Epigenome and Paleogenome>> Evolution of the bovine genome during domestication

Continuing the study of the phylogeography of bovine populations during domestication, we develop palaeogenomic approaches to identify the genomic modifications occurring during the domestication of the aurochs. This is an example of accelerated evolution of certain parts of the genome that have been (more or less consciously) selected by humans during the last 10,000 years. At present, we develop approaches for library construction and sequence capture for high throughput sequencing from very low quantities and highly degraded DNA in ancient bone material to improve the quantity and quality of the produced data. Ultimately, we will study the effects of domestication on the evolution of the bovine genome as a function of the historical period and the society certain phenotypic traits rather than others.  We also aim at analyzing the evolution of infectious diseases produced by bacteria and parasites that arose during the Neolithic migrations of domestic animals through confrontation with autochthonous wild life in newly-colonised territories and through increasing population densities.

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