The Institut Jacques-Monod, funded jointly by the CNRS and the University Paris Diderot, is one of the main centers for basic research in biology in the Paris area.
It is headed by Michel Werner, Research Director.

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IJM News

  • May 2018: “Regulation of Actin Assembly Dynamics”

    It is now well established that formins are central players in the regulation of the dynamics of almost all actin networks in cells. But how their activities are modulated by biochemistry and mechanics is far less well understood. Researchers from the ‘Regulation of Actin Assembly Dynamics’ team of the Institut Jacques Monod have studied in vitro actin filament elongation induced by mDia1 and mDia2 mammalian formins. This work, published in eLife, has shown that filament length can be increased by the presence of profilin, a protein that forms binary complexes with actin, but is highly diminished if a pulling force is applied between formins and actin filaments. How cells limit formin dissociation under tension is now a key question for future studies.

  • May 2018: Watching broken DNA get repaired, one molecule at a time

    The DNA of every cell is constantly undergoing damage, and the cell cannot survive without actively repairing these lesions using specialized molecular systems. Defects in DNA repair systems are frequently associated with the apparition of cancers. Among the most complex forms of damage that DNA must be rescued from involve double-strand breaks in the double helix. In humans these breaks are repaired by a system comprised of no less than six distinct proteins. So as to understand how this multitude of proteins can assemble in a timely fashion into a functional system, the lab of T. Strick (Institut Jacques Monod and Ecole normale supérieure) has developped new nanotechnologcial approaches which allow for real-time observation of repair of DNA double-strand breaks. This study highlights the functional redundancy which allows this system to function in a robust and efficient manner despite its molecular complexity. It paves the way for quantitative analysis of new therapeutic molecules targeting this process. This study was published on May 21st 2018 in Nature Structural and Molecular Biology.

  • Mai 2018 : Comment ajuster la biogénèse d’un complexe multiprotéique

    Si de nombreuses activités cellulaires mettent en jeu des édifices protéiques formés de plusieurs sous-unités, les régulations contrôlant leur homéostasie restent mal connues. Un groupe de chercheurs, mené par Benoit Palancade à l’Institut Jacques Monod, a utilisé le complexe du pore nucléaire (NPC) comme paradigme pour déchiffrer les mécanismes qui assurent la biogénèse de tels assemblages, et maintiennent leur stœchiométrie. Leurs travaux, publiés dans la revue Nature communications, révèlent une boucle de régulation par laquelle la biogenèse des sous-unités du NPC est ajustée en fonction de l’intégrité du complexe.

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Come and join us!

September 2018: Post-doctoral position, Palancade group
September 2018: Post-doctoral position, Leon lab
July 2018: A post-doctoral position, october 2018 - CDD (2 years)

Next events

  • Tuesday30 October2018

    Séminaire de l'Institut

    Nicolas PADE

    The European Marine Biological Resource Centre in France, EMBRC-France
  • Friday09 November2018

    Séminaire de l'Institut

    Guillaume DUMENIL

    Mechanics of vascular colonizatin by Neisseria meningitidis
  • Friday30 November2018

    Séminaire de l'Institut

    Jérôme GROS

    Imaging and regulation of the cellular events that shape the vertebrate embryo

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