Oncologie moléculaire et pathologies ovariennes>> Publications


Caburet S, Arboleda VA, Llano E, Overbeek PA, Barbero JL, Oka K, Harrison W, Vaiman D, Ben-Neriah Z, García-Tuñón I, Fellous M, Pendás AM, Veitia RA, Vilain E. Mutant Cohesin in Premature Ovarian Failure.
The New England Journal of Medecine
, 2014; ; 370:943-949.


Gibson TJ, Seiler M, Veitia RA. The transience of transient overexpression.
Nat Methods. 2013 Aug;10(8):715-21.


May Penrad-Mobayed, Caroline Perrin, Jean-Antoine Lepesant. Precocious detection on amphibian oocyte lampbrush chromosomes of subtle changes in the cellular localisation of the Ro52 protein induced by in vitro culture.
Chromosome Research: Volume 20, Issue 8 (2012), Page 1033-1044

Birchler JA, Veitia RA. Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines.
Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14746-53.

Benayoun BA, Anttonen M, L'hôte D, Bailly-Bechet M, Andersson N, Heikinheimo M, Veitia RA. Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation.
Oncogene. 2012 Jul 16.

L'Hôte D, Georges A, Todeschini AL, Kim JH, Benayoun BA, Bae J, Veitia RA. Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles.
Hum Mol Genet. 2012 Jul 15;21(14):3264-74.

M. Penrad−Mobayed, C. Perrin, J.−A. Lepesant (2012) Precocious detection on amphibian oocyte lampbrush chromosomes of subtle changes in the cellular localisation of the Ro52 protein induced by in−vitro culture.
Chromosome Res

Fillatre J, Delacour D, Van Hove L, Bagarre T, Houssin N, Soulika M, Veitia RA, Moreau J. Dynamics of the subcellular localization of RalBP1/RLIP through the cell cycle: the role of targeting signals and of protein-protein interactions.FASEB J. 2012 Feb 8.


Baillet A, Mandon-Pépin B, Veitia R, Cotinot C. [Genetics of early ovarian differentiation: recent data]. Biol Aujourdhui. 2011;205(4):201-21. French.

Georges A, Benayoun BA, Marongiu M, Dipietromaria A, L'Hôte D, Todeschini AL, Auer J, Crisponi L, Veitia RA. SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies. PLoS One. 2011;6(10):e25463.

Caburet S, Georges A, L'hôte D, Todeschini AL, Benayoun BA, Veitia RA. The transcription factor FOXL2: At the crossroads of ovarian physiology and pathology. Mol Cell Endocrinol. 2011 Jul 8. [Epub ahead of print]

Lelièvre EC, Benayoun BA, Mahieu L, Roger JE, Sahel JA, Sennlaub F, Veitia RA, Goureau O, Guillonneau X. A regulatory domain is required for foxn4 activity during retinogenesis. J Mol Neurosci. 2012 Feb;46(2):315-23.

Todeschini AL, Dipietromaria A, L'hôte D, Boucham FZ, Georges AB, Pandaranayaka PJ, Krishnaswamy S, Rivals I, Bazin C, Veitia RA. Mutational probing of the forkhead domain of the transcription factor FOXL2 provides insights into the pathogenicity of naturally occurring mutations. Hum Mol Genet. 2011 Sep 1;20(17):3376-85.

Benayoun BA, Caburet S, Veitia RA. Forkhead transcription factors: key players in health and disease. Trends Genet. 2011 Jun;27(6):224-32. Review.

Bouhali K, Dipietromaria A, Fontaine A, Caburet S, Barbieri O, Bellessort B, Fellous M, Veitia RA, Levi G. Allelic reduction of Dlx5 and Dlx6 results in early follicular depletion: a new mouse model of primary ovarian insufficiency. Hum Mol Genet. 2011 Jul 1;20(13):2642-50.

R. Kanhoush, D. Praseuth, C. Perrin, D. Chardard, J. Vinh, M. Penrad-Mobayed (2011). Differential RNA-binding activity of the hnRNP G protein correlated with the sex genotype in the amphibian oocyte. Nucleic Acid Rearch. 39: 4109-4121

Baron D, Dubois E, Bihouée A, Teusan R, Steenman M, Jourdon P, Magot A, Péréon Y, Veitia R, Savagner F, Ramstein G, Houlgatte R. Meta-analysis of muscle transcriptome data using the MADMuscle database reveals biologically relevant gene patterns. BMC Genomics. 2011 Feb 16;12:113.

