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DTSTART;TZID=Europe/Paris:20240705T114500
DTEND;TZID=Europe/Paris:20240705T130000
DTSTAMP:20260425T163833
CREATED:20240620T092116Z
LAST-MODIFIED:20240620T092116Z
UID:19559-1720179900-1720184400@www.ijm.fr
SUMMARY:IJM Seminar – Roland Le Borgne
DESCRIPTION:Invited by the Guichet Lab\, Roland Le Borgne (Institut de Génétique et Développement de rennes) will present an Institut Jacques Monod on the theme: \nInvestigation the Role of Cadherin and Integrin during Epithelial Cell Rearrangements \n  \nAbstract: \nEpithelia are robust tissues whose mechanical cohesion requires the formation of cell-cell adhesive contacts supported by adherens junctions (AJs)\, mainly composed of E-Cadherin clusters stabilized by actomyosin filaments. The mechanical sealing properties of epithelia are constantly challenged by cell-cell rearrangements that occur during delamination\, intercalation and cell division. During these events\, E-Cadherin contacts are dismantled\, yet neighbor exchange occurs without the tissue tearing apart. The interplay between actomyosin contractility and the remodelling of AJs are proposed to be sufficient to mechanically support these multicellular rearrangements. However\, and unexpectedly\, we discovered that during cell intercalation and cytokinesis in the Drosophila pupal epithelium\, focal adhesions (FAs) containing alpha-\, beta-integrin receptors and Talin\, are transiently assembled at sites of AJ remodeling. AJs and FAs are two main adhesive structures that ensure the formation of robust mechanical contacts enabling the transmission of cytoskeletal force to support changes in cell and tissue shape. Using state-of-the-art genetic\, super-resolution imaging and biophysical approaches\, we propose to study the assembly of FAs\, their connection to actomyosin force generation and their functions during cytokinesis and cell intercalation in invertebrate and vertebrates model systems. Our working hypothesis is that the cleavage furrow ingression at cytokinesis and the junction shrinkage during cell intercalation cause a shear stress that triggers the local dismantling of AJs and\, concomitantly\, the assembly of FAs\, in the plane of AJs. This multidisciplinary proposal will provide a comprehensive understanding of the cooperation and interdependence between cadherin and integrin-mediated intercellular adhesion required to ensure tissue tensional homeostasis.
URL:https://www.ijm.fr/event/ijm-seminar-roland-le-borgne/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
CATEGORIES:IJM Seminar
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/05/WP-seminaire-IJM_Roland-Leborgne-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240906T114500
DTEND;TZID=Europe/Paris:20240906T130000
DTSTAMP:20260425T163833
CREATED:20240814T140519Z
LAST-MODIFIED:20240902T143032Z
UID:22772-1725623100-1725627600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Amir Aharoni
DESCRIPTION:Invited by the Palancade Lab\, Amir Aharoni (Department of Life Sciences and the National Institute for Biotechnology in the Negev\, Ben-Gurion University of the Negev\, Israel) will present an Institut Jacques Monod Seminar on the theme: \nReal-time monitoring of replication fork progression through damaged DNA \n  \nAbstract: \nDespite the frequent occurrence of AP sites in the eukaryotic genome\, understanding how replication forks bypass non-repaired AP sites remains elusive. While an error-prone and an error-free DNA damage bypass pathways exist\, the choice and timing of activation of each bypass pathway during AP sites replication are still unknown. Here\, we have established and examined a system for measuring replication fork progression through site-specific AP sites in live yeast cells\, for monitoring DNA damage bypass in real time. In this system\, AP sites are introduced site-specifically between two bacterial fluorescent repressor-operator systems (FROS) during the G1 phase\, using catalytically inactive Cas9 fused to DNA glycosidase. Time-lapse fluorescent microscopy is then used to monitor the progression of single replisomes through the AP sites and to reveal the timing of AP bypass. Using this real-time microscopy system\, we revealed the cellular choice between replication associated and post replicative AP sites bypass pathways controlling replication fork stalling at AP sites and cell survival.
URL:https://www.ijm.fr/event/seminaire-ijm-amir-aharoni/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/08/WP-seminaire-IJM_Amir-Aharoni-2-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240913T133000
DTEND;TZID=Europe/Paris:20240913T170000
DTSTAMP:20260425T163833
CREATED:20240822T132718Z
LAST-MODIFIED:20240822T132718Z
UID:23482-1726234200-1726246800@www.ijm.fr
SUMMARY:Thesis defense - Aurore Vullien
DESCRIPTION:Aurore Vullien (équipe Gazave) will defend her thesis: \n“Evolutionary conservation and roles of ROS signalling in the initiation of regeneration. Insight from the cnidarian Nematostella vectensis and the annelid Platynereis dumerilii.” \nThe defense will be held in French on Friday September 13 at 1:30pm in the amphitheater of the Centre Antoine-Lacassagne (33\, avenue de Valombrose) in Nice. \nThe jury will be composed of: \n\nLucas Leclère\, CR\, Sorbonne Université (reporter)\nMorgane Locker\, Pr\, Université Paris-Saclay (reporter)\nHadi Boukhatmi\, CR\, Université de Rennes 1 (examiner)\nNathalie Mazure\, DR\, Université Côte d’Azur (examiner)\nChristine Rampon\, MCU\, Université Paris Cité (examiner)\nValérie Vouret\, DR\, Université Côte d’Azur (examiner)\nEve Gazave\, CR\, Université Paris Cité (thesis director)\nEric Röttinger\, DR\, Université Côte d’Azur (thesis director)\n\n 
URL:https://www.ijm.fr/event/thesis-defense-aurore-vullien/?lang=en
LOCATION:Université Côte d’Azur – Amphithéâtre du centre Antoine-Lacassagne\, 33 avenue de valombrose\, Nice\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/08/These-bandeau-Aurore-Vullien-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240919T140000
DTEND;TZID=Europe/Paris:20240919T170000
DTSTAMP:20260425T163833
CREATED:20240821T112729Z
LAST-MODIFIED:20240822T080615Z
UID:23049-1726754400-1726765200@www.ijm.fr
SUMMARY:Thesis defense - Raphaël Mangione
DESCRIPTION:Raphaël MANGIONE (équipe Palancade) will defend his thesis: \nCharacterizing the Interplay Between DNA:RNA Hybrids and Genome Stability \n  \nThe defense will take place on Thursday\, September 19th\, at 2pm\, in the François Jacob room of the Institut Jacques Monod (15 Rue Hélène Brion\, 75013 Paris)\, and will be conducted in English. \nThe jury members are: \n\nDr. Valérie BORDE\, Directrice de Recherche\, Sorbonne Université\, Rapportrice\nDr. Michael CHANG\, Associate Professor\, Université de Groningen\, Rapporteur\nDr. Aline MARNEF\, Chargée de Recherche\, Université Toulouse III\, Examinatrice\nDr. Jérôme POLI\, Maître de Conférences\, Université de Montpellier\, Examinateur\nDr. Stéphane MARCAND\, Directeur de Recherche\, Université Paris-Saclay\, Examinateur\nDr. Benoît PALANCADE\, Directeur de Recherche\, Université Paris Cité\, Directeur de thèse
