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DTSTART;TZID=Europe/Paris:20241108T114500
DTEND;TZID=Europe/Paris:20241108T130000
DTSTAMP:20260425T091538
CREATED:20241023T133709Z
LAST-MODIFIED:20241023T135451Z
UID:25397-1731066300-1731070800@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Leon Peshkin
DESCRIPTION:Invited by the Doye Lab\, Leon Peshkin (Mayor-Rotschild visiting professor at the Institut Curie and Principal Research Faculty at the Department of systems biology\, Harvard Medical School) will present an Institut Jacques Monod Seminar on the theme: \n(Phospho)-proteomics of oocyte meiotic division \nAbstract: \nOocyte meiotic divisions represent a critical process in sexual reproduction\, as diploid non-dividing oocyte transforms into a haploid fertilizable egg\, preparing embryonic divisions and differentiation. Although cell differentiation and proliferation are governed by transcription\, oocyte maturation and early embryonic divisions depend entirely on changes in protein abundance and post-translational modifications. Here\, we analyze the abundance and phosphorylation of proteins during Xenopus oocyte meiotic maturation. We reveal significant shifts in protein stability\, related to spindle assembly\, DNA replication and RNA-binding. Our analysis pinpoints broad changes in phosphorylation correlating with key cytological meiotic milestones\, noteworthy changes in membrane trafficking\, nuclear envelope disassembly and modifications in microtubule dynamics. Additionally\, specific phosphorylation events target regulators of protein translation\, Cdk1 and the Mos/MAPK pathway\, providing insights into the dynamics of Cdk1 activity related to the meiotic cell cycle. This study sheds light on the orchestration of protein dynamics and phosphorylation events during oocyte meiotic divisions\, providing a rich resource for understanding the molecular pathways orchestrating meiotic progression in the frog\, and most likely applicable to other vertebrate species. \nBiography: \nLeon Peshkin is a Mayor-Rotschild visiting professor at the Inst Curie and Principal Research Faculty at the Department of systems biology\, Harvard Medical School. His PhD was done in the field of Machine Learning and AI. His eclectic interests range from pharmaco-biology to evo-devo\, to embryology\, to Machine Learning applications in Systems Biology\, but all he does has connection to biology of aging.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-leon-peshkin/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/Bandeau-web-seminar-Leon-Peshkin-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241112T090000
DTEND;TZID=Europe/Paris:20241112T180000
DTSTAMP:20260425T091538
CREATED:20241002T144902Z
LAST-MODIFIED:20241002T144902Z
UID:25106-1731402000-1731434400@www.ijm.fr
SUMMARY:5th Fungal Genetics Ile-de-France Symposium
DESCRIPTION:Registration is now open for the 5th symposium on fungal genetics in Ile-de-France! \n  \nThe symposium seeks to: \n\nPromote the exchange of ideas and results on fungal genetics topics pursued in the Paris region;\nEncourage the participation of young researchers (PhD students and post-docs);\n Address technical and scientific challenges faced by our fungal research community.\n\nAll the topics related to fungal genetics are welcome including: \n\nPathogenicity\, effectors & secondary metabolism;\nDevelopment and sexual reproduction;\nGenome structure and chromatin-based regulation;\nPopulation genetics and epidemiology;\n Fungal genetic engineering & biotechnology.\n\nThe symposium will take place on November 12\, at the Institut Jacques Monod\, amphitheater Buffon\, bat. Buffon\, 15 rue Hélène Brion\, 75013 Paris. \nRegistration is free but required. A number of oral presentations will be chosen from submitted abstracts. A poster session will also be organized. The abstracts should be submitted by email to fungi.idf@gmail.com. The deadline for registering and submitting your abstract is October 28. \nRegister here \nThe scientific organization committee includes Frederique Bidard-Michelot (IFPEN)\, Isabelle Fudal (INRAE)\, Jeanne Ropars (CNRS)\, Eugene Gladyshev (Institut Pasteur)\, Fabienne Malagnac (Université Paris-Saclay)\, and Sylvain Brun (Université Paris Cité).
URL:https://www.ijm.fr/event/5th-fungal-genetics-ile-de-france-symposium/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/png:https://www.ijm.fr/wp-content/uploads/2024/10/ffiche-symposium-FunGenIDF.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241112T140000
DTEND;TZID=Europe/Paris:20241112T170000
DTSTAMP:20260425T091538
CREATED:20241028T145726Z
LAST-MODIFIED:20241028T145726Z
UID:25511-1731420000-1731430800@www.ijm.fr
SUMMARY:Thesis defense - Sudheer Peneti
DESCRIPTION:Sudheer PENETI (équipe Ladoux/Mège) will defend his thesis: \nVimentin modulates collective cell migration by regulating Epithelial Leader cell Mechanics \n  \nThe defense will take place on Tuesday\, 12th November in room François Jacob and will be held in English. \nThe jury will be composed of: \n\nMdm. ADA CAVALCANTI-ADAM DR\, University of Heidelberg\, Rapporteur\nMdm. CARIEN NIESSEN Professor\, University of Cologne Rapporteur\nGREGORY GIANNONE DR\, University of Bordeaux Examinateur\nMdm. SYLVIE HENON Professor\, University of Paris Cité Examinatrice\nBENOIT LADOUX Professor\, Friedrich-Alexander-University Invité\nRENE-MARC MEGE Professor\, Institut Jacques Monod Directeur de thèse
URL:https://www.ijm.fr/event/thesis-defense-sudheer-peneti/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/These-bandeau-Sudheer-PENETI-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241115T090000
DTEND;TZID=Europe/Paris:20241115T180000
DTSTAMP:20260425T091538
CREATED:20240903T101342Z
LAST-MODIFIED:20240903T102138Z
UID:23796-1731661200-1731693600@www.ijm.fr
SUMMARY:Paris Cytoskeleton Day
DESCRIPTION:On Friday\, November 15\, 2024\, the parisian Cytoskeleton club is organizing the fourth edition of the Paris Cytoskeleton Day! \nThe meeting will be entirely in-person in Auditorium Buffon (Institut Jacques Monod\, Paris) \nDeadlines\nRegistration and abstract submission are now open : link.\nAbstract submission closes on October 20th.\nRegistration (45 euros) closes on November 8th. \nKeynote speakers\nBuzz Baum (Cambridge\, UK)\nGaia Pigino (Human Technopole\, Milan\, IT) \nInvited speakers\nDaria Bonazzi (Institut Pasteur)\nPaul Conduit (Institut Jacques Monod)\nJean-Léon Maître (Institut Curie)\nMarie-Hélène Verlhac (Collège de France) \nShort talks\nSeveral short presentations will be selected from abstracts. \nPosters\nA poster session will take place during the day.
