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DTSTART;VALUE=DATE:20241119
DTEND;VALUE=DATE:20241217
DTSTAMP:20260425T072231
CREATED:20241126T141035Z
LAST-MODIFIED:20241126T141035Z
UID:25897-1731974400-1734393599@www.ijm.fr
SUMMARY:AGRIPOP exhibition - Paleogenetics and archaeology - Neolithic revolution and migration
DESCRIPTION:Exhibition at Université Paris Cité\, Hall A of the Grands-Moulins\, from November 14 to December 16\, 2024 \nThis exhibition opens the doors of the CNRS “Epigenome & Paleogenome” research laboratory at the Institut Jacques Monod\, Université Paris Cité. \nIn 2010\, the first Neanderthal genome was sequenced. This marked the birth of paleogenomics. Since then\, paleogenomics – the analysis of ancient DNA preserved in archaeological bones – has become a rapidly expanding field of research. It provides information on the genetic identity of individuals from the past – humans and animals – on kinship relationships\, genealogies\, migrations\, interbreeding and certain characteristics of their physical appearance. This information enables scientists to reconstruct more accurately the reality of a given moment in the past. \nFrom Çatalhöyük\, in Anatolia\, to the Aisne valley\, the AGRIPOP exhibition invites you to follow the discoveries of archaeologists and paleogeneticists to understand how humans evolved towards the sedentary lifestyle of producers-farmers that is still our present. \nAccessible to all\, this exhibition highlights the collaborative and interdisciplinary practices of researchers on an international scale. Above all\, it makes more tangible our knowledge of the settlement of northern France in the Neolithic by the first farmers of Anatolian origin (modern-day Türkiye) 7\,000 years ago. AGRIPOP sheds new light on the origins of the way our societies function today. The texts in the exhibition are in French but the accompanying booklets are also provided in English.
URL:https://www.ijm.fr/event/agripop-exhibition-paleogenetics-and-archaeology-neolithic-revolution-and-migration/?lang=en
LOCATION:Université Paris-Cité\, Hall A du bâtiment des Grands Moulins de Paris\, 5 rue Thomas Mann\, 75013 Paris\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/Capture-decran-2024-11-26-151811.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241203T114500
DTEND;TZID=Europe/Paris:20241203T130000
DTSTAMP:20260425T072231
CREATED:20241121T133233Z
LAST-MODIFIED:20241121T133233Z
UID:25833-1733226300-1733230800@www.ijm.fr
SUMMARY:Paris Postdocs Seminars - Ahlem Assali
DESCRIPTION:Invited by the Institut Jacques Monod\, Ahlem Assali (Institut du cerveau\, Paris) will present a Paris Postdoc Seminar on the theme: \nPregnancy induces cerebrovascular plasticity involved in the emergence of maternal behaviors \n  \nAbstract: \nThe adult cerebrovascular system is viewed as a very stable network\, mainly required to provide nutrients and oxygen to the brain\, and adapting to changes in neuronal activity via vasomotricity mechanisms (vasodilation and vasoconstriction). Using advanced 3D whole-brain immunolabeling/clearing protocols (iDisco+)\, light-sheet imaging\, and computational tools (ClearMap)\, enabling accurate reconstruction of the brain vasculature\, we were able to challenge this static conception of the cerebrovascular network in the context of neurophysiological adaptations occurring during and after pregnancy. Pregnant mice displayed an increase in vascular branch points in different brain regions compared to virgin females\, starting at least at gestational day 6 (GD6)\, peaking around GD15\, and reversed postweaning. This increased vascularization was notably found in the preoptic region of the hypothalamus\, involved in pregnancy regulation and maternal behavior\, and in cortical areas\, such as the somatosensory cortex. GD15 females also displayed an increase in Erg+ endothelial cells in the same brain regions. In addition\, GD6 and GD15 females showed an increase in the number of endothelial tip cells in the hypothalamic preoptic region. These data revealed a progressive vascular remodeling during pregnancy\, associated to potential angiogenesis\, in adulthood and healthy conditions. To identify molecular mechanisms driving this vascular plasticity\, we explored the effects of steroid hormones on the vascular network. Interestingly\, implants releasing estradiol induced an increase in the number of vascular branch points and of endothelial tip cells in the preoptic region of virgin females\, recapitulating the changes found in pregnant females. These data suggest that estradiol hormones regulate\, at least partially\, the pregnancy-induced vascular plasticity. Importantly\, using 3D whole-brain fluorescent in situ hybridization\, we found an increase in Vegfa expression (vascular endothelial growth factor) in the hypothalamic preoptic region and somatosensory cortex. Vegfa downregulation by shRNA in the preoptic area blocked the pregnancy-induced vascular densification\, and induced defects in maternal behavior post-birth using the pup retrieval assay.  Future transcriptomics experiments in the preoptic region will allow an agnostic search for further cellular and molecular mechanisms underlying pregnancy-induced vascular adaptations. Our data suggest an active role of vascular remodeling in shaping pregnancy- and maternal behaviors-related neuronal functions.
