BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institut Jacques Monod - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Institut Jacques Monod
X-ORIGINAL-URL:https://www.ijm.fr/?lang=en
X-WR-CALDESC:Events for Institut Jacques Monod
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250409
DTEND;VALUE=DATE:20250412
DTSTAMP:20260425T182701
CREATED:20241209T104027Z
LAST-MODIFIED:20241209T104027Z
UID:26072-1744156800-1744415999@www.ijm.fr
SUMMARY:Paris - Munich Epigenetics Workshop & Symposium 2025
DESCRIPTION:The second edition of the Paris-Munich Epigenetics meeting will be held from 9 to 11 April 2025 in the Buffon amphitheater. Attendance is free of charge but registration is mandatory. \nPlease visit the website to find out more about the program and to register. \nThe Paris-Munich Epigenetics Worshop & Symposium has two parts: \n\nthe SYMPOSIUM\, open for all students and researchers in the Paris/Munich communities and beyond\na WORKSHOP for selected doctoral or postdoctoral researchers that are new to the field of Epigenetics\n\nThe WORKSHOP takes place on April 9 prior to the symposium\, and is open for selected early stage doctoral and postdoctoral researchers new to the field of Epigenetics. The workshop focussed on the core concepts of cutting-edge Epigenetics research\, taught by senior academic experts\, as well as career orientation and communication skills\, presented by alumna and professionals in the field. Workshop participants will have the opportunity to network and exchange\, with discussions during the workshop\, as well as with featured short talks and posters during the symposium. \n  \nThe SYMPOSIUM takes place from April 9-11\, 2025  and is open for all interested students and scientists from the Paris and Munich communities and beyond. During the Symposium renowned speakers from the two communities present their latest insights into Epigenetics in sessions on chromatin environment\, organization\, remodelling and reprogramming. Short talks and poster presentations from early career (doctoral and postdoctoral) researchers will be selected from the submitted abstracts. \n  \nThe deadline for both abstract submissions and workshop applications is January 15\, 2025.
URL:https://www.ijm.fr/event/paris-munich-epigenetics-workshop-symposium-2025/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250409T093000
DTEND;TZID=Europe/Paris:20250409T110000
DTSTAMP:20260425T182701
CREATED:20250331T094740Z
LAST-MODIFIED:20250331T094740Z
UID:27738-1744191000-1744196400@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\,9th at the Institut Pasteur: \n\nIngrid Billault-Chaumartin (post-doc\,  Romet-Lemonne/Jegou team\, IJM) will present “How similar is actin assembly between distant species ? »\nNicolas Joly ( Researcher \,  Pintard tema\, IJM)  will present “Mechanistic Insights into Katanin Activation: Coupling Microtubule Binding with ATP Hydrolysis
URL:https://www.ijm.fr/event/cytoskeleton-club-6/?lang=en
LOCATION:Institut Pasteur\, 28 rue du dr roux\, 75015 Paris\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250319bandeau-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250411T114500
DTEND;TZID=Europe/Paris:20250411T130000
DTSTAMP:20260425T182701
CREATED:20250313T131823Z
LAST-MODIFIED:20250313T135245Z
UID:27626-1744371900-1744376400@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Marion Silies
DESCRIPTION:Invited by the Konstantinides Lab\, Dr. Marion Silies (Johannes-Gutenberg-University Mainz\, Germany) will present an Institut Jacques Monod seminar on the theme: \nHeterogeneity of connectivity and function in the fly visual system \nAbstract: \nVisual systems are considered homogeneous structures where repeating visual units contain the same circuit motifs that fulfil the same functional role\, leading to translation invariance. However\, our recent work\, analyzing full fly brain connectomes\, revealed remarkable heterogeneity\, even within anatomically and genetically identifiable cell types. I will describe this heterogeneity in synaptic connectivity\, and address where it arises developmentally. Furthermore\, I will discuss how heterogeneous circuit motifs can lead to degeneracy of neuronal function\, and thus to both\, reliablility and flexiblity of neuronal information processing in the visual system.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-marion-silies/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/Bandeau-web-seminar-Marion-Silies-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250505T140000
DTEND;TZID=Europe/Paris:20250505T150000
DTSTAMP:20260425T182701
CREATED:20250429T084034Z
LAST-MODIFIED:20250429T084034Z
UID:27972-1746453600-1746457200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Sumin Jang
DESCRIPTION:Invited by the Ribes/Nedelec Lab\, Sumin Jang (Department of Pathology and Cell biology\, Columbia University\, New York\, USA) will present an Institut Jacques Monod seminar on the theme : \nHuman-specific progenitors extend and expand neurogenesis in the spinal cord \n  \nHer research explores the evolution of developmental programs and their implications for the increasing complexity of the human nervous system. \nShe combines single-cell omics with mouse and human organoids\, to investigate these questions. \n  \nSelection of publications: \nIndependent control of neurogenesis and dorsoventral patterning by NKX2-2 Jang S\, Abarinov E\, Dobkin J\, Wichterle H. bioRxiv [Preprint]. 2024 Oct 13:2024.10.13.618113. doi: 10.1101/2024.10.13.618113. PMID: 39415990 Free PMC article. Preprint \nA human-specific progenitor sub-domain extends neurogenesis and increases motor neuron production Jang S\, Gumnit E\, Wichterle H.Nat Neurosci. 2024 Oct;27(10):1945-1953. doi: 10.1038/s41593-024-01739-8. Epub 2024 Aug 29.PMID: 39210067 \nTranscriptional dynamics of murine motor neuron maturation in vivo and in vitro. Patel T\, Hammelman J\, Aziz S\, Jang S\, Closser M\, Michaels TL\, Blum JA\, Gifford DK\, Wichterle H.Nat Commun. 2022 Sep 15;13(1):5427. doi: 10.1038/s41467-022-33022-4.PMID: 36109497Free PMC article. \nAn expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity. Closser M\, Guo Y\, Wang P\, Patel T\, Jang S\, Hammelman J\, De Nooij JC\, Kopunova R\, Mazzoni EO\, Ruan Y\, Gifford DK\, Wichterle H.Neuron. 2022 Jan 5;110(1):70-85.e6. doi: 10.1016/j.neuron.2021.10.014. Epub 2021 Nov 1.PMID: 34727520Free PMC article.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-sumin-jang/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/04/Bandeau-web-seminar-Sumin-Jang-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250514T093000
DTEND;TZID=Europe/Paris:20250514T110000
DTSTAMP:20260425T182701
CREATED:20250512T123230Z
LAST-MODIFIED:20250512T123230Z
UID:28082-1747215000-1747220400@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next cytoskeleton club meeting will take place on Wednesday\, May 14th at th Institut Jacques Monod: \n\nSandra Carvalho (PhD student \, A. Guichet’s Lab\, Institut Jacques Monod) will talk about:  “How do actin pulses at tricellular AJs provide forces for 3D cell intercalation ?” \nDaniel Plura (PhD student\, F. Robin’s  Lab\,  IBPS) will talk about: “Adaptability of the actomyosin network during C.elegans embryo development”
URL:https://www.ijm.fr/event/cytoskeleton-club-7/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/20250514-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250522T150000
DTEND;TZID=Europe/Paris:20250522T160000
DTSTAMP:20260425T182701
CREATED:20250417T095621Z
LAST-MODIFIED:20250417T095621Z
UID:27854-1747926000-1747929600@www.ijm.fr
SUMMARY:Seminar - Daehan Lee
DESCRIPTION:Invited by the Courtier lab and the Konstantinides Lab\, Daehan Lee (Department of Biological Sciences\, College of Natural Sciences\, Sungkyunkwan University\nSuwon 16419\, Republic of Korea) will present a seminar on the theme: \nEcological Transitions Across Scales: Rewiring Sense\, Losing Sex\, Dodging Death\, and Becoming Complex \nAbstract: \nEcological transitions—changes in the physical\, chemical\, or biotic environment experienced by organisms—can have profound effects on developmental\, physiological\, and evolutionary trajectories. In this seminar\, I will examine how ecological shifts across multiple scales drive remodeling of biological systems\, from gene regulatory networks to life history strategies. Using a set of diverse model organisms\, I will present evidence for ecological transitions as catalysts of evolutionary change: sensory system reorganization during host specialization in Drosophila sechellia; the evolutionary loss of sexual reproduction under laboratory conditions in Caenorhabditis elegans; stage-specific aging and regeneration linked to ecological niches in the life cycle of jellyfish; and the emergence of multicellularity in choanoflagellates in response to environmental and social cues. Together\, these studies illustrate how ecological context shapes the evolution of complexity\, modulates developmental plasticity\, and alters fundamental features of animal biology.