URL:https://www.ijm.fr/event/soutenance-de-these-raphael-mangione/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/08/These-bandeau-MANGIONE-1-scaled.jpg
ORGANIZER;CN="Institut Jacques Monod":MAILTO:service.communication@ijm.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240920T114500
DTEND;TZID=Europe/Paris:20240920T130000
DTSTAMP:20260425T163833
CREATED:20240821T095129Z
LAST-MODIFIED:20240903T093341Z
UID:23038-1726832700-1726837200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Thibault Brunet
DESCRIPTION:Invited by the Gazave Lab\, Thibault Brunet (Evolutionary Cell Biology and Evolution of Morphogenesis team\, Institut Pasteur\, Paris) will an Institut Jacques Monod seminar on the theme: \nThe origin and evolution of animal morphogenesis: insights from our closest relatives \n  \nAbstract: \nAll animals are characterized by a recognizable\, species-specific adult shape\, which results from a controlled process of morphogenesis during embryonic development. Morphogenesis relies on a small core set of cellular mechanisms: cell adhesion\, migration\, division\, deformation\, and apoptosis. The mechanisms that shape animal embryos did not always exist\, but gradually evolved as their single-celled ancestors successively acquired multicellularity\, development\, and cell differentiation more than 600 million years ago. While the origin of animals has only left few fossil traces\, insights can be gained by the study of modern groups. In recent years\, important concepts have emerged from the study of choanoflagellates\, the closest living relatives of animals. \nChoanoflagellates are free-living aquatic protists that possess multiple features informative on the origin of animal development: they display a polarized cell architecture (with apical flagellum and microvilli) reminiscent of that of epithelial cells; their genome encodes an animal-like developmental molecular toolkit (including cadherins\, integrins\, collagens\, actomyosin and its regulators); and they can facultatively develop into multicellular colonies that resemble early animal embryos. Our work combines functional genetics and high-resolution imaging to understand how choanoflagellate cell shape is generated\, how shapes of individual cells underlie emerging multicellular shapes and behaviors\, and how these findings inform our understanding of the origin of animal morphogenesis.
URL:https://www.ijm.fr/event/ijm-seminar-thibault-brunet/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
CATEGORIES:IJM Seminar
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/08/Bandeau-web-seminar-Thibaut-Brunet-scaled.jpg
ORGANIZER;CN="Institut Jacques Monod":MAILTO:service.communication@ijm.fr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240924T150000
DTEND;TZID=Europe/Paris:20240924T180000
DTSTAMP:20260425T163833
CREATED:20240911T085334Z
LAST-MODIFIED:20240911T085334Z
UID:24061-1727190000-1727200800@www.ijm.fr
SUMMARY:Thesis defense - Lesley Caitlin Martin
DESCRIPTION:Lesley Caitlin MARTIN (Grange / Geigl Lab) will defend her thesis: \nThe legacy of human disease:\nPaleogenomic insights into genetic disease endurance in France and selection in wider Europe \n  \nThe defense will take place on Tuesday September 24th\, at 3pm\, in the Alan Turing Amphitheatre of the Sophie Germain building (8 Place Aurélie Nemours\, 75013 Paris\, less than a 2 minute walk from the IJM) and will be conducted in English. \nThe jury members are: \n\n\n\nDr. Anne Stone\, Professor\, Arizona State University\, Rapportrice\nDr. Albert Zink\, Professor\, EURAC Institute for Mummy Studies\, Rapporteur\nDr. Pavlos Pavlidis\, Professor\, University of Crete\, Examinateur\nDr. Julia Gamble\, Associate Professor\, University of Manitoba\, Examinatrice\nDr. Johnathan Weitzman\, Professeur\, Université Paris Cité\, Examinateur\nDr. Thierry Grange\, Directeur de Recherche\, CNRS\, Institut Jacques Monod\, Directeur de thèse\nDr. Eva-Maria Geigl\, Directrice de Recherche Emerite\, CNRS\, Institut Jacques Monod\, co-directrice de thèse\n\n\n\n 
URL:https://www.ijm.fr/event/thesis-defense-lesley-caitlin-martin/?lang=en
LOCATION:Amphithéâtre Alan Turing – Bâtiment Sophie Germain\, 8 place Aurélie Nemours\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/These-bandeau-Lesley-Caitlin-MARTIN-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241009T093000
DTEND;TZID=Europe/Paris:20241009T103000
DTSTAMP:20260425T163833
CREATED:20240930T132744Z
LAST-MODIFIED:20240930T132744Z
UID:25032-1728466200-1728469800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on October 9th at the Institut Jacques Monod. \nDuring this meeting\, \n\nArya Krishnan (PhD student\, Janke’s team\, Institute Curie) will present “Tubulin Code: Generating recognition patterns to selectively direct Microtubule-Associated Proteins »\nArtem Fokin (post-doc\, Gautreau’s team\, Ecole Polytechnique) will present “Identification of Novel Coordinators of Collective Cell Migration »
URL:https://www.ijm.fr/event/cytoskeleton-club/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/20241009-bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241011T114500
DTEND;TZID=Europe/Paris:20241011T130000
DTSTAMP:20260425T163833
CREATED:20240909T092859Z
LAST-MODIFIED:20240909T092859Z
UID:24024-1728647100-1728651600@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Peter Bieling
DESCRIPTION:Invited by the Romet-Lemonne/Jégou Lab\, Peter Bieling (Max Planck Institute of Molecular Physiology\, Dortmund) présentera un séminaire de l’Institut Jacques Monod sur le thème : \nThe end in sight – an in-depth perspective on actin filament dynamics \n  \nAbstract: \nAll eukaryotic cells actively establish and change their shape through a spatially diversified actin cytoskeleton. The ends of actin filaments have emerged as important regulatory sites\, to which a diverse set of regulators bind to control cytoskeleton dynamics. Recently\, we have overcome the biophysical challenges associated with generating uniform populations of short actin filaments. This paved the way for the structural characterization of filament ends not only on their own\, but also in complex with small molecule drugs and actin end-binding proteins. First\, this allowed us to identify the mechanism underlying the biochemical aging of actin subunits after their incorporation into the filament.  Second\, it enabled us to understand at the molecular level how a diversity of regulatory factors controls the speed of subunit addition and loss at the end of actin filaments. \n 
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-peter-bieling/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/Bandeau-web-seminar-Peter-Bieling-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241011T140000
DTEND;TZID=Europe/Paris:20241011T170000
DTSTAMP:20260425T163833
CREATED:20240930T085857Z
LAST-MODIFIED:20240930T085857Z
UID:25020-1728655200-1728666000@www.ijm.fr
SUMMARY:Thesis defense - Louis Laurent
DESCRIPTION:Louis LAURENT (Borghi Lab) will defend his thesis: \nMechanisms of cell density sensitivity in an epithelium by focal adhesions \n  \nThe defens will be held on Friday\, October 11\, 2024 at 2pm in the François Jacob room at the Institut Jacques Monod.(15 rue Hélène Brion\, 75013\, Paris). \nThe defense will be conducted in French.
