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X-WR-CALDESC:Events for Institut Jacques Monod
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DTSTART;TZID=Europe/Paris:20250110T114500
DTEND;TZID=Europe/Paris:20250110T130000
DTSTAMP:20260425T052654
CREATED:20241205T145404Z
LAST-MODIFIED:20241205T145404Z
UID:26050-1736509500-1736514000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Lendert Gelens
DESCRIPTION:Invited by the Wassmann Lab\, Lendert Gelens (Laboratory of Dynamics in Biological Systems\, University of Leuven\, Belgium) will present an Institut Jacques Monod seminar on the theme: \nNuclei coordinate the cell cycle in space and time \n  \nAbstract: \nProliferating cells replicate their DNA and components before dividing\, but how subcellular localization impacts cell cycle timing remains unclear. Using frog egg extracts encapsulated in droplets\, we studied cell cycle oscillations with and without nuclei [1]. Time-lapse microscopy revealed that nuclei increase cell cycle duration\, with increasing nuclear volume correlating with longer periods across different Xenopus species. This relationship persisted without DNA replication or transcription but was disrupted by inhibiting nuclear import or Wee1 kinase. A computational model incorporating nuclear-cytoplasmic compartmentalization and periodic nuclear envelope dynamics reproduced these findings\, linking nuclear size to cycle timing. These results explain the lengthening of the cell cycle at the midblastula transition when cells become smaller\, and the nuclear-cytoplasmic ratio increases. \nIn early Xenopus embryos (~1.2 mm)\, mitotic waves coordinate the cell cycle over long distances\, as diffusion alone is insufficient. Using X. laevis egg extracts and a Cdk1 FRET sensor\, we observed a transition from phase to trigger wave dynamics in initially homogeneous cytosol [2]. Spatial heterogeneity and nuclei accelerated this transition\, while metaphase-arrested extracts induced an immediate shift. Simulations revealed transient phase waves as trigger waves required time to entrain the system. Both wave types emerge as part of a unified process for coordinating the cell cycle across large distances. \n[1] Pineros\, L. *; Frolov\, N. *; Ruiz-Reynés\, D.; Eynde\, A. Van; Cavin-Meza\, G.; Heald\, R.; Gelens\, L.; The nuclear-cytoplasmic ratio controls the cell cycle period in compartmentalized frog egg extract; BioRxiv\, 2024. \n[2] Puls*\, O.; Ruiz-Reynés*\, D.; Tavella\, F.; Jin\, M.; Kim\, Y.; Gelens*\, L.; Yang*\, Q.; Spatial heterogeneity accelerates phase-to-trigger wave transitions in frog egg extracts; Nature Communications\, vol. 15\, no. 10455\, 2024.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-lendert-gelens/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/Bandeau-web-seminar-Lendert-Gelens-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250115T093000
DTEND;TZID=Europe/Paris:20250115T110000
DTSTAMP:20260425T052654
CREATED:20250113T141600Z
LAST-MODIFIED:20250113T141700Z
UID:26547-1736933400-1736938800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The first meeting of 2025 of the cytoskeleton club will take place next Wednesday at the Institut Pasteur: \n– Charlotte Mallart (post-doc\, Minc lab\, Institute Jacques Monod) will talk about:  “Regulation of cytoplasm rheology by bulk F-Actin networks”. \n– Noemi Zollo (PhD student\, Verlhac/ Terret lab\, CIRB Collège de France) will talk about:  “A novel RNP compartment allows mouse oocytes to adapt translational levels during late growth”.
URL:https://www.ijm.fr/event/cytoskeleton-club-3/?lang=en
LOCATION:Institut Pasteur Auditorium François Jacob\, 28 rue du docteur roux\, Paris\, 75015\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/20250115-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250116T090000
DTEND;TZID=Europe/Paris:20250116T180000
DTSTAMP:20260425T052654
CREATED:20241028T102411Z
LAST-MODIFIED:20241028T102411Z
UID:25485-1737018000-1737050400@www.ijm.fr
SUMMARY:Second workshop on new microscopies in cell biology
DESCRIPTION:The two GDRs AQV (Quantitative approaches to living systems) and IMABIO (Imaging in Biology) are organising a joint workshop on 16 January 2025 at the Institut Jacques Monod in Paris on new microscopies in cell biology. The aim is to bring together scientists from biology\, physics\, engineering and data science to discuss new imaging strategies for : \n\nmeasuring physical descriptors of cellular organisation and function;\nimproving imaging resolution;\nmaking smart microscopes more effective at capturing processes of interest.\n\nConfirmed speakers : \n\nJuliette Azimzadeh\, Institut Jacques Monod\, Paris\nVictor Barolle\, Institut Langevin\, Paris\nRicardo Henriques\, Instituto Gulbenkian de Ciência\, Oeiras and University College London\nKheya Sengupta\, Interdisciplinary Centre for Nanoscience\, Marseille\nVincent Studer\, Interdisciplinary Neuroscience Institute\, Bordeaux\nIlaria Testa\, KTH Royal Institute of Technology\, Stockholm\n\nOral presentations and posters will also be selected from the abstracts submitted. \nRegistration is free but compulsory and is now open here: https://newmic4cellbio2.sciencesconf.org/ \nThe organisers\nPierre Bon\, Nicolas Borghi\, Cécile Leduc\, Loic Le Goff\, Pierre-Henri Puech
URL:https://www.ijm.fr/event/second-workshop-on-new-microscopies-in-cell-biology/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/bandeau-web-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250117T114500
DTEND;TZID=Europe/Paris:20250117T130000
DTSTAMP:20260425T052654
CREATED:20241125T114034Z
LAST-MODIFIED:20241125T114034Z
UID:25863-1737114300-1737118800@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Zayna Chaker
