The Institut Jacques-Monod, funded jointly by the CNRS and the University Paris Diderot, is one of the main centers for basic research in biology in the Paris area.
It is headed by Michel Werner, Research Director.

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IJM News

  • October 2018: A mutation contributing to the simultaneous evolution of two sensory organs

    Male genitals evolve very quickly in animals. Studying the mechanisms underlying their evolution is crucial to understand the phenomenon of speciation. However, the genes involved in genital differences between species are poorly known. A work published in the journal Current Biology in October, resulting from a collaboration between the Jacques Monod Institute, the CNRS, the Paris Museum, the EGCE laboratory of Gif-sur-Yvette and two teams in the United States, constitutes a first step forward in Drosophila. The mutation of a single letter in the DNA contributes to both the loss of sensory organs under the phallus and the increase in size of a sexual comb located on the legs. This is the first time that a single mutation is observed to contribute to the evolution of two organs between species.

  • May 2018: “Regulation of Actin Assembly Dynamics”

    It is now well established that formins are central players in the regulation of the dynamics of almost all actin networks in cells. But how their activities are modulated by biochemistry and mechanics is far less well understood. Researchers from the ‘Regulation of Actin Assembly Dynamics’ team of the Institut Jacques Monod have studied in vitro actin filament elongation induced by mDia1 and mDia2 mammalian formins. This work, published in eLife, has shown that filament length can be increased by the presence of profilin, a protein that forms binary complexes with actin, but is highly diminished if a pulling force is applied between formins and actin filaments. How cells limit formin dissociation under tension is now a key question for future studies.

  • May 2018: Watching broken DNA get repaired, one molecule at a time

    The DNA of every cell is constantly undergoing damage, and the cell cannot survive without actively repairing these lesions using specialized molecular systems. Defects in DNA repair systems are frequently associated with the apparition of cancers. Among the most complex forms of damage that DNA must be rescued from involve double-strand breaks in the double helix. In humans these breaks are repaired by a system comprised of no less than six distinct proteins. So as to understand how this multitude of proteins can assemble in a timely fashion into a functional system, the lab of T. Strick (Institut Jacques Monod and Ecole normale supérieure) has developped new nanotechnologcial approaches which allow for real-time observation of repair of DNA double-strand breaks. This study highlights the functional redundancy which allows this system to function in a robust and efficient manner despite its molecular complexity. It paves the way for quantitative analysis of new therapeutic molecules targeting this process. This study was published on May 21st 2018 in Nature Structural and Molecular Biology.

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September 2018: Post-doctoral position, Leon lab
July 2018: A post-doctoral position, october 2018 - CDD (2 years)

Next events

  • Tuesday13 November2018

    Séminaire de l'Institut

    Wolfgang HAAK

    Into the great wide open: the genomic history of the Greater Caucasus
  • Wednesday14 November2018

    Soutenance de thèse

    Samantha BRUNEL

    Paleogenomics of human population dynamics on the French territory between 7000 and 2000 before present.
  • Friday30 November2018

    Séminaire de l'Institut

    Jérôme GROS

    Imaging and regulation of the cellular events that shape the vertebrate embryo

All events

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