A multi-faceted enzyme silences repeats in the genome

In plants and animals, histone proteins bind to DNA and carry different chemical modifications, which can repress the expression of genes or of mobile genetic elements. Sandra Duharcourt’s team characterized the properties of an unconventional enzyme in the unicellular eukaryote Paramecium, which catalyses two distinct silent histone modifications and silences genomic repeats. This work published in Nature Communications reveals that these two modifications share a common ancestral role in keeping silent transposable elements.

More details :

The Polycomb protein Ezl1 mediates H3K9 and H3K27 methylation to repress transposable elements in Paramecium.
Frapporti A, Miró Pina C, Arnaiz O, Holoch D, Kawaguchi T, Humbert A, Eleftheriou E, Lombard B, Loew D, Sperling L, Guitot K, Margueron R, Duharcourt S.
Nat Commun. 2019 Jun 20;10(1):2710. doi: 10.1038/s41467-019-10648-5.

Contact

Sandra Duharcourt

Group leader CNRS at Jacques Monod Institute (IJM) - (CNRS/Univ. Paris Diderot)

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