The Institut Jacques-Monod, funded jointly by the CNRS and the University Paris Diderot, is one of the main centers for basic research in biology in the Paris area.
It is headed by Michel Werner, Research Director.

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IJM News

  • The transformation of the genomes of the inhabitants of France during the Protohistory

    The protohistory of France was punctuated by two migration waves, one during the Neolithic that started around 6300 years ago and one during the Bronze Age 4200 years ago. This is the major result of a new paleogenomic study published in the “Proceedings of the National Academy of Sciences” (PNAS) of the “Epigenome and Paleogenome” group of the Institut Jacques Monod, Université de Paris, CNRS in collaboration with numerous French archaeologists and paleoanthropologists affiliated to the INRAP, the CNRS, universities and archaeological companies.

  • New insights into the polarization of multicellular epithelia

    Multi-ciliated epithelia play an important role in respiratory function. In humans, multi-ciliated cells are particularly needed for respiratory clearance, a mechanism that allows renewing the protective mucus barrier protecting the lungs from pathogens and dust. Disturbances in the function of these cells caused by certain genetic mutations can thus be at the origin of severe respiratory diseases. An international collaboration between two teams form the IJM and the Max Planck Institute in Dresden has highlighted a novel mechanism for controlling the direction of ciliary beat in a multicellular epithelium. Using an invertebrate model, the planarian Schmidtea mediterranea, researchers have shown that the joint action of two conserved signaling pathways can generate a ciliary pattern that reflects the bilateral symmetry of the animal itself. However, the elements of the cytoskeleton on which the polarity signals act to orient the cilia exhibit chiral asymmetry. This work thus allowed to identify new molecular actors in the polarization of multi-ciliated epithelia, but also to understand how the so-called Bilaterian animals, of which we are part, can generate a bilateral symmetry from chiral molecules or structures.

  • Des pincettes en ADN pour étudier l’interaction entre une médicament et sa cible à l’échelle molécule-unique

    L’efficacité d’un médicament est fortement liée au temps que la molécule médicamenteuse passe accolée à sa cible, typiquement une protéine. Bien souvent si l’interaction est de longue durée la drogue aura un effet plus fort que si l’interaction est de courte durée. Une équipe pluridisciplinaire vient de décrire dans la revue Nature Nanotechnology une nouvelle approche à très haute résolution permettant d’observer, en temps réel, l’interaction d’une seule molécule médicamenteuse avec une seule molécule de cible. Cette observation du « quantum » d’interaction moléculaire ouvre de nouvelles perspectives dans le développement des médicaments mais aussi des anticorps thérapeutiques et de la science des matériaux.

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