The Institut Jacques-Monod, funded jointly by the CNRS and the University Paris Diderot, is one of the main centers for basic research in biology in the Paris area.
It is headed by Michel Werner, Research Director.

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IJM News

  • News from the third branch of humanity, the Denisovans

    A tiny fragment of a finger bone from Denisova cave in Siberia containing exceptionally well preserved DNA led in 2010, through the analysis of its genome, to the discovery of a previously unknown human population, the Denisovans, a sister-group of Neandertals. Denisovans have been documented living in the Middle and Upper Pleistocene (at least between 50,000 and 195,000 years ago) in southern Siberia and Tibet, but have left traces in the genomes of present-day populations in Melanesia and, to a lesser extent, in some populations in Asia. Yet, due to the scarcity of identified skeletal remains, almost nothing is known about their physical appearance. In the framework of an international, interdisciplinary collaboration coordinated by Eva-Maria Geigl, the Epigenome & Paleogenome group of the Institut Jacques Monod measured and photographed another fragment of the phalanx, analyzed its mitochondrial genome and demonstrated that it as the larger part of the famous phalanx that had yielded the first Denisovan genome. Paleoanthropologists from PACEA, University of Bordeaux, and from the Department of Anthropology, University of Toronto, Canada, reconstructed the image of the complete phalanx (Figure) and performed careful morphometric analyses of the measurements and pictures of the phalanx and comparison with finger phalanges of Neandertals and anatomically modern humans. This analysis shows that the finger phalanx of the Denisovan woman is close in shape to that of anatomically modern humans, in contrast to the molars and a recently identified mandible from Tibet. Thus, Denisovans seem to have mosaic characters that may challenge paleoanthropologists searching for Denisovan skeletal remains to better characterize morphologically this “third” branch of humanity.

  • Une stratégie de résistance à un inhibiteur métabolique découverte grâce à la levure

    Les cellules cancéreuses prolifèrent de manière incontrôlée. Ceci s’accompagne d’une capacité accrue à importer les nutriments et à les métaboliser. Le dérivé toxique d’un sucre, le 2-désoxyglucose (2DG), est préférentiellement importé par les cellules cancéreuses et inhibe leur croissance. En utilisant la levure de boulanger comme organisme modèle, les chercheurs ont précisé les effets cellulaires de cette drogue et les mécanismes de résistance associés. Ces résultats sont publiés dans la revue Science Signaling.

  • A multi-faceted enzyme silences repeats in the genome

    In plants and animals, histone proteins bind to DNA and carry different chemical modifications, which can repress the expression of genes or of mobile genetic elements. Sandra Duharcourt’s team characterized the properties of an unconventional enzyme in the unicellular eukaryote Paramecium, which catalyses two distinct silent histone modifications and silences genomic repeats. This work published in Nature Communications reveals that these two modifications share a common ancestral role in keeping silent transposable elements.

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Juin 2019 : Ingénieur d'Études en CDD 12 ou 24 mois, plateforme imagoSeine

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  • Tuesday17 September2019

    Séminaire de l'Institut

    Yu Suk CHOI

    3D linear stiffness gradient hydrogel to study the effect of cell volume expansion in stem cell mechanotransduction and differentiation
  • Wednesday18 September2019

    Soutenance de thèse

    Cécile GASTON

    Rôle d’EpCAM sur l’activité du réseau d’actomyosine et impact sur le maintien de l’organisation épithéliale
  • Friday20 September2019

    Séminaire de l'Institut

    Cécile LEDUC

    Organization and dynamics of intermediate filaments in glial cell migration

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