URL:https://www.ijm.fr/event/seminar-daehan-lee/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/04/Bandeau-web-seminar-Daehan-Lee-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250523T114500
DTEND;TZID=Europe/Paris:20250523T130000
DTSTAMP:20260425T182701
CREATED:20250415T085222Z
LAST-MODIFIED:20250415T085222Z
UID:27840-1748000700-1748005200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Frédéric Pincet
DESCRIPTION:Invited by the Romet-Lemonne/Jégou\, Frédéric Pincet (CNRS/ENS-PLS\, Paris) will present an Institut Jacques Monod seminar on the theme: \nThe Dual Role of Golgins in Maintaining Golgi Structure and Mediating Vesicle Traffic \n  \nAbstract: \nThe architecture of the Golgi apparatus is remarkably complex. In mammalian cells\, it is composed of stacks of disk-shaped membrane compartments that are laterally connected to form a ribbon-like structure. These stacks are polarized along the cis-to-trans axis and are embedded within a dense protein matrix\, whose primary components belong to the Golgin protein family. This refined organization is transiently lost during mitosis\, when the Golgi apparatus disperses into small vesicular and tubular remnants. However\, during telophase\, these remnants rapidly reassemble within minutes\, restoring the original architecture and cisternal composition. Even during interphase\, the integrity of the Golgi architecture is continuously challenged by dynamic processes\, including intensive vesicular trafficking both within the Golgi and with neighboring compartments\, as well as by cisternal maturation. As a result\, the Golgi apparatus presents a seemingly paradoxical combination of dynamic plasticity and structural robustness. In this seminar\, I will propose that Golgins act as key regulators balancing this duality. Golgins can function both as vesicle tethers\, facilitating trafficking\, and as structural scaffolds\, promoting the spontaneous organization of the Golgi matrix. We tested this hypothesis using a combination of in vitro biophysical and biochemical assays\, as well as super-resolution imaging of Golgin localization. Our results show that Golgins can self-assemble into two-dimensional condensates exhibiting a hierarchical set of interactions correlated with Golgi organization. Simultaneously\, Golgins and their condensates are capable of specifically tethering vesicles\, thus maintaining efficient vesicular trafficking within the matrix.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-frederic-pincet/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/04/Bandeau-web-seminar-Frederic-Pincet-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250523T140000
DTEND;TZID=Europe/Paris:20250523T170000
DTSTAMP:20260425T182701
CREATED:20250429T132943Z
LAST-MODIFIED:20250429T132943Z
UID:27977-1748008800-1748019600@www.ijm.fr
SUMMARY:Authorization to supervise research (HDR) - Isabelle Becam
DESCRIPTION:Isabelle Becam (Conduit Lab) will defend his Authorization to supervise research (HDR): \n“Hétérogénéité dans la formation des microtubules et son rôle fonctionnel dans les cellules” \n  \nThe defense will take place on Friday\, May 23 in François Jacob room. \nThe jury will be composed of: \n\nAgnès Audibert\, Rapporteur\nGisela d’Angelo\, Rapporteur\nVeronique Marthiens\, Rapporteur\nAlexandre Baffet\, Examinateur\nCarsten Janke\, Examinateur
URL:https://www.ijm.fr/event/authorization-to-supervise-research-hdr-isabelle-becam/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/04/HDR-bandeau-Isabelle-Becam-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250603T114500
DTEND;TZID=Europe/Paris:20250603T130000
DTSTAMP:20260425T182701
CREATED:20250520T130321Z
LAST-MODIFIED:20250520T130321Z
UID:28205-1748951100-1748955600@www.ijm.fr
SUMMARY:Seminar - Irene Basili
DESCRIPTION:Invited by the Institut Jacques Monod\, Irene Basili will present a seminar on the theme: \nAMBRA1 controls the Sonic Hedgehog signaling pathway and SHH-medulloblastoma \nAbstract: \nAMBRA1 (Autophagy and Beclin 1 Regulator 1) is primarily recognized as a tumor suppressor\, however its role as a tumor promoter has garnered increasing attention. Here\, leveraging clinical data of an international multi-omic medulloblastoma (MB) cohort\, we identified that elevated AMBRA1 protein levels\, independently of its mRNA expression\, correlate with poor prognosis in the Sonic Hedgehog subgroup (MBSHH) compared to other MB variants. Mechanistically\, AMBRA1 enhances SHH signaling by stabilizing GLI1\, the pathway’s final effector\, via inhibition of its βTrCP-mediated degradation. Additionally\, AMBRA1 protein stability is modulated by the REN E3 ubiquitin ligase\, a tumor suppressor gene lost in MBSHH. Inhibition of AMBRA1 blocks MBSHH growth in murine and patient-derived pre-clinical models\, highlighting its therapeutic potential. Moreover\, combining AMBRA1 knockdown with FDA-approved SHH inhibitors enhances antitumor efficacy. These findings identify the AMBRA1/βTrCP/REN axis as a key regulatory mechanism in SHH signaling and discover an unrecognized function of AMBRA1 in MBSHH\, providing actionable insights for innovative targeted therapies. \nThis seminar is part of the Paris Postdoc seminar series.