DESCRIPTION:Invited by the Konstantinides Lab\, Zayna Chaker (Institute of Functional Genomics of Lyon (IGFL) Ens de Lyon\, CNRS) will present an Institut Jacques Monod Seminar on the theme: \nSpatio-Temporal coordination of neural stem cells in the adult brain: A functional and evolutionary perspective \n  \nAbstract: \nResearch over the last three decades has demonstrated that new neurons can be generated in the adult brain\, and integrate into pre-existing complex circuits. The process of adult neurogenesis is evolutionary conserved among vertebrates\, including fishes\, frogs\, reptiles\, birds\, rodents and primates. It is sustained by a small population of undifferentiated cells\, called neural stem cells (NSCs)\, which persist as embryonic vestiges in adult brains. These cells reside in tightly controlled micro-environments called niches. The addition of young cells constitutes an important layer of adult brain plasticity\, further enhancing its ability to adapt to diverse life experiences. However\, the physiological relevance of adult-born neurons as well as the regenerative power of NSCs after injury are still highly debated to date\, especially in mammals. \nBesides constitutive neurogenesis\, we recently showed that regionally-defined subpopulations of NSCs in the adult ventricular niche produce transient waves of functionally-relevant interneurons in response to pregnancy and motherhood. This process finely tunes the mother’s olfactory sensitivity to own versus alien pup odor (Chaker et al. 2023). In my lab\, we are now investigating the cellular and molecular mechanisms allowing regionally-distinct pools of NSCs to coordinate their behavior in space (across all niches) and time (from embryo to different phases in adulthood)\, under specific physiological and pathological conditions.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-zayna-chaker/?lang=en
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/Bandeau-web-seminar-Chaker-Zayna-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250121T114500
DTEND;TZID=Europe/Paris:20250121T130000
DTSTAMP:20260425T052654
CREATED:20241230T140129Z
LAST-MODIFIED:20250115T101830Z
UID:26317-1737459900-1737464400@www.ijm.fr
SUMMARY:Paris Postdoc Seminar - Lucas Alves Tavares
DESCRIPTION:Invited by the Institut Jacques Monod\, Lucas Alves Tavares (Center for Virology Research and Department of Cell and Molecular Biology\, University of São Paulo (USP) & Institut Curie\, Paris) will present a Paris Postdoc Seminar on the theme: \nUnraveling the role of AP-1γ2 in the Endosome Maturation and Extracellular Vesicles Release \n  \nAbstract: \nThe adaptor protein (AP) complexes are heterotetrameric complexes that coordinate protein trafficking in the endocytic and secretory pathways. AP-1\, a complex of four distinct subunits (γ\, β1\, μ1\, and σ1)\, is thought to mediate protein trafficking between the trans-Golgi network (TGN) and endosomes and Lysosomes Related Organelles (LROs) though clathrin-coated vesicles (CCV). The human genome encodes two isoforms of the γ-adaptin (γ1 and γ2) subunit that form two variants of AP-1 (AP-1γ1 and AP-1γ2). Previous studies demonstrated that γ2 may form an AP-1 complex variant\, but the knowledge is limited regarding the cellular roles played by this alternative AP-1 complex. We previously reported that γ2 is part of a functional AP-1 complex variant hijacked by HIV-1 Nef for targeting CD4 and MHC-I for lysosomal degradation. Moreover\, we recently demonstrated that the retrograde transport of CI-MPR and ATP7B requires AP-1γ2. During my internship at Graça Raposo laboratory (Institut Curie)\, we are investigating the participation of AP-1γ2 in the maturation of early endosomes to late endosomes and also for the Extracellular Vesicles (EVs) secretion by using immunofluorescence\, nanoparticle tracking analysis\, western blot\, immuno-electron microscopy analysis and conventional transmission electron microscopy analysis. Therefore\, this study has the potential to contribute to the understanding of fundamental processes in the regulation of protein and membrane trafficking involved in the endosome maturation and EVs shedding.
URL:https://www.ijm.fr/event/paris-postdoc-seminar-lucas-alves-tavares/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/20250123-Lucas-Alves-Tavares-web-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250121T140000
DTEND;TZID=Europe/Paris:20250121T170000
DTSTAMP:20260425T052654
CREATED:20241230T133205Z
LAST-MODIFIED:20241230T133205Z
UID:26312-1737468000-1737478800@www.ijm.fr
SUMMARY:Authorization to supervise research (HDR) - Jérémy Sallé
DESCRIPTION:Jérémy Sallé (Minc Lab) will defend his Authorization to supervise research (HDR): \n« Géométrie des clivages embryonnaires : Mécanismes et Implications » \n  \nThe defense will take place on Tuesday\, January 21st 2025 at 2 pm\, in room François Jacob (IJM) \nThe jury will be composed of: \n\nJenifer Croce (LBDV – Villefranche-sur-Mer)\nRémi Dumollard (LBDV – Villefranche-sur-Mer)\nPatrick Lemaire (CRBM – Montpellier)\nLionel Pintard (IJM – Paris)\nMarie-Hélène Verlhac (Collège de France – Paris)\nNicolas Minc (IJM – Paris)
URL:https://www.ijm.fr/event/authorization-to-supervise-research-hdr-jeremy-salle/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/HDR-bandeau-Jeremy-Salle-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250206T190000
DTEND;TZID=Europe/Paris:20250206T213000
DTSTAMP:20260425T052654
CREATED:20250115T091647Z
LAST-MODIFIED:20250115T091647Z
UID:26597-1738868400-1738877400@www.ijm.fr
SUMMARY:Dance conference: Move your science
DESCRIPTION:Dance conference: MOVE YOUR SCIENCE\nThursday\, February 6\, 7pm | Hall Buffon\, Institut Jacques Monod\nFree with registration\nCollective creation with doctoral students Kenza Alaoui Sossé\, Amandine Albizzati\, Mariam Bougma\, Stéphanie Brunot\, Mert Can\, Johanna Exenberger\, Audrey Gosset\, Capucine Gros\, Emile Le Lièvre and Joséphine Schelle \nChoreography and dance/science research: Cosetta Graffione and Namiko Gahier-Ogawa \nScientific coordination and dance/science research: Mélina Heuzé\, teacher-researcher \nSince September\, ten doctoral students from all disciplines at Université Paris Cité have been working with choreographers Cosetta Graffione and Namiko Gahier-Ogawa and teacher-researcher Mélina Heuzé to share their scientific project in a spirit of mediation with the general public.\nIn a dialogue between art and science\, the public will be able to experience the scientific principles of their thesis work through dance sequences that bring out the poetry of the body. \nThis four-part dance conference will be followed by a discussion with the audience over a friendly drink.