Benayoun BA, Georges AB, L'Hôte D, Andersson N, Dipietromaria A, Todeschini AL, Caburet S, Bazin C, Anttonen M, Veitia RA. Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase. Hum Mol Genet. 2011 May 1;20(9):1673-86.

Veitia RA, Vaiman D. Exploring the mechanistic bases of heterosis from the perspective of macromolecular complexes. FASEB J. 2011 Feb;25(2):476-82.


Birchler JA, Yao H, Chudalayandi S, Vaiman D, Veitia RA. Heterosis. Plant Cell. 2010 . Jul;22(7):2105-12.

Veitia RA. FOXL2 versus SOX9: a lifelong "battle of the sexes". Bioessays. 2010 May;32(5):375-80.

Lakhal B, Braham R, Berguigua R, Bouali N, Zaouali M, Chaieb M, Veitia RA, Saad A, Elghezal H. Cytogenetic analyses of premature ovarian failure using karyotyping and interphase fluorescence in situ hybridization (FISH) in a group of 1000 patients. Clin Genet. 2010 Aug;78(2):181-5.

M. Penrad-Mobayed, R. Kanhoush, C. Perrin (2010). Tips and tricks for preparing lampbrush chromosome spreads from Xenopus tropicalis oocytes. Methods. 51: 37-44

D'haene B, Nevado J, Pugeat M, Pierquin G, Lowry RB, Reardon W, Delicado A, García-Miñaur S, Palomares M, Courtens W, Stefanova M, Wallace S, Watkins W, Shelling AN, Wieczorek D, Veitia RA, De Paepe A, Lapunzina P, De Baere E. FOXL2 copy number changes in the molecular pathogenesis of BPES: unique cohort of 17 deletions. Hum Mutat. 2010 May;31(5):E1332-47.

Benayoun BA, Caburet S, Dipietromaria A, Georges A, D'Haene B, Pandaranayaka PJ, L'Hôte D, Todeschini AL, Krishnaswamy S, Fellous M, De Baere E, Veitia RA. Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G). PLoS One. 2010 Jan 20;5(1):e8789.

L'Hôte D, Laissue P, Serres C, Montagutelli X, Veitia RA, Vaiman D. Interspecific resources: a major tool for quantitative trait locus cloning and speciation research. Bioessays. 2010 Feb;32(2):132-42.

De Baere E, Fellous M, Veitia RA. The transcription factor FOXL2 in ovarian function and dysfunction. Folia Histochem Cytobiol. 2009;47(5):S43-9.

Veitia RA, Bottani S. Whole genome duplications and a 'function' for junk DNA? Facts and hypotheses. PLoS One. ;4(12):e8201.

Veitia RA. A generalized model of gene dosage and dominant negative effects in macromolecular complexes. FASEB J. 2010 Apr;24(4):994-1002.

Birchler JA, Veitia RA. The gene balance hypothesis: implications for gene regulation, quantitative traits and evolution. New Phytol. 2010 Apr;186(1):54-62.

Veitia RA, Birchler JA. Dominance and gene dosage balance in health and disease: why levels matter! J Pathol. 2010 Jan;220(2):174-85.

Méduri G, Bachelot A, Duflos C, Bständig B, Poirot C, Genestie C, Veitia R, De Baere E, Touraine P. FOXL2 mutations lead to different ovarian phenotypes in BPES patients: Case Report. Hum Reprod. 2010 Jan;25(1):235-43.

Georges AB, Benayoun BA, Caburet S, Veitia RA. Generic binding sites, generic DNA-binding domains: where does specific promoter recognition come from? FASEB J. 2010 Feb;24(2):346-56.

Benayoun BA, Kalfa N, Sultan C, Veitia RA. The forkhead factor FOXL2: a novel tumor suppressor? BBA Reviews on Cancer 2010 Jan;1805(1):1-5.