URL:https://www.ijm.fr/event/seminar-irene-basili/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/20250603-Irene-Basili-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250606T114500
DTEND;TZID=Europe/Paris:20250606T130000
DTSTAMP:20260425T182701
CREATED:20250513T093808Z
LAST-MODIFIED:20250513T094229Z
UID:28088-1749210300-1749214800@www.ijm.fr
SUMMARY:Institut Jacques Monod seminar - Aydan Karslioglu
DESCRIPTION:Invited by the Greenberg Lab and the Epigenetic & cell fate\, Aydan Karslioglu (Group Leader\, Max Planck Institute for Molecular Genetics) will present an Institut Jacques Monod seminar on the theme: \nAdjusting the timing of mammalian development \nAbstract: \nOur lab focuses on mechanisms regulating stem cell state transitions and fate commitment. Specifically\, we study how cells communicate signals from their surroundings to the gene expression machinery\, especially in the context of cell fate decisions in development and disease. To delineate principles of stemness\, we use in vitro and in vivo models and probe molecular processes critical for the emergence\, maintenance\, and resolution of stem states in physiological and adverse conditions.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-aydan-karslioglu/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/Bandeau-web-seminar-Aydan-Karslioglu-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250613T114500
DTEND;TZID=Europe/Paris:20250613T130000
DTSTAMP:20260425T182701
CREATED:20250515T085936Z
LAST-MODIFIED:20250515T101058Z
UID:28136-1749815100-1749819600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Frank Maixner et Sabry Sarhan
DESCRIPTION:Invited by the Grange/Geigl\, Frank Maixner and Sabry Sarhan (Eurac Research – Institute for Mummy Studies\, Bolzano\, Italy) will present an Institut Jacques Monod seminar on theme: \nGenome wide data of a Penicillium roqueforti strain from Iron Age Austria: the oldest molecular evidence for fermented blue cheese. \nAbstract: \nThe application of metagenomic analysis on dated ancient human specimens opens a window into the past that enables scientists to address unique evolutionary research questions. Paleofeces are an important source of information to study the evolution of dietary habits and human health. The UNESCO World Heritage region of Hallstatt-Dachstein/Salzkammergut is one of Europe’s oldest cultural and industrial landscapes; its underground salt mines dating back at least to the 14th century BC are one of the few archaeological sites where paleofeces are well preserved. Here we subjected human paleofeces dated from the Bronze Age to early Modern Times to an in-depth microscopic\, metagenomic and proteomic analysis. This allowed us to reconstruct the diet of the former population and gain insights into their ancient gut microbiome composition. Dietary survey identified a highly fibrous\, carbohydrate-rich diet supplemented with proteins from broad beans and occasionally with fruits\, nuts\, or animal food. Linked to these traditional dietary habits all ancient miners up to the early Modern times have gut microbiome structures akin to modern non-Westernized individuals which may indicate a shift in the gut community composition of modern Westernized populations due to quite recent dietary and lifestyle changes. When we extended our microbial survey to fungi present in the paleofeces\, we observed in one of the Iron Age samples a high abundance of Penicillium roqueforti DNA. Genome-wide analysis placed the ancient P. roqueforti strain into the current non-Roquefort blue cheese diversity next to modern variants from different parts of the Alps (e.g. Termignon). Our findings present the earliest molecular evidence for blue cheese consumption during Iron Age Europe\, which opens a new opportunity to better understand the domestication history of blue cheese fermentation.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-frank-maixner-et-sabry-sarhan/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/Bandeau-web-seminar-Frank-Maixner-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250618T093000
DTEND;TZID=Europe/Paris:20250618T110000
DTSTAMP:20260425T182701
CREATED:20250610T115259Z
LAST-MODIFIED:20250610T115259Z
UID:28379-1750239000-1750244400@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The las Cytoskeleton club meeting of the 2024-2025 season will take place on Wednesday June 18th. \nDuring this meeting: \n– Julie Homsen (Phd student\, A. Echard’s lab\, Institut Pasteur) will talk about «  GPRC5A is a potential component of the abscission checkpoint preventing premature chromatin bridge breakage »  \n– Baptiste Vauleon (PhD student\, M. Piel’s lab\, Institut Curie/IPPG) will talk about : «  Mechanical polarity of the cortex and single cell morphogenesis ». 
URL:https://www.ijm.fr/event/cytoskeleton-club-8/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/06/20250618-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250620T114500
DTEND;TZID=Europe/Paris:20250620T130000
DTSTAMP:20260425T182701
CREATED:20250513T094631Z
LAST-MODIFIED:20250513T094631Z
UID:28095-1750419900-1750424400@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Carlos Estella
DESCRIPTION:Invited by the Konstantinides Lab\, Carlos Estella (Laboratory of stress response and morphogenesis. Centro de Biología Molecular CSIC-UAM\, Madrid\, Spain) will present an Institut Jacques Monod seminar on the theme: \nA cross talk between p53 and the cell cycle regulates apoptotic induction and tumor formation in Drosophila \nAbstract: \nCell division is essential for tissue regeneration and organismal survival. However\, errors in this process can lead to uncontrolled cell proliferation and cancer. The tumor suppressor gene p53 plays a critical role in maintaining genomic integrity by coordinating cellular responses to stress\, such as DNA damage. These responses include cell cycle arrest\, DNA repair\, senescence\, or apoptosis. Importantly\, how these responses are precisely coordinated to maintain tissue homeostasis remains poorly understood. \nTo address this challenge\, simple genetic models are needed to study the precise regulation of cellular responses triggered by p53 and its role in tumorigenesis. To simplify the study of p53’s functions\, we use Drosophila melanogaster\, which has a single p53 homolog. Drosophila serves as a powerful genetic model due to its highly conserved pathways and sophisticated genetic tools. Notably\, approximately 85% of human cancer-related genes have orthologs in flies. In this seminar I´ll discuss recent work from our laboratory that demonstrated how the cellular context and proliferative status of a cell significantly impact p53’s ability to regulate the various responses triggered by DNA damage. In addition\, I´ll present the tumorigenic potential of p53 when its apoptotic role is inhibited. We find that cells with chronic p53 activity that have inhibited its apoptotic potential acquire a persistent activity of the JNK pathway\, which drives them into a senescent-like status and induce the non-autonomous overgrowth of the surrounding tissue. These results lead us to propose a model in which cell cycle progression and p53 pro-apoptotic activity are molecularly connected to coordinate the appropriate response after DNA damage.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-carlos-estella/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/Bandeau-web-seminar-Carlos-Estella-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250623T090000
DTEND;TZID=Europe/Paris:20250623T180000
DTSTAMP:20260425T182701
CREATED:20250520T084255Z
LAST-MODIFIED:20250520T084255Z
UID:28194-1750669200-1750701600@www.ijm.fr
SUMMARY:VIP & DIF 2025
DESCRIPTION:Registration for the VIP & DIF Day #5 is open !  \nWhere: Institut Jacques Monod (Amphi  Buffon – 15 rue Hélène Brion – 75013 Paris)\nWhen: Monday 23rd of June 2025. \nThis year\, we will have the pleasure to welcome the two following keynote speakers: \n\n    Maria-Cristina Gambetta\, from University of Lausanne\n\n\n    Alper Akay\, from University of East Anglia\n\nSubmit your Poster or Short Talk abstracts.\nhttps://sites.google.com/view/vipdif/registration-2025 \nParticipation is free but registration is mandatory for everyone.\nDeadline for registration is the 1st of June 2025.