URL:https://www.ijm.fr/event/paris-cytoskeleton-day/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/PCD-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20241119
DTEND;VALUE=DATE:20241120
DTSTAMP:20260425T091538
CREATED:20240920T130703Z
LAST-MODIFIED:20241004T140523Z
UID:24143-1731974400-1732060799@www.ijm.fr
SUMMARY:[Symphosium & Exhibition]The peopling of France and the origins of the agricultural lifestyle
DESCRIPTION:A one-day international symposium will present to the general public on novembre 19\, 2024 at Buffon amphitheater of the Université Paris-Cité\, 15 rue Hélène Brion\, 75013 Paris\, both individual and collaborative achievements of the Turkish and French partners of the international project NEOMATRIX that studied the Neolithic expansion from the archaeogenetic perspective. \nThis symposium will accompany an exhibition conceived and organized by Eva-Maria Geigl and Thierry Grange\, (Université Paris-Cité\, CNRS\, Institut Jacques Monod) in collaboration with a team of UMR8215-Trajectoires\, and by the team of the cultural service of the Université Paris-Cité\, funded by the Université Paris-Cité and NEOMATRIX: \n\nNovember 19 to December 16\, 2024\nUniversité Paris-Cité\, Hall 1\, Building Grands Moulins de Paris\, 5 rue Thomas Mann\, 75013 Paris.\nIntroductory ceremony: November 19\, 2024\, follow the symposium.\n\nRegistration at eva-maria.geigl@ijm.fr \n  \nSymposium : \nThe Neolithic expansion from Anatolia to France\nNovembre 19\, 2024\, Université Paris-Cité\, Amphithéâtre Buffon\, 15\, rue Hélène Brion\, 75013 Paris \nProgram: \n9:00  E.-M. Geigl (IJM): Bienvenue \n9:05  M. Somel (METU): Welcome address \n9:15 – 9:50  C. Atakuman (METU): The archaeological perspective of the Neolithic revolution in the Middle East (avec diapos et résumé en français) \n10:00 – 10:20  E.-M. Geigl (IJM): La Paléo-/Archéogénétique (with English slides and summary) \n10:30 – 11:05  M. Somel (METU): Archeogenetics of the Neolithic in the Middle East / Genetic clues into Çatalhöyük society (avec diapos et résumé en français) \n11:15 – 11:45  Coffee \n11:45 – 12:05  F. Ozer (HU): Anatolian Neolithic sheep and shepherds: from Anatolia to Europe (avec diapos et résumé en français) \n12:10 – 12:45  J.-P. Demoule (IUF): L’archéologie de l’expansion néolithique en Europe (with English slides and summary) \n13:00 – 14:30  Pause déjeuner/Lunch break \n14:30 – 15:05  O. Parasayan et E.-M. Geigl (IJM): Archeogenetics of the Neolithic in Europe with particular emphasis on northern France (avec diapos et résumé en français) \n15:15 – 15:35  T. Grange (IJM): Domestication des bovins en Anatolie et propagation en Europe (with English slides and summary) \n15:40 – 15:55  E.-M. Geigl IJM): Introduction à l’exposition AGRIPOP (with English slides and summary) \n15:55 – 16:30  N.E. Altinisik (HU): The science of the genetics of past populations and individuals: beyond science \n16:40 – 17:00: General Discussion \n17 :30  Opening Ceremony Exhibition AGRIPOP \nAttendance is free\, but registration is required : eva-maria.geigl@ijm.fr \n  \nIJM : Institut Jacques Monod\, Université Paris-Cité\, CNRS\, France \nMETU : Middle Eastern Technical University\, Ankara\, Türkiye \nHU : Hacettepe Üniversitesi\, Ankara\, Türkiye \nIUF : Institut Universitaire de France & Université de Paris I\, France
URL:https://www.ijm.fr/event/symphosium-exhibitionthe-peopling-of-france-and-the-origins-of-the-agricultural-lifestyle/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/geigl-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20241119
DTEND;VALUE=DATE:20241217
DTSTAMP:20260425T091538
CREATED:20241126T141035Z
LAST-MODIFIED:20241126T141035Z
UID:25897-1731974400-1734393599@www.ijm.fr
SUMMARY:AGRIPOP exhibition - Paleogenetics and archaeology - Neolithic revolution and migration
DESCRIPTION:Exhibition at Université Paris Cité\, Hall A of the Grands-Moulins\, from November 14 to December 16\, 2024 \nThis exhibition opens the doors of the CNRS “Epigenome & Paleogenome” research laboratory at the Institut Jacques Monod\, Université Paris Cité. \nIn 2010\, the first Neanderthal genome was sequenced. This marked the birth of paleogenomics. Since then\, paleogenomics – the analysis of ancient DNA preserved in archaeological bones – has become a rapidly expanding field of research. It provides information on the genetic identity of individuals from the past – humans and animals – on kinship relationships\, genealogies\, migrations\, interbreeding and certain characteristics of their physical appearance. This information enables scientists to reconstruct more accurately the reality of a given moment in the past. \nFrom Çatalhöyük\, in Anatolia\, to the Aisne valley\, the AGRIPOP exhibition invites you to follow the discoveries of archaeologists and paleogeneticists to understand how humans evolved towards the sedentary lifestyle of producers-farmers that is still our present. \nAccessible to all\, this exhibition highlights the collaborative and interdisciplinary practices of researchers on an international scale. Above all\, it makes more tangible our knowledge of the settlement of northern France in the Neolithic by the first farmers of Anatolian origin (modern-day Türkiye) 7\,000 years ago. AGRIPOP sheds new light on the origins of the way our societies function today. The texts in the exhibition are in French but the accompanying booklets are also provided in English.