Kalfa N, Veitia RA, Benayoun BA, Boizet-Bonhoure B, Sultan C. The new molecular biology of granulosa cell tumors of the ovary. Genome Med. 2009 Aug 25;1(8):81.

Veitia RA, Caburet S. Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape. Biol Direct. 2009 16;4:22.

Veitia RA. Dominant negative factors in health and disease. J Pathol. 2009;218(4):409-18.

Dipietromaria A, Benayoun BA, Todeschini AL, Rivals I, Bazin C, Veitia RA. Towards a functional classification of pathogenic FOXL2 mutations using transactivation reporter systems. Hum Mol Genet. 2009 Sep 1;18(17):3324-33

Lakhal B, Laissue P, Braham R, Elghezal H, Saâd A, Fellous M, Veitia RA. BMP15 and premature ovarian failure: causal mutations, variants, polymorphisms? Clin Endocrinol (Oxf). 2009 Jun 8.

M. Penrad-Mobayed, A. El Jamil, R. Kanhoush, C. Perrin (2009). Working map of the lampbrush chromosomes of Xenopus tropicalis: A new tool for cytogenetic analyses. Dev Dyn 30, 238(6): 1492-1501

R. Kanhoush, B. Beenders, C. Perrin, J. Moreau, M. Bellini, M. Penrad-Mobayed (2009). Novel domains in the hnRNPG/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts. Nucleus 1 (1) : 109-122

Benayoun BA, Veitia RA. A post-translational modification code for transcription factors: sorting through a sea of signals. Trends Cell Biol. 2009 May;19(5):189-97.

Laissue P, Lakhal B, Benayoun B, Dipietromaria A, Braham R, Elghezal H, Philibert P, Saâd A, Sultan C, Fellous M, and Veitia R.A. Functional evidence implicating FOXL2 in non syndromic premature ovarian failure and in the regulation of the transcription factor OSR2. J. Med Genet.

Lakhal B, Laissue P, Braham R, Elghezal H, Saâd A, Fellous M and Veitia R.A. A novel BMP15 variant, potentially affecting the signal peptide, in a familial case of premature ovarian failure. Clin Endocrinology (Oxford)

Veitia RA. On gene dosage balance in protein complexes. A comment on Semple JI, Vavouri T, Lehner B. A simple principle concerning the robustness of protein complex activity to changes in gene expression. BMC Syst Biol. 2008, 3:16.

Benayoun BA, Batista F, Auer J, Dipietromaria A, L'hôte D, De Baere E, Veitia RA. Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations. Hum Mol Genet. 2009, 18(4):632-44.

Penrad-Mobayed M., El Jamil A,  Kanhoush R, Perrin C A working map of the lampbrush chromosomes of Xenopus tropicalis: A new tool for cytogenetic analyses Dev Dyn  (in press)


A. El Jamil, S. Magre, A. Mazabraud, M. Penrad-Mobayed (2008). Early aspects of gonadal sex differentiation in Xenopus tropicalis with reference to an antero-posterior gradient. J Exp Zool 309A:127-137

A. El Jamil, R. Kanhoush, S. Magre, Brigitte Boizet-Bonhoure, M. Penrad-Mobayed (2008). Sex-Specific Expression of SOX9 during Gonadogenesis in the amphibian Xenopus tropicalis. Dev Dyn 237: 2996 –3005

Veitia RA. One thousand and one ways of making functionally similar transcriptional enhancers. Bioessays. 2008 Nov;30(11-12):1052-7.

Albà  MM, Tompa P, Veitia RA. Amino acid repeats and the structure and evolution of proteins. Genome Dyn. 2007;3:119-30.

L'Hôte D, Serres C, Veitia RA, Montagutelli X, Oulmouden A, Vaiman D. Gene expression regulation in the context of mouse interspecific mosaic genomes. Genome Biol. 2008;9(8):R133.

Vinci G, Xia X, Veitia RA. Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. PLoS ONE. 2008 Aug 6;3(8):e2883.

Beysen D, De Jaegere S, …, Veitia RA, De Paepe A, De Baere E. Identification of 34 novel and 56 known FOXL2 mutations in patients with Blepharophimosis syndrome. Hum Mutat. 2008 Nov;29(11):E205-19.