URL:https://www.ijm.fr/event/vip-dif-2025/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/web-image-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250706
DTEND;VALUE=DATE:20250713
DTSTAMP:20260425T182701
CREATED:20250121T110058Z
LAST-MODIFIED:20250403T140159Z
UID:26710-1751760000-1752364799@www.ijm.fr
SUMMARY:Mechanobiology Conference III 2025
DESCRIPTION:The conference “Mechanobiology Conference III: From Fundamental Research to Applications” that will be held at the conference center in ICISE Quy Nhon\, central Vietnam on July 06-12\, 2025. Three members of the IJM team\, Benoit Ladoux\, René-Marc Mége and Wang Xi\, are part of the Organizing Committee. \nPlease visit the website or check out the flyer for more information. \nThe registration and abstract submission is now open. Students and postdocs are strongly encouraged to submit their work for oral or poster contributions. A limited number of travel grants for students and postdocs will be considered upon request. \nSome important dates are: \n\n30 April: Deadline for abstract submission.\n23 May: Deadline for early bird registration.\n06 June: Deadline for standard registration.\n\nThe conference will focus on the latest advances in mechanobiology\, with topics including\, but not limited to: \n\n Cell/Molecular signaling\n Disease Development and Biomedical applications\n Morphogenesis and multicellular processes\n Biomaterials/Bioengineering\n Single-cell migration\n Theoretical biophysics\n\nIf you have any further questions\, please do not hesitate to contact: \n\nAdministrative and logistic information: Thao Do\, rencontres.vietnam@gmail.com\nScientific program:  Wang Xi\, wang.xi@ijm.fr and Carles Blanch carles.blanch-mercader@curie.fr
URL:https://www.ijm.fr/event/mechanobiology-conference-iii-2025/?lang=en
LOCATION:ICISE Quy Nhon\, Vietnam\, 7 Đại lộ Khoa học\, khu vực 2\,\, Quy Nhơn\, Bình Định\,\, Viet Nam
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/vietnam-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250707T080000
DTEND;TZID=Europe/Paris:20250707T140000
DTSTAMP:20260425T182701
CREATED:20250623T134032Z
LAST-MODIFIED:20250623T134032Z
UID:28488-1751875200-1751896800@www.ijm.fr
SUMMARY:PhD thesis defense - Safia El Jailani
DESCRIPTION:Safia El Jailani (Wassmann Lab) will defense her PhD thesis on Monday\, July 7th: \nMechanisms ensuring tight control of cohesin cleavage to prevent aneuploidies in oocytes \n  \nThe defense will take place in English in the Alan Turing amphitheater (Bâtiment Sophie Germain) Place Aurélie Nemours\, 75013 Paris). \nThe jury will be composed of: \n\nJulien Dumont\nMarie-Hélène Verlhac\nAdele Marston\nAnthi Karaiskou\nAndreas Boland
URL:https://www.ijm.fr/event/phd-thesis-defense-safia-el-jailani/?lang=en
LOCATION:Amphithéâtre Alan Turing – Bâtiment Sophie Germain\, 8 place Aurélie Nemours\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/06/These-bandeau-Safia-El-Jailani-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250708T114500
DTEND;TZID=Europe/Paris:20250708T130000
DTSTAMP:20260425T182701
CREATED:20250603T131610Z
LAST-MODIFIED:20250603T131610Z
UID:28329-1751975100-1751979600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Adèle Marston
DESCRIPTION:Invited by the Wassmann lab\, Professor Adele L. Marston (Centre for Cell Biology\, University of Edinburgh) will present an Institut Jacques Monod seminar on the theme: \nFunctional organisation of pericentromeres in mitosis and meiosis \nAbstract: \nOur overall goal is to understand how cells inherit the correct number of chromosomes during mitosis and meiosis. Deviations in chromosome number\, called aneuploidy\, are a hallmark of cancer and cause birth defects\, miscarriages and infertility. Mitosis generates genetically identical daughter cells by evenly segregating the sister chromatids. Meiosis partitions half the genome into gametes through two consecutive segregation events: homologs segregate in meiosis-I\, followed by sister chromatids in meiosis-II. Meiosis is especially error-prone: around 1% of human sperm and up to 30% of oocytes are aneuploid. To discover molecular mechanisms\, we exploit the tractability of yeast\, combined with work in frog\, mouse and human oocytes. Our approach is guided by the research question\, leading to the employment and development of a wide range of cell biological\, genomic\, proteomic and biochemical assays. Our group discovered unanticipated roles for pericentromeres\, discrete chromosomal domains flanking centromeres\, and specialised functions for kinetochores in orienting chromosomes to ensure accurate segregation. In my seminar I will discuss our recent work revealing how pericentromere organization directs accurate chromosome segregation in mitosis and meiosis\, in both yeast and oocytes.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-adele-marston/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/06/Bandeau-web-seminar-Adele-Marston-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250711T114500
DTEND;TZID=Europe/Paris:20250711T130000
DTSTAMP:20260425T182701
CREATED:20250612T114114Z
LAST-MODIFIED:20250612T114114Z
UID:28409-1752234300-1752238800@www.ijm.fr
SUMMARY:Institut Jacques Monod Lecture - Gijsje Koenderink
DESCRIPTION:On July 11th\, Gijsje Koenderink (Department of Bionanoscience\, Kavli Institute of Nanoscience Delft\, Delft University of Technology) will present an Institut Jacques Monod lecture on the theme: \nHow cytoskeletal crosstalk makes cells strong \nAbstract: \nOur bodies are built up of cells and tissues with unique physical properties. Cells and tissues are dynamic but also need to withstand large mechanical loads. This paradoxical mechanical behavior is governed by fibrous protein scaffolds known as the cytoskeleton and the extracellular matrix. Fibrous networks have many advantageous mechanical properties: fibers can form space-filling elastic networks at low volume fractions and they reversibly stress-stiffen\, which provides protection from damage. However\, it is still poorly understood how biopolymer networks can combine these features with the ability to dynamically adapt their structure and mechanics. In this seminar I will focus on the cytoskeleton: how can the cytoskeleton combine mechanical strength with the ability to dynamically adapt its structure and mechanics? I will summarize our recent insights in this question obtained via quantitative measurements on living cells coupled with experiments on cell-free model systems. I will focus on the role of mechanical crosstalk between the actin\, intermediate filament\, and septin cytoskeletal networkds\, three key determinants of cell mechanics. These three filamentous systems contribute different structural and dynamical properties\, but their activities are closely coordinated. I will show that combining cell and cell-free assays allows us to dissect the collaborative and individual roles of the cytoskeletal systems. Our findings may eventually be interesting to guide the search for selective anticancer drugs\, since cancer cells often overexpress specific intermediate filaments or septins leading to abnormal mechanical behaviors.