URL:https://www.ijm.fr/event/paris-postdocs-seminars-ahlem-assali/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/20241203-Ahlem-Assali-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241206T114500
DTEND;TZID=Europe/Paris:20241206T130000
DTSTAMP:20260425T072231
CREATED:20241118T125120Z
LAST-MODIFIED:20241118T125120Z
UID:25686-1733485500-1733490000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Yohanns Bellaiche
DESCRIPTION:Invited by the Ladoux / Mege Lab\, Yohanns Bellaiche (Institut CURIE UM3215 U934\, Equipe Polarité Division Morphogenèse) will present an Institut Jacques Monod Seminar on the theme: \nHow epithelial shaping is tailored by cell and tissue size \nAbstract: \nEverywhere Nature works true to scale\, and everything has its proper size accordingly” – with these words\, D’Arcy Thompson in “On Growth and Form” elegantly captured one of biology’s profound mysteries: the scaling of biological structures and substructures with size (length\, area\, or volume). At the cellular level\, scaling plays central roles in organelle dynamics during cell division and metabolic regulation. At the organismal level\, studies of scaling properties have led to discoveries in animal physiology\, bone and limb proportions\, and gene expression patterns. \nIn this seminar\, I will present our recent work linking cell and tissue size to the morphodynamics of tissue development. First\, I will discuss our findings on the mechanisms by which cells probe their size to scale their geometrical and mechanical properties\, thereby regulating cell proliferation and apoptosis. Then\, I will describe how tissue morphogenesis adapts to overall animal size to ensure robust and invariant development across the physiological range of sizes within a species.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-yohanns-bellaiche/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/Bandeau-web-seminar-Yohanns-Bellaiche-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241209T091500
DTEND;TZID=Europe/Paris:20241213T180000
DTSTAMP:20260425T072231
CREATED:20241023T114430Z
LAST-MODIFIED:20241023T114842Z
UID:25390-1733735700-1734112800@www.ijm.fr
SUMMARY:International Workshop : Cycling to divide\, Across Scales\, Species and Evolution
DESCRIPTION:The Magistère Européen de Génétique\, with the support of Circle U and the Jacques Monod Institute\, is organizing an International Workshop from December 3rd to December 9th\, which will be held in the Amphi Turing in the Sophie Germain building\, Campus Grands-Moulins (Place Aurélie Nemours). \nThe topic of this workshop is Cell Cycle and Cell Division\, which will be addressed through talks and lectures by distinguished speakers from the Jacques Monod Institute and other Parisian and International institutions. This workshop will broadly cover various aspects of the cell cycle and cell division\, such as mitosis\, meiosis\, asymmetric cell division\, chromosome segregation\, DNA replication\, and cytokinesis\, using a range of model organisms\, each with specific technical advantages. The speakers come from diverse scientific backgrounds\, using a variety of model systems and approaches.\nThe number of participants is limited to 70 attendees. \nRegistrations are open until November 29th: here \nSpeakers: \n\nBuzz Baum (LMB\, Univ. Cambridge)\nPierre Chymkowitch (Univ. of Oslo)\nGautam Dey (EMBL)\nInes Drinnenberg (Curie Institute)\nJulien Dumont (Institut Jacques Monod)\nArnaud Echard (Pasteur Institute)\nUlrike Eggert (King’s College London)\nSimona Giunta (Roma\, La Sapienza)\nJean-René Huynh (Collège de France)\nJens Januschke (Univ. Dundee)\nJoao Matos (Univ. of Vienna\, Max Perutz)\nNicolas Minc (Institut Jacques Monod)\nLionel Pintard (Institut Jacques Monod)\nMarie-Noelle Prioleau (Institut Jacques Monod)\nKatja Wassmann (Institut Jacques Monod)
URL:https://www.ijm.fr/event/international-workshop-cycling-to-divide-across-scales-species-and-evolution/?lang=en
LOCATION:Amphithéâtre Alan Turing – Bâtiment Sophie Germain\, 8 place Aurélie Nemours\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241211T093000
DTEND;TZID=Europe/Paris:20241211T110000
DTSTAMP:20260425T072231
CREATED:20241203T151811Z
LAST-MODIFIED:20241203T151811Z
UID:26020-1733909400-1733914800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday 11th December: \n\nKotryna Voidziulyte (post-doc\, Piel’s team) will present “Atypical nuclear phenotypes in confined cancer cells“\nSamya Zerkoune (PhD student\, Nicol/ Fassier’s team) will present “Fignl1/RAD51 complex drives axon midline crossing through timely tuned F-actin nucleation inhibition”
URL:https://www.ijm.fr/event/cytoskeleton-club-2/?lang=en
LOCATION:Amphithéâtre de l’Institut Pierre-Gilles de Gene\, 6 rue Jean Clavin\, Paris
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/20241211-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241213T114500
DTEND;TZID=Europe/Paris:20241213T130000
DTSTAMP:20260425T072231
CREATED:20241118T125824Z
LAST-MODIFIED:20241118T125824Z
UID:25694-1734090300-1734094800@www.ijm.fr
SUMMARY:Institut Jacques Monod seminars - Laurent Formery
DESCRIPTION:Invited by the Gazave Lab\, Laurent Formery (Department of Biology\, Stanford University) will present an Institut Jacques Monod seminar on the theme: \nEchinoderm evolution: Testing the limits of axial patterning plasticity \nAbstract: \nThe discovery that distantly related animals establish their body plans through conserved developmental programs is one of the most transformative findings in evolutionary biology. Similar antero-posterior (AP) and dorso-ventral (DV) patterning programs have now been identified in a large sample of bilaterian animals. However\, because most of the species that we have investigated so far follow the basic blueprint of the bilateral symmetry\, it remains unclear whether\, in case of drastically divergent body plan evolution\, these patterning program are flexible enough to support major deviation from bilateral symmetry\, or if they act as developmental constraint on body plan diversity that need to be disassembled first. My research aims to investigate this question using echinoderms\, which evolved a unique pentaradial symmetry and represent a fascinating natural experiment on body plan plasticity. By looking at adult body plan development in sea stars\, brittle stars and sea cucumbers using modern molecular tools\, I have been able to identify that some part of the antero-posterior patterning program are highly conserved during the formation of the pentaradial body plan\, albeit in an unexpected spatial configuration. This indicates that despite the absence of a morphological AP axis\, the molecular system used for AP patterning is surprisingly tolerant to radical morphological changes. With these new molecular data\, we are now starting to piece together the evolution of axial properties across echinoderm classes and with their bilateral relatives. Beyond the fascinating history of this particular phylum\, these data are important to decipher to what extent conserved molecular programs have shaped the evolution of morphological novelty.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-laurent-formery/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/Bandeau-web-seminar-Laurent-Formery-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241219T143000