URL:https://www.ijm.fr/event/agripop-exhibition-paleogenetics-and-archaeology-neolithic-revolution-and-migration/?lang=en
LOCATION:Université Paris-Cité\, Hall A du bâtiment des Grands Moulins de Paris\, 5 rue Thomas Mann\, 75013 Paris\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/Capture-decran-2024-11-26-151811.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241122T143000
DTEND;TZID=Europe/Paris:20241122T170000
DTSTAMP:20260425T091538
CREATED:20241014T123111Z
LAST-MODIFIED:20241014T123440Z
UID:25298-1732285800-1732294800@www.ijm.fr
SUMMARY:HDR defense - Claire Dugast
DESCRIPTION:Claire DUGAST (Ribes Lab) will defense her “Habilitation à Diriger les Recherches”: \nDynamiques moléculaires de PAX3 et PAX7 associées à la commutation activation/répression de leur activité transcriptionnelle \n  \nThe defense will take place on Friday\, November 22nd at 2:30 pm in room François Jacob and will be held in French. \nThe jury will be composed of: \n\nDr. Mounia Lagha\nDr. Raphael Margueron\nPr. Délara Saberan Djoneidi\nDr. Christine Vesque\nDr. Domenico Flagiello\nDr. Mathieu Coppey
URL:https://www.ijm.fr/event/hdr-defense-claire-dugast/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/HDR-bandeau-Claire-DUGAST-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241129T114500
DTEND;TZID=Europe/Paris:20241129T130000
DTSTAMP:20260425T091538
CREATED:20241025T093536Z
LAST-MODIFIED:20241025T093536Z
UID:25447-1732880700-1732885200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Jens Lüders
DESCRIPTION:Invited by the Conduit Lab\, Jens Lüders (Institute for Research in Biomedicine Barcelona) will present an Institut Jacques Monod Seminars on the theme: \nMolecular basis and regulation of microtubule nucleation \n  \nAbstract: \nFormation of new microtubules\, termed nucleation\, is at the heart of organizing\, maintaining\, and remodeling complex microtubule networks. For this reason\, cells tightly control microtubule nucleation in space and time. While microtubules can assemble spontaneously in vitro\, in cells this process requires a nucleator. The main microtubule nucleator is the multi-subunit\, cone-shaped g-tubulin ring complex (gTuRC)\, which has been proposed to nucleate microtubules by a template mechanism. However\, the molecular details underlying its activity and how it is regulated to nucleate microtubules with 13-fold symmetry has remained poorly understood. \nIn my seminar I will present our recent advances in elucidating this process through the generation of recombinant gTuRC and its structural and functional analysis using cryo-EM as well as in vitro and cell-based assays. Key to reconstitution of recombinant gTuRC was the inclusion of the chaperone-like RUVBL1/2 complex in the recombinant expression system\, which greatly improves multi-subunit complex assembly. Surprisingly\, we found that gTuRC has a splayed structure that does not match microtubule symmetry and appears to be a poor nucleation template. However\, when bound to an activator\, the centrosomin motif 1 (CM1) of the gTuRC adapter protein CDK5RAP2\, gTuRC acquires the ability to adopt microtubule-like conformations and becomes an efficient nucleator. Activation involves binding of multiple CM1 dimers to five distinct sites around the outside of the gTuRC cone\, which modulates lateral interactions among the GCP subunits that form the cone-like structure. This facilitates microtubule-like conformations and release of luminal actin that is integral to non-activated gTuRC. \nWe propose a model where generation of gTuRC with an expanded conformational range\, rather than perfect symmetry\, is sufficient to boost nucleation activity.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-jens-luders/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/Bandeau-web-seminar-Jens-Luders-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241129T140000
DTEND;TZID=Europe/Paris:20241129T170000
DTSTAMP:20260425T091538
CREATED:20241113T155355Z
LAST-MODIFIED:20241113T155355Z
UID:25664-1732888800-1732899600@www.ijm.fr
SUMMARY:Thesis defense - Adria Chorro I Satorra
DESCRIPTION:Adria CHORRO I SATORRA (Conduit Lab) will defend his thesis: \nDendritic bubbles as a novel Class I-specific MTOC in Drosophila melanogaster ddaE neurons \n  \nThe defense will take place on Friday\, November 29th at 2 pm in room François Jacob and will be held in English. \nThe jury will be composed of: \nReporters:  \n\nDr. Coralie Fassier\, DR\, INSERM\, Sorbonne University\, Institut de la Vision\, France\nDr. Jens Lüders\, DR\, Institute for Research in Biomedicine (IRB)\, Barcelona\, Spain\n\nExaminers: \n\nDr. Filippo Del Bene\, DR\, INSERM\, Sorbonne University\, Institute de la Vision\, France\nDr. Juliette Azimzadeh\, DR\, CNRS\, University of Paris Cite\, Institut Jacques Monod\, France\n\nThesis director: \n\nDr. Paul Conduit\, DR\, CNRS\, Institute Jacques Monod\, France
URL:https://www.ijm.fr/event/thesis-defense-adria-chorro-i-satorra/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/These-bandeau-Adria-CHORRO-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241203T114500
DTEND;TZID=Europe/Paris:20241203T130000
DTSTAMP:20260425T091538
CREATED:20241121T133233Z
LAST-MODIFIED:20241121T133233Z
UID:25833-1733226300-1733230800@www.ijm.fr
SUMMARY:Paris Postdocs Seminars - Ahlem Assali
DESCRIPTION:Invited by the Institut Jacques Monod\, Ahlem Assali (Institut du cerveau\, Paris) will present a Paris Postdoc Seminar on the theme: \nPregnancy induces cerebrovascular plasticity involved in the emergence of maternal behaviors \n  \nAbstract: \nThe adult cerebrovascular system is viewed as a very stable network\, mainly required to provide nutrients and oxygen to the brain\, and adapting to changes in neuronal activity via vasomotricity mechanisms (vasodilation and vasoconstriction). Using advanced 3D whole-brain immunolabeling/clearing protocols (iDisco+)\, light-sheet imaging\, and computational tools (ClearMap)\, enabling accurate reconstruction of the brain vasculature\, we were able to challenge this static conception of the cerebrovascular network in the context of neurophysiological adaptations occurring during and after pregnancy. Pregnant mice displayed an increase in vascular branch points in different brain regions compared to virgin females\, starting at least at gestational day 6 (GD6)\, peaking around GD15\, and reversed postweaning. This increased vascularization was notably found in the preoptic region of the hypothalamus\, involved in pregnancy regulation and maternal behavior\, and in cortical areas\, such as the somatosensory cortex. GD15 females also displayed an increase in Erg+ endothelial cells in the same brain regions. In addition\, GD6 and GD15 females showed an increase in the number of endothelial tip cells in the hypothalamic preoptic region. These data revealed a progressive vascular remodeling during pregnancy\, associated to potential angiogenesis\, in adulthood and healthy conditions. To identify molecular mechanisms driving this vascular plasticity\, we explored the effects of steroid hormones on the vascular network. Interestingly\, implants releasing estradiol induced an increase in the number of vascular branch points and of endothelial tip cells in the preoptic region of virgin females\, recapitulating the changes found in pregnant females. These data suggest that estradiol hormones regulate\, at least partially\, the pregnancy-induced vascular plasticity. Importantly\, using 3D whole-brain fluorescent in situ hybridization\, we found an increase in Vegfa expression (vascular endothelial growth factor) in the hypothalamic preoptic region and somatosensory cortex. Vegfa downregulation by shRNA in the preoptic area blocked the pregnancy-induced vascular densification\, and induced defects in maternal behavior post-birth using the pup retrieval assay.  Future transcriptomics experiments in the preoptic region will allow an agnostic search for further cellular and molecular mechanisms underlying pregnancy-induced vascular adaptations. Our data suggest an active role of vascular remodeling in shaping pregnancy- and maternal behaviors-related neuronal functions.