URL:https://www.ijm.fr/event/thesis-defense-louis-laurent/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/These-bandeau-Louis-LAURENT-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241018T114500
DTEND;TZID=Europe/Paris:20241018T130000
DTSTAMP:20260425T163833
CREATED:20240903T120506Z
LAST-MODIFIED:20240903T120506Z
UID:23814-1729251900-1729256400@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Till Bartke
DESCRIPTION:Invited by the Duharcourt Lab\, Till Bartke (Institute of Functional Epigenetics – Helmholtz Zentrum München) will present an Institut Jacques Monod Seminars on the theme: \nDecoding chromatin states by proteomic profiling of modification-dependent nucleosome readers \n  \nAbstract: \nDNA and histone modifications combine into characteristic patterns that demarcate functional regions of the genome. While many “readers” of individual modifications have been described\, how composite modification signatures\, histone variants\, and inter-nucleosomal linkers are interpreted by the epigenetic machinery is still an open question. To obtain a comprehensive understanding of how chromatin readers decode complex chromatin states we have created a library of around 80 modified di-nucleosomes representing promoter\, enhancer\, and heterochromatin states using chemical biology approaches. We have used these di-nucleosomes in SILAC and label-free nucleosome affinity purifications to profile the interactions of ~2000 nuclear proteins with the different modification states by quantitative proteomics. Systematic quantification of their binding to the differently modified di-nucleosomes using tailored computational analysis methods has enabled us to predict modification features recognised by several hundred chromatin readers and to identify networks of co-regulated proteins\, thereby allowing us to describe complex chromatin modification read-outs at a large scale. Apart from highly distinctive binding responses to different modification features\, we find that many factors recognise multiple features and that nucleosomal modifications and linker DNA operate largely independently in recruiting proteins to chromatin. To make the data easily accessible\, we have developed the interactive online resource MARCS (the ‘Modification Atlas of Regulation by Chromatin States’) which provides computational tools to analyse and visualise the data. Our results bridge the gap between chromatin states and chromatin readers\, and through MARCS we provide a valuable information source to the community to further advance the discovery of fundamental principles of genome regulation. \n  \nBiosketch – Till Bartke \nTill Bartke is the Deputy Director of the Institute of Functional Epigenetics (IFE) at Helmholtz Munich (Germany). He has a long-standing interest in the epigenetic regulation of chromatin by chemical modifications of histone proteins and the DNA. After completing his PhD at the Max Planck Institute of Biochemistry in Martinsried (Germany) under the supervision of Stefan Jentsch and postdoctoral research with Tony Kouzarides at the Gurdon Institute at the University of Cambridge (UK)\, Till established his own group at the MRC Laboratory of Medical Sciences\, Imperial College London (UK). He joined the IFE as Deputy Director in April 2017. Till’s research combines chemical biology\, quantitative proteomics\, genomics\, and computational approaches to investigate the cellular functions of readers of complex epigenetic modification signatures at molecular and systems-wide scales. \n 
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-till-bartke/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/Bandeau-web-seminar-Till-Bartke-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241018T140000
DTEND;TZID=Europe/Paris:20241018T170000
DTSTAMP:20260425T163833
CREATED:20240923T125438Z
LAST-MODIFIED:20240923T125726Z
UID:24175-1729260000-1729270800@www.ijm.fr
SUMMARY:Thesis defense - Lina-Marie Briu
DESCRIPTION:Lina-Marie BRIU (Cadoret Lab) will defend her thesis: \nMolecular functions of PARylation on the dynamics of DNA Replication \nThis will take place on Friday\, October 18th\, at 2PM in the François Jacob room of the Institute Jacques Monod (15 rue Hélène Brion\, 75013\, Paris). \nThe defense will be held in French. The jury will be composed of: \n\nFrançoise DANTZER\, DR\, Université de Strasbourg\, Rapportrice\nFilippo ROSSELLI\, DR\, Université Paris-Saclay\, Rapporteur\nPatricia KANNOUCHE\, DR\, Université Paris-Saclay\, Examinatrice\nCyril RIBEYRE\, CR-HDR\, Université de Montpellier\, Examinateur\nSébastien HUET\, Professeur\, Université de Rennes\, Examinateur\nJean-Charles CADORET\, Professeur\, Université Paris-Cité\, Directeur de thèse
URL:https://www.ijm.fr/event/thesis-defense-lina-marie-briu/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/These-bandeau-Lina-Marie-BRIU-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241022T114500
DTEND;TZID=Europe/Paris:20241022T130000
DTSTAMP:20260425T163833
CREATED:20240930T091132Z
LAST-MODIFIED:20240930T091132Z
UID:25027-1729597500-1729602000@www.ijm.fr
SUMMARY:Paris Postdoc Seminars - Alexandre Garneau
DESCRIPTION:Invited by the Institut Jacques Monod\, Alexandre Garneau (Université Paris Cité\, INSERM U1151\, Institut Necker-Enfants Malades\, Paris\, France) will present an Paris Postdoc Seminars on the theme: \nImpact of the AKT2E17K gain-of-function mutation in mouse models \n  \nAbstract \nAlexandre obtained a PhD in Physical activity sciences from Université de Montréal (Canada) in 2022. During his doctoral studies under the cosupervision of cardiovascular physiologist Julie L. Lavoie (CHUM Research Center) and nephrologist Dr. Paul Isenring (L’Hôtel-Dieu de Québec Research Center)\, he investigated the cardiovascular and metabolic phenotype displayed by a mouse model of neuropathy which was knocked out for the ion transporter KCC3. He also conducted an internship at Vanderbilt University (Nashville\, USA) under the supervision of Prof. Eric Delpire in order to characterize a corresponding gain-of-function mouse model. \nAlexandre joined Dr. Guillaume Canaud’s team in April 2022 as a postdoctoral researcher to study the role of AKT2 in metabolic and cellular physiology. His interest is focused particularly on the implication of AKT2 in energy metabolism and cell survival. He will present his data obtained using systemic and tissue-specific inducible mouse models expressing a gain-of-function variant found in humans.
