-web-seminar-Marion-Silies-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250409T093000
DTEND;TZID=Europe/Paris:20250409T110000
DTSTAMP:20250331T094740Z
CREATED:20250331T094740Z
LAST-MODIFIED:20250331T094740Z
UID:27738-1744191000-1744196400@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\,9th at the Institut Pasteur: \n\nIngrid Billault-Chaumartin (post-doc\,  Romet-Lemonne/Jegou team\, IJM) will present “How similar is actin assembly between distant species ? »\nNicolas Joly ( Researcher \,  Pintard tema\, IJM)  will present “Mechanistic Insights into Katanin Activation: Coupling Microtubule Binding with ATP Hydrolysis
URL:https://www.ijm.fr/event/cytoskeleton-club-6/?lang=en
LOCATION:Institut Pasteur\, 28 rue du dr roux\, 75015 Paris\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250319bandeau-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250409
DTEND;VALUE=DATE:20250412
DTSTAMP:20241209T104027Z
CREATED:20241209T104027Z
LAST-MODIFIED:20241209T104027Z
UID:26072-1744156800-1744415999@www.ijm.fr
SUMMARY:Paris - Munich Epigenetics Workshop & Symposium 2025
DESCRIPTION:The second edition of the Paris-Munich Epigenetics meeting will be held from 9 to 11 April 2025 in the Buffon amphitheater. Attendance is free of charge but registration is mandatory. \nPlease visit the website to find out more about the program and to register. \nThe Paris-Munich Epigenetics Worshop & Symposium has two parts: \n\nthe SYMPOSIUM\, open for all students and researchers in the Paris/Munich communities and beyond\na WORKSHOP for selected doctoral or postdoctoral researchers that are new to the field of Epigenetics\n\nThe WORKSHOP takes place on April 9 prior to the symposium\, and is open for selected early stage doctoral and postdoctoral researchers new to the field of Epigenetics. The workshop focussed on the core concepts of cutting-edge Epigenetics research\, taught by senior academic experts\, as well as career orientation and communication skills\, presented by alumna and professionals in the field. Workshop participants will have the opportunity to network and exchange\, with discussions during the workshop\, as well as with featured short talks and posters during the symposium. \n  \nThe SYMPOSIUM takes place from April 9-11\, 2025  and is open for all interested students and scientists from the Paris and Munich communities and beyond. During the Symposium renowned speakers from the two communities present their latest insights into Epigenetics in sessions on chromatin environment\, organization\, remodelling and reprogramming. Short talks and poster presentations from early career (doctoral and postdoctoral) researchers will be selected from the submitted abstracts. \n  \nThe deadline for both abstract submissions and workshop applications is January 15\, 2025.
URL:https://www.ijm.fr/event/paris-munich-epigenetics-workshop-symposium-2025/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250408T114500
DTEND;TZID=Europe/Paris:20250408T130000
DTSTAMP:20250326T143945Z
CREATED:20250326T143945Z
LAST-MODIFIED:20250326T143945Z
UID:27705-1744112700-1744117200@www.ijm.fr
SUMMARY:Seminar - Suzette Lust
DESCRIPTION:Invited by the Institut Jacques Monod\, Suzette Lust (Postdoctoral researcher in Danijela Matic Vignjevic’s team – Cell migration and invasion Laboratory at Institut Curie) will present a seminar on the theme: \nUnderstanding the role of interstitial flow in vascular smooth muscle cell phenotype in the context of aortic aneurysms \n  \nThis seminar is part of the Paris Postdocs Seminars series. \nAbstract: \nAortic aneurysms are abnormal enlargements of blood vessel diameter caused by aberrant extra-cellular matrix (ECM) remodelling. As the tissue dilates\, it loses its mechanical integrity\, exposing patients to risk of highly fatal aortic dissections or ruptures. This is mediated in part by phenotypic switching and or apoptosis of the intima-resident vascular smooth muscles (VSMCs). What drives this pathology is not well understood\, particularly in the case of aneurysms in Bicuspid Aortic Valve disease (BAV) patients\, a congenital condition characterised by the malformation of the aortic valve resulting in only 2 leaflets. Improvements in imaging techniques have now allowed pathological blood flow patterns to be correlated to aneurysm morphology and indeed there is increasing evidence that mechanotransduction from flow may be a driver of aneurysm development. Blood flow imparts mechanical forces to cells through stretching and frictional shear forces and we are focused here on the interstitial flow driven into the wall by differential pressure gradients within the aorta. \nWe