URL:https://www.ijm.fr/event/institut-jacques-monod-lecture-gijsje-koenderink/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/06/bandeau-IJM-Lectures-Gijsje-Koenderink-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250826T103000
DTEND;TZID=Europe/Paris:20250826T153000
DTSTAMP:20260425T182701
CREATED:20250722T084441Z
LAST-MODIFIED:20250722T084611Z
UID:29098-1756204200-1756222200@www.ijm.fr
SUMMARY:Neuro/Evo/Devo in Japan and Paris
DESCRIPTION:Neuro/evo/devo in Japan and Paris\nMeeting regarding the latest research on development\, evolution and neurobiology using as model organisms birds\, fishes\, butterflies and Drosophila\nOrganised by Virginie Courtier (contact) \nProgram\n10:30: Welcome coffee\n11:00 – 11:05: Introduction (V. COURTIER-ORGOGOZO)\n11:05 – 11:25: A key pleiotropic gene underlying the diversification of seasonal reproduction in sticklebacks (Asano ISHIKAWA)\n11:25 – 11:45: Developmental bases of trends and variation in color patterns (Marie MANCEAU)\n11:45 – 12:05: Drosophila pigmentation: a model to study the impact of environmental and natural genetic variations and the role of developmental constraints (Jean-Michel GIBERT)\n12:05 – 14:00: Lunch\n14:00 – 14:20: Evolution of Drosophila glue (Virginie COURTIER-ORGOGOZO)\n14:20 – 14:40: How Fish Stay Upright: Neural Mechanisms of Head Tilt Sensing and Balance Control in Zebrafish (Masashi TANIMOTO)\n14:40 – 15:00: From ecology to neural adaptation in flower-visiting Drosophila elegans (Yuki ISHIKAWA)\n15:00 – 15:20: From ecological divergence to genetic architecture: what is driving sympatric speciation? (Violaine LLAURENS)\n15:20: End of the meeting \n  \nAbstracts (alphabetical order of names)\nEvolution of Drosophila glue\nVirginie COURTIER-ORGOGOZO\nAt the end of the larval stage\, Drosophila larvae produce a proteinaceous glue that allows the animal to adhere to a substrate for several days during metamorphosis. We are currently using Drosophila powerful genetic tools to identify the genes involved in glue adhesion and understand how they have changed during evolution so that the glue can stick to various substrates in diverse environments. We developed a new assay to quantify Drosophila glue adhesiveness and compared adhesion between different Drosophila melanogaster populations and Drosophila species. We identified one particular Drosophila species with highly adhesive glue. Furthermore\, we also explore natural environments (rotten fruits\, soil\, etc.) to understand better this fascinating biomaterial that is Drosophila glue. Our ultimate goal is not only to better understand adaptation but also to develop new bioadhesives inspired from Drosophila glue. \nDrosophila pigmentation: a model to study the impact of environmental and natural genetic variations and the role of developmental constraints\nJean-Michel GIBERT\nDrosophila pigmentation is involved in many adaptive process such as thermoregulation or protection against UV\, parasites or pathogens. Furthermore\, in Drosophila melanogaster pigmentation is genetically variable and modulated by temperature during development. Using female abdominal pigmentation as a model\, we analyzed the genetic bases of these phenomenon. We found that temperature modulates the expression of regulatory and effector genes involved in pigmentation\, and\, interestingly\, that these genes carry variation modulating pigmentation in natural populations. In addition\, we showed that a particular pigmentation pattern on the thorax is linked to developmental constraints\, as it is shaped by flight muscle attachment sites. \nA key pleiotropic gene underlying the diversification of seasonal reproduction in sticklebacks\nAsano ISHIKAWA\nReproductive timing is a key life-history trait that affects fitness\, with populations often undergoing diversification in reproductive patterns to adapt to varying seasonal environments. However\, the molecular genetic mechanisms underlying differences in reproductive seasonality are not well understood. To address this\, we use the three-spined stickleback (Gasterosteus aculeatus) as a model. While marine ecotypes of sticklebacks reproduce in early summer\, freshwater ecotypes show significant variation in reproductive timing\, with stream ecotypes at lower latitudes breeding almost year-round. Our study reveals that marine sticklebacks exhibit a photoperiodic response in gonad development\, while this response is lost in stream ecotypes\, which evolved independently in Japan and North America. Transcriptome analysis identified the thyroid stimulating hormone beta 2 (TSHβ2) gene as a key regulator of this response. Knocking out TSHβ2 in marine ecotypes led to earlier maturation under short photoperiods\, similar to stream ecotypes in terms of behavior\, body size\, hormone levels\, and brain transcriptome. Linkage mapping revealed that the loss of seasonality in stream ecotypes is due to convergent mutations in the TSHβ2 pathway—cis-regulatory in North America and trans-regulatory in Japan. Single-cell analysis detected a novel TSHβ2-expressing 2 pituitary cell cluster\, and we observed increased TSHβ2 expression and chromatin accessibility under short-day conditions. These findings suggest that transcriptional and epigenetic mechanisms drive the evolution of reproductive seasonality in sticklebacks. \n  \nFrom ecology to neural adaptation in flower-visiting Drosophila elegans\nYuki ISHIKAWA\nFlower-visiting behavior in insects is essential for plant reproduction and the stability of terrestrial ecosystems. Although insects have existed on Earth long before the evolution of flowering plants\, they developed flower-visiting behavior in parallel with the adaptive radiation of angiosperms. However\, the neural basis of this behavioral evolution remains unclear.\nTo investigate this\, we studied Drosophila elegans\, a flower-breeding species closely related to the non-flower-visiting model organism D. melanogaster. D. elegans has evolved a flower-dependent life cycle and exhibits pronounced flower-visiting behavior in its natural habitat. Field observations revealed that it relies on specific flower species for both breeding and feeding. These ecological preferences suggest behavioral and neural adaptations that enable recognition of appropriate flowers. Behavioral assays showed that visual cues—especially color—are crucial for flower recognition. Comparative analyses suggest that its visual system is adapted to detect relevant flower colors\, and genome editing identified specific photoreceptor cells that are essential for this behavior.\nIn this talk\, I will discuss how ecological specialization and neural adaptation have together contributed to the evolution of flower-visiting behavior in this species. \nFrom ecological divergence to genetic architecture: what is driving sympatric speciation?