URL:https://www.ijm.fr/event/dance-conference-move-your-science/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/heuze-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250207T114500
DTEND;TZID=Europe/Paris:20250207T130000
DTSTAMP:20260425T052654
CREATED:20241219T104206Z
LAST-MODIFIED:20241219T104206Z
UID:26252-1738928700-1738933200@www.ijm.fr
SUMMARY:Institut Jacques Monod lecture - Sophie G. Martin
DESCRIPTION:On Friday\, February 7th 2025\, Sophie G. Martin (Department of Molecular and Cellular Biology\, University of Geneva\, Switzerland) will present an Institut Jacques Monod lecture on the theme: \nSignaling and actin focus architecture for cell-cell fusion \n  \nAbstract: \nSexual reproduction is ubiquitous amongst eukaryotes. This requires alternation of cell-cell (gamete) fusion and genome reduction through meiosis. My lab has been using the yeast sexual reproduction pathway to study how cells polarize to find a mate and mount a fusion reaction. In the fission yeast Schizosaccharomyces pombe\, sexual reproduction occurs between P and M cells\, which communicate through pheromone-GPCR-MAPK signaling\, driving the formation of cell pairs. Transition from gametes to zygote involves local cell wall digestion at the point of gamete contact\, while preserving cell integrity. We have shown that cell-cell fusion requires the actin fusion focus\, an aster-like assembly of linear actin filaments assembled by the formin Fus1\, which concentrates both signaling molecules and secretory vesicles carrying cell wall digestion enyzmes. I will present our recent work on the molecular mechanisms of formation of the actin fusion focus\, which require both formation of a formin biomolecular condensate and cytoskeletal focusing through formin-myosin feedback. I will also describe our progress in understanding the roles of local MAPK and PAK signaling for cells to pierce their cell wall once and only once.
URL:https://www.ijm.fr/event/institut-jacques-monod-lecture-sophie-g-martin/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/WP-IJM-Lectures-Sophie-Martin-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250211T114500
DTEND;TZID=Europe/Paris:20250211T130000
DTSTAMP:20260425T052654
CREATED:20241223T131853Z
LAST-MODIFIED:20241223T131853Z
UID:26288-1739274300-1739278800@www.ijm.fr
SUMMARY:Institut Jacques Monod  lectures- Richard Benton
DESCRIPTION:On Tuesday\, February 11th\, Richard Benton (Center for Integrative Genomics\, University of Lausanne) will present an Institut Jacques Monod lectures on the theme: \nFatal chemosensation\, and how insects fight back \n  \nAbstract: \nInsecticide resistance is a widespread challenge for the management of vectors transmitting pathogens and agricultural pests\, requiring a better understanding of the genetic mechanisms underlying the evolution of resistance. Drosophila sechellia is a compelling model for such studies as it naturally evolved resistance to octanoic acid\, an abundant chemical of its noni fruit host that is toxic for other insects\, including close relatives D. simulans and D. melanogaster. We have used a multi-pronged strategy to identify genes contributing to octanoic acid resistance. We began by experimentally-evolving D. simulans strains with higher tolerance to octanoic acid and determined the resulting genetic architecture. To identify specific candidate genes\, we integrated this analysis with a genome-wide association study of octanoic acid resistance in D. simulans and a genome-wide CRISPR selection screen upon octanoic acid exposure in D. melanogaster S2R+ cultured cells. We identified four candidates\, with diverse predicted molecular and expression properties\, and validated their relevance using genetic analyses in D. melanogaster. Two of these genes displayed an increased expression in the experimentally-evolved strains\, paralleling their higher levels of expression in D. sechellia. Our results suggest an adaptive role of these genes in shaping toxin resistance both under laboratory conditions and during D. sechellia’s evolutionary history.
URL:https://www.ijm.fr/event/institut-jacques-monod-lectures-richard-benton/?lang=en
LOCATION:Bâtiment Condorcet Amphithéâtre Pierre Gilles de Gennes\, 4 rue Elsa Morante\, Paris\, Sélectionner un État :\, 75013\, France
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250212T140000
DTEND;TZID=Europe/Paris:20250212T150000
DTSTAMP:20260425T052654
CREATED:20250127T140538Z
LAST-MODIFIED:20250127T140538Z
UID:26833-1739368800-1739372400@www.ijm.fr
SUMMARY:Seminar - Felix Ruhnow
DESCRIPTION:Invited by the Centre for Genomic Regulation\, Felix Ruhnow will present a seminar on the theme: \nNuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends \n  \nAbstract: \nNuclear mitotic apparatus protein (NuMA) is indispensable for the mitotic functions of the major microtubule minus-end directed motor cytoplasmic dynein 1. NuMA and dynein are both essential for correct spindle pole organization. How these proteins cooperate to gather microtubule minus ends at spindle poles remains unclear. Here we use microscopy-based in vitro reconstitutions to demonstrate that NuMA is a dynein adaptor\, activating processive dynein motility together with dynein’s cofactors dynactin and Lissencephaly-1 (Lis1). Additionally\, we find that NuMA binds and stabilizes microtubule minus ends\, allowing dynein/dynactin/NuMA. to transport microtubule minus ends as cargo to other minus ends. We further show that the microtubule-nucleating γ-tubulin ring complex (γTuRC) hinders NuMA binding and that NuMA can only cap minus ends of γTuRC-nucleated microtubules after γTuRC release. These results provide new mechanistic insight into how dynein\, dynactin\, NuMA\, Lis1 together with γTuRC and uncapping proteins cooperate to organize spindle poles in cells.
