December 2018: BUB-1 is a multi-talented kinase
In an article published in December in eLife, the Dumont team at the Institut Jacques Monod shows that the kinase BUB-1 controls chromosome segregation by modulating the activity of various kinetochore components. Surprisingly, this function of BUB-1 is independent of its kinase activity.
To learn more:
BUB-1 promotes amphitelic chromosome biorientation via multiple activities at the kinetochore.
Edwards, F., Maton, G., Gareil, N., Canman, J.C. & Dumont, J.