URL:https://www.ijm.fr/event/paris-postdocs-seminars-ahlem-assali/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/20241203-Ahlem-Assali-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241206T114500
DTEND;TZID=Europe/Paris:20241206T130000
DTSTAMP:20260425T091538
CREATED:20241118T125120Z
LAST-MODIFIED:20241118T125120Z
UID:25686-1733485500-1733490000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Yohanns Bellaiche
DESCRIPTION:Invited by the Ladoux / Mege Lab\, Yohanns Bellaiche (Institut CURIE UM3215 U934\, Equipe Polarité Division Morphogenèse) will present an Institut Jacques Monod Seminar on the theme: \nHow epithelial shaping is tailored by cell and tissue size \nAbstract: \nEverywhere Nature works true to scale\, and everything has its proper size accordingly” – with these words\, D’Arcy Thompson in “On Growth and Form” elegantly captured one of biology’s profound mysteries: the scaling of biological structures and substructures with size (length\, area\, or volume). At the cellular level\, scaling plays central roles in organelle dynamics during cell division and metabolic regulation. At the organismal level\, studies of scaling properties have led to discoveries in animal physiology\, bone and limb proportions\, and gene expression patterns. \nIn this seminar\, I will present our recent work linking cell and tissue size to the morphodynamics of tissue development. First\, I will discuss our findings on the mechanisms by which cells probe their size to scale their geometrical and mechanical properties\, thereby regulating cell proliferation and apoptosis. Then\, I will describe how tissue morphogenesis adapts to overall animal size to ensure robust and invariant development across the physiological range of sizes within a species.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-yohanns-bellaiche/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/Bandeau-web-seminar-Yohanns-Bellaiche-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241209T091500
DTEND;TZID=Europe/Paris:20241213T180000
DTSTAMP:20260425T091538
CREATED:20241023T114430Z
LAST-MODIFIED:20241023T114842Z
UID:25390-1733735700-1734112800@www.ijm.fr
SUMMARY:International Workshop : Cycling to divide\, Across Scales\, Species and Evolution
DESCRIPTION:The Magistère Européen de Génétique\, with the support of Circle U and the Jacques Monod Institute\, is organizing an International Workshop from December 3rd to December 9th\, which will be held in the Amphi Turing in the Sophie Germain building\, Campus Grands-Moulins (Place Aurélie Nemours). \nThe topic of this workshop is Cell Cycle and Cell Division\, which will be addressed through talks and lectures by distinguished speakers from the Jacques Monod Institute and other Parisian and International institutions. This workshop will broadly cover various aspects of the cell cycle and cell division\, such as mitosis\, meiosis\, asymmetric cell division\, chromosome segregation\, DNA replication\, and cytokinesis\, using a range of model organisms\, each with specific technical advantages. The speakers come from diverse scientific backgrounds\, using a variety of model systems and approaches.\nThe number of participants is limited to 70 attendees. \nRegistrations are open until November 29th: here \nSpeakers: \n\nBuzz Baum (LMB\, Univ. Cambridge)\nPierre Chymkowitch (Univ. of Oslo)\nGautam Dey (EMBL)\nInes Drinnenberg (Curie Institute)\nJulien Dumont (Institut Jacques Monod)\nArnaud Echard (Pasteur Institute)\nUlrike Eggert (King’s College London)\nSimona Giunta (Roma\, La Sapienza)\nJean-René Huynh (Collège de France)\nJens Januschke (Univ. Dundee)\nJoao Matos (Univ. of Vienna\, Max Perutz)\nNicolas Minc (Institut Jacques Monod)\nLionel Pintard (Institut Jacques Monod)\nMarie-Noelle Prioleau (Institut Jacques Monod)\nKatja Wassmann (Institut Jacques Monod)
URL:https://www.ijm.fr/event/international-workshop-cycling-to-divide-across-scales-species-and-evolution/?lang=en
LOCATION:Amphithéâtre Alan Turing – Bâtiment Sophie Germain\, 8 place Aurélie Nemours\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241211T093000
DTEND;TZID=Europe/Paris:20241211T110000
DTSTAMP:20260425T091538
CREATED:20241203T151811Z
LAST-MODIFIED:20241203T151811Z
UID:26020-1733909400-1733914800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday 11th December: \n\nKotryna Voidziulyte (post-doc\, Piel’s team) will present “Atypical nuclear phenotypes in confined cancer cells“\nSamya Zerkoune (PhD student\, Nicol/ Fassier’s team) will present “Fignl1/RAD51 complex drives axon midline crossing through timely tuned F-actin nucleation inhibition”
URL:https://www.ijm.fr/event/cytoskeleton-club-2/?lang=en
LOCATION:Amphithéâtre de l’Institut Pierre-Gilles de Gene\, 6 rue Jean Clavin\, Paris
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/20241211-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241213T114500
DTEND;TZID=Europe/Paris:20241213T130000
DTSTAMP:20260425T091538
CREATED:20241118T125824Z
LAST-MODIFIED:20241118T125824Z
UID:25694-1734090300-1734094800@www.ijm.fr
SUMMARY:Institut Jacques Monod seminars - Laurent Formery
DESCRIPTION:Invited by the Gazave Lab\, Laurent Formery (Department of Biology\, Stanford University) will present an Institut Jacques Monod seminar on the theme: \nEchinoderm evolution: Testing the limits of axial patterning plasticity \nAbstract: \nThe discovery that distantly related animals establish their body plans through conserved developmental programs is one of the most transformative findings in evolutionary biology. Similar antero-posterior (AP) and dorso-ventral (DV) patterning programs have now been identified in a large sample of bilaterian animals. However\, because most of the species that we have investigated so far follow the basic blueprint of the bilateral symmetry\, it remains unclear whether\, in case of drastically divergent body plan evolution\, these patterning program are flexible enough to support major deviation from bilateral symmetry\, or if they act as developmental constraint on body plan diversity that need to be disassembled first. My research aims to investigate this question using echinoderms\, which evolved a unique pentaradial symmetry and represent a fascinating natural experiment on body plan plasticity. By looking at adult body plan development in sea stars\, brittle stars and sea cucumbers using modern molecular tools\, I have been able to identify that some part of the antero-posterior patterning program are highly conserved during the formation of the pentaradial body plan\, albeit in an unexpected spatial configuration. This indicates that despite the absence of a morphological AP axis\, the molecular system used for AP patterning is surprisingly tolerant to radical morphological changes. With these new molecular data\, we are now starting to piece together the evolution of axial properties across echinoderm classes and with their bilateral relatives. Beyond the fascinating history of this particular phylum\, these data are important to decipher to what extent conserved molecular programs have shaped the evolution of morphological novelty.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-laurent-formery/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/Bandeau-web-seminar-Laurent-Formery-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241219T143000