\nViolaine LLAURENS\nDetermining the evolutionary forces initiating and fuelling the speciation process is challenging\, especially when population divergence occurs in sympatry. Sympatric speciation often involves complex interactions between ecological specialization generating divergent selection and the accumulation of genetic barriers to gene flow. Here we focus on a pair of sister-species of butterflies (M. achilles and M. helenor) observed in sympatry throughout the Amazonian basin\, and sharing similar micro-habitat but diverging in the timing of male patrolling behaviour. Since M. helenor has a larger geographical range\, we compared the temporal niche in sympatric and allopatric populations of this species and found a significant shift in patrolling hours\, suggesting that the evolution of temporal niches might contribute to the speciation or reinforcement process. Using population genomics\, we then reconstructed the history of speciation between these two species and investigated the heterogeneity in the level of genetic divergence throughout the genome. We found a very strong differentiation in the sexual chromosome (Z) as compared to the autosomes between species but not between populations within species. We then specifically tested for the effect of selection in such increased rate of evolution in the Z chromosomes and found significantly higher signals of positive selection in the Z vs. the autosomes in sympatric population\, while such a signal was missing in the allopatric ones. Furthermore\, by testing the association between the temporal niche and genomic variations across populations of M. helenor\, we found significant signals on two loci within the Z-chromosome\, including one non-coding region located between the circadian genes PDP1 and Period. Altogether\, our results raise questions on the implication of the Z chromosome in ecological specialization and speciation in sympatry. \n  \nDevelopmental bases of trends and variation in color patterns\nMarie MANCEAU\nThe color patterns that adorn animals’ coats exhibit extensive diversity linked to various ecological functions\, but also display recurrences in geometry\, orientation or body location. How processes of pattern formation shape such phenotypic trends remains a mystery. We surveyed plumage color patterns in poultry birds and passerine finches respectively displaying variation in striped pattern and color domain distribution\, and identified conserved features that we linked to embryonic pre-patterns (i.e. putative embryonic skin regions outlined by the combinatory expression of few genetic markers). We showed that these pre-patterns are instructed by early developmental tissues\, variation resulting from late dose-dependent mechanisms controlling stripe width\, or pigmentation choices that mask or display skin domains. This work revealed that early conserved landmarks and molecular pathways are a major cause of phenotypic trends. \nHow Fish Stay Upright: Neural Mechanisms of Head Tilt Sensing and Balance Control in Zebrafish\nMasashi TANIMOTO\nBody equilibrium is vital for all living organisms. In vertebrates\, vestibular signals from the inner ear play pivotal roles in maintaining balance. Larval zebrafish serve as an advantageous model since their transparent tissues facilitate live imaging of neural mechanisms during behavior. We developed an imaging system that simultaneously visualizes neural activity and behavior while controlling fish orientation. Using this approach\, we revealed the neural mechanisms of head tilt sensing and posture control. I will share what fish study can tell us about vertebrate balance control.
URL:https://www.ijm.fr/event/neuro-evo-devo-in-japan-and-paris/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/07/Bandeau-web-seminar-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250905T114500
DTEND;TZID=Europe/Paris:20250905T130000
DTSTAMP:20260425T182701
CREATED:20250818T122422Z
LAST-MODIFIED:20250818T122422Z
UID:29415-1757072700-1757077200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Olivier Destaing
DESCRIPTION:Invited by the Ribes / Nedelec lab\, Olivier Destaing (PhD-HDR (DR2 CNRS)\, Group INVADE à l’institut pour l’avancée des Biosciences UMR 5309 (CNRS\, Inserm\, UGA) ) will present an Institut Jacques Monod seminar on the theme: \nUnderstanding specificity and redundancy in cell signaling. Let’s put a bit of light in SRC signaling \nAbstract: \nThe discovery of the concept of homeostasis has highlighted the dynamic nature of biological systems at all scales\, from the cell to the whole organism. Biological systems are characterized by their ability to maintain a dynamic equilibrium in response to sensing and adaptation to their environment. This property is based on intracellular signaling network able to detect\, amplify and generate adapted cellular responses. Although classical approaches in biology\, such as genetics and pharmacology\, can modulate these systems\, they are problematic to act both on time and space scales . The introduction of optogenetics has made possible to interact dynamically with biological systems on scales characteristic of these systems\, ranging from seconds to days\, and from micrometers to centimeters. \n  \nOur team has focused on developing methods\, probes and optical systems to enable a wide range of optogenetic approaches aimed at controlling multiple and diverse biological functions. These causal approaches to biology are perfectly attuned to the characteristic timing of the targeted biological processes. In addition to previous collaborative works on mechanosensitive transcription factors or inflammatory organelles\, we have recently proposed new molecular bases for basic principles of cell signaling\, such as decision making or signal redundancy\, in cancer and immune cells. To do\, we focused on the interplays between SRC signaling kinases (SFKs) in the biology of epithelial cells and macrophages. These synthetic biology approaches can even beused for  new approaches in biotechnology. Optogenetics is an approach for causal manipulation at multiple levels of biochemical regulation\, enabling new conceptual interactions at the physics-biology interface.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-olivier-destaing/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/08/Bandeau-web-seminar-Olivier-Destaing-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250911T113000
DTEND;TZID=Europe/Paris:20250911T123000
DTSTAMP:20260425T182702
CREATED:20250820T084524Z
LAST-MODIFIED:20250820T084524Z
UID:29442-1757590200-1757593800@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Stéphanie Ellis