DTEND;TZID=Europe/Paris:20241219T170000
DTSTAMP:20260425T072231
CREATED:20241203T144714Z
LAST-MODIFIED:20241203T144714Z
UID:26006-1734618600-1734627600@www.ijm.fr
SUMMARY:Soutenance de thèse - Juliette Mandelbrojt
DESCRIPTION:Juliette Mandelbrojt (équipe Prioleau) va défendre sa thèse : \nHow do transcription and chromosomal context interfere with an efficient replication origin? \n  \nLa soutenance se tiendra le jeudi 19 décembre 2024 à 14h30 en salle François Jacob ( 15 rue Hélène Brion 75013 Paris) et sera en anglais. \nLe jury sera composé de : \n\nDr Sarah LAMBERT\, DR\, Université Paris Saclay\, Rapporteur\nDr Julian SALE\, Senior group leader\, University of Cambridge\, Rapporteur\nPr Jean-Charles CADORET\, PU\, Université Paris Cité\, Examinateur\nDr Stéphane KOUNDRIOUKOFF\, MCF-HDR\, Sorbonne Université\, Examinateur\nDr Marie-Noëlle PRIOLEAU\, DR\, Université Paris Cité\, Directrice de thèse \nDr Caroline DONCARLI\, PhD\, Université Paris Cité\, Membre invitée Co encadrante 
URL:https://www.ijm.fr/event/soutenance-de-these-juliette-mandelbrojt/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/These-bandeau-Juliette-MANDELBROJT-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250110T114500
DTEND;TZID=Europe/Paris:20250110T130000
DTSTAMP:20260425T072231
CREATED:20241205T145404Z
LAST-MODIFIED:20241205T145404Z
UID:26050-1736509500-1736514000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Lendert Gelens
DESCRIPTION:Invited by the Wassmann Lab\, Lendert Gelens (Laboratory of Dynamics in Biological Systems\, University of Leuven\, Belgium) will present an Institut Jacques Monod seminar on the theme: \nNuclei coordinate the cell cycle in space and time \n  \nAbstract: \nProliferating cells replicate their DNA and components before dividing\, but how subcellular localization impacts cell cycle timing remains unclear. Using frog egg extracts encapsulated in droplets\, we studied cell cycle oscillations with and without nuclei [1]. Time-lapse microscopy revealed that nuclei increase cell cycle duration\, with increasing nuclear volume correlating with longer periods across different Xenopus species. This relationship persisted without DNA replication or transcription but was disrupted by inhibiting nuclear import or Wee1 kinase. A computational model incorporating nuclear-cytoplasmic compartmentalization and periodic nuclear envelope dynamics reproduced these findings\, linking nuclear size to cycle timing. These results explain the lengthening of the cell cycle at the midblastula transition when cells become smaller\, and the nuclear-cytoplasmic ratio increases. \nIn early Xenopus embryos (~1.2 mm)\, mitotic waves coordinate the cell cycle over long distances\, as diffusion alone is insufficient. Using X. laevis egg extracts and a Cdk1 FRET sensor\, we observed a transition from phase to trigger wave dynamics in initially homogeneous cytosol [2]. Spatial heterogeneity and nuclei accelerated this transition\, while metaphase-arrested extracts induced an immediate shift. Simulations revealed transient phase waves as trigger waves required time to entrain the system. Both wave types emerge as part of a unified process for coordinating the cell cycle across large distances. \n[1] Pineros\, L. *; Frolov\, N. *; Ruiz-Reynés\, D.; Eynde\, A. Van; Cavin-Meza\, G.; Heald\, R.; Gelens\, L.; The nuclear-cytoplasmic ratio controls the cell cycle period in compartmentalized frog egg extract; BioRxiv\, 2024. \n[2] Puls*\, O.; Ruiz-Reynés*\, D.; Tavella\, F.; Jin\, M.; Kim\, Y.; Gelens*\, L.; Yang*\, Q.; Spatial heterogeneity accelerates phase-to-trigger wave transitions in frog egg extracts; Nature Communications\, vol. 15\, no. 10455\, 2024.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-lendert-gelens/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/Bandeau-web-seminar-Lendert-Gelens-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250115T093000
DTEND;TZID=Europe/Paris:20250115T110000
DTSTAMP:20260425T072231
CREATED:20250113T141600Z
LAST-MODIFIED:20250113T141700Z
UID:26547-1736933400-1736938800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The first meeting of 2025 of the cytoskeleton club will take place next Wednesday at the Institut Pasteur: \n– Charlotte Mallart (post-doc\, Minc lab\, Institute Jacques Monod) will talk about:  “Regulation of cytoplasm rheology by bulk F-Actin networks”. \n– Noemi Zollo (PhD student\, Verlhac/ Terret lab\, CIRB Collège de France) will talk about:  “A novel RNP compartment allows mouse oocytes to adapt translational levels during late growth”.
URL:https://www.ijm.fr/event/cytoskeleton-club-3/?lang=en
LOCATION:Institut Pasteur Auditorium François Jacob\, 28 rue du docteur roux\, Paris\, 75015\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/20250115-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250116T090000
DTEND;TZID=Europe/Paris:20250116T180000
DTSTAMP:20260425T072231
CREATED:20241028T102411Z
LAST-MODIFIED:20241028T102411Z
UID:25485-1737018000-1737050400@www.ijm.fr
SUMMARY:Second workshop on new microscopies in cell biology
DESCRIPTION:The two GDRs AQV (Quantitative approaches to living systems) and IMABIO (Imaging in Biology) are organising a joint workshop on 16 January 2025 at the Institut Jacques Monod in Paris on new microscopies in cell biology. The aim is to bring together scientists from biology\, physics\, engineering and data science to discuss new imaging strategies for : \n\nmeasuring physical descriptors of cellular organisation and function;\nimproving imaging resolution;\nmaking smart microscopes more effective at capturing processes of interest.\n\nConfirmed speakers : \n\nJuliette Azimzadeh\, Institut Jacques Monod\, Paris\nVictor Barolle\, Institut Langevin\, Paris\nRicardo Henriques\, Instituto Gulbenkian de Ciência\, Oeiras and University College London\nKheya Sengupta\, Interdisciplinary Centre for Nanoscience\, Marseille\nVincent Studer\, Interdisciplinary Neuroscience Institute\, Bordeaux\nIlaria Testa\, KTH Royal Institute of Technology\, Stockholm\n\nOral presentations and posters will also be selected from the abstracts submitted. \nRegistration is free but compulsory and is now open here: https://newmic4cellbio2.sciencesconf.org/ \nThe organisers\nPierre Bon\, Nicolas Borghi\, Cécile Leduc\, Loic Le Goff\, Pierre-Henri Puech
URL:https://www.ijm.fr/event/second-workshop-on-new-microscopies-in-cell-biology/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/bandeau-web-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250117T114500
