The Institut Jacques-Monod, funded jointly by the CNRS and the University Paris Diderot, is one of the main centers for basic research in biology in the Paris area.
It is headed by Michel Werner, Research Director.

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IJM News

  • May 2018: Watching broken DNA get repaired, one molecule at a time

    The DNA of every cell is constantly undergoing damage, and the cell cannot survive without actively repairing these lesions using specialized molecular systems. Defects in DNA repair systems are frequently associated with the apparition of cancers. Among the most complex forms of damage that DNA must be rescued from involve double-strand breaks in the double helix. In humans these breaks are repaired by a system comprised of no less than six distinct proteins. So as to understand how this multitude of proteins can assemble in a timely fashion into a functional system, the lab of T. Strick (Institut Jacques Monod and Ecole normale supérieure) has developped new nanotechnologcial approaches which allow for real-time observation of repair of DNA double-strand breaks. This study highlights the functional redundancy which allows this system to function in a robust and efficient manner despite its molecular complexity. It paves the way for quantitative analysis of new therapeutic molecules targeting this process. This study was published on May 21st 2018 in Nature Structural and Molecular Biology.

  • Mai 2018 : Comment ajuster la biogénèse d’un complexe multiprotéique

    Si de nombreuses activités cellulaires mettent en jeu des édifices protéiques formés de plusieurs sous-unités, les régulations contrôlant leur homéostasie restent mal connues. Un groupe de chercheurs, mené par Benoit Palancade à l’Institut Jacques Monod, a utilisé le complexe du pore nucléaire (NPC) comme paradigme pour déchiffrer les mécanismes qui assurent la biogénèse de tels assemblages, et maintiennent leur stœchiométrie. Leurs travaux, publiés dans la revue Nature communications, révèlent une boucle de régulation par laquelle la biogenèse des sous-unités du NPC est ajustée en fonction de l’intégrité du complexe.

  • April 2018: Another Brick in the Cell Wall

    In an article published on April 23rd, and featured on the cover of Developmental Cell, the team Minc at Institut Jacques Monod establishes a new live imaging method to study the dynamics of cell wall assembly in living cells.

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January 2018: A post-doctoral position October 2017: CDD - 1 Engineer Assistant/Engineer; 1 Engineer Assistant

Next events

  • Friday22 June2018

    Séminaire de l'Institut

    Géraldine SEYDOUX

    How to build an RNA granule: phase separation of intrinsically-disordered proteins
  • Tuesday26 June2018

    Séminaire de l'Institut


    Mediator complex in transcription regulation and DNA repair
  • Tuesday03 July2018

    Séminaire de l'Institut


    Molecular insights into how the microtubule-based motor dynein is recruited to its cargo

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