URL:https://www.ijm.fr/event/paris-postdoc-seminars-alexandre-garneau/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/20241022-Alexander-Garneau-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241022T160000
DTEND;TZID=Europe/Paris:20241022T173000
DTSTAMP:20260425T163833
CREATED:20240923T134507Z
LAST-MODIFIED:20240923T134507Z
UID:24183-1729612800-1729618200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Kelly G. Ten Hagen
DESCRIPTION:Invited by the Courtier Lab\, Kelly G. Ten Hagen (Senior Investigator and Chief\, Developmental Glycobiology Section\, Associate Scientific Director for Diversity\, Equity\, Inclusion and Accessibility\, National Institute of Dental and Craniofacial Research\, National Institutes of Health\, USA) présentera un Séminaire de l’Institut Jacques Monod sur le thème : \nMucins and O-glycosylation in Health and Disease \n  \nAbstract: \nMucins are evolutionarily conserved transmembrane and extracellular matrix molecules that mediate cell communication and signaling events\, and also serve as a protective barrier on the external surface of cells.  Many of the unique functional properties of mucins are due to the abundant O-linked glycans present. Defects in mucin-type O-linked glycosylation are responsible for a number of diseases and are also associated with tumor progression and metastasis; HDL-cholesterol and triglyceride levels; congenital defects; and bone mineral density alterations.  Our research investigates the role of this conserved protein modification in normal organ development and function to gain a mechanistic understanding of how alterations in O-glycosylation and mucin biosynthesis contribute to disease susceptibility and progression.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-kelly-g-ten-hagen/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/Bandeau-web-seminar-Kelly-Hagen-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241025T114500
DTEND;TZID=Europe/Paris:20241025T130000
DTSTAMP:20260425T163833
CREATED:20240924T073417Z
LAST-MODIFIED:20240924T073417Z
UID:24188-1729856700-1729861200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Joël Lemière
DESCRIPTION:Invited by the Romet-Lemonne / Jégou Lab\, Joël Lemière (Assistant Researcher in the Department of Cell and Tissue Biology at UCSF\, San Francisco\, USA) will present an Institut Jacques Monod Seminars on the theme: \nOsmotic control of nuclear size and the N/C ratio in fission yeast \nAbstract: \nThe size of the nucleus scales robustly with cell size so that the nuclear-to-cell volume ratio (N/C ratio) is typically maintained as a constant in many cell types. Previous studies show that the N/C ratio is not determined merely by the amount of DNA but is influenced by nuclear envelope transport and mechanics. We recently developed a quantitative model for nuclear size control based upon a balance of colloid osmotic pressures in the nucleoplasm and cytoplasm. This model posits that the N/C ratio is determined by the numbers of macromolecules in the nucleoplasm and cytoplasm as well as the nuclear envelope membrane tension. \nIn the fission yeast S. pombe\, the nucleus behaves as an ideal osmometer whose volume is primarily dictated by osmotic forces\, with no detectable contribution of membrane tension. Thus\, we predict that the key determinants of nuclear size in fission yeast are simply the numbers of macromolecules in the nucleoplasm and cytoplasm. Here\, to test this model\, we quantified the effects of massive overexpression (~10^7molecules) of exogenous proteins targeted to either the nucleus or the cytoplasm. In both cases\, the resulting N/C ratio quantitatively aligned with our model’s prediction. We have thus developed a tunable system for altering the N/C ratio by overexpression of a single exogenous protein. These data provide critical quantitative support for the osmotic model for nuclear size control.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-joel-lemiere/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/Bandeau-web-seminar-Joel-Lemiere-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241108T114500
DTEND;TZID=Europe/Paris:20241108T130000
DTSTAMP:20260425T163833
CREATED:20241023T133709Z
LAST-MODIFIED:20241023T135451Z
UID:25397-1731066300-1731070800@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Leon Peshkin
DESCRIPTION:Invited by the Doye Lab\, Leon Peshkin (Mayor-Rotschild visiting professor at the Institut Curie and Principal Research Faculty at the Department of systems biology\, Harvard Medical School) will present an Institut Jacques Monod Seminar on the theme: \n(Phospho)-proteomics of oocyte meiotic division \nAbstract: \nOocyte meiotic divisions represent a critical process in sexual reproduction\, as diploid non-dividing oocyte transforms into a haploid fertilizable egg\, preparing embryonic divisions and differentiation. Although cell differentiation and proliferation are governed by transcription\, oocyte maturation and early embryonic divisions depend entirely on changes in protein abundance and post-translational modifications. Here\, we analyze the abundance and phosphorylation of proteins during Xenopus oocyte meiotic maturation. We reveal significant shifts in protein stability\, related to spindle assembly\, DNA replication and RNA-binding. Our analysis pinpoints broad changes in phosphorylation correlating with key cytological meiotic milestones\, noteworthy changes in membrane trafficking\, nuclear envelope disassembly and modifications in microtubule dynamics. Additionally\, specific phosphorylation events target regulators of protein translation\, Cdk1 and the Mos/MAPK pathway\, providing insights into the dynamics of Cdk1 activity related to the meiotic cell cycle. This study sheds light on the orchestration of protein dynamics and phosphorylation events during oocyte meiotic divisions\, providing a rich resource for understanding the molecular pathways orchestrating meiotic progression in the frog\, and most likely applicable to other vertebrate species. \nBiography: \nLeon Peshkin is a Mayor-Rotschild visiting professor at the Inst Curie and Principal Research Faculty at the Department of systems biology\, Harvard Medical School. His PhD was done in the field of Machine Learning and AI. His eclectic interests range from pharmaco-biology to evo-devo\, to embryology\, to Machine Learning applications in Systems Biology\, but all he does has connection to biology of aging.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-leon-peshkin/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/Bandeau-web-seminar-Leon-Peshkin-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241112T090000
DTEND;TZID=Europe/Paris:20241112T180000
DTSTAMP:20260425T163833
CREATED:20241002T144902Z
LAST-MODIFIED:20241002T144902Z
UID:25106-1731402000-1731434400@www.ijm.fr
SUMMARY:5th Fungal Genetics Ile-de-France Symposium
DESCRIPTION:Registration is now open for the 5th symposium on fungal genetics in Ile-de-France! \n  \nThe symposium seeks to: \n\nPromote the exchange of ideas and results on fungal genetics topics pursued in the Paris region;\nEncourage the participation of young researchers (PhD students and post-docs);\n Address technical and scientific challenges faced by our fungal research community.\n\nAll the topics related to fungal genetics are welcome including: \n\nPathogenicity\, effectors & secondary metabolism;\nDevelopment and sexual reproduction;\nGenome structure and chromatin-based regulation;\nPopulation genetics and epidemiology;\n Fungal genetic engineering & biotechnology.\n\nThe symposium will take place on November 12\, at the Institut Jacques Monod\, amphitheater Buffon\, bat. Buffon\, 15 rue Hélène Brion\, 75013 Paris. \nRegistration is free but required. A number of oral presentations will be chosen from submitted abstracts. A poster session will also be organized. The abstracts should be submitted by email to fungi.idf@gmail.com. The deadline for registering and submitting your abstract is October 28. \nRegister here \nThe scientific organization committee includes Frederique Bidard-Michelot (IFPEN)\, Isabelle Fudal (INRAE)\, Jeanne Ropars (CNRS)\, Eugene Gladyshev (Institut Pasteur)\, Fabienne Malagnac (Université Paris-Saclay)\, and Sylvain Brun (Université Paris Cité).