URL:https://www.ijm.fr/event/seminar-felix-ruhnow/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/Bandeau-web-seminar-2-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250214T114500
DTEND;TZID=Europe/Paris:20250214T130000
DTSTAMP:20260425T052654
CREATED:20241217T133040Z
LAST-MODIFIED:20241217T133040Z
UID:26236-1739533500-1739538000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Peter Andolfatto
DESCRIPTION:Invited by the Courtier\, Peter Andolfatto (Professor\, Dept. of Biological Sciences\, Columbia University) will present an Institut Jacques Monod seminar on the theme: \nThe evolution of toxin-resistant Na+\,K+-ATPases: new insights from frogs and fireflies  \n  \nWe study the process of adaptive evolution through the lens of repeated adaptation of many distantly species to a similar selection pressure (i.e. “parallel evolution”). Over the past decade\, we have explored patterns of adaptation in the context of animals that have specialized in eating plants\, or other animals\, that contain toxic cardiotonic steroids (CTS). CTS are toxic to animals because they inhibit sodium-potassium ATPase\, a key enzyme in animals needed in everything from maintaining cell homeostasis\, muscle contraction to neuron activity. Here I review our most recent work combining comparative molecular evolution\, molecular and biochemical assays and in vivo engineering of Drosophila to deduce the rules governing the adaptive evolution of CTS resistance in animals. Together\, our results have interesting implications for how epistasis and pleiotropy both limit the rate of adaptive protein evolution and increase its predictability.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-peter-andolfatto/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/Bandeau-web-seminar-Peter-Andolfatto-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250219T093000
DTEND;TZID=Europe/Paris:20250219T110000
DTSTAMP:20260425T052654
CREATED:20250205T110041Z
LAST-MODIFIED:20250205T110041Z
UID:27113-1739957400-1739962800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\, February 19th: \n\nRayane Dibsy (post-doc\, A. Echard’s Lab\, Institut Pasteur présentera  «  The proteasome promotes cytokinetic abscission by relieving Aurora B kinase-mediated inhibition of ESCRT-III turnover. »\nJonathan Fouchard ( Researcher\, Laboratoire de Biologie du Développement\, IBPS) présentera ‘Three-dimensional cell shape\, focal adhesions and vimentin during spreading’
URL:https://www.ijm.fr/event/cytoskeleton-club-4/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/02/20250219bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250224T114500
DTEND;TZID=Europe/Paris:20250224T130000
DTSTAMP:20260425T052654
CREATED:20250128T140351Z
LAST-MODIFIED:20250214T094643Z
UID:26858-1740397500-1740402000@www.ijm.fr
SUMMARY:[Cancelled] Institut Jacques Monod Seminars - Marla Sokolowski
DESCRIPTION:This seminar is cancelled.\n  \nInvited by the par l’équipe Courtier\, Marla Sokolowski (Department of Ecology and Evolutionary Biology\, University of Toronto) will present an Institut Jacques Monod Seminar on the theme: \nThe foraging gene: will that be for here or to go? \nAbstract: \nThe Drosophila melanogaster foraging (for) gene\, with its rover and sitter larval foraging variants\, is an established behaviour genetics model. Orthologues of the foraging gene also modulate the individual and social behaviour of a wide range of species including the regulation of behaviour in eusocial insects. In Drosophila\, foraging modifies the expression of multiple traits\, including feeding and foraging\, stress tolerance\, sleep\, metabolism\, dispersal\, escape responses\, social behaviour\, and learning and memory. From a social context perspective\, Drosophila foraging affects larval clustering during foraging under high larval densities\, adult social behaviour and social networks\, and social learning. We wondered how foraging accomplishes its behavioural pleiotropy at the molecular level. We found that D. melanogaster foraging has a complex modular genomic structure with four promoters\, 21 transcripts\, and eight protein isoforms. The four promoter modules are differentially regulated during development and in a timescale\, tissue\, and cell-type dependent manner. Two examples illustrate these findings: the epigenetic regulation of the adult rover-sitter foraging-related phenotypes by G9a\, a histone methyltransferase\, and the regulation of differences in the latency of rover compared to sitter larval escape responses to noxious stimuli such as parasitoid wasps. Our work provides a nuanced picture of the molecular basis of foraging’s pleiotropy.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-marla-sokolowski/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/Bandeau-web-seminar-Marla-Sokolowski-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250225T114500
DTEND;TZID=Europe/Paris:20250225T130000
DTSTAMP:20260425T052654
CREATED:20250123T141141Z
LAST-MODIFIED:20250123T141141Z
UID:26792-1740483900-1740488400@www.ijm.fr
SUMMARY:Paris Postdoc Seminar - Nathaniel Henneman
DESCRIPTION:Invited by the Institut Jacques Monod\, Nathaniel Henneman (team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM)) will present a Paris Postdoc Seminar on the theme: \nNuclear functions of nutrient sensing signaling for metabolic adaptation \n  \nIntroduction & abstract: \nI am a Postdoc in the team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM). I graduated from Bates College (USA) in 2016\, majoring in Biology. I then spent two years working on retinal degeneration at Emory University before obtaining my master’s degree at University of Paris Descartes in 2019 and defended my PhD in December 2023. \nOne of the key questions I am to address in my work is how cellular metabolism\, gene expression and transcription\, are all coordinated. Energy stress in fasting is managed by activating autophagy and promoting the transcriptional remodeling of metabolism. Cytosolic nutrient sensors coordinate extracellular nutrient availability with intracellular metabolic processes to allow for cell survival. Class 3 PI3K is a highly conserved nutrient sensor known to regulate autophagy and endocytosis in response to varying nutrient conditions. It’s direct role in transcription\, however\, was only suggested in few studies in yeast and plants. However\, we believe there is a nuclear pool of class 3 PI3K that directly regulates gene expression for metabolic adaptation. My work aims to address this unmet burden in the field. We find that nuclear class 3 PI3K regulates the transcriptional response to nutrient stress by controlling RNA Polymerase II\, the Set1/COMPASS methyltransferase\, and nuclear methionine to SAM flux. I aim to understand how these players are needed for our fasting adaptation and how these mechanisms could affect our metabolic resilience.