DTEND;TZID=Europe/Paris:20241219T170000
DTSTAMP:20260425T091538
CREATED:20241203T144714Z
LAST-MODIFIED:20241203T144714Z
UID:26006-1734618600-1734627600@www.ijm.fr
SUMMARY:Soutenance de thèse - Juliette Mandelbrojt
DESCRIPTION:Juliette Mandelbrojt (équipe Prioleau) va défendre sa thèse : \nHow do transcription and chromosomal context interfere with an efficient replication origin? \n  \nLa soutenance se tiendra le jeudi 19 décembre 2024 à 14h30 en salle François Jacob ( 15 rue Hélène Brion 75013 Paris) et sera en anglais. \nLe jury sera composé de : \n\nDr Sarah LAMBERT\, DR\, Université Paris Saclay\, Rapporteur\nDr Julian SALE\, Senior group leader\, University of Cambridge\, Rapporteur\nPr Jean-Charles CADORET\, PU\, Université Paris Cité\, Examinateur\nDr Stéphane KOUNDRIOUKOFF\, MCF-HDR\, Sorbonne Université\, Examinateur\nDr Marie-Noëlle PRIOLEAU\, DR\, Université Paris Cité\, Directrice de thèse \nDr Caroline DONCARLI\, PhD\, Université Paris Cité\, Membre invitée Co encadrante 
URL:https://www.ijm.fr/event/soutenance-de-these-juliette-mandelbrojt/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/These-bandeau-Juliette-MANDELBROJT-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250110T114500
DTEND;TZID=Europe/Paris:20250110T130000
DTSTAMP:20260425T091538
CREATED:20241205T145404Z
LAST-MODIFIED:20241205T145404Z
UID:26050-1736509500-1736514000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Lendert Gelens
DESCRIPTION:Invited by the Wassmann Lab\, Lendert Gelens (Laboratory of Dynamics in Biological Systems\, University of Leuven\, Belgium) will present an Institut Jacques Monod seminar on the theme: \nNuclei coordinate the cell cycle in space and time \n  \nAbstract: \nProliferating cells replicate their DNA and components before dividing\, but how subcellular localization impacts cell cycle timing remains unclear. Using frog egg extracts encapsulated in droplets\, we studied cell cycle oscillations with and without nuclei [1]. Time-lapse microscopy revealed that nuclei increase cell cycle duration\, with increasing nuclear volume correlating with longer periods across different Xenopus species. This relationship persisted without DNA replication or transcription but was disrupted by inhibiting nuclear import or Wee1 kinase. A computational model incorporating nuclear-cytoplasmic compartmentalization and periodic nuclear envelope dynamics reproduced these findings\, linking nuclear size to cycle timing. These results explain the lengthening of the cell cycle at the midblastula transition when cells become smaller\, and the nuclear-cytoplasmic ratio increases. \nIn early Xenopus embryos (~1.2 mm)\, mitotic waves coordinate the cell cycle over long distances\, as diffusion alone is insufficient. Using X. laevis egg extracts and a Cdk1 FRET sensor\, we observed a transition from phase to trigger wave dynamics in initially homogeneous cytosol [2]. Spatial heterogeneity and nuclei accelerated this transition\, while metaphase-arrested extracts induced an immediate shift. Simulations revealed transient phase waves as trigger waves required time to entrain the system. Both wave types emerge as part of a unified process for coordinating the cell cycle across large distances. \n[1] Pineros\, L. *; Frolov\, N. *; Ruiz-Reynés\, D.; Eynde\, A. Van; Cavin-Meza\, G.; Heald\, R.; Gelens\, L.; The nuclear-cytoplasmic ratio controls the cell cycle period in compartmentalized frog egg extract; BioRxiv\, 2024. \n[2] Puls*\, O.; Ruiz-Reynés*\, D.; Tavella\, F.; Jin\, M.; Kim\, Y.; Gelens*\, L.; Yang*\, Q.; Spatial heterogeneity accelerates phase-to-trigger wave transitions in frog egg extracts; Nature Communications\, vol. 15\, no. 10455\, 2024.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-lendert-gelens/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/Bandeau-web-seminar-Lendert-Gelens-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250115T093000
DTEND;TZID=Europe/Paris:20250115T110000
DTSTAMP:20260425T091538
CREATED:20250113T141600Z
LAST-MODIFIED:20250113T141700Z
UID:26547-1736933400-1736938800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The first meeting of 2025 of the cytoskeleton club will take place next Wednesday at the Institut Pasteur: \n– Charlotte Mallart (post-doc\, Minc lab\, Institute Jacques Monod) will talk about:  “Regulation of cytoplasm rheology by bulk F-Actin networks”. \n– Noemi Zollo (PhD student\, Verlhac/ Terret lab\, CIRB Collège de France) will talk about:  “A novel RNP compartment allows mouse oocytes to adapt translational levels during late growth”.
URL:https://www.ijm.fr/event/cytoskeleton-club-3/?lang=en
LOCATION:Institut Pasteur Auditorium François Jacob\, 28 rue du docteur roux\, Paris\, 75015\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/20250115-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250116T090000
DTEND;TZID=Europe/Paris:20250116T180000
DTSTAMP:20260425T091538
CREATED:20241028T102411Z
LAST-MODIFIED:20241028T102411Z
UID:25485-1737018000-1737050400@www.ijm.fr
SUMMARY:Second workshop on new microscopies in cell biology
DESCRIPTION:The two GDRs AQV (Quantitative approaches to living systems) and IMABIO (Imaging in Biology) are organising a joint workshop on 16 January 2025 at the Institut Jacques Monod in Paris on new microscopies in cell biology. The aim is to bring together scientists from biology\, physics\, engineering and data science to discuss new imaging strategies for : \n\nmeasuring physical descriptors of cellular organisation and function;\nimproving imaging resolution;\nmaking smart microscopes more effective at capturing processes of interest.\n\nConfirmed speakers : \n\nJuliette Azimzadeh\, Institut Jacques Monod\, Paris\nVictor Barolle\, Institut Langevin\, Paris\nRicardo Henriques\, Instituto Gulbenkian de Ciência\, Oeiras and University College London\nKheya Sengupta\, Interdisciplinary Centre for Nanoscience\, Marseille\nVincent Studer\, Interdisciplinary Neuroscience Institute\, Bordeaux\nIlaria Testa\, KTH Royal Institute of Technology\, Stockholm\n\nOral presentations and posters will also be selected from the abstracts submitted. \nRegistration is free but compulsory and is now open here: https://newmic4cellbio2.sciencesconf.org/ \nThe organisers\nPierre Bon\, Nicolas Borghi\, Cécile Leduc\, Loic Le Goff\, Pierre-Henri Puech
URL:https://www.ijm.fr/event/second-workshop-on-new-microscopies-in-cell-biology/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/bandeau-web-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250117T114500