DTEND;TZID=Europe/Paris:20250117T130000
DTSTAMP:20260425T072231
CREATED:20241125T114034Z
LAST-MODIFIED:20241125T114034Z
UID:25863-1737114300-1737118800@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Zayna Chaker
DESCRIPTION:Invited by the Konstantinides Lab\, Zayna Chaker (Institute of Functional Genomics of Lyon (IGFL) Ens de Lyon\, CNRS) will present an Institut Jacques Monod Seminar on the theme: \nSpatio-Temporal coordination of neural stem cells in the adult brain: A functional and evolutionary perspective \n  \nAbstract: \nResearch over the last three decades has demonstrated that new neurons can be generated in the adult brain\, and integrate into pre-existing complex circuits. The process of adult neurogenesis is evolutionary conserved among vertebrates\, including fishes\, frogs\, reptiles\, birds\, rodents and primates. It is sustained by a small population of undifferentiated cells\, called neural stem cells (NSCs)\, which persist as embryonic vestiges in adult brains. These cells reside in tightly controlled micro-environments called niches. The addition of young cells constitutes an important layer of adult brain plasticity\, further enhancing its ability to adapt to diverse life experiences. However\, the physiological relevance of adult-born neurons as well as the regenerative power of NSCs after injury are still highly debated to date\, especially in mammals. \nBesides constitutive neurogenesis\, we recently showed that regionally-defined subpopulations of NSCs in the adult ventricular niche produce transient waves of functionally-relevant interneurons in response to pregnancy and motherhood. This process finely tunes the mother’s olfactory sensitivity to own versus alien pup odor (Chaker et al. 2023). In my lab\, we are now investigating the cellular and molecular mechanisms allowing regionally-distinct pools of NSCs to coordinate their behavior in space (across all niches) and time (from embryo to different phases in adulthood)\, under specific physiological and pathological conditions.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-zayna-chaker/?lang=en
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/Bandeau-web-seminar-Chaker-Zayna-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250121T114500
DTEND;TZID=Europe/Paris:20250121T130000
DTSTAMP:20260425T072231
CREATED:20241230T140129Z
LAST-MODIFIED:20250115T101830Z
UID:26317-1737459900-1737464400@www.ijm.fr
SUMMARY:Paris Postdoc Seminar - Lucas Alves Tavares
DESCRIPTION:Invited by the Institut Jacques Monod\, Lucas Alves Tavares (Center for Virology Research and Department of Cell and Molecular Biology\, University of São Paulo (USP) & Institut Curie\, Paris) will present a Paris Postdoc Seminar on the theme: \nUnraveling the role of AP-1γ2 in the Endosome Maturation and Extracellular Vesicles Release \n  \nAbstract: \nThe adaptor protein (AP) complexes are heterotetrameric complexes that coordinate protein trafficking in the endocytic and secretory pathways. AP-1\, a complex of four distinct subunits (γ\, β1\, μ1\, and σ1)\, is thought to mediate protein trafficking between the trans-Golgi network (TGN) and endosomes and Lysosomes Related Organelles (LROs) though clathrin-coated vesicles (CCV). The human genome encodes two isoforms of the γ-adaptin (γ1 and γ2) subunit that form two variants of AP-1 (AP-1γ1 and AP-1γ2). Previous studies demonstrated that γ2 may form an AP-1 complex variant\, but the knowledge is limited regarding the cellular roles played by this alternative AP-1 complex. We previously reported that γ2 is part of a functional AP-1 complex variant hijacked by HIV-1 Nef for targeting CD4 and MHC-I for lysosomal degradation. Moreover\, we recently demonstrated that the retrograde transport of CI-MPR and ATP7B requires AP-1γ2. During my internship at Graça Raposo laboratory (Institut Curie)\, we are investigating the participation of AP-1γ2 in the maturation of early endosomes to late endosomes and also for the Extracellular Vesicles (EVs) secretion by using immunofluorescence\, nanoparticle tracking analysis\, western blot\, immuno-electron microscopy analysis and conventional transmission electron microscopy analysis. Therefore\, this study has the potential to contribute to the understanding of fundamental processes in the regulation of protein and membrane trafficking involved in the endosome maturation and EVs shedding.
URL:https://www.ijm.fr/event/paris-postdoc-seminar-lucas-alves-tavares/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/20250123-Lucas-Alves-Tavares-web-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250121T140000
DTEND;TZID=Europe/Paris:20250121T170000
DTSTAMP:20260425T072231
CREATED:20241230T133205Z
LAST-MODIFIED:20241230T133205Z
UID:26312-1737468000-1737478800@www.ijm.fr
SUMMARY:Authorization to supervise research (HDR) - Jérémy Sallé
DESCRIPTION:Jérémy Sallé (Minc Lab) will defend his Authorization to supervise research (HDR): \n« Géométrie des clivages embryonnaires : Mécanismes et Implications » \n  \nThe defense will take place on Tuesday\, January 21st 2025 at 2 pm\, in room François Jacob (IJM) \nThe jury will be composed of: \n\nJenifer Croce (LBDV – Villefranche-sur-Mer)\nRémi Dumollard (LBDV – Villefranche-sur-Mer)\nPatrick Lemaire (CRBM – Montpellier)\nLionel Pintard (IJM – Paris)\nMarie-Hélène Verlhac (Collège de France – Paris)\nNicolas Minc (IJM – Paris)
URL:https://www.ijm.fr/event/authorization-to-supervise-research-hdr-jeremy-salle/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/HDR-bandeau-Jeremy-Salle-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250206T190000
DTEND;TZID=Europe/Paris:20250206T213000
DTSTAMP:20260425T072231
CREATED:20250115T091647Z
LAST-MODIFIED:20250115T091647Z
UID:26597-1738868400-1738877400@www.ijm.fr
SUMMARY:Dance conference: Move your science
DESCRIPTION:Dance conference: MOVE YOUR SCIENCE\nThursday\, February 6\, 7pm | Hall Buffon\, Institut Jacques Monod\nFree with registration\nCollective creation with doctoral students Kenza Alaoui Sossé\, Amandine Albizzati\, Mariam Bougma\, Stéphanie Brunot\, Mert Can\, Johanna Exenberger\, Audrey Gosset\, Capucine Gros\, Emile Le Lièvre and Joséphine Schelle \nChoreography and dance/science research: Cosetta Graffione and Namiko Gahier-Ogawa \nScientific coordination and dance/science research: Mélina Heuzé\, teacher-researcher \nSince September\, ten doctoral students from all disciplines at Université Paris Cité have been working with choreographers Cosetta Graffione and Namiko Gahier-Ogawa and teacher-researcher Mélina Heuzé to share their scientific project in a spirit of mediation with the general public.\nIn a dialogue between art and science\, the public will be able to experience the scientific principles of their thesis work through dance sequences that bring out the poetry of the body. \nThis four-part dance conference will be followed by a discussion with the audience over a friendly drink.
