The Institut Jacques-Monod, funded jointly by the CNRS and the University Paris Diderot, is one of the main centers for basic research in biology in the Paris area.
It is headed by Michel Werner, Research Director.

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IJM News

  • Nesprins are mechanotransducers that discriminate epithelial–mesenchymal transition programs

    LINC complexes are assemblies of transmembrane proteins that physically link the nucleoskeleton and cytoskeleton through the nuclear envelope. Dysfunctions of LINC complexes are associated with cancer and muscle pathologies. The mechanical roles of LINC complexes in these diseases are poorly understood. To remedy this, an IJM team has used FRET molecular tension biosensors genetically encoded in nesprin, a protein of the LINC complex, in fibroblast and epithelial cells in culture.

  • Comment s’établissent les domaines de réplication précoce ?

    Les génomes des vertébrés se répliquent selon un programme temporel précis, fortement corrélé avec leur organisation en compartiments A/B (ouverts/fermés). A ce jour cependant, les mécanismes moléculaires impliqués dans la formation des domaines de réplication précoce restent encore largement incompris.

  • Paleogenetics uncovers the introduction of domestic horses in southwest Asia 4,000 years ago

    The domestication of wild animals is a crucial step in the development of past societies. While the first animals that were domesticated ca. 10-9,000 years ago for economic reasons in the Fertile Crescent in southwest Asia to increase the reliability of the subsistence resources, horses were domesticated much later, supposedly around 5,000 years ago.

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