DTEND;TZID=Europe/Paris:20250117T130000
DTSTAMP:20260425T091538
CREATED:20241125T114034Z
LAST-MODIFIED:20241125T114034Z
UID:25863-1737114300-1737118800@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Zayna Chaker
DESCRIPTION:Invited by the Konstantinides Lab\, Zayna Chaker (Institute of Functional Genomics of Lyon (IGFL) Ens de Lyon\, CNRS) will present an Institut Jacques Monod Seminar on the theme: \nSpatio-Temporal coordination of neural stem cells in the adult brain: A functional and evolutionary perspective \n  \nAbstract: \nResearch over the last three decades has demonstrated that new neurons can be generated in the adult brain\, and integrate into pre-existing complex circuits. The process of adult neurogenesis is evolutionary conserved among vertebrates\, including fishes\, frogs\, reptiles\, birds\, rodents and primates. It is sustained by a small population of undifferentiated cells\, called neural stem cells (NSCs)\, which persist as embryonic vestiges in adult brains. These cells reside in tightly controlled micro-environments called niches. The addition of young cells constitutes an important layer of adult brain plasticity\, further enhancing its ability to adapt to diverse life experiences. However\, the physiological relevance of adult-born neurons as well as the regenerative power of NSCs after injury are still highly debated to date\, especially in mammals. \nBesides constitutive neurogenesis\, we recently showed that regionally-defined subpopulations of NSCs in the adult ventricular niche produce transient waves of functionally-relevant interneurons in response to pregnancy and motherhood. This process finely tunes the mother’s olfactory sensitivity to own versus alien pup odor (Chaker et al. 2023). In my lab\, we are now investigating the cellular and molecular mechanisms allowing regionally-distinct pools of NSCs to coordinate their behavior in space (across all niches) and time (from embryo to different phases in adulthood)\, under specific physiological and pathological conditions.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-zayna-chaker/?lang=en
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/Bandeau-web-seminar-Chaker-Zayna-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250121T114500
DTEND;TZID=Europe/Paris:20250121T130000
DTSTAMP:20260425T091538
CREATED:20241230T140129Z
LAST-MODIFIED:20250115T101830Z
UID:26317-1737459900-1737464400@www.ijm.fr
SUMMARY:Paris Postdoc Seminar - Lucas Alves Tavares
DESCRIPTION:Invited by the Institut Jacques Monod\, Lucas Alves Tavares (Center for Virology Research and Department of Cell and Molecular Biology\, University of São Paulo (USP) & Institut Curie\, Paris) will present a Paris Postdoc Seminar on the theme: \nUnraveling the role of AP-1γ2 in the Endosome Maturation and Extracellular Vesicles Release \n  \nAbstract: \nThe adaptor protein (AP) complexes are heterotetrameric complexes that coordinate protein trafficking in the endocytic and secretory pathways. AP-1\, a complex of four distinct subunits (γ\, β1\, μ1\, and σ1)\, is thought to mediate protein trafficking between the trans-Golgi network (TGN) and endosomes and Lysosomes Related Organelles (LROs) though clathrin-coated vesicles (CCV). The human genome encodes two isoforms of the γ-adaptin (γ1 and γ2) subunit that form two variants of AP-1 (AP-1γ1 and AP-1γ2). Previous studies demonstrated that γ2 may form an AP-1 complex variant\, but the knowledge is limited regarding the cellular roles played by this alternative AP-1 complex. We previously reported that γ2 is part of a functional AP-1 complex variant hijacked by HIV-1 Nef for targeting CD4 and MHC-I for lysosomal degradation. Moreover\, we recently demonstrated that the retrograde transport of CI-MPR and ATP7B requires AP-1γ2. During my internship at Graça Raposo laboratory (Institut Curie)\, we are investigating the participation of AP-1γ2 in the maturation of early endosomes to late endosomes and also for the Extracellular Vesicles (EVs) secretion by using immunofluorescence\, nanoparticle tracking analysis\, western blot\, immuno-electron microscopy analysis and conventional transmission electron microscopy analysis. Therefore\, this study has the potential to contribute to the understanding of fundamental processes in the regulation of protein and membrane trafficking involved in the endosome maturation and EVs shedding.
URL:https://www.ijm.fr/event/paris-postdoc-seminar-lucas-alves-tavares/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/20250123-Lucas-Alves-Tavares-web-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250121T140000
DTEND;TZID=Europe/Paris:20250121T170000
DTSTAMP:20260425T091538
CREATED:20241230T133205Z
LAST-MODIFIED:20241230T133205Z
UID:26312-1737468000-1737478800@www.ijm.fr
SUMMARY:Authorization to supervise research (HDR) - Jérémy Sallé
DESCRIPTION:Jérémy Sallé (Minc Lab) will defend his Authorization to supervise research (HDR): \n« Géométrie des clivages embryonnaires : Mécanismes et Implications » \n  \nThe defense will take place on Tuesday\, January 21st 2025 at 2 pm\, in room François Jacob (IJM) \nThe jury will be composed of: \n\nJenifer Croce (LBDV – Villefranche-sur-Mer)\nRémi Dumollard (LBDV – Villefranche-sur-Mer)\nPatrick Lemaire (CRBM – Montpellier)\nLionel Pintard (IJM – Paris)\nMarie-Hélène Verlhac (Collège de France – Paris)\nNicolas Minc (IJM – Paris)
URL:https://www.ijm.fr/event/authorization-to-supervise-research-hdr-jeremy-salle/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/HDR-bandeau-Jeremy-Salle-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250206T190000
DTEND;TZID=Europe/Paris:20250206T213000
DTSTAMP:20260425T091538
CREATED:20250115T091647Z
LAST-MODIFIED:20250115T091647Z
UID:26597-1738868400-1738877400@www.ijm.fr
SUMMARY:Dance conference: Move your science
DESCRIPTION:Dance conference: MOVE YOUR SCIENCE\nThursday\, February 6\, 7pm | Hall Buffon\, Institut Jacques Monod\nFree with registration\nCollective creation with doctoral students Kenza Alaoui Sossé\, Amandine Albizzati\, Mariam Bougma\, Stéphanie Brunot\, Mert Can\, Johanna Exenberger\, Audrey Gosset\, Capucine Gros\, Emile Le Lièvre and Joséphine Schelle \nChoreography and dance/science research: Cosetta Graffione and Namiko Gahier-Ogawa \nScientific coordination and dance/science research: Mélina Heuzé\, teacher-researcher \nSince September\, ten doctoral students from all disciplines at Université Paris Cité have been working with choreographers Cosetta Graffione and Namiko Gahier-Ogawa and teacher-researcher Mélina Heuzé to share their scientific project in a spirit of mediation with the general public.\nIn a dialogue between art and science\, the public will be able to experience the scientific principles of their thesis work through dance sequences that bring out the poetry of the body. \nThis four-part dance conference will be followed by a discussion with the audience over a friendly drink.