hypothesise that interstitial flow plays a crucial role in regulating VSMC phenotype and ECM interactions and that this may be used to correlate disrupted flow patterns seen in BAV patients to the morphology changes in their aortas. \nTo test this hypothesis\, we created a reductionist in-vitro model culturing VSMCs in 3D under interstitial flow. We combined a synthetic PEG based ECM mimicking hydrogel with primary cultures of VSCMs with a microfluidics setup. \nWe showed hydrogels doctored with degradable bioactive peptides could be broken down by exogenous and cell derived MMPs. We measured hydrogel permeability using 2 separate techniques which confirmed the material to have a low permeability compared to other standard hydrogels\, on the order of 10−16 m2. Furthermore\, we characterised mass transport of solutes within hydrogels and were able to demonstrate a negligible impact of changing polymer solid content on diffusivity in hydrogels of up to 5% weight/volume for molecules up to 40 kDa in size. Via production of MMPs\, VSMCs break down the hydrogel and importantly by day 7 of culture\, we detected newly synthesised fibronectin\, collagen 1 and 4 proteins. We stimulated encapsulated cells with interstitial flows demonstrating that cells align to the flow direction. Finally\, we performed RNA sequencing on 3 human patient samples comparing standard culture conditions\, non-flow stimulated encapsulated cells and interstitial-flow stimulated cells. The data set reveals significant upregulation of genes in multiple pathways associated with cyclic AMP production\, which plays a crucial role in regulating VSMC contractility and calcium signalling and hence phenotype. The data suggests that this is mediated via activation of G-protein receptors leading to increased expression of adenylyl cyclase but this remains to be confirmed. \nIn conclusion\, we developed a novel in-vitro platform to study the impact of interstitial flow on VSMC behaviour. Our data suggests that interstitial flow may play a regulating role in determining VSMC phenotype with potential consequences for matrix remodelling in disease.
URL:https://www.ijm.fr/event/seminar-suzette-lust/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250408-Suzette-Lust-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250404T114500
DTEND;TZID=Europe/Paris:20250404T130000
DTSTAMP:20250324T145408Z
CREATED:20250324T145408Z
LAST-MODIFIED:20250324T145408Z
UID:27690-1743767100-1743771600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Lionel Christiaen
DESCRIPTION:Invited by the Minc Lab\, Lionel Christiaen (Michael Sars Centre\, University of Bergen\, Bergen\, Norway) will present an Institut Jacques Monod Seminar on the theme: \nRegulation of deterministic development \nAbstract: \nChristiaen’s research aims at understanding how tissue-specific regulatory programs and cell-cell communication coordinate cellular behavior in the context of animal development\, regeneration and evolution. His laboratory focuses on mesodermal lineages that produce both heart and head muscles\, using the ascidian Ciona as model. His laboratory has contributed seminal findings in developmental and evolutionary biology\, identifying key processes contributing to human congenital disorders. The Ciona model provides a unique opportunity to study the regulation of chordate development at single cell resolution\, thanks to a highly deterministic (“hard-wired”) mode of embryogenesis. However\, recent attempts to uncover the impact of varying temperatures in a changing world are beginning to reveal regulative mechanisms of thermal adaptation.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-lionel-christiaen/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/Bandeau-web-seminar-Lionel-Christiaen-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250331T133000
DTEND;TZID=Europe/Paris:20250331T170000
DTSTAMP:20250303T154654Z
CREATED:20250303T154408Z
LAST-MODIFIED:20250303T154654Z
UID:27523-1743427800-1743440400@www.ijm.fr
SUMMARY:PhD thesis defense - Alberto Ballin
DESCRIPTION:Alberto Ballin (Léon Lab) will defense his PhD thesis defense: \n“Glucose signaling through Snf1/AMPK in Saccharomyces cerevisiae: mechanistic insights from 2-deoxyglucose-resistant mutants” \nThe defense will be held in English on Monday\, March 31st at 1.30 pm in room François Jacob at the Institut Jacques Monod. \nThe members of the jury are: \n\nAlexandre Soulard (Lyon) as rapporteur ;\nPaola Coccetti (Milan) as rapportice;\nSimonetta Piatti (Montpellier) as examinatrice;\nBenoit Viollet (Paris) as examinateur;\nGwenael Rabut (Rennes) as invited member ;\nSébastien Leon (directeur de thèse).