DESCRIPTION:Invited by the Ladoux/Mege\, Stéphanie Ellis (Max Perutz Labs/University of Vienna/Vienna Biocenter Campus) will present an Institut Jacques Monod on the theme: \nUnderstanding mosaic tissue dynamics through cell competition. \n  \nAbstract: \nWhat are the cellular principles of growth control in complex tissues as they grow\, differentiate\, reach their final size\, and contend with threats to their homeostasis? In the Ellis Lab\, we study this question through the lens of cell competition\, a conserved\, yet poorly understood\, phenomenon of growth control. Cell competition is likely to have serious implications for heterogeneous cell-cell interactions within tissues during development\, homeostasis\, and in disease. Research in my group explores the molecular and cellular mechanisms that underlie competitive behaviours and their consequences for establishing and maintaining robust tissue function across distinct physiological states. We recently established the murine skin epidermis as a physiologically-relevant\, genetically tractable model for the study of cell competition in mammals. In my talk\, I will summarize our ongoing efforts to probe the molecular and cellular mechanisms of cell competition and fitness sensing in three specific contexts: 1- normal development; 2- tumour initiation; 3- X-linked inflammatory disease. Using a combination of genetic and genomic approaches\, lineage tracing\, time-lapse microscopy\, functional assays\, and disease models we have uncovered evidence suggesting that skin barrier function critically depends on cell competition. Intriguingly\, we find that the strategy the skin uses to eliminate less fit cells undergoes a transition as tissue architecture becomes more complex during morphogenesis\, and that this may also be linked to changes in tissue mechanics. Based on our preliminary data\, we propose that cell competition maintains homeostasis and optimises organ function by shaping tissue-level responses to stresses that are inevitably encountered over long\, unpredictable lifetimes.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-stephanie-ellis/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/08/Bandeau-web-seminar-Stephanie-Ellis-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250911T113000
DTEND;TZID=Europe/Paris:20250911T130000
DTSTAMP:20260425T182702
CREATED:20250908T134321Z
LAST-MODIFIED:20250908T135329Z
UID:29609-1757590200-1757595600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Stéphanie Ellis
DESCRIPTION:Invited by the Ladoux/Mege\, Stéphanie Ellis (Max Perutz Labs/University of Vienna/Vienna Biocenter Campus) will present an Institut Jacques Monod Seminar on the theme: \nUnderstanding mosaic tissue dynamics through cell competition \nAbstract: \nWhat are the cellular principles of growth control in complex tissues as they grow\, differentiate\, reach their final size\, and contend with threats to their homeostasis? In the Ellis Lab\, we study this question through the lens of cell competition\, a conserved\, yet poorly understood\, phenomenon of growth control. Cell competition is likely to have serious implications for heterogeneous cell-cell interactions within tissues during development\, homeostasis\, and in disease. Research in my group explores the molecular and cellular mechanisms that underlie competitive behaviours and their consequences for establishing and maintaining robust tissue function across distinct physiological states. We recently established the murine skin epidermis as a physiologically-relevant\, genetically tractable model for the study of cell competition in mammals. In my talk\, I will summarize our ongoing efforts to probe the molecular and cellular mechanisms of cell competition and fitness sensing in three specific contexts: 1- normal development; 2- tumour initiation; 3- X-linked inflammatory disease. Using a combination of genetic and genomic approaches\, lineage tracing\, time-lapse microscopy\, functional assays\, and disease models we have uncovered evidence suggesting that skin barrier function critically depends on cell competition. Intriguingly\, we find that the strategy the skin uses to eliminate less fit cells undergoes a transition as tissue architecture becomes more complex during morphogenesis\, and that this may also be linked to changes in tissue mechanics. Based on our preliminary data\, we propose that cell competition maintains homeostasis and optimises organ function by shaping tissue-level responses to stresses that are inevitably encountered over long\, unpredictable lifetimes.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-stephanie-ellis-2/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/09/Bandeau-web-seminar-Stephanie-Ellis-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250911T140000
DTEND;TZID=Europe/Paris:20250911T170000
DTSTAMP:20260425T182702
CREATED:20250715T141209Z
LAST-MODIFIED:20250715T141209Z
UID:29006-1757599200-1757610000@www.ijm.fr
SUMMARY:PhD thesis defense - Andreas Schoenit
DESCRIPTION:Andreas Schoenit (Ladoux/Mège Lab) will defense his PhD thesis: \nMechanical forces in cell competition and epidermal stratification \nThe jury will be composed of: \n\nPierre-François LENNE\, DR – IBDM Marseille – Rapporteur\nStephanie ELLIS\, Group leader – University of Vienna\, Austria – Rapportrice\nVanessa RIBES\, DR – Institut Jacques Monod – Examinatrice\nGuillaume CHARRAS\, Professor – University College London\, UK – Examinateur\nCarien NIESSEN\, Professor – University of Cologne\, Germany – Membre invité\nRené Marc MEGE\, DR – Institut Jacques Monod – Membre invité\nBenoît LADOUX\, DR – Institut Jacques Monod – Directeur de thèse
URL:https://www.ijm.fr/event/phd-thesis-defense-andreas-schoenit/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/07/These-bandeau-Andreas-Schoenit-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250912T114500
DTEND;TZID=Europe/Paris:20250912T130000
DTSTAMP:20260425T182702
CREATED:20250715T144805Z
LAST-MODIFIED:20250715T144805Z
UID:29011-1757677500-1757682000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Jan Brugues
DESCRIPTION:Invited by the équipe Minc Lab\, Jan Brugues (Physics of Life Excellence Cluster\, TU Dresden ) will present an Institut Jacques Monod seminar: \nSelf-organization of the cytoplasm by physical instabilities \nAbstract: \nEarly development across vertebrates and insects critically relies on robustly reorganizing the cytoplasm of fertilized eggs into individualized cells. This intricate process is orchestrated by large microtubule structures that traverse the embryo\, partitioning the cytoplasm into physically distinct and stable compartments. Despite the robustness of embryonic development\, here we uncover an intrinsic instability in cytoplasmic partitioning driven by the microtubule cytoskeleton. We reveal that embryos circumvent this instability through two distinct mechanisms: either by matching the cell cycle duration to the time needed for the instability to unfold or by limiting microtubule nucleation. These regulatory mechanisms give rise to two possible strategies to fill the cytoplasm\, which we experimentally demonstrate in vitro and in zebrafish and Drosophila embryos. Our results indicate that the temporal control of microtubule dynamics could have driven the evolutionary emergence of species-specific mechanisms for effective cytoplasmic organization. Furthermore\, our study unveils a fundamental synergy between physical instabilities and biological clocks\, uncovering universal strategies for rapid\, robust\, and efficient spatial ordering in biological systems.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-jan-brugues/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/07/Bandeau-web-seminar-Jan-Brugues-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250912T140000
DTEND;TZID=Europe/Paris:20250912T170000
DTSTAMP:20260425T182702
CREATED:20250818T123258Z
LAST-MODIFIED:20250818T123258Z