URL:https://www.ijm.fr/event/dance-conference-move-your-science/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/heuze-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250207T114500
DTEND;TZID=Europe/Paris:20250207T130000
DTSTAMP:20260425T072231
CREATED:20241219T104206Z
LAST-MODIFIED:20241219T104206Z
UID:26252-1738928700-1738933200@www.ijm.fr
SUMMARY:Institut Jacques Monod lecture - Sophie G. Martin
DESCRIPTION:On Friday\, February 7th 2025\, Sophie G. Martin (Department of Molecular and Cellular Biology\, University of Geneva\, Switzerland) will present an Institut Jacques Monod lecture on the theme: \nSignaling and actin focus architecture for cell-cell fusion \n  \nAbstract: \nSexual reproduction is ubiquitous amongst eukaryotes. This requires alternation of cell-cell (gamete) fusion and genome reduction through meiosis. My lab has been using the yeast sexual reproduction pathway to study how cells polarize to find a mate and mount a fusion reaction. In the fission yeast Schizosaccharomyces pombe\, sexual reproduction occurs between P and M cells\, which communicate through pheromone-GPCR-MAPK signaling\, driving the formation of cell pairs. Transition from gametes to zygote involves local cell wall digestion at the point of gamete contact\, while preserving cell integrity. We have shown that cell-cell fusion requires the actin fusion focus\, an aster-like assembly of linear actin filaments assembled by the formin Fus1\, which concentrates both signaling molecules and secretory vesicles carrying cell wall digestion enyzmes. I will present our recent work on the molecular mechanisms of formation of the actin fusion focus\, which require both formation of a formin biomolecular condensate and cytoskeletal focusing through formin-myosin feedback. I will also describe our progress in understanding the roles of local MAPK and PAK signaling for cells to pierce their cell wall once and only once.
URL:https://www.ijm.fr/event/institut-jacques-monod-lecture-sophie-g-martin/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/WP-IJM-Lectures-Sophie-Martin-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250211T114500
DTEND;TZID=Europe/Paris:20250211T130000
DTSTAMP:20260425T072231
CREATED:20241223T131853Z
LAST-MODIFIED:20241223T131853Z
UID:26288-1739274300-1739278800@www.ijm.fr
SUMMARY:Institut Jacques Monod  lectures- Richard Benton
DESCRIPTION:On Tuesday\, February 11th\, Richard Benton (Center for Integrative Genomics\, University of Lausanne) will present an Institut Jacques Monod lectures on the theme: \nFatal chemosensation\, and how insects fight back \n  \nAbstract: \nInsecticide resistance is a widespread challenge for the management of vectors transmitting pathogens and agricultural pests\, requiring a better understanding of the genetic mechanisms underlying the evolution of resistance. Drosophila sechellia is a compelling model for such studies as it naturally evolved resistance to octanoic acid\, an abundant chemical of its noni fruit host that is toxic for other insects\, including close relatives D. simulans and D. melanogaster. We have used a multi-pronged strategy to identify genes contributing to octanoic acid resistance. We began by experimentally-evolving D. simulans strains with higher tolerance to octanoic acid and determined the resulting genetic architecture. To identify specific candidate genes\, we integrated this analysis with a genome-wide association study of octanoic acid resistance in D. simulans and a genome-wide CRISPR selection screen upon octanoic acid exposure in D. melanogaster S2R+ cultured cells. We identified four candidates\, with diverse predicted molecular and expression properties\, and validated their relevance using genetic analyses in D. melanogaster. Two of these genes displayed an increased expression in the experimentally-evolved strains\, paralleling their higher levels of expression in D. sechellia. Our results suggest an adaptive role of these genes in shaping toxin resistance both under laboratory conditions and during D. sechellia’s evolutionary history.
URL:https://www.ijm.fr/event/institut-jacques-monod-lectures-richard-benton/?lang=en
LOCATION:Bâtiment Condorcet Amphithéâtre Pierre Gilles de Gennes\, 4 rue Elsa Morante\, Paris\, Sélectionner un État :\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/WP-IJM-Lectures-Richard-Benton-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250212T140000
DTEND;TZID=Europe/Paris:20250212T150000
DTSTAMP:20260425T072231
CREATED:20250127T140538Z
LAST-MODIFIED:20250127T140538Z
UID:26833-1739368800-1739372400@www.ijm.fr
SUMMARY:Seminar - Felix Ruhnow
DESCRIPTION:Invited by the Centre for Genomic Regulation\, Felix Ruhnow will present a seminar on the theme: \nNuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends \n  \nAbstract: \nNuclear mitotic apparatus protein (NuMA) is indispensable for the mitotic functions of the major microtubule minus-end directed motor cytoplasmic dynein 1. NuMA and dynein are both essential for correct spindle pole organization. How these proteins cooperate to gather microtubule minus ends at spindle poles remains unclear. Here we use microscopy-based in vitro reconstitutions to demonstrate that NuMA is a dynein adaptor\, activating processive dynein motility together with dynein’s cofactors dynactin and Lissencephaly-1 (Lis1). Additionally\, we find that NuMA binds and stabilizes microtubule minus ends\, allowing dynein/dynactin/NuMA. to transport microtubule minus ends as cargo to other minus ends. We further show that the microtubule-nucleating γ-tubulin ring complex (γTuRC) hinders NuMA binding and that NuMA can only cap minus ends of γTuRC-nucleated microtubules after γTuRC release. These results provide new mechanistic insight into how dynein\, dynactin\, NuMA\, Lis1 together with γTuRC and uncapping proteins cooperate to organize spindle poles in cells.