URL:https://www.ijm.fr/event/5th-fungal-genetics-ile-de-france-symposium/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/png:https://www.ijm.fr/wp-content/uploads/2024/10/ffiche-symposium-FunGenIDF.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241112T140000
DTEND;TZID=Europe/Paris:20241112T170000
DTSTAMP:20260425T163833
CREATED:20241028T145726Z
LAST-MODIFIED:20241028T145726Z
UID:25511-1731420000-1731430800@www.ijm.fr
SUMMARY:Thesis defense - Sudheer Peneti
DESCRIPTION:Sudheer PENETI (équipe Ladoux/Mège) will defend his thesis: \nVimentin modulates collective cell migration by regulating Epithelial Leader cell Mechanics \n  \nThe defense will take place on Tuesday\, 12th November in room François Jacob and will be held in English. \nThe jury will be composed of: \n\nMdm. ADA CAVALCANTI-ADAM DR\, University of Heidelberg\, Rapporteur\nMdm. CARIEN NIESSEN Professor\, University of Cologne Rapporteur\nGREGORY GIANNONE DR\, University of Bordeaux Examinateur\nMdm. SYLVIE HENON Professor\, University of Paris Cité Examinatrice\nBENOIT LADOUX Professor\, Friedrich-Alexander-University Invité\nRENE-MARC MEGE Professor\, Institut Jacques Monod Directeur de thèse
URL:https://www.ijm.fr/event/thesis-defense-sudheer-peneti/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/These-bandeau-Sudheer-PENETI-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241115T090000
DTEND;TZID=Europe/Paris:20241115T180000
DTSTAMP:20260425T163833
CREATED:20240903T101342Z
LAST-MODIFIED:20240903T102138Z
UID:23796-1731661200-1731693600@www.ijm.fr
SUMMARY:Paris Cytoskeleton Day
DESCRIPTION:On Friday\, November 15\, 2024\, the parisian Cytoskeleton club is organizing the fourth edition of the Paris Cytoskeleton Day! \nThe meeting will be entirely in-person in Auditorium Buffon (Institut Jacques Monod\, Paris) \nDeadlines\nRegistration and abstract submission are now open : link.\nAbstract submission closes on October 20th.\nRegistration (45 euros) closes on November 8th. \nKeynote speakers\nBuzz Baum (Cambridge\, UK)\nGaia Pigino (Human Technopole\, Milan\, IT) \nInvited speakers\nDaria Bonazzi (Institut Pasteur)\nPaul Conduit (Institut Jacques Monod)\nJean-Léon Maître (Institut Curie)\nMarie-Hélène Verlhac (Collège de France) \nShort talks\nSeveral short presentations will be selected from abstracts. \nPosters\nA poster session will take place during the day.
URL:https://www.ijm.fr/event/paris-cytoskeleton-day/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/PCD-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20241119
DTEND;VALUE=DATE:20241120
DTSTAMP:20260425T163833
CREATED:20240920T130703Z
LAST-MODIFIED:20241004T140523Z
UID:24143-1731974400-1732060799@www.ijm.fr
SUMMARY:[Symphosium & Exhibition]The peopling of France and the origins of the agricultural lifestyle
DESCRIPTION:A one-day international symposium will present to the general public on novembre 19\, 2024 at Buffon amphitheater of the Université Paris-Cité\, 15 rue Hélène Brion\, 75013 Paris\, both individual and collaborative achievements of the Turkish and French partners of the international project NEOMATRIX that studied the Neolithic expansion from the archaeogenetic perspective. \nThis symposium will accompany an exhibition conceived and organized by Eva-Maria Geigl and Thierry Grange\, (Université Paris-Cité\, CNRS\, Institut Jacques Monod) in collaboration with a team of UMR8215-Trajectoires\, and by the team of the cultural service of the Université Paris-Cité\, funded by the Université Paris-Cité and NEOMATRIX: \n\nNovember 19 to December 16\, 2024\nUniversité Paris-Cité\, Hall 1\, Building Grands Moulins de Paris\, 5 rue Thomas Mann\, 75013 Paris.\nIntroductory ceremony: November 19\, 2024\, follow the symposium.\n\nRegistration at eva-maria.geigl@ijm.fr \n  \nSymposium : \nThe Neolithic expansion from Anatolia to France\nNovembre 19\, 2024\, Université Paris-Cité\, Amphithéâtre Buffon\, 15\, rue Hélène Brion\, 75013 Paris \nProgram: \n9:00  E.-M. Geigl (IJM): Bienvenue \n9:05  M. Somel (METU): Welcome address \n9:15 – 9:50  C. Atakuman (METU): The archaeological perspective of the Neolithic revolution in the Middle East (avec diapos et résumé en français) \n10:00 – 10:20  E.-M. Geigl (IJM): La Paléo-/Archéogénétique (with English slides and summary) \n10:30 – 11:05  M. Somel (METU): Archeogenetics of the Neolithic in the Middle East / Genetic clues into Çatalhöyük society (avec diapos et résumé en français) \n11:15 – 11:45  Coffee \n11:45 – 12:05  F. Ozer (HU): Anatolian Neolithic sheep and shepherds: from Anatolia to Europe (avec diapos et résumé en français) \n12:10 – 12:45  J.-P. Demoule (IUF): L’archéologie de l’expansion néolithique en Europe (with English slides and summary) \n13:00 – 14:30  Pause déjeuner/Lunch break \n14:30 – 15:05  O. Parasayan et E.-M. Geigl (IJM): Archeogenetics of the Neolithic in Europe with particular emphasis on northern France (avec diapos et résumé en français) \n15:15 – 15:35  T. Grange (IJM): Domestication des bovins en Anatolie et propagation en Europe (with English slides and summary) \n15:40 – 15:55  E.-M. Geigl IJM): Introduction à l’exposition AGRIPOP (with English slides and summary) \n15:55 – 16:30  N.E. Altinisik (HU): The science of the genetics of past populations and individuals: beyond science \n16:40 – 17:00: General Discussion \n17 :30  Opening Ceremony Exhibition AGRIPOP \nAttendance is free\, but registration is required : eva-maria.geigl@ijm.fr \n  \nIJM : Institut Jacques Monod\, Université Paris-Cité\, CNRS\, France \nMETU : Middle Eastern Technical University\, Ankara\, Türkiye \nHU : Hacettepe Üniversitesi\, Ankara\, Türkiye \nIUF : Institut Universitaire de France & Université de Paris I\, France
URL:https://www.ijm.fr/event/symphosium-exhibitionthe-peopling-of-france-and-the-origins-of-the-agricultural-lifestyle/?lang=en
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/09/geigl-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20241119
DTEND;VALUE=DATE:20241217
DTSTAMP:20260425T163833
CREATED:20241126T141035Z
LAST-MODIFIED:20241126T141035Z
UID:25897-1731974400-1734393599@www.ijm.fr
SUMMARY:AGRIPOP exhibition - Paleogenetics and archaeology - Neolithic revolution and migration
DESCRIPTION:Exhibition at Université Paris Cité\, Hall A of the Grands-Moulins\, from November 14 to December 16\, 2024 \nThis exhibition opens the doors of the CNRS “Epigenome & Paleogenome” research laboratory at the Institut Jacques Monod\, Université Paris Cité. \nIn 2010\, the first Neanderthal genome was sequenced. This marked the birth of paleogenomics. Since then\, paleogenomics – the analysis of ancient DNA preserved in archaeological bones – has become a rapidly expanding field of research. It provides information on the genetic identity of individuals from the past – humans and animals – on kinship relationships\, genealogies\, migrations\, interbreeding and certain characteristics of their physical appearance. This information enables scientists to reconstruct more accurately the reality of a given moment in the past. \nFrom Çatalhöyük\, in Anatolia\, to the Aisne valley\, the AGRIPOP exhibition invites you to follow the discoveries of archaeologists and paleogeneticists to understand how humans evolved towards the sedentary lifestyle of producers-farmers that is still our present. \nAccessible to all\, this exhibition highlights the collaborative and interdisciplinary practices of researchers on an international scale. Above all\, it makes more tangible our knowledge of the settlement of northern France in the Neolithic by the first farmers of Anatolian origin (modern-day Türkiye) 7\,000 years ago. AGRIPOP sheds new light on the origins of the way our societies function today. The texts in the exhibition are in French but the accompanying booklets are also provided in English.
