The Institut Jacques-Monod, funded jointly by the CNRS and the University Paris Diderot, is one of the main centers for basic research in biology in the Paris area.
It is headed by Michel Werner, Research Director.

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IJM News

  • March 2019: Is the replication timing control constant through S phase?

    Before each cell division, the full genome has to be entirely and faithfully duplicated thereby each daughter cell inherits the complete genetic information. This duplication occurs under the control of a highly sophisticated replication program during the restricted time period corresponding to S phase. DNA replication is initiated at a large number of sites, known as origins of replication, on the chromosomes of eukaryotic cells. In one individual cell, only a part of the origins licensed in G1 phase are activated during S phase thus illustrating the flexible origin choice which is directly related to the stochastic nature of the eukaryotic replication program. Another particularity of the program is that origin activation is also subject to temporal regulation. Like this, some domains of hundred kilobases are replicated in early S phase, others are replicated in mid S phase and the remainders in late S phase. This temporal control is very strict. To date, the factors responsible for the establishment, regulation and maintenance of these domains throughout the cell cycle remain largely unknown. As a first step towards a better comprehension of this temporal program, the team of MN Prioleau has investigated whether the stochasticity of the timing program is changing along the S phase.

  • January 2019: when Transcription Meets Replication

    Conflicting activities necessary for the expression, the maintenance and the propagation of genomes need to be coordinated. Just like one's liberty to swing fists ends where another's nose begins, coordination is achieved through a tight control of where and when directly opposed activities take place. In a study published recently in eLife, researchers from the Libri team are now showing that replication factors generally "protect" sites where replication initiates by terminating incoming transcription, and that the low levels of transcription that enter origins of replication affect their firing efficiency.

  • January 2019 : Cell shape changes and cytoskeleton adaptation to migrate into complex environments

    Cell migration is an essential biological process that drives tissue and organ formation during embryo development, and also helps protect the body through immune response and wound healing mechanisms.

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July 2018: A post-doctoral position, october 2018 - CDD (2 years)

Next events

  • Friday24 May2019

    Séminaire de l'Institut

    Atef ASNACIOS


    Interplay between single-cell mechanics and functions
  • Monday27 May2019

    Habilitation à diriger des recherches

    Serge DMITRIEFF

    Discrete and continuous models of intra-cellular mechanics
  • Tuesday28 May2019

    Séminaire de l'Institut

    Pr Rodney ROTHSTEIN

    The building yeast RNR regulator, Sm11, is an ortholog of Mis18 and plays a dNTP-independent role in chromosome segregation

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