URL:https://www.ijm.fr/event/seminar-felix-ruhnow/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/Bandeau-web-seminar-2-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250214T114500
DTEND;TZID=Europe/Paris:20250214T130000
DTSTAMP:20260425T072231
CREATED:20241217T133040Z
LAST-MODIFIED:20241217T133040Z
UID:26236-1739533500-1739538000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Peter Andolfatto
DESCRIPTION:Invited by the Courtier\, Peter Andolfatto (Professor\, Dept. of Biological Sciences\, Columbia University) will present an Institut Jacques Monod seminar on the theme: \nThe evolution of toxin-resistant Na+\,K+-ATPases: new insights from frogs and fireflies  \n  \nWe study the process of adaptive evolution through the lens of repeated adaptation of many distantly species to a similar selection pressure (i.e. “parallel evolution”). Over the past decade\, we have explored patterns of adaptation in the context of animals that have specialized in eating plants\, or other animals\, that contain toxic cardiotonic steroids (CTS). CTS are toxic to animals because they inhibit sodium-potassium ATPase\, a key enzyme in animals needed in everything from maintaining cell homeostasis\, muscle contraction to neuron activity. Here I review our most recent work combining comparative molecular evolution\, molecular and biochemical assays and in vivo engineering of Drosophila to deduce the rules governing the adaptive evolution of CTS resistance in animals. Together\, our results have interesting implications for how epistasis and pleiotropy both limit the rate of adaptive protein evolution and increase its predictability.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-peter-andolfatto/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/Bandeau-web-seminar-Peter-Andolfatto-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250219T093000
DTEND;TZID=Europe/Paris:20250219T110000
DTSTAMP:20260425T072231
CREATED:20250205T110041Z
LAST-MODIFIED:20250205T110041Z
UID:27113-1739957400-1739962800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\, February 19th: \n\nRayane Dibsy (post-doc\, A. Echard’s Lab\, Institut Pasteur présentera  «  The proteasome promotes cytokinetic abscission by relieving Aurora B kinase-mediated inhibition of ESCRT-III turnover. »\nJonathan Fouchard ( Researcher\, Laboratoire de Biologie du Développement\, IBPS) présentera ‘Three-dimensional cell shape\, focal adhesions and vimentin during spreading’
URL:https://www.ijm.fr/event/cytoskeleton-club-4/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/02/20250219bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250224T114500
DTEND;TZID=Europe/Paris:20250224T130000
DTSTAMP:20260425T072231
CREATED:20250128T140351Z
LAST-MODIFIED:20250214T094643Z
UID:26858-1740397500-1740402000@www.ijm.fr
SUMMARY:[Cancelled] Institut Jacques Monod Seminars - Marla Sokolowski
DESCRIPTION:This seminar is cancelled.\n  \nInvited by the par l’équipe Courtier\, Marla Sokolowski (Department of Ecology and Evolutionary Biology\, University of Toronto) will present an Institut Jacques Monod Seminar on the theme: \nThe foraging gene: will that be for here or to go? \nAbstract: \nThe Drosophila melanogaster foraging (for) gene\, with its rover and sitter larval foraging variants\, is an established behaviour genetics model. Orthologues of the foraging gene also modulate the individual and social behaviour of a wide range of species including the regulation of behaviour in eusocial insects. In Drosophila\, foraging modifies the expression of multiple traits\, including feeding and foraging\, stress tolerance\, sleep\, metabolism\, dispersal\, escape responses\, social behaviour\, and learning and memory. From a social context perspective\, Drosophila foraging affects larval clustering during foraging under high larval densities\, adult social behaviour and social networks\, and social learning. We wondered how foraging accomplishes its behavioural pleiotropy at the molecular level. We found that D. melanogaster foraging has a complex modular genomic structure with four promoters\, 21 transcripts\, and eight protein isoforms. The four promoter modules are differentially regulated during development and in a timescale\, tissue\, and cell-type dependent manner. Two examples illustrate these findings: the epigenetic regulation of the adult rover-sitter foraging-related phenotypes by G9a\, a histone methyltransferase\, and the regulation of differences in the latency of rover compared to sitter larval escape responses to noxious stimuli such as parasitoid wasps. Our work provides a nuanced picture of the molecular basis of foraging’s pleiotropy.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-marla-sokolowski/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/Bandeau-web-seminar-Marla-Sokolowski-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250225T114500
DTEND;TZID=Europe/Paris:20250225T130000
DTSTAMP:20260425T072231
CREATED:20250123T141141Z
LAST-MODIFIED:20250123T141141Z
UID:26792-1740483900-1740488400@www.ijm.fr
SUMMARY:Paris Postdoc Seminar - Nathaniel Henneman
DESCRIPTION:Invited by the Institut Jacques Monod\, Nathaniel Henneman (team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM)) will present a Paris Postdoc Seminar on the theme: \nNuclear functions of nutrient sensing signaling for metabolic adaptation \n  \nIntroduction & abstract: \nI am a Postdoc in the team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM). I graduated from Bates College (USA) in 2016\, majoring in Biology. I then spent two years working on retinal degeneration at Emory University before obtaining my master’s degree at University of Paris Descartes in 2019 and defended my PhD in December 2023. \nOne of the key questions I am to address in my work is how cellular metabolism\, gene expression and transcription\, are all coordinated. Energy stress in fasting is managed by activating autophagy and promoting the transcriptional remodeling of metabolism. Cytosolic nutrient sensors coordinate extracellular nutrient availability with intracellular metabolic processes to allow for cell survival. Class 3 PI3K is a highly conserved nutrient sensor known to regulate autophagy and endocytosis in response to varying nutrient conditions. It’s direct role in transcription\, however\, was only suggested in few studies in yeast and plants. However\, we believe there is a nuclear pool of class 3 PI3K that directly regulates gene expression for metabolic adaptation. My work aims to address this unmet burden in the field. We find that nuclear class 3 PI3K regulates the transcriptional response to nutrient stress by controlling RNA Polymerase II\, the Set1/COMPASS methyltransferase\, and nuclear methionine to SAM flux. I aim to understand how these players are needed for our fasting adaptation and how these mechanisms could affect our metabolic resilience.
URL:https://www.ijm.fr/event/paris-postdoc-seminar-nathaniel-henneman/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/20250225-Nathaniel-Hennman-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250307T114500
DTEND;TZID=Europe/Paris:20250307T130000
DTSTAMP:20260425T072231
CREATED:20250127T142106Z
LAST-MODIFIED:20250212T155220Z
UID:26838-1741347900-1741352400@www.ijm.fr
SUMMARY:Institut Jacques Monod Lecture - Andrea Musacchio
DESCRIPTION:On Friday\, March 7th\, Andrea Musacchio (Max Planck Institute of Molecular physiology) will present a Institut Jacques Monod Lecture on the theme: \nFeedback control of mitosis in the context of the kinetochore \n  \nAbstract: \nKinetochores provide chromosomes with points of attachment to spindle microtubules during cell division\, and are therefore essential for genome inheritance and the propagation of life. In addition to binding microtubules\, kinetochores control mitotic surveillance mechanisms that promote chromosome bi-orientation (the error correction mechanism) and prevent premature mitotic exit in presence of incomplete or incorrect microtubule attachments (spindle assembly checkpoint\, SAC). Elimination of the NDC80 complex\, the main microtubule receptor of kinetochores\, causes a SAC deficiency\, identifying this complex as a crucial regulatory focus for checkpoint function. In recent years\, there has been considerable progress in understanding how the SAC effector\, known as the mitotic checkpoint complex (MCC)\, assembles from its individual components to inhibit its target\, the anaphase promoting complex/cyclosome (APC/C). Conversely\, how microtubule attachment to kinetochores regulates the SAC remains incompletely understood. From a molecular perspective\, answering this question implies investigating the mechanisms that promote targeting of the SAC proteins to unattached kinetochores\, and suppress it upon microtubule binding and biorientation. In our recent work\, we have combined biochemical reconstitutions\, structural biology/modelling\, and cell biology to gain insights into this fundamental biological question.