URL:https://www.ijm.fr/event/agripop-exhibition-paleogenetics-and-archaeology-neolithic-revolution-and-migration/?lang=en
LOCATION:Université Paris-Cité\, Hall A du bâtiment des Grands Moulins de Paris\, 5 rue Thomas Mann\, 75013 Paris\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/Capture-decran-2024-11-26-151811.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241122T143000
DTEND;TZID=Europe/Paris:20241122T170000
DTSTAMP:20260425T163833
CREATED:20241014T123111Z
LAST-MODIFIED:20241014T123440Z
UID:25298-1732285800-1732294800@www.ijm.fr
SUMMARY:HDR defense - Claire Dugast
DESCRIPTION:Claire DUGAST (Ribes Lab) will defense her “Habilitation à Diriger les Recherches”: \nDynamiques moléculaires de PAX3 et PAX7 associées à la commutation activation/répression de leur activité transcriptionnelle \n  \nThe defense will take place on Friday\, November 22nd at 2:30 pm in room François Jacob and will be held in French. \nThe jury will be composed of: \n\nDr. Mounia Lagha\nDr. Raphael Margueron\nPr. Délara Saberan Djoneidi\nDr. Christine Vesque\nDr. Domenico Flagiello\nDr. Mathieu Coppey
URL:https://www.ijm.fr/event/hdr-defense-claire-dugast/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/HDR-bandeau-Claire-DUGAST-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241129T114500
DTEND;TZID=Europe/Paris:20241129T130000
DTSTAMP:20260425T163833
CREATED:20241025T093536Z
LAST-MODIFIED:20241025T093536Z
UID:25447-1732880700-1732885200@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Jens Lüders
DESCRIPTION:Invited by the Conduit Lab\, Jens Lüders (Institute for Research in Biomedicine Barcelona) will present an Institut Jacques Monod Seminars on the theme: \nMolecular basis and regulation of microtubule nucleation \n  \nAbstract: \nFormation of new microtubules\, termed nucleation\, is at the heart of organizing\, maintaining\, and remodeling complex microtubule networks. For this reason\, cells tightly control microtubule nucleation in space and time. While microtubules can assemble spontaneously in vitro\, in cells this process requires a nucleator. The main microtubule nucleator is the multi-subunit\, cone-shaped g-tubulin ring complex (gTuRC)\, which has been proposed to nucleate microtubules by a template mechanism. However\, the molecular details underlying its activity and how it is regulated to nucleate microtubules with 13-fold symmetry has remained poorly understood. \nIn my seminar I will present our recent advances in elucidating this process through the generation of recombinant gTuRC and its structural and functional analysis using cryo-EM as well as in vitro and cell-based assays. Key to reconstitution of recombinant gTuRC was the inclusion of the chaperone-like RUVBL1/2 complex in the recombinant expression system\, which greatly improves multi-subunit complex assembly. Surprisingly\, we found that gTuRC has a splayed structure that does not match microtubule symmetry and appears to be a poor nucleation template. However\, when bound to an activator\, the centrosomin motif 1 (CM1) of the gTuRC adapter protein CDK5RAP2\, gTuRC acquires the ability to adopt microtubule-like conformations and becomes an efficient nucleator. Activation involves binding of multiple CM1 dimers to five distinct sites around the outside of the gTuRC cone\, which modulates lateral interactions among the GCP subunits that form the cone-like structure. This facilitates microtubule-like conformations and release of luminal actin that is integral to non-activated gTuRC. \nWe propose a model where generation of gTuRC with an expanded conformational range\, rather than perfect symmetry\, is sufficient to boost nucleation activity.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-jens-luders/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/Bandeau-web-seminar-Jens-Luders-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241129T140000
DTEND;TZID=Europe/Paris:20241129T170000
DTSTAMP:20260425T163833
CREATED:20241113T155355Z
LAST-MODIFIED:20241113T155355Z
UID:25664-1732888800-1732899600@www.ijm.fr
SUMMARY:Thesis defense - Adria Chorro I Satorra
DESCRIPTION:Adria CHORRO I SATORRA (Conduit Lab) will defend his thesis: \nDendritic bubbles as a novel Class I-specific MTOC in Drosophila melanogaster ddaE neurons \n  \nThe defense will take place on Friday\, November 29th at 2 pm in room François Jacob and will be held in English. \nThe jury will be composed of: \nReporters:  \n\nDr. Coralie Fassier\, DR\, INSERM\, Sorbonne University\, Institut de la Vision\, France\nDr. Jens Lüders\, DR\, Institute for Research in Biomedicine (IRB)\, Barcelona\, Spain\n\nExaminers: \n\nDr. Filippo Del Bene\, DR\, INSERM\, Sorbonne University\, Institute de la Vision\, France\nDr. Juliette Azimzadeh\, DR\, CNRS\, University of Paris Cite\, Institut Jacques Monod\, France\n\nThesis director: \n\nDr. Paul Conduit\, DR\, CNRS\, Institute Jacques Monod\, France
URL:https://www.ijm.fr/event/thesis-defense-adria-chorro-i-satorra/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/These-bandeau-Adria-CHORRO-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241203T114500
DTEND;TZID=Europe/Paris:20241203T130000
DTSTAMP:20260425T163833
CREATED:20241121T133233Z
LAST-MODIFIED:20241121T133233Z
UID:25833-1733226300-1733230800@www.ijm.fr
SUMMARY:Paris Postdocs Seminars - Ahlem Assali
DESCRIPTION:Invited by the Institut Jacques Monod\, Ahlem Assali (Institut du cerveau\, Paris) will present a Paris Postdoc Seminar on the theme: \nPregnancy induces cerebrovascular plasticity involved in the emergence of maternal behaviors \n  \nAbstract: \nThe adult cerebrovascular system is viewed as a very stable network\, mainly required to provide nutrients and oxygen to the brain\, and adapting to changes in neuronal activity via vasomotricity mechanisms (vasodilation and vasoconstriction). Using advanced 3D whole-brain immunolabeling/clearing protocols (iDisco+)\, light-sheet imaging\, and computational tools (ClearMap)\, enabling accurate reconstruction of the brain vasculature\, we were able to challenge this static conception of the cerebrovascular network in the context of neurophysiological adaptations occurring during and after pregnancy. Pregnant mice displayed an increase in vascular branch points in different brain regions compared to virgin females\, starting at least at gestational day 6 (GD6)\, peaking around GD15\, and reversed postweaning. This increased vascularization was notably found in the preoptic region of the hypothalamus\, involved in pregnancy regulation and