URL:https://www.ijm.fr/event/paris-postdoc-seminar-nathaniel-henneman/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/20250225-Nathaniel-Hennman-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250307T114500
DTEND;TZID=Europe/Paris:20250307T130000
DTSTAMP:20260425T052654
CREATED:20250127T142106Z
LAST-MODIFIED:20250212T155220Z
UID:26838-1741347900-1741352400@www.ijm.fr
SUMMARY:Institut Jacques Monod Lecture - Andrea Musacchio
DESCRIPTION:On Friday\, March 7th\, Andrea Musacchio (Max Planck Institute of Molecular physiology) will present a Institut Jacques Monod Lecture on the theme: \nFeedback control of mitosis in the context of the kinetochore \n  \nAbstract: \nKinetochores provide chromosomes with points of attachment to spindle microtubules during cell division\, and are therefore essential for genome inheritance and the propagation of life. In addition to binding microtubules\, kinetochores control mitotic surveillance mechanisms that promote chromosome bi-orientation (the error correction mechanism) and prevent premature mitotic exit in presence of incomplete or incorrect microtubule attachments (spindle assembly checkpoint\, SAC). Elimination of the NDC80 complex\, the main microtubule receptor of kinetochores\, causes a SAC deficiency\, identifying this complex as a crucial regulatory focus for checkpoint function. In recent years\, there has been considerable progress in understanding how the SAC effector\, known as the mitotic checkpoint complex (MCC)\, assembles from its individual components to inhibit its target\, the anaphase promoting complex/cyclosome (APC/C). Conversely\, how microtubule attachment to kinetochores regulates the SAC remains incompletely understood. From a molecular perspective\, answering this question implies investigating the mechanisms that promote targeting of the SAC proteins to unattached kinetochores\, and suppress it upon microtubule binding and biorientation. In our recent work\, we have combined biochemical reconstitutions\, structural biology/modelling\, and cell biology to gain insights into this fundamental biological question.
URL:https://www.ijm.fr/event/institut-jacques-monod-lecture-andrea-musacchio/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/bandeau-IJM-Lectures-Andrea-Musacchio-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250311T114500
DTEND;TZID=Europe/Paris:20250311T130000
DTSTAMP:20260425T052654
CREATED:20250211T153305Z
LAST-MODIFIED:20250211T153305Z
UID:27291-1741693500-1741698000@www.ijm.fr
SUMMARY:Institut Jacques Monod seminar - Mateusz C. Ambrozkiewicz
DESCRIPTION:Invited by the Konstantinides Lab\, Dr. Mateusz C. Ambrozkiewicz\, FENS-Kavli Scholar (Institute for Cell Biology and Neurobiology\, Charité University Hospital\, Berlin\, Germany) will present an Institut Jacques Monod seminar on the theme: \nProteostatic Mechanisms of Cellular Diversification in the Developing Brain \nAbstract: \nFormation of functional circuits in the adult brain is a biological fundament for its executive role in the living organism and requires specification of neurons\, their correct positioning\, formation of dendrites and synapses. In this talk\, I will present our current research on the translational mechanisms and post-translational modifications orchestrating neuronal diversification in the developing brain. Particularly\, I will shed light on the specific post-transcriptional requirements for neuronal progenitors\, including the dynamics of protein synthesis as well as the role of ubiquitination-dependent degradation in healthy and diseased brain. I will show how deciphering a molecular mechanism at the basis of neurodevelopmental disease etiology can be used to propose therapeutic strategy impinging on modulating the activity of cellular proteostasis effectors\, such as the E3 ubiquitin ligases.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-mateusz-c-ambrozkiewicz/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/02/Bandeau-web-seminar-Mateusz-C.-Ambrozkiewicz-2-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250314T114500
DTEND;TZID=Europe/Paris:20250314T130000
DTSTAMP:20260425T052654
CREATED:20250212T123210Z
LAST-MODIFIED:20250212T123210Z
UID:27374-1741952700-1741957200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Maud Borensztein
DESCRIPTION:Invited by the Greenberg Lab \, Maud Borensztein (Team Epigenetic Reprogramming and Mammalian Development\, IGMM\, CNRS\, University of Montpellier) will present an Institut Jacques Monod Seminar on the theme: \nReprogramming the X chromosome: insights from mammalian development and germline \n  \nAbstract: \nMaud Borensztein team focuses on epigenetic mechanisms in mammalian development and reproduction\, with a particular emphasis on X-chromosome dosage compensation. Since establishing her group at the Institut de Génétique Moléculaire de Montpellier (IGMM) in 2021\, they have developed innovative tools to study gametogenesis and X-chromosome dynamics\, both in vivo (using mouse models) and in vitro (using Primordial Germ Cell-like cells). Investigating the reactivation of the inactive X chromosome during germline specification in females—a unique epigenetic reprogramming process that highlights fine gene-regulation control—\, they aim to uncover its timing\, mechanisms\, and biological implications.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-maud-borensztein/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/02/Bandeau-web-seminar-Maud-Borensztein-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250319T093000
DTEND;TZID=Europe/Paris:20250319T110000
DTSTAMP:20260425T052654
CREATED:20250313T100517Z
LAST-MODIFIED:20250313T100517Z
UID:27621-1742376600-1742382000@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\, 19th: \n\nMeriem Boumendjel (PhD student\, Azimzadeh Lab\, Institut Jacques Monod ) will present “Centriole rotational polarity is required for daughter centriole repositioning during primary cilium formation“\nAlfredo SCIORTINO  ( Post-doc\, Manuel Thery Lab\, ESPCI\, IPGG) will present “Filament transport supports contractile steady states of actin networks”\n\n 
URL:https://www.ijm.fr/event/cytoskeleton-club-5/?lang=en
LOCATION:Institut Curie\, 26 rue d'Ulm 75005 Paris\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250319bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250331T133000
DTEND;TZID=Europe/Paris:20250331T170000
DTSTAMP:20260425T052654
CREATED:20250303T154408Z
LAST-MODIFIED:20250303T154654Z
UID:27523-1743427800-1743440400@www.ijm.fr
SUMMARY:PhD thesis defense - Alberto Ballin
DESCRIPTION:Alberto Ballin (Léon Lab) will defense his PhD thesis defense: \n“Glucose signaling through Snf1/AMPK in Saccharomyces cerevisiae: mechanistic insights from 2-deoxyglucose-resistant mutants” \nThe defense will be held in English on Monday\, March 31st at 1.30 pm in room François Jacob at the Institut Jacques Monod. \nThe members of the jury are: \n\nAlexandre Soulard (Lyon) as rapporteur ;\nPaola Coccetti (Milan) as rapportice;\nSimonetta Piatti (Montpellier) as examinatrice;\nBenoit Viollet (Paris) as examinateur;\nGwenael Rabut (Rennes) as invited member ;\nSébastien Leon (directeur de thèse).