URL:https://www.ijm.fr/event/dance-conference-move-your-science/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/heuze-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250207T114500
DTEND;TZID=Europe/Paris:20250207T130000
DTSTAMP:20260425T091538
CREATED:20241219T104206Z
LAST-MODIFIED:20241219T104206Z
UID:26252-1738928700-1738933200@www.ijm.fr
SUMMARY:Institut Jacques Monod lecture - Sophie G. Martin
DESCRIPTION:On Friday\, February 7th 2025\, Sophie G. Martin (Department of Molecular and Cellular Biology\, University of Geneva\, Switzerland) will present an Institut Jacques Monod lecture on the theme: \nSignaling and actin focus architecture for cell-cell fusion \n  \nAbstract: \nSexual reproduction is ubiquitous amongst eukaryotes. This requires alternation of cell-cell (gamete) fusion and genome reduction through meiosis. My lab has been using the yeast sexual reproduction pathway to study how cells polarize to find a mate and mount a fusion reaction. In the fission yeast Schizosaccharomyces pombe\, sexual reproduction occurs between P and M cells\, which communicate through pheromone-GPCR-MAPK signaling\, driving the formation of cell pairs. Transition from gametes to zygote involves local cell wall digestion at the point of gamete contact\, while preserving cell integrity. We have shown that cell-cell fusion requires the actin fusion focus\, an aster-like assembly of linear actin filaments assembled by the formin Fus1\, which concentrates both signaling molecules and secretory vesicles carrying cell wall digestion enyzmes. I will present our recent work on the molecular mechanisms of formation of the actin fusion focus\, which require both formation of a formin biomolecular condensate and cytoskeletal focusing through formin-myosin feedback. I will also describe our progress in understanding the roles of local MAPK and PAK signaling for cells to pierce their cell wall once and only once.
URL:https://www.ijm.fr/event/institut-jacques-monod-lecture-sophie-g-martin/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/WP-IJM-Lectures-Sophie-Martin-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250211T114500
DTEND;TZID=Europe/Paris:20250211T130000
DTSTAMP:20260425T091538
CREATED:20241223T131853Z
LAST-MODIFIED:20241223T131853Z
UID:26288-1739274300-1739278800@www.ijm.fr
SUMMARY:Institut Jacques Monod  lectures- Richard Benton
DESCRIPTION:On Tuesday\, February 11th\, Richard Benton (Center for Integrative Genomics\, University of Lausanne) will present an Institut Jacques Monod lectures on the theme: \nFatal chemosensation\, and how insects fight back \n  \nAbstract: \nInsecticide resistance is a widespread challenge for the management of vectors transmitting pathogens and agricultural pests\, requiring a better understanding of the genetic mechanisms underlying the evolution of resistance. Drosophila sechellia is a compelling model for such studies as it naturally evolved resistance to octanoic acid\, an abundant chemical of its noni fruit host that is toxic for other insects\, including close relatives D. simulans and D. melanogaster. We have used a multi-pronged strategy to identify genes contributing to octanoic acid resistance. We began by experimentally-evolving D. simulans strains with higher tolerance to octanoic acid and determined the resulting genetic architecture. To identify specific candidate genes\, we integrated this analysis with a genome-wide association study of octanoic acid resistance in D. simulans and a genome-wide CRISPR selection screen upon octanoic acid exposure in D. melanogaster S2R+ cultured cells. We identified four candidates\, with diverse predicted molecular and expression properties\, and validated their relevance using genetic analyses in D. melanogaster. Two of these genes displayed an increased expression in the experimentally-evolved strains\, paralleling their higher levels of expression in D. sechellia. Our results suggest an adaptive role of these genes in shaping toxin resistance both under laboratory conditions and during D. sechellia’s evolutionary history.
URL:https://www.ijm.fr/event/institut-jacques-monod-lectures-richard-benton/?lang=en
LOCATION:Bâtiment Condorcet Amphithéâtre Pierre Gilles de Gennes\, 4 rue Elsa Morante\, Paris\, Sélectionner un État :\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/WP-IJM-Lectures-Richard-Benton-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250212T140000
DTEND;TZID=Europe/Paris:20250212T150000
DTSTAMP:20260425T091538
CREATED:20250127T140538Z
LAST-MODIFIED:20250127T140538Z
UID:26833-1739368800-1739372400@www.ijm.fr
SUMMARY:Seminar - Felix Ruhnow
DESCRIPTION:Invited by the Centre for Genomic Regulation\, Felix Ruhnow will present a seminar on the theme: \nNuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends \n  \nAbstract: \nNuclear mitotic apparatus protein (NuMA) is indispensable for the mitotic functions of the major microtubule minus-end directed motor cytoplasmic dynein 1. NuMA and dynein are both essential for correct spindle pole organization. How these proteins cooperate to gather microtubule minus ends at spindle poles remains unclear. Here we use microscopy-based in vitro reconstitutions to demonstrate that NuMA is a dynein adaptor\, activating processive dynein motility together with dynein’s cofactors dynactin and Lissencephaly-1 (Lis1). Additionally\, we find that NuMA binds and stabilizes microtubule minus ends\, allowing dynein/dynactin/NuMA. to transport microtubule minus ends as cargo to other minus ends. We further show that the microtubule-nucleating γ-tubulin ring complex (γTuRC) hinders NuMA binding and that NuMA can only cap minus ends of γTuRC-nucleated microtubules after γTuRC release. These results provide new mechanistic insight into how dynein\, dynactin\, NuMA\, Lis1 together with γTuRC and uncapping proteins cooperate to organize spindle poles in cells.