URL:https://www.ijm.fr/event/institut-jacques-monod-lecture-andrea-musacchio/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/bandeau-IJM-Lectures-Andrea-Musacchio-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250311T114500
DTEND;TZID=Europe/Paris:20250311T130000
DTSTAMP:20260425T072231
CREATED:20250211T153305Z
LAST-MODIFIED:20250211T153305Z
UID:27291-1741693500-1741698000@www.ijm.fr
SUMMARY:Institut Jacques Monod seminar - Mateusz C. Ambrozkiewicz
DESCRIPTION:Invited by the Konstantinides Lab\, Dr. Mateusz C. Ambrozkiewicz\, FENS-Kavli Scholar (Institute for Cell Biology and Neurobiology\, Charité University Hospital\, Berlin\, Germany) will present an Institut Jacques Monod seminar on the theme: \nProteostatic Mechanisms of Cellular Diversification in the Developing Brain \nAbstract: \nFormation of functional circuits in the adult brain is a biological fundament for its executive role in the living organism and requires specification of neurons\, their correct positioning\, formation of dendrites and synapses. In this talk\, I will present our current research on the translational mechanisms and post-translational modifications orchestrating neuronal diversification in the developing brain. Particularly\, I will shed light on the specific post-transcriptional requirements for neuronal progenitors\, including the dynamics of protein synthesis as well as the role of ubiquitination-dependent degradation in healthy and diseased brain. I will show how deciphering a molecular mechanism at the basis of neurodevelopmental disease etiology can be used to propose therapeutic strategy impinging on modulating the activity of cellular proteostasis effectors\, such as the E3 ubiquitin ligases.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-mateusz-c-ambrozkiewicz/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/02/Bandeau-web-seminar-Mateusz-C.-Ambrozkiewicz-2-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250314T114500
DTEND;TZID=Europe/Paris:20250314T130000
DTSTAMP:20260425T072231
CREATED:20250212T123210Z
LAST-MODIFIED:20250212T123210Z
UID:27374-1741952700-1741957200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Maud Borensztein
DESCRIPTION:Invited by the Greenberg Lab \, Maud Borensztein (Team Epigenetic Reprogramming and Mammalian Development\, IGMM\, CNRS\, University of Montpellier) will present an Institut Jacques Monod Seminar on the theme: \nReprogramming the X chromosome: insights from mammalian development and germline \n  \nAbstract: \nMaud Borensztein team focuses on epigenetic mechanisms in mammalian development and reproduction\, with a particular emphasis on X-chromosome dosage compensation. Since establishing her group at the Institut de Génétique Moléculaire de Montpellier (IGMM) in 2021\, they have developed innovative tools to study gametogenesis and X-chromosome dynamics\, both in vivo (using mouse models) and in vitro (using Primordial Germ Cell-like cells). Investigating the reactivation of the inactive X chromosome during germline specification in females—a unique epigenetic reprogramming process that highlights fine gene-regulation control—\, they aim to uncover its timing\, mechanisms\, and biological implications.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-maud-borensztein/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/02/Bandeau-web-seminar-Maud-Borensztein-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250319T093000
DTEND;TZID=Europe/Paris:20250319T110000
DTSTAMP:20260425T072231
CREATED:20250313T100517Z
LAST-MODIFIED:20250313T100517Z
UID:27621-1742376600-1742382000@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\, 19th: \n\nMeriem Boumendjel (PhD student\, Azimzadeh Lab\, Institut Jacques Monod ) will present “Centriole rotational polarity is required for daughter centriole repositioning during primary cilium formation“\nAlfredo SCIORTINO  ( Post-doc\, Manuel Thery Lab\, ESPCI\, IPGG) will present “Filament transport supports contractile steady states of actin networks”\n\n 
URL:https://www.ijm.fr/event/cytoskeleton-club-5/?lang=en
LOCATION:Institut Curie\, 26 rue d'Ulm 75005 Paris\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250319bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250331T133000
DTEND;TZID=Europe/Paris:20250331T170000
DTSTAMP:20260425T072231
CREATED:20250303T154408Z
LAST-MODIFIED:20250303T154654Z
UID:27523-1743427800-1743440400@www.ijm.fr
SUMMARY:PhD thesis defense - Alberto Ballin
DESCRIPTION:Alberto Ballin (Léon Lab) will defense his PhD thesis defense: \n“Glucose signaling through Snf1/AMPK in Saccharomyces cerevisiae: mechanistic insights from 2-deoxyglucose-resistant mutants” \nThe defense will be held in English on Monday\, March 31st at 1.30 pm in room François Jacob at the Institut Jacques Monod. \nThe members of the jury are: \n\nAlexandre Soulard (Lyon) as rapporteur ;\nPaola Coccetti (Milan) as rapportice;\nSimonetta Piatti (Montpellier) as examinatrice;\nBenoit Viollet (Paris) as examinateur;\nGwenael Rabut (Rennes) as invited member ;\nSébastien Leon (directeur de thèse).