URL:https://www.ijm.fr/event/soutenance-de-these-alberto-ballin/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/These-bandeau-Alberto-Ballin-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250404T114500
DTEND;TZID=Europe/Paris:20250404T130000
DTSTAMP:20260425T052654
CREATED:20250324T145408Z
LAST-MODIFIED:20250324T145408Z
UID:27690-1743767100-1743771600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Lionel Christiaen
DESCRIPTION:Invited by the Minc Lab\, Lionel Christiaen (Michael Sars Centre\, University of Bergen\, Bergen\, Norway) will present an Institut Jacques Monod Seminar on the theme: \nRegulation of deterministic development \nAbstract: \nChristiaen’s research aims at understanding how tissue-specific regulatory programs and cell-cell communication coordinate cellular behavior in the context of animal development\, regeneration and evolution. His laboratory focuses on mesodermal lineages that produce both heart and head muscles\, using the ascidian Ciona as model. His laboratory has contributed seminal findings in developmental and evolutionary biology\, identifying key processes contributing to human congenital disorders. The Ciona model provides a unique opportunity to study the regulation of chordate development at single cell resolution\, thanks to a highly deterministic (“hard-wired”) mode of embryogenesis. However\, recent attempts to uncover the impact of varying temperatures in a changing world are beginning to reveal regulative mechanisms of thermal adaptation.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-lionel-christiaen/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/Bandeau-web-seminar-Lionel-Christiaen-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250408T114500
DTEND;TZID=Europe/Paris:20250408T130000
DTSTAMP:20260425T052654
CREATED:20250326T143945Z
LAST-MODIFIED:20250326T143945Z
UID:27705-1744112700-1744117200@www.ijm.fr
SUMMARY:Seminar - Suzette Lust
DESCRIPTION:Invited by the Institut Jacques Monod\, Suzette Lust (Postdoctoral researcher in Danijela Matic Vignjevic’s team – Cell migration and invasion Laboratory at Institut Curie) will present a seminar on the theme: \nUnderstanding the role of interstitial flow in vascular smooth muscle cell phenotype in the context of aortic aneurysms \n  \nThis seminar is part of the Paris Postdocs Seminars series. \nAbstract: \nAortic aneurysms are abnormal enlargements of blood vessel diameter caused by aberrant extra-cellular matrix (ECM) remodelling. As the tissue dilates\, it loses its mechanical integrity\, exposing patients to risk of highly fatal aortic dissections or ruptures. This is mediated in part by phenotypic switching and or apoptosis of the intima-resident vascular smooth muscles (VSMCs). What drives this pathology is not well understood\, particularly in the case of aneurysms in Bicuspid Aortic Valve disease (BAV) patients\, a congenital condition characterised by the malformation of the aortic valve resulting in only 2 leaflets. Improvements in imaging techniques have now allowed pathological blood flow patterns to be correlated to aneurysm morphology and indeed there is increasing evidence that mechanotransduction from flow may be a driver of aneurysm development. Blood flow imparts mechanical forces to cells through stretching and frictional shear forces and we are focused here on the interstitial flow driven into the wall by differential pressure gradients within the aorta. \nWe hypothesise that interstitial flow plays a crucial role in regulating VSMC phenotype and ECM interactions and that this may be used to correlate disrupted flow patterns seen in BAV patients to the morphology changes in their aortas. \nTo test this hypothesis\, we created a reductionist in-vitro model culturing VSMCs in 3D under interstitial flow. We combined a synthetic PEG based ECM mimicking hydrogel with primary cultures of VSCMs with a microfluidics setup. \nWe showed hydrogels doctored with degradable bioactive peptides could be broken down by exogenous and cell derived MMPs. We measured hydrogel permeability using 2 separate techniques which confirmed the material to have a low permeability compared to other standard hydrogels\, on the order of 10−16 m2. Furthermore\, we characterised mass transport of solutes within hydrogels and were able to demonstrate a negligible impact of changing polymer solid content on diffusivity in hydrogels of up to 5% weight/volume for molecules up to 40 kDa in size. Via production of MMPs\, VSMCs break down the hydrogel and importantly by day 7 of culture\, we detected newly synthesised fibronectin\, collagen 1 and 4 proteins. We stimulated encapsulated cells with interstitial flows demonstrating that cells align to the flow direction. Finally\, we performed RNA sequencing on 3 human patient samples comparing standard culture conditions\, non-flow stimulated encapsulated cells and interstitial-flow stimulated cells. The data set reveals significant upregulation of genes in multiple pathways associated with cyclic AMP production\, which plays a crucial role in regulating VSMC contractility and calcium signalling and hence phenotype. The data suggests that this is mediated via activation of G-protein receptors leading to increased expression of adenylyl cyclase but this remains to be confirmed. \nIn conclusion\, we developed a novel in-vitro platform to study the impact of interstitial flow on VSMC behaviour. Our data suggests that interstitial flow may play a regulating role in determining VSMC phenotype with potential consequences for matrix remodelling in disease.
URL:https://www.ijm.fr/event/seminar-suzette-lust/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250408-Suzette-Lust-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250409
DTEND;VALUE=DATE:20250412
DTSTAMP:20260425T052654
CREATED:20241209T104027Z
LAST-MODIFIED:20241209T104027Z
UID:26072-1744156800-1744415999@www.ijm.fr
SUMMARY:Paris - Munich Epigenetics Workshop & Symposium 2025
DESCRIPTION:The second edition of the Paris-Munich Epigenetics meeting will be held from 9 to 11 April 2025 in the Buffon amphitheater. Attendance is free of charge but registration is mandatory. \nPlease visit the website to find out more about the program and to register. \nThe Paris-Munich Epigenetics Worshop & Symposium has two parts: \n\nthe SYMPOSIUM\, open for all students and researchers in the Paris/Munich communities and beyond\na WORKSHOP for selected doctoral or postdoctoral researchers that are new to the field of Epigenetics\n\nThe WORKSHOP takes place on April 9 prior to the symposium\, and is open for selected early stage doctoral and postdoctoral researchers new to the field of Epigenetics. The workshop focussed on the core concepts of cutting-edge Epigenetics research\, taught by senior academic experts\, as well as career orientation and communication skills\, presented by alumna and professionals in the field. Workshop participants will have the opportunity to network and exchange\, with discussions during the workshop\, as well as with featured short talks and posters during the symposium. \n  \nThe SYMPOSIUM takes place from April 9-11\, 2025  and is open for all interested students and scientists from the Paris and Munich communities and beyond. During the Symposium renowned speakers from the two communities present their latest insights into Epigenetics in sessions on chromatin environment\, organization\, remodelling and reprogramming. Short talks and poster presentations from early career (doctoral and postdoctoral) researchers will be selected from the submitted abstracts. \n  \nThe deadline for both abstract submissions and workshop applications is January 15\, 2025.