URL:https://www.ijm.fr/event/seminar-felix-ruhnow/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/Bandeau-web-seminar-2-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250214T114500
DTEND;TZID=Europe/Paris:20250214T130000
DTSTAMP:20260425T091538
CREATED:20241217T133040Z
LAST-MODIFIED:20241217T133040Z
UID:26236-1739533500-1739538000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminar - Peter Andolfatto
DESCRIPTION:Invited by the Courtier\, Peter Andolfatto (Professor\, Dept. of Biological Sciences\, Columbia University) will present an Institut Jacques Monod seminar on the theme: \nThe evolution of toxin-resistant Na+\,K+-ATPases: new insights from frogs and fireflies  \n  \nWe study the process of adaptive evolution through the lens of repeated adaptation of many distantly species to a similar selection pressure (i.e. “parallel evolution”). Over the past decade\, we have explored patterns of adaptation in the context of animals that have specialized in eating plants\, or other animals\, that contain toxic cardiotonic steroids (CTS). CTS are toxic to animals because they inhibit sodium-potassium ATPase\, a key enzyme in animals needed in everything from maintaining cell homeostasis\, muscle contraction to neuron activity. Here I review our most recent work combining comparative molecular evolution\, molecular and biochemical assays and in vivo engineering of Drosophila to deduce the rules governing the adaptive evolution of CTS resistance in animals. Together\, our results have interesting implications for how epistasis and pleiotropy both limit the rate of adaptive protein evolution and increase its predictability.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminar-peter-andolfatto/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/Bandeau-web-seminar-Peter-Andolfatto-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250219T093000
DTEND;TZID=Europe/Paris:20250219T110000
DTSTAMP:20260425T091538
CREATED:20250205T110041Z
LAST-MODIFIED:20250205T110041Z
UID:27113-1739957400-1739962800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday\, February 19th: \n\nRayane Dibsy (post-doc\, A. Echard’s Lab\, Institut Pasteur présentera  «  The proteasome promotes cytokinetic abscission by relieving Aurora B kinase-mediated inhibition of ESCRT-III turnover. »\nJonathan Fouchard ( Researcher\, Laboratoire de Biologie du Développement\, IBPS) présentera ‘Three-dimensional cell shape\, focal adhesions and vimentin during spreading’
URL:https://www.ijm.fr/event/cytoskeleton-club-4/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/02/20250219bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250224T114500
DTEND;TZID=Europe/Paris:20250224T130000
DTSTAMP:20260425T091538
CREATED:20250128T140351Z
LAST-MODIFIED:20250214T094643Z
UID:26858-1740397500-1740402000@www.ijm.fr
SUMMARY:[Cancelled] Institut Jacques Monod Seminars - Marla Sokolowski
DESCRIPTION:This seminar is cancelled.\n  \nInvited by the par l’équipe Courtier\, Marla Sokolowski (Department of Ecology and Evolutionary Biology\, University of Toronto) will present an Institut Jacques Monod Seminar on the theme: \nThe foraging gene: will that be for here or to go? \nAbstract: \nThe Drosophila melanogaster foraging (for) gene\, with its rover and sitter larval foraging variants\, is an established behaviour genetics model. Orthologues of the foraging gene also modulate the individual and social behaviour of a wide range of species including the regulation of behaviour in eusocial insects. In Drosophila\, foraging modifies the expression of multiple traits\, including feeding and foraging\, stress tolerance\, sleep\, metabolism\, dispersal\, escape responses\, social behaviour\, and learning and memory. From a social context perspective\, Drosophila foraging affects larval clustering during foraging under high larval densities\, adult social behaviour and social networks\, and social learning. We wondered how foraging accomplishes its behavioural pleiotropy at the molecular level. We found that D. melanogaster foraging has a complex modular genomic structure with four promoters\, 21 transcripts\, and eight protein isoforms. The four promoter modules are differentially regulated during development and in a timescale\, tissue\, and cell-type dependent manner. Two examples illustrate these findings: the epigenetic regulation of the adult rover-sitter foraging-related phenotypes by G9a\, a histone methyltransferase\, and the regulation of differences in the latency of rover compared to sitter larval escape responses to noxious stimuli such as parasitoid wasps. Our work provides a nuanced picture of the molecular basis of foraging’s pleiotropy.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-marla-sokolowski/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
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DTSTART;TZID=Europe/Paris:20250225T114500
DTEND;TZID=Europe/Paris:20250225T130000
DTSTAMP:20260425T091538
CREATED:20250123T141141Z
LAST-MODIFIED:20250123T141141Z
UID:26792-1740483900-1740488400@www.ijm.fr
SUMMARY:Paris Postdoc Seminar - Nathaniel Henneman
DESCRIPTION:Invited by the Institut Jacques Monod\, Nathaniel Henneman (team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM)) will present a Paris Postdoc Seminar on the theme: \nNuclear functions of nutrient sensing signaling for metabolic adaptation \n  \nIntroduction & abstract: \nI am a Postdoc in the team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM). I graduated from Bates College (USA) in 2016\, majoring in Biology. I then spent two years working on retinal degeneration at Emory University before obtaining my master’s degree at University of Paris Descartes in 2019 and defended my PhD in December 2023. \nOne of the key questions I am to address in my work is how cellular metabolism\, gene expression and transcription\, are all coordinated. Energy stress in fasting is managed by activating autophagy and promoting the transcriptional remodeling of metabolism. Cytosolic nutrient sensors coordinate extracellular nutrient availability with intracellular metabolic processes to allow for cell survival. Class 3 PI3K is a highly conserved nutrient sensor known to regulate autophagy and endocytosis in response to varying nutrient conditions. It’s direct role in transcription\, however\, was only suggested in few studies in yeast and plants. However\, we believe there is a nuclear pool of class 3 PI3K that directly regulates gene expression for metabolic adaptation. My work aims to address this unmet burden in the field. We find that nuclear class 3 PI3K regulates the transcriptional response to nutrient stress by controlling RNA Polymerase II\, the Set1/COMPASS methyltransferase\, and nuclear methionine to SAM flux. I aim to understand how these players are needed for our fasting adaptation and how these mechanisms could affect our metabolic resilience.
URL:https://www.ijm.fr/event/paris-postdoc-seminar-nathaniel-henneman/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
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DTSTART;TZID=Europe/Paris:20250307T114500
DTEND;TZID=Europe/Paris:20250307T130000
DTSTAMP:20260425T091538
CREATED:20250127T142106Z
LAST-MODIFIED:20250212T155220Z
UID:26838-1741347900-1741352400@www.ijm.fr
SUMMARY:Institut Jacques Monod Lecture - Andrea Musacchio
DESCRIPTION:On Friday\, March 7th\, Andrea Musacchio (Max Planck Institute of Molecular physiology) will present a Institut Jacques Monod Lecture on the theme: \nFeedback control of mitosis in the context of the kinetochore \n  \nAbstract: \nKinetochores provide chromosomes with points of attachment to spindle microtubules during cell division\, and are therefore essential for genome inheritance and the propagation of life. In addition to binding microtubules\, kinetochores control mitotic surveillance mechanisms that promote chromosome bi-orientation (the error correction mechanism) and prevent premature mitotic exit in presence of incomplete or incorrect microtubule attachments (spindle assembly checkpoint\, SAC). Elimination of the NDC80 complex\, the main microtubule receptor of kinetochores\, causes a SAC deficiency\, identifying this complex as a crucial regulatory focus for checkpoint function. In recent years\, there has been considerable progress in understanding how the SAC effector\, known as the mitotic checkpoint complex (MCC)\, assembles from its individual components to inhibit its target\, the anaphase promoting complex/cyclosome (APC/C). Conversely\, how microtubule attachment to kinetochores regulates the SAC remains incompletely understood. From a molecular perspective\, answering this question implies investigating the mechanisms that promote targeting of the SAC proteins to unattached kinetochores\, and suppress it upon microtubule binding and biorientation. In our recent work\, we have combined biochemical reconstitutions\, structural biology/modelling\, and cell biology to gain insights into this fundamental biological question.
URL:https://www.ijm.fr/event/institut-jacques-monod-lecture-andrea-musacchio/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
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