maternal behavior\, and in cortical areas\, such as the somatosensory cortex. GD15 females also displayed an increase in Erg+ endothelial cells in the same brain regions. In addition\, GD6 and GD15 females showed an increase in the number of endothelial tip cells in the hypothalamic preoptic region. These data revealed a progressive vascular remodeling during pregnancy\, associated to potential angiogenesis\, in adulthood and healthy conditions. To identify molecular mechanisms driving this vascular plasticity\, we explored the effects of steroid hormones on the vascular network. Interestingly\, implants releasing estradiol induced an increase in the number of vascular branch points and of endothelial tip cells in the preoptic region of virgin females\, recapitulating the changes found in pregnant females. These data suggest that estradiol hormones regulate\, at least partially\, the pregnancy-induced vascular plasticity. Importantly\, using 3D whole-brain fluorescent in situ hybridization\, we found an increase in Vegfa expression (vascular endothelial growth factor) in the hypothalamic preoptic region and somatosensory cortex. Vegfa downregulation by shRNA in the preoptic area blocked the pregnancy-induced vascular densification\, and induced defects in maternal behavior post-birth using the pup retrieval assay.  Future transcriptomics experiments in the preoptic region will allow an agnostic search for further cellular and molecular mechanisms underlying pregnancy-induced vascular adaptations. Our data suggest an active role of vascular remodeling in shaping pregnancy- and maternal behaviors-related neuronal functions.
URL:https://www.ijm.fr/event/paris-postdocs-seminars-ahlem-assali/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/20241203-Ahlem-Assali-web-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241206T114500
DTEND;TZID=Europe/Paris:20241206T130000
DTSTAMP:20260425T163833
CREATED:20241118T125120Z
LAST-MODIFIED:20241118T125120Z
UID:25686-1733485500-1733490000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Yohanns Bellaiche
DESCRIPTION:Invited by the Ladoux / Mege Lab\, Yohanns Bellaiche (Institut CURIE UM3215 U934\, Equipe Polarité Division Morphogenèse) will present an Institut Jacques Monod Seminar on the theme: \nHow epithelial shaping is tailored by cell and tissue size \nAbstract: \nEverywhere Nature works true to scale\, and everything has its proper size accordingly” – with these words\, D’Arcy Thompson in “On Growth and Form” elegantly captured one of biology’s profound mysteries: the scaling of biological structures and substructures with size (length\, area\, or volume). At the cellular level\, scaling plays central roles in organelle dynamics during cell division and metabolic regulation. At the organismal level\, studies of scaling properties have led to discoveries in animal physiology\, bone and limb proportions\, and gene expression patterns. \nIn this seminar\, I will present our recent work linking cell and tissue size to the morphodynamics of tissue development. First\, I will discuss our findings on the mechanisms by which cells probe their size to scale their geometrical and mechanical properties\, thereby regulating cell proliferation and apoptosis. Then\, I will describe how tissue morphogenesis adapts to overall animal size to ensure robust and invariant development across the physiological range of sizes within a species.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-yohanns-bellaiche/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/Bandeau-web-seminar-Yohanns-Bellaiche-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241209T091500
DTEND;TZID=Europe/Paris:20241213T180000
DTSTAMP:20260425T163833
CREATED:20241023T114430Z
LAST-MODIFIED:20241023T114842Z
UID:25390-1733735700-1734112800@www.ijm.fr
SUMMARY:International Workshop : Cycling to divide\, Across Scales\, Species and Evolution
DESCRIPTION:The Magistère Européen de Génétique\, with the support of Circle U and the Jacques Monod Institute\, is organizing an International Workshop from December 3rd to December 9th\, which will be held in the Amphi Turing in the Sophie Germain building\, Campus Grands-Moulins (Place Aurélie Nemours). \nThe topic of this workshop is Cell Cycle and Cell Division\, which will be addressed through talks and lectures by distinguished speakers from the Jacques Monod Institute and other Parisian and International institutions. This workshop will broadly cover various aspects of the cell cycle and cell division\, such as mitosis\, meiosis\, asymmetric cell division\, chromosome segregation\, DNA replication\, and cytokinesis\, using a range of model organisms\, each with specific technical advantages. The speakers come from diverse scientific backgrounds\, using a variety of model systems and approaches.\nThe number of participants is limited to 70 attendees. \nRegistrations are open until November 29th: here \nSpeakers: \n\nBuzz Baum (LMB\, Univ. Cambridge)\nPierre Chymkowitch (Univ. of Oslo)\nGautam Dey (EMBL)\nInes Drinnenberg (Curie Institute)\nJulien Dumont (Institut Jacques Monod)\nArnaud Echard (Pasteur Institute)\nUlrike Eggert (King’s College London)\nSimona Giunta (Roma\, La Sapienza)\nJean-René Huynh (Collège de France)\nJens Januschke (Univ. Dundee)\nJoao Matos (Univ. of Vienna\, Max Perutz)\nNicolas Minc (Institut Jacques Monod)\nLionel Pintard (Institut Jacques Monod)\nMarie-Noelle Prioleau (Institut Jacques Monod)\nKatja Wassmann (Institut Jacques Monod)
URL:https://www.ijm.fr/event/international-workshop-cycling-to-divide-across-scales-species-and-evolution/?lang=en
LOCATION:Amphithéâtre Alan Turing – Bâtiment Sophie Germain\, 8 place Aurélie Nemours\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/10/bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241211T093000
DTEND;TZID=Europe/Paris:20241211T110000
DTSTAMP:20260425T163833
CREATED:20241203T151811Z
LAST-MODIFIED:20241203T151811Z
UID:26020-1733909400-1733914800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:The next Cytoskeleton club meeting will take place on Wednesday 11th December: \n\nKotryna Voidziulyte (post-doc\, Piel’s team) will present “Atypical nuclear phenotypes in confined cancer cells“\nSamya Zerkoune (PhD student\, Nicol/ Fassier’s team) will present “Fignl1/RAD51 complex drives axon midline crossing through timely tuned F-actin nucleation inhibition”
URL:https://www.ijm.fr/event/cytoskeleton-club-2/?lang=en
LOCATION:Amphithéâtre de l’Institut Pierre-Gilles de Gene\, 6 rue Jean Clavin\, Paris