URL:https://www.ijm.fr/event/paris-munich-epigenetics-workshop-symposium-2025/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250409T093000
DTEND;TZID=Europe/Paris:20250409T110000
DTSTAMP:20260425T052654
CREATED:20250331T094740Z
LAST-MODIFIED:20250331T094740Z
UID:27738-1744191000-1744196400@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\,9th at the Institut Pasteur: \n\nIngrid Billault-Chaumartin (post-doc\,  Romet-Lemonne/Jegou team\, IJM) will present “How similar is actin assembly between distant species ? »\nNicolas Joly ( Researcher \,  Pintard tema\, IJM)  will present “Mechanistic Insights into Katanin Activation: Coupling Microtubule Binding with ATP Hydrolysis
URL:https://www.ijm.fr/event/cytoskeleton-club-6/?lang=en
LOCATION:Institut Pasteur\, 28 rue du dr roux\, 75015 Paris\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250319bandeau-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250411T114500
DTEND;TZID=Europe/Paris:20250411T130000
DTSTAMP:20260425T052654
CREATED:20250313T131823Z
LAST-MODIFIED:20250313T135245Z
UID:27626-1744371900-1744376400@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Marion Silies
DESCRIPTION:Invited by the Konstantinides Lab\, Dr. Marion Silies (Johannes-Gutenberg-University Mainz\, Germany) will present an Institut Jacques Monod seminar on the theme: \nHeterogeneity of connectivity and function in the fly visual system \nAbstract: \nVisual systems are considered homogeneous structures where repeating visual units contain the same circuit motifs that fulfil the same functional role\, leading to translation invariance. However\, our recent work\, analyzing full fly brain connectomes\, revealed remarkable heterogeneity\, even within anatomically and genetically identifiable cell types. I will describe this heterogeneity in synaptic connectivity\, and address where it arises developmentally. Furthermore\, I will discuss how heterogeneous circuit motifs can lead to degeneracy of neuronal function\, and thus to both\, reliablility and flexiblity of neuronal information processing in the visual system.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-marion-silies/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/Bandeau-web-seminar-Marion-Silies-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250505T140000
DTEND;TZID=Europe/Paris:20250505T150000
DTSTAMP:20260425T052654
CREATED:20250429T084034Z
LAST-MODIFIED:20250429T084034Z
UID:27972-1746453600-1746457200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Sumin Jang
DESCRIPTION:Invited by the Ribes/Nedelec Lab\, Sumin Jang (Department of Pathology and Cell biology\, Columbia University\, New York\, USA) will present an Institut Jacques Monod seminar on the theme : \nHuman-specific progenitors extend and expand neurogenesis in the spinal cord \n  \nHer research explores the evolution of developmental programs and their implications for the increasing complexity of the human nervous system. \nShe combines single-cell omics with mouse and human organoids\, to investigate these questions. \n  \nSelection of publications: \nIndependent control of neurogenesis and dorsoventral patterning by NKX2-2 Jang S\, Abarinov E\, Dobkin J\, Wichterle H. bioRxiv [Preprint]. 2024 Oct 13:2024.10.13.618113. doi: 10.1101/2024.10.13.618113. PMID: 39415990 Free PMC article. Preprint \nA human-specific progenitor sub-domain extends neurogenesis and increases motor neuron production Jang S\, Gumnit E\, Wichterle H.Nat Neurosci. 2024 Oct;27(10):1945-1953. doi: 10.1038/s41593-024-01739-8. Epub 2024 Aug 29.PMID: 39210067 \nTranscriptional dynamics of murine motor neuron maturation in vivo and in vitro. Patel T\, Hammelman J\, Aziz S\, Jang S\, Closser M\, Michaels TL\, Blum JA\, Gifford DK\, Wichterle H.Nat Commun. 2022 Sep 15;13(1):5427. doi: 10.1038/s41467-022-33022-4.PMID: 36109497Free PMC article. \nAn expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity. Closser M\, Guo Y\, Wang P\, Patel T\, Jang S\, Hammelman J\, De Nooij JC\, Kopunova R\, Mazzoni EO\, Ruan Y\, Gifford DK\, Wichterle H.Neuron. 2022 Jan 5;110(1):70-85.e6. doi: 10.1016/j.neuron.2021.10.014. Epub 2021 Nov 1.PMID: 34727520Free PMC article.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-sumin-jang/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/04/Bandeau-web-seminar-Sumin-Jang-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250514T093000
DTEND;TZID=Europe/Paris:20250514T110000
DTSTAMP:20260425T052654
CREATED:20250512T123230Z
LAST-MODIFIED:20250512T123230Z
UID:28082-1747215000-1747220400@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next cytoskeleton club meeting will take place on Wednesday\, May 14th at th Institut Jacques Monod: \n\nSandra Carvalho (PhD student \, A. Guichet’s Lab\, Institut Jacques Monod) will talk about:  “How do actin pulses at tricellular AJs provide forces for 3D cell intercalation ?” \nDaniel Plura (PhD student\, F. Robin’s  Lab\,  IBPS) will talk about: “Adaptability of the actomyosin network during C.elegans embryo development”
URL:https://www.ijm.fr/event/cytoskeleton-club-7/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/20250514-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250522T150000
DTEND;TZID=Europe/Paris:20250522T160000
DTSTAMP:20260425T052654
CREATED:20250417T095621Z
LAST-MODIFIED:20250417T095621Z
UID:27854-1747926000-1747929600@www.ijm.fr
SUMMARY:Seminar - Daehan Lee
DESCRIPTION:Invited by the Courtier lab and the Konstantinides Lab\, Daehan Lee (Department of Biological Sciences\, College of Natural Sciences\, Sungkyunkwan University\nSuwon 16419\, Republic of Korea) will present a seminar on the theme: \nEcological Transitions Across Scales: Rewiring Sense\, Losing Sex\, Dodging Death\, and Becoming Complex \nAbstract: \nEcological transitions—changes in the physical\, chemical\, or biotic environment experienced by organisms—can have profound effects on developmental\, physiological\, and evolutionary trajectories. In this seminar\, I will examine how ecological shifts across multiple scales drive remodeling of biological systems\, from gene regulatory networks to life history strategies. Using a set of diverse model organisms\, I will present evidence for ecological transitions as catalysts of evolutionary change: sensory system reorganization during host specialization in Drosophila sechellia; the evolutionary loss of sexual reproduction under laboratory conditions in Caenorhabditis elegans; stage-specific aging and regeneration linked to ecological niches in the life cycle of jellyfish; and the emergence of multicellularity in choanoflagellates in response to environmental and social cues. Together\, these studies illustrate how ecological context shapes the evolution of complexity\, modulates developmental plasticity\, and alters fundamental features of animal biology.