UID:29423-1757685600-1757696400@www.ijm.fr
SUMMARY:Authorization to supervise research (HDR) defense - Sandra Touati
DESCRIPTION:Sandra Touati (Wassmann Lab) will defend her Authorization to supervise research (HDR) : \n« Cell cycle regulation – Let’s crack the phosphocode » \n  \nThe defense will take place on Friday September 12th at 2 pm in François Jacob room (IJM). \nThe jury will be composed of: \n\nValérie Borde\nThierry Lorca\nSimonetta Piatti\nLionel Pintard\nZhou Xu
URL:https://www.ijm.fr/event/authorization-to-supervise-research-hdr-defense-sandra-touati/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/08/HDR-bandeau-Sandra-Touati.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250917T140000
DTEND;TZID=Europe/Paris:20250917T170000
DTSTAMP:20260425T182702
CREATED:20250820T130219Z
LAST-MODIFIED:20250820T130219Z
UID:29462-1758117600-1758128400@www.ijm.fr
SUMMARY:PhD thesis defense - Fanny Roland-Gosselin
DESCRIPTION:Fanny Roland-Gosselin (Guichet Lab) will defend her PhD thesis : \nCaractérisation d’un réseau membranaire de microtubules impliqué dans le positionnement du noyau de l’ovocyte de Drosophila melanogaster \nThe jury will be composed of: \n\nMagali SUZANNE\, Rapporteur\nAlexandre BAFFET\, Rapporteur\nMarianne MALARTRE\, Examinateur\nBruno CADOT\, Examinateur\nAntoine GUICHET\, Membre invité\nFred BERNARD\, Directeur de thèse
URL:https://www.ijm.fr/event/phd-thesis-defense-fanny-roland-gosselin-2/?lang=en
LOCATION:Amphithéâtre Alan Turing – Bâtiment Sophie Germain\, 8 place Aurélie Nemours\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/07/These-bandeau-Fanny-Roland-Gosselin-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250918T114500
DTEND;TZID=Europe/Paris:20250918T130000
DTSTAMP:20260425T182702
CREATED:20250818T121205Z
LAST-MODIFIED:20250818T121205Z
UID:29408-1758195900-1758200400@www.ijm.fr
SUMMARY:Institut Jacques Monod seminar - Peter Andersen
DESCRIPTION:Invited by the Duharcourt Lab\, Peter Andersen (Associate Professor at the Department of Molecular Biology and Genetics at Aarhus University) will present an Institut Jacques Monod seminar on the theme: \nRunning to stand still – Recurrent innovation of animal germline genome regulation \nAbstract: \nGene expression relies on core protein machineries that function at almost all protein-coding genes\, including basal transcription factors and co-transcriptional processing factors. Animal germ cells\, however\, express alternative\, paralog-based core machineries that enable gametogenesis. The molecular mechanism and gene regulatory impact of such paralog-based genome regulation\, however\, remain underexplored. We have identified and characterized several germline-specific basal transcription factor paralogs in the Drosophila melanogaster animal model organism. Our findings uncover how such paralogs form specialized gene expression pathways that bend and bypass the known textbook rules of RNA Polymerase II-based gene expression to ensure germline genome integrity and proper germ cell development. Surprisingly\, while the identified paralogs are all essential for fertility\, we find rapid evolution to be a shared feature of paralog-based germline gene expression pathways and we uncover functional molecular innovation underlying such evolutionary signatures. We propose that such paralog-based complexes represent valuable model systems for mechanistic and evolutionary investigation of animal germline genome regulation.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-peter-andersen/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/08/Bandeau-web-seminar-Peter-Andersen-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250918T140000
DTEND;TZID=Europe/Paris:20250918T170000
DTSTAMP:20260425T182702
CREATED:20250715T150033Z
LAST-MODIFIED:20250715T150033Z
UID:29018-1758204000-1758214800@www.ijm.fr
SUMMARY:PhD thesis defense - Meriem Boumendjel
DESCRIPTION:Meriem Boumendjel (Azimzadeh Lab) will defense her PhD thesis defense: \nÉlucider les bases moléculaires de l’asymétrie rotationnelle des centrioles et son rôle au centrosome et au cil primaire \nThe jury will be composed of: \n\nDr Bénédicte Durand : Rapportrice\, Professeur HDR\, Univ Lyon1\, Lyon\nDr Manuel Théry : Rapporteur\, DR\, PSL\, Paris\nDr Alice Meunier : Examinatrice\, DR\, IBENS\, Paris\nDr Alexandre Benmerah : Examinateur\, DR\, UPC\, Paris\nDr Juliette Azimzadeh : Directrice de thèse\, DR\, UPC\, Paris
URL:https://www.ijm.fr/event/phd-thesis-defense-meriem-boumendjel/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/07/These-bandeau-Meriem-Boumendjel-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250919T140000
DTEND;TZID=Europe/Paris:20250919T170000
DTSTAMP:20260425T182702
CREATED:20250820T080042Z
LAST-MODIFIED:20250820T080042Z
UID:29430-1758290400-1758301200@www.ijm.fr
SUMMARY:PhD thesis defense  - Thomas Balan
DESCRIPTION:Thomas Balan (Duharcourt Lab) will defense his PhD defense: \nCharacterization of proteins involved in the dynamics of histone modifications during programmed DNA elimination in Paramecium tetraurelia \nThe jury will be composed of: \n\nAngélique DELERIS\, Chargée de recherche CNRS\, Institut de Biologie Intégrative de la Cellule\, Université Paris Saclay\, Rapportrice\nPeter ANDERSEN\, Assistant Professor\, Department of Molecular Biology and Genetics\, Aarhus University\, Rapporteur\nAntoine MOLARO\, Chargé de recherche CNRS\, Institut Génétique reproduction et développement\, Université Clermont Auvergne\, Examinateur\nSophie POLO\, Directrice de recherche CNRS\, Unité Épigénétique et Destin Cellulaire\, Université Paris Cité\, Examinatrice\nGermano CECERE\, Directeur de recherche CNRS\, Institut Pasteur\, Université Paris Cité\, Examinateur\nClaire DUGAST\, Maîtresse de conférence\, Institut Jacques Monod\, Université Paris Cité\, Membre invitée\nSandra DUHARCOURT\, Directrice de recherche CNRS\, Institut Jacques Monod\, Université de Paris\, Directrice de Thèse
URL:https://www.ijm.fr/event/phd-thesis-defense-thomas-balan/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/08/These-bandeau-Thomas-Balan-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250922T133000
DTEND;TZID=Europe/Paris:20250922T170000
DTSTAMP:20260425T182702
CREATED:20250724T073434Z
LAST-MODIFIED:20250724T073434Z
UID:29179-1758547800-1758560400@www.ijm.fr
SUMMARY:PhD thesis defense - Teresa Urli
DESCRIPTION:Teresa Urli (Greenberg Lab) will defend her PhD thesis defense: \nUnraveling the functions and mechanisms of epigenetic switching in mammals \nThe jury will be composed of: \nReporters: \n\nDr Courtney HANNA\, Research Director – University of Cambridge\nDr Michael WEBER\, DR – CNRS | BSC Université de Strasbourg\n\nExaminers: \n\nDr Reini F. DE LUCO\, DR – CNRS | Curie\, UMR3348 Orsay\, Université PSL\nDr Jamie HACKETT\, Research Director – EMBL Rome\, Heidelberg University\nDr Sandra DUHARCOURT\, DR – Institut Jacques Monod\, CNRS | UPC\n\nThesis director: \n\nDr Maxim GREENBERG\, CR – Institut Jacques Monod\, CNRS | UPC
URL:https://www.ijm.fr/event/phd-thesis-defense-teresa-urli/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/07/These-bandeau-Teresa-Urli-scaled.jpg
END:VEVENT
END:VCALENDAR