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/20241211-bandeau-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241213T114500
DTEND;TZID=Europe/Paris:20241213T130000
DTSTAMP:20260425T163833
CREATED:20241118T125824Z
LAST-MODIFIED:20241118T125824Z
UID:25694-1734090300-1734094800@www.ijm.fr
SUMMARY:Institut Jacques Monod seminars - Laurent Formery
DESCRIPTION:Invited by the Gazave Lab\, Laurent Formery (Department of Biology\, Stanford University) will present an Institut Jacques Monod seminar on the theme: \nEchinoderm evolution: Testing the limits of axial patterning plasticity \nAbstract: \nThe discovery that distantly related animals establish their body plans through conserved developmental programs is one of the most transformative findings in evolutionary biology. Similar antero-posterior (AP) and dorso-ventral (DV) patterning programs have now been identified in a large sample of bilaterian animals. However\, because most of the species that we have investigated so far follow the basic blueprint of the bilateral symmetry\, it remains unclear whether\, in case of drastically divergent body plan evolution\, these patterning program are flexible enough to support major deviation from bilateral symmetry\, or if they act as developmental constraint on body plan diversity that need to be disassembled first. My research aims to investigate this question using echinoderms\, which evolved a unique pentaradial symmetry and represent a fascinating natural experiment on body plan plasticity. By looking at adult body plan development in sea stars\, brittle stars and sea cucumbers using modern molecular tools\, I have been able to identify that some part of the antero-posterior patterning program are highly conserved during the formation of the pentaradial body plan\, albeit in an unexpected spatial configuration. This indicates that despite the absence of a morphological AP axis\, the molecular system used for AP patterning is surprisingly tolerant to radical morphological changes. With these new molecular data\, we are now starting to piece together the evolution of axial properties across echinoderm classes and with their bilateral relatives. Beyond the fascinating history of this particular phylum\, these data are important to decipher to what extent conserved molecular programs have shaped the evolution of morphological novelty.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-laurent-formery/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/11/Bandeau-web-seminar-Laurent-Formery-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20241219T143000
DTEND;TZID=Europe/Paris:20241219T170000
DTSTAMP:20260425T163833
CREATED:20241203T144714Z
LAST-MODIFIED:20241203T144714Z
UID:26006-1734618600-1734627600@www.ijm.fr
SUMMARY:Soutenance de thèse - Juliette Mandelbrojt
DESCRIPTION:Juliette Mandelbrojt (équipe Prioleau) va défendre sa thèse : \nHow do transcription and chromosomal context interfere with an efficient replication origin? \n  \nLa soutenance se tiendra le jeudi 19 décembre 2024 à 14h30 en salle François Jacob ( 15 rue Hélène Brion 75013 Paris) et sera en anglais. \nLe jury sera composé de : \n\nDr Sarah LAMBERT\, DR\, Université Paris Saclay\, Rapporteur\nDr Julian SALE\, Senior group leader\, University of Cambridge\, Rapporteur\nPr Jean-Charles CADORET\, PU\, Université Paris Cité\, Examinateur\nDr Stéphane KOUNDRIOUKOFF\, MCF-HDR\, Sorbonne Université\, Examinateur\nDr Marie-Noëlle PRIOLEAU\, DR\, Université Paris Cité\, Directrice de thèse \nDr Caroline DONCARLI\, PhD\, Université Paris Cité\, Membre invitée Co encadrante 
URL:https://www.ijm.fr/event/soutenance-de-these-juliette-mandelbrojt/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/These-bandeau-Juliette-MANDELBROJT-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250110T114500
DTEND;TZID=Europe/Paris:20250110T130000
DTSTAMP:20260425T163833
CREATED:20241205T145404Z
LAST-MODIFIED:20241205T145404Z
UID:26050-1736509500-1736514000@www.ijm.fr
SUMMARY:Institut Jacques Monod Seminars - Lendert Gelens
DESCRIPTION:Invited by the Wassmann Lab\, Lendert Gelens (Laboratory of Dynamics in Biological Systems\, University of Leuven\, Belgium) will present an Institut Jacques Monod seminar on the theme: \nNuclei coordinate the cell cycle in space and time \n  \nAbstract: \nProliferating cells replicate their DNA and components before dividing\, but how subcellular localization impacts cell cycle timing remains unclear. Using frog egg extracts encapsulated in droplets\, we studied cell cycle oscillations with and without nuclei [1]. Time-lapse microscopy revealed that nuclei increase cell cycle duration\, with increasing nuclear volume correlating with longer periods across different Xenopus species. This relationship persisted without DNA replication or transcription but was disrupted by inhibiting nuclear import or Wee1 kinase. A computational model incorporating nuclear-cytoplasmic compartmentalization and periodic nuclear envelope dynamics reproduced these findings\, linking nuclear size to cycle timing. These results explain the lengthening of the cell cycle at the midblastula transition when cells become smaller\, and the nuclear-cytoplasmic ratio increases. \nIn early Xenopus embryos (~1.2 mm)\, mitotic waves coordinate the cell cycle over long distances\, as diffusion alone is insufficient. Using X. laevis egg extracts and a Cdk1 FRET sensor\, we observed a transition from phase to trigger wave dynamics in initially homogeneous cytosol [2]. Spatial heterogeneity and nuclei accelerated this transition\, while metaphase-arrested extracts induced an immediate shift. Simulations revealed transient phase waves as trigger waves required time to entrain the system. Both wave types emerge as part of a unified process for coordinating the cell cycle across large distances. \n[1] Pineros\, L. *; Frolov\, N. *; Ruiz-Reynés\, D.; Eynde\, A. Van; Cavin-Meza\, G.; Heald\, R.; Gelens\, L.; The nuclear-cytoplasmic ratio controls the cell cycle period in compartmentalized frog egg extract; BioRxiv\, 2024. \n[2] Puls*\, O.; Ruiz-Reynés*\, D.; Tavella\, F.; Jin\, M.; Kim\, Y.; Gelens*\, L.; Yang*\, Q.; Spatial heterogeneity accelerates phase-to-trigger wave transitions in frog egg extracts; Nature Communications\, vol. 15\, no. 10455\, 2024.
URL:https://www.ijm.fr/event/institut-jacques-monod-seminars-lendert-gelens/?lang=en
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/Bandeau-web-seminar-Lendert-Gelens-scaled.jpg
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