URL:https://www.ijm.fr/event/seminar-daehan-lee/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/04/Bandeau-web-seminar-Daehan-Lee-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250523T114500
DTEND;TZID=Europe/Paris:20250523T130000
DTSTAMP:20260425T052654
CREATED:20250415T085222Z
LAST-MODIFIED:20250415T085222Z
UID:27840-1748000700-1748005200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Frédéric Pincet
DESCRIPTION:Invited by the Romet-Lemonne/Jégou\, Frédéric Pincet (CNRS/ENS-PLS\, Paris) will present an Institut Jacques Monod seminar on the theme: \nThe Dual Role of Golgins in Maintaining Golgi Structure and Mediating Vesicle Traffic \n  \nAbstract: \nThe architecture of the Golgi apparatus is remarkably complex. In mammalian cells\, it is composed of stacks of disk-shaped membrane compartments that are laterally connected to form a ribbon-like structure. These stacks are polarized along the cis-to-trans axis and are embedded within a dense protein matrix\, whose primary components belong to the Golgin protein family. This refined organization is transiently lost during mitosis\, when the Golgi apparatus disperses into small vesicular and tubular remnants. However\, during telophase\, these remnants rapidly reassemble within minutes\, restoring the original architecture and cisternal composition. Even during interphase\, the integrity of the Golgi architecture is continuously challenged by dynamic processes\, including intensive vesicular trafficking both within the Golgi and with neighboring compartments\, as well as by cisternal maturation. As a result\, the Golgi apparatus presents a seemingly paradoxical combination of dynamic plasticity and structural robustness. In this seminar\, I will propose that Golgins act as key regulators balancing this duality. Golgins can function both as vesicle tethers\, facilitating trafficking\, and as structural scaffolds\, promoting the spontaneous organization of the Golgi matrix. We tested this hypothesis using a combination of in vitro biophysical and biochemical assays\, as well as super-resolution imaging of Golgin localization. Our results show that Golgins can self-assemble into two-dimensional condensates exhibiting a hierarchical set of interactions correlated with Golgi organization. Simultaneously\, Golgins and their condensates are capable of specifically tethering vesicles\, thus maintaining efficient vesicular trafficking within the matrix.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-frederic-pincet/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/04/Bandeau-web-seminar-Frederic-Pincet-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250523T140000
DTEND;TZID=Europe/Paris:20250523T170000
DTSTAMP:20260425T052654
CREATED:20250429T132943Z
LAST-MODIFIED:20250429T132943Z
UID:27977-1748008800-1748019600@www.ijm.fr
SUMMARY:Authorization to supervise research (HDR) - Isabelle Becam
DESCRIPTION:Isabelle Becam (Conduit Lab) will defend his Authorization to supervise research (HDR): \n“Hétérogénéité dans la formation des microtubules et son rôle fonctionnel dans les cellules” \n  \nThe defense will take place on Friday\, May 23 in François Jacob room. \nThe jury will be composed of: \n\nAgnès Audibert\, Rapporteur\nGisela d’Angelo\, Rapporteur\nVeronique Marthiens\, Rapporteur\nAlexandre Baffet\, Examinateur\nCarsten Janke\, Examinateur
URL:https://www.ijm.fr/event/authorization-to-supervise-research-hdr-isabelle-becam/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/04/HDR-bandeau-Isabelle-Becam-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250603T114500
DTEND;TZID=Europe/Paris:20250603T130000
DTSTAMP:20260425T052654
CREATED:20250520T130321Z
LAST-MODIFIED:20250520T130321Z
UID:28205-1748951100-1748955600@www.ijm.fr
SUMMARY:Seminar - Irene Basili
DESCRIPTION:Invited by the Institut Jacques Monod\, Irene Basili will present a seminar on the theme: \nAMBRA1 controls the Sonic Hedgehog signaling pathway and SHH-medulloblastoma \nAbstract: \nAMBRA1 (Autophagy and Beclin 1 Regulator 1) is primarily recognized as a tumor suppressor\, however its role as a tumor promoter has garnered increasing attention. Here\, leveraging clinical data of an international multi-omic medulloblastoma (MB) cohort\, we identified that elevated AMBRA1 protein levels\, independently of its mRNA expression\, correlate with poor prognosis in the Sonic Hedgehog subgroup (MBSHH) compared to other MB variants. Mechanistically\, AMBRA1 enhances SHH signaling by stabilizing GLI1\, the pathway’s final effector\, via inhibition of its βTrCP-mediated degradation. Additionally\, AMBRA1 protein stability is modulated by the REN E3 ubiquitin ligase\, a tumor suppressor gene lost in MBSHH. Inhibition of AMBRA1 blocks MBSHH growth in murine and patient-derived pre-clinical models\, highlighting its therapeutic potential. Moreover\, combining AMBRA1 knockdown with FDA-approved SHH inhibitors enhances antitumor efficacy. These findings identify the AMBRA1/βTrCP/REN axis as a key regulatory mechanism in SHH signaling and discover an unrecognized function of AMBRA1 in MBSHH\, providing actionable insights for innovative targeted therapies. \nThis seminar is part of the Paris Postdoc seminar series.
URL:https://www.ijm.fr/event/seminar-irene-basili/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/05/20250603-Irene-Basili-web-scaled.jpg
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