URL:https://www.ijm.fr/event/soutenance-de-these-alberto-ballin/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/These-bandeau-Alberto-Ballin-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250319T093000
DTEND;TZID=Europe/Paris:20250319T110000
DTSTAMP:20250313T100517Z
CREATED:20250313T100517Z
LAST-MODIFIED:20250313T100517Z
UID:27621-1742376600-1742382000@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\, 19th: \n\nMeriem Boumendjel (PhD student\, Azimzadeh Lab\, Institut Jacques Monod ) will present “Centriole rotational polarity is required for daughter centriole repositioning during primary cilium formation“\nAlfredo SCIORTINO  ( Post-doc\, Manuel Thery Lab\, ESPCI\, IPGG) will present “Filament transport supports contractile steady states of actin networks”\n\n 
URL:https://www.ijm.fr/event/cytoskeleton-club-5/?lang=en
LOCATION:Institut Curie\, 26 rue d'Ulm 75005 Paris\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250319bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250314T114500
DTEND;TZID=Europe/Paris:20250314T130000
DTSTAMP:20250212T123210Z
CREATED:20250212T123210Z
LAST-MODIFIED:20250212T123210Z
UID:27374-1741952700-1741957200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Maud Borensztein
DESCRIPTION:Invited by the Greenberg Lab \, Maud Borensztein (Team Epigenetic Reprogramming and Mammalian Development\, IGMM\, CNRS\, University of Montpellier) will present an Institut Jacques Monod Seminar on the theme: \nReprogramming the X chromosome: insights from mammalian development and germline \n  \nAbstract: \nMaud Borensztein team focuses on epigenetic mechanisms in mammalian development and reproduction\, with a particular emphasis on X-chromosome dosage compensation. Since establishing her group at the Institut de Génétique Moléculaire de Montpellier (IGMM) in 2021\, they have developed innovative tools to study gametogenesis and X-chromosome dynamics\, both in vivo (using mouse models) and in vitro (using Primordial Germ Cell-like cells). Investigating the reactivation of the inactive X chromosome during germline specification in females—a unique epigenetic reprogramming process that highlights fine gene-regulation control—\, they aim to uncover its timing\, mechanisms\, and biological implications.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-maud-borensztein/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/02/Bandeau-web-seminar-Maud-Borensztein-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250311T114500
DTEND;TZID=Europe/Paris:20250311T130000
DTSTAMP:20250211T153305Z
CREATED:20250211T153305Z
LAST-MODIFIED:20250211T153305Z
UID:27291-1741693500-1741698000@www.ijm.fr
SUMMARY:Institut Jacques Monod seminar - Mateusz C. Ambrozkiewicz
DESCRIPTION:Invited by the Konstantinides Lab\, Dr. Mateusz C. Ambrozkiewicz\, FENS-Kavli Scholar (Institute for Cell Biology and Neurobiology\, Charité University Hospital\, Berlin\, Germany) will present an Institut Jacques Monod seminar on the theme: \nProteostatic Mechanisms of Cellular Diversification in the Developing Brain \nAbstract: \nFormation of functional circuits in the adult brain is a biological fundament for its executive role in the living organism and requires specification of neurons\, their correct positioning\, formation of dendrites and synapses. In this talk\, I will present our current research on the translational mechanisms and post-translational modifications orchestrating neuronal diversification in the developing brain. Particularly\, I will shed light on the specific post-transcriptional requirements for neuronal progenitors\, including the dynamics of protein synthesis as well as the role of ubiquitination-dependent degradation in healthy and diseased brain. I will show how deciphering a molecular mechanism at the basis of neurodevelopmental disease etiology can be used to propose therapeutic strategy impinging on modulating the activity of cellular proteostasis effectors\, such as the E3 ubiquitin ligases.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-mateusz-c-ambrozkiewicz/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/02/Bandeau-web-seminar-Mateusz-C.-Ambrozkiewicz-2-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250307T114500
DTEND;TZID=Europe/Paris:20250307T130000
DTSTAMP:20250212T155220Z
CREATED:20250127T142106Z
LAST-MODIFIED:20250212T155220Z
UID:26838-1741347900-1741352400@www.ijm.fr
SUMMARY:Institut Jacques Monod Lecture - Andrea Musacchio
DESCRIPTION:On Friday\, March 7th\, Andrea Musacchio (Max Planck Institute of Molecular physiology) will present a Institut Jacques Monod Lecture on the theme: \nFeedback control of mitosis in the context of the kinetochore \n  \nAbstract: \nKinetochores provide chromosomes with points of attachment to spindle microtubules during cell division\, and are therefore essential for genome inheritance and the propagation of life. In addition to binding microtubules\, kinetochores control mitotic surveillance mechanisms that promote chromosome bi-orientation (the error correction mechanism) and prevent premature mitotic exit in presence of incomplete or incorrect microtubule attachments (spindle assembly checkpoint\, SAC). Elimination of the NDC80 complex\, the main microtubule receptor of kinetochores\, causes a SAC deficiency\, identifying this complex as a crucial regulatory focus for checkpoint function. In recent years\, there has been considerable progress in understanding how the SAC effector\, known as the mitotic checkpoint complex (MCC)\, assembles from its individual components to inhibit its target\, the anaphase promoting complex/cyclosome (APC/C). Conversely\, how microtubule attachment to kinetochores regulates the SAC remains incompletely understood. From a molecular perspective\, answering this question implies investigating the mechanisms that promote targeting of the SAC proteins to unattached kinetochores\, and suppress it upon microtubule binding and biorientation. In our recent work\, we have combined biochemical reconstitutions\, structural biology/modelling\, and cell biology to gain insights into this fundamental biological question.