URL:https://www.ijm.fr/event/soutenance-de-these-alberto-ballin/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/These-bandeau-Alberto-Ballin-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250404T114500
DTEND;TZID=Europe/Paris:20250404T130000
DTSTAMP:20260425T072231
CREATED:20250324T145408Z
LAST-MODIFIED:20250324T145408Z
UID:27690-1743767100-1743771600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Lionel Christiaen
DESCRIPTION:Invited by the Minc Lab\, Lionel Christiaen (Michael Sars Centre\, University of Bergen\, Bergen\, Norway) will present an Institut Jacques Monod Seminar on the theme: \nRegulation of deterministic development \nAbstract: \nChristiaen’s research aims at understanding how tissue-specific regulatory programs and cell-cell communication coordinate cellular behavior in the context of animal development\, regeneration and evolution. His laboratory focuses on mesodermal lineages that produce both heart and head muscles\, using the ascidian Ciona as model. His laboratory has contributed seminal findings in developmental and evolutionary biology\, identifying key processes contributing to human congenital disorders. The Ciona model provides a unique opportunity to study the regulation of chordate development at single cell resolution\, thanks to a highly deterministic (“hard-wired”) mode of embryogenesis. However\, recent attempts to uncover the impact of varying temperatures in a changing world are beginning to reveal regulative mechanisms of thermal adaptation.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-lionel-christiaen/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/Bandeau-web-seminar-Lionel-Christiaen-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250408T114500
DTEND;TZID=Europe/Paris:20250408T130000
DTSTAMP:20260425T072231
CREATED:20250326T143945Z
LAST-MODIFIED:20250326T143945Z
UID:27705-1744112700-1744117200@www.ijm.fr
SUMMARY:Seminar - Suzette Lust
DESCRIPTION:Invited by the Institut Jacques Monod\, Suzette Lust (Postdoctoral researcher in Danijela Matic Vignjevic’s team – Cell migration and invasion Laboratory at Institut Curie) will present a seminar on the theme: \nUnderstanding the role of interstitial flow in vascular smooth muscle cell phenotype in the context of aortic aneurysms \n  \nThis seminar is part of the Paris Postdocs Seminars series. \nAbstract: \nAortic aneurysms are abnormal enlargements of blood vessel diameter caused by aberrant extra-cellular matrix (ECM) remodelling. As the tissue dilates\, it loses its mechanical integrity\, exposing patients to risk of highly fatal aortic dissections or ruptures. This is mediated in part by phenotypic switching and or apoptosis of the intima-resident vascular smooth muscles (VSMCs). What drives this pathology is not well understood\, particularly in the case of aneurysms in Bicuspid Aortic Valve disease (BAV) patients\, a congenital condition characterised by the malformation of the aortic valve resulting in only 2 leaflets. Improvements in imaging techniques have now allowed pathological blood flow patterns to be correlated to aneurysm morphology and indeed there is increasing evidence that mechanotransduction from flow may be a driver of aneurysm development. Blood flow imparts mechanical forces to cells through stretching and frictional shear forces and we are focused here on the interstitial flow driven into the wall by differential pressure gradients within the aorta. \nWe hypothesise that interstitial flow plays a crucial role in regulating VSMC phenotype and ECM interactions and that this may be used to correlate disrupted flow patterns seen in BAV patients to the morphology changes in their aortas. \nTo test this hypothesis\, we created a reductionist in-vitro model culturing VSMCs in 3D under interstitial flow. We combined a synthetic PEG based ECM mimicking hydrogel with primary cultures of VSCMs with a microfluidics setup. \nWe showed hydrogels doctored with degradable bioactive peptides could be broken down by exogenous and cell derived MMPs. We measured hydrogel permeability using 2 separate techniques which confirmed the material to have a low permeability compared to other standard hydrogels\, on the order of 10−16 m2. Furthermore\, we characterised mass transport of solutes within hydrogels and were able to demonstrate a negligible impact of changing polymer solid content on diffusivity in hydrogels of up to 5% weight/volume for molecules up to 40 kDa in size. Via production of MMPs\, VSMCs break down the hydrogel and importantly by day 7 of culture\, we detected newly synthesised fibronectin\, collagen 1 and 4 proteins. We stimulated encapsulated cells with interstitial flows demonstrating that cells align to the flow direction. Finally\, we performed RNA sequencing on 3 human patient samples comparing standard culture conditions\, non-flow stimulated encapsulated cells and interstitial-flow stimulated cells. The data set reveals significant upregulation of genes in multiple pathways associated with cyclic AMP production\, which plays a crucial role in regulating VSMC contractility and calcium signalling and hence phenotype. The data suggests that this is mediated via activation of G-protein receptors leading to increased expression of adenylyl cyclase but this remains to be confirmed. \nIn conclusion\, we developed a novel in-vitro platform to study the impact of interstitial flow on VSMC behaviour. Our data suggests that interstitial flow may play a regulating role in determining VSMC phenotype with potential consequences for matrix remodelling in disease.
URL:https://www.ijm.fr/event/seminar-suzette-lust/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250408-Suzette-Lust-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250409
DTEND;VALUE=DATE:20250412
DTSTAMP:20260425T072231
CREATED:20241209T104027Z
LAST-MODIFIED:20241209T104027Z
UID:26072-1744156800-1744415999@www.ijm.fr
SUMMARY:Paris - Munich Epigenetics Workshop & Symposium 2025
DESCRIPTION:The second edition of the Paris-Munich Epigenetics meeting will be held from 9 to 11 April 2025 in the Buffon amphitheater. Attendance is free of charge but registration is mandatory. \nPlease visit the website to find out more about the program and to register. \nThe Paris-Munich Epigenetics Worshop & Symposium has two parts: \n\nthe SYMPOSIUM\, open for all students and researchers in the Paris/Munich communities and beyond\na WORKSHOP for selected doctoral or postdoctoral researchers that are new to the field of Epigenetics\n\nThe WORKSHOP takes place on April 9 prior to the symposium\, and is open for selected early stage doctoral and postdoctoral researchers new to the field of Epigenetics. The workshop focussed on the core concepts of cutting-edge Epigenetics research\, taught by senior academic experts\, as well as career orientation and communication skills\, presented by alumna and professionals in the field. Workshop participants will have the opportunity to network and exchange\, with discussions during the workshop\, as well as with featured short talks and posters during the symposium. \n  \nThe SYMPOSIUM takes place from April 9-11\, 2025  and is open for all interested students and scientists from the Paris and Munich communities and beyond. During the Symposium renowned speakers from the two communities present their latest insights into Epigenetics in sessions on chromatin environment\, organization\, remodelling and reprogramming. Short talks and poster presentations from early career (doctoral and postdoctoral) researchers will be selected from the submitted abstracts. \n  \nThe deadline for both abstract submissions and workshop applications is January 15\, 2025.
URL:https://www.ijm.fr/event/paris-munich-epigenetics-workshop-symposium-2025/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/bandeau-scaled.jpg
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DTSTART;TZID=Europe/Paris:20250409T093000
DTEND;TZID=Europe/Paris:20250409T110000
DTSTAMP:20260425T072231
CREATED:20250331T094740Z
LAST-MODIFIED:20250331T094740Z
UID:27738-1744191000-1744196400@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\,9th at the Institut Pasteur: \n\nIngrid Billault-Chaumartin (post-doc\,  Romet-Lemonne/Jegou team\, IJM) will present “How similar is actin assembly between distant species ? »\nNicolas Joly ( Researcher \,  Pintard tema\, IJM)  will present “Mechanistic Insights into Katanin Activation: Coupling Microtubule Binding with ATP Hydrolysis
URL:https://www.ijm.fr/event/cytoskeleton-club-6/?lang=en
LOCATION:Institut Pasteur\, 28 rue du dr roux\, 75015 Paris\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250319bandeau-1-scaled.jpg
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