URL:https://www.ijm.fr/event/institut-jacques-monod-lecture-andrea-musacchio/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/bandeau-IJM-Lectures-Andrea-Musacchio-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250225T114500
DTEND;TZID=Europe/Paris:20250225T130000
DTSTAMP:20250123T141141Z
CREATED:20250123T141141Z
LAST-MODIFIED:20250123T141141Z
UID:26792-1740483900-1740488400@www.ijm.fr
SUMMARY:Paris Postdoc Seminar - Nathaniel Henneman
DESCRIPTION:Invited by the Institut Jacques Monod\, Nathaniel Henneman (team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM)) will present a Paris Postdoc Seminar on the theme: \nNuclear functions of nutrient sensing signaling for metabolic adaptation \n  \nIntroduction & abstract: \nI am a Postdoc in the team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM). I graduated from Bates College (USA) in 2016\, majoring in Biology. I then spent two years working on retinal degeneration at Emory University before obtaining my master’s degree at University of Paris Descartes in 2019 and defended my PhD in December 2023. \nOne of the key questions I am to address in my work is how cellular metabolism\, gene expression and transcription\, are all coordinated. Energy stress in fasting is managed by activating autophagy and promoting the transcriptional remodeling of metabolism. Cytosolic nutrient sensors coordinate extracellular nutrient availability with intracellular metabolic processes to allow for cell survival. Class 3 PI3K is a highly conserved nutrient sensor known to regulate autophagy and endocytosis in response to varying nutrient conditions. It’s direct role in transcription\, however\, was only suggested in few studies in yeast and plants. However\, we believe there is a nuclear pool of class 3 PI3K that directly regulates gene expression for metabolic adaptation. My work aims to address this unmet burden in the field. We find that nuclear class 3 PI3K regulates the transcriptional response to nutrient stress by controlling RNA Polymerase II\, the Set1/COMPASS methyltransferase\, and nuclear methionine to SAM flux. I aim to understand how these players are needed for our fasting adaptation and how these mechanisms could affect our metabolic resilience.
URL:https://www.ijm.fr/event/paris-postdoc-seminar-nathaniel-henneman/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/20250225-Nathaniel-Hennman-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250224T114500
DTEND;TZID=Europe/Paris:20250224T130000
DTSTAMP:20250214T094643Z
CREATED:20250128T140351Z
LAST-MODIFIED:20250214T094643Z
UID:26858-1740397500-1740402000@www.ijm.fr
SUMMARY:[Cancelled] Institut Jacques Monod Seminars - Marla Sokolowski
DESCRIPTION:This seminar is cancelled.\n  \nInvited by the par l’équipe Courtier\, Marla Sokolowski (Department of Ecology and Evolutionary Biology\, University of Toronto) will present an Institut Jacques Monod Seminar on the theme: \nThe foraging gene: will that be for here or to go? \nAbstract: \nThe Drosophila melanogaster foraging (for) gene\, with its rover and sitter larval foraging variants\, is an established behaviour genetics model. Orthologues of the foraging gene also modulate the individual and social behaviour of a wide range of species including the regulation of behaviour in eusocial insects. In Drosophila\, foraging modifies the expression of multiple traits\, including feeding and foraging\, stress tolerance\, sleep\, metabolism\, dispersal\, escape responses\, social behaviour\, and learning and memory. From a social context perspective\, Drosophila foraging affects larval clustering during foraging under high larval densities\, adult social behaviour and social networks\, and social learning. We wondered how foraging accomplishes its behavioural pleiotropy at the molecular level. We found that D. melanogaster foraging has a complex modular genomic structure with four promoters\, 21 transcripts\, and eight protein isoforms. The four promoter modules are differentially regulated during development and in a timescale\, tissue\, and cell-type dependent manner. Two examples illustrate these findings: the epigenetic regulation of the adult rover-sitter foraging-related phenotypes by G9a\, a histone methyltransferase\, and the regulation of differences in the latency of rover compared to sitter larval escape responses to noxious stimuli such as parasitoid wasps. Our work provides a nuanced picture of the molecular basis of foraging’s pleiotropy.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-marla-sokolowski/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/Bandeau-web-seminar-Marla-Sokolowski-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250219T093000
DTEND;TZID=Europe/Paris:20250219T110000
DTSTAMP:20250205T110041Z
CREATED:20250205T110041Z
LAST-MODIFIED:20250205T110041Z
UID:27113-1739957400-1739962800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\, February 19th: \n\nRayane Dibsy (post-doc\, A. Echard’s Lab\, Institut Pasteur présentera  «  The proteasome promotes cytokinetic abscission by relieving Aurora B kinase-mediated inhibition of ESCRT-III turnover. »\nJonathan Fouchard ( Researcher\, Laboratoire de Biologie du Développement\, IBPS) présentera ‘Three-dimensional cell shape\, focal adhesions and vimentin during spreading’
URL:https://www.ijm.fr/event/cytoskeleton-club-4/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/02/20250219bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250214T114500
DTEND;TZID=Europe/Paris:20250214T130000
DTSTAMP:20241217T133040Z
CREATED:20241217T133040Z
LAST-MODIFIED:20241217T133040Z
UID:26236-1739533500-1739538000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Peter Andolfatto
DESCRIPTION:Invited by the Courtier\, Peter Andolfatto (Professor\, Dept. of Biological Sciences\, Columbia University) will present an Institut Jacques Monod seminar on the theme: \nThe evolution of toxin-resistant Na+\,K+-ATPases: new insights from frogs and fireflies  \n  \nWe study the process of adaptive evolution through the lens of repeated adaptation of many distantly species to a similar selection pressure (i.e. “parallel evolution”). Over the past decade\, we have explored patterns of adaptation in the context of animals that have specialized in eating plants\, or other animals\, that contain toxic cardiotonic steroids (CTS). CTS are toxic to animals because they inhibit sodium-potassium ATPase\, a key enzyme in animals needed in everything from maintaining cell homeostasis\, muscle contraction to neuron activity. Here I review our most recent work combining comparative molecular evolution\, molecular and biochemical assays and in vivo engineering of Drosophila to deduce the rules governing the adaptive evolution of CTS resistance in animals. Together\, our results have interesting implications for how epistasis and pleiotropy both limit the rate of adaptive protein evolution and increase its predictability.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-peter-andolfatto/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/Bandeau-web-seminar-Peter-Andolfatto-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250212T140000
DTEND;TZID=Europe/Paris:20250212T150000
DTSTAMP:20250127T140538Z
CREATED:20250127T140538Z
LAST-MODIFIED:20250127T140538Z
UID:26833-1739368800-1739372400@www.ijm.fr
SUMMARY:Seminar - Felix Ruhnow
DESCRIPTION:Invited by the Centre for Genomic Regulation\, Felix Ruhnow will present a seminar on the theme: \nNuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends \n  \nAbstract: \nNuclear mitotic apparatus protein (NuMA) is indispensable for the mitotic functions of the major microtubule minus-end directed motor cytoplasmic dynein 1. NuMA and dynein are both essential for correct spindle pole organization. How these proteins cooperate to gather microtubule minus ends at spindle poles remains unclear. Here we use microscopy-based in vitro reconstitutions to demonstrate that NuMA is a dynein adaptor\, activating processive dynein motility together with dynein’s cofactors dynactin and Lissencephaly-1 (Lis1). Additionally\, we find that NuMA binds and stabilizes microtubule minus ends\, allowing dynein/dynactin/NuMA. to transport microtubule minus ends as cargo to other minus ends. We further show that the microtubule-nucleating γ-tubulin ring complex (γTuRC) hinders NuMA binding and that NuMA can only cap minus ends of γTuRC-nucleated microtubules after γTuRC release. These results provide new mechanistic insight into how dynein\, dynactin\, NuMA\, Lis1 together with γTuRC and uncapping proteins cooperate to organize spindle poles in cells.
URL:https://www.ijm.fr/event/seminar-felix-ruhnow/?lang=en
LOCATION:Institut Jacques Monod – Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
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