Benayoun BA, Caburet S, Dipietromaria A, Bailly-Bechet M, Batista F, Fellous M, Vaiman D, Veitia RA. The identification and characterization of a FOXL2 response element provides insights into the pathogenesis of mutant alleles. Hum Mol Genet. 2008 Oct 15;17(20):3118-27.

Benayoun BA, Auer J, Caburet S, Veitia RA. The post-translational modification profile of the forkhead transcription factor FOXL2 suggests the existence of parallel processive/concerted modification pathways. Proteomics. 2008 Aug;8(15):3118-23.

Veitia RA, Bottani S, Birchler JA. Cellular reactions to gene dosage imbalance: genomic, transcriptomic and proteomic effects. Trends Genet. 2008 Aug;24(8):390-7.

Nallathambi J, Laissue P, Batista F, Benayoun BA, Lesaffre C, Moumné L, Pandaranayaka PE, Usha K, Krishnaswamy S, Sundaresan P, Veitia RA. Differential functional effects of novel mutations of the  transcription factor FOXL2 in BPES patients. Hum Mutat. 2008 May 16;29(8):E123-E131.

Beysen D, Moumné L, Veitia R, Peters H, Leroy BP, De Paepe A, De Baere E. Missense mutations in the forkhead domain of FOXL2 lead to subcellular mislocalization, protein aggregation and impaired transactivation. Hum Mol Genet. 2008 Jul 1;17(13):2030-8.

Hersmus R, Kalfa N, de Leeuw B, Stoop H, Oosterhuis JW, de Krijger R, Wolffenbuttel KP, Drop SL, Veitia RA, Fellous M, Jaubert F, Looijenga LH. FOXL2 and SOX9 as parameters of female and male gonadal differentiation in patients with various forms of disorders of sex development (DSD). J Pathol. 2008 May;215(1):31-8.

Laissue P, Vinci G, Veitia RA, Fellous M. Recent advances in the study of genes involved in non-syndromic premature ovarian failure. Mol Cell Endocrinol. 2008 Jan 30;282(1-2):101-11.

Moumné L, Dipietromaria A, Batista F, Kocer A, Fellous M, Pailhoux E, Veitia RA. Differential aggregation and functional impairment induced by polyalanine expansions in FOXL2, a transcription factor involved in cranio-facial and ovarian development. Hum Mol Genet. 2008 Apr 1;17(7):1010-9.

Moumné L, Batista F, Benayoun BA, Nallathambi J, Fellous M, Sundaresan P, Veitia RA. The mutations and potential targets of the forkhead transcription factor FOXL2. Mol Cell Endocrinol. 2008 Jan 30;282(1-2):2-11.

Hemadevi B, Veitia RA, Srinivasan M, Arunkumar J, Prajna NV, Lesaffre C, Sundaresan P. Identification of mutations in the SLC4A11 gene in patients with recessive congenital hereditary endothelial dystrophy. Arch Ophthalmol. 2008 May;126(5):700-8.

El Jamil A , Magre S, Mazabraud A and Penrad-Mobayed M. Early aspects of gonadal sex differentiation in Xenopus tropicalis with reference to an antero-posterior gradient. J Exp Zool, 309A:127-137.

El Jamil A, Kanhoush R, Magre S, Boizet-Bonhoure B, and Penrad-Mobayed M. Sex-Specific expression of SOX9 during gonadogenesis in the amphibian Xenopus tropicalis. Dev Dyn 237:2996–3005.


Veitia RA. Exploring the molecular etiology of dominant-negative mutations. Plant Cell. 2007 Dec;19(12):3843-51.

Vinci G, Christin-Maitre S, Pasquier M, Bouchard P, Fellous M, Veitia RA. FOXO3a variants in patients with premature ovarian failure. Clin Endocrinol (Oxf). 2008 Mar;68(3):495-7.

Veitia RA, Salazar-Ciudad I. Commonalities in fly embryogenesis and mammalian pituitary patterning. Trends Endocrinol Metab. 18(7):261-5.

Veitia RA, Gluckman E, Fellous M, Soulier J. Recovery of female fertility after chemotherapy, irradiation, and bone marrow allograft: further evidence against massive oocyte regeneration by bone marrow-derived germline stem cells. Stem Cells. 25(5):1334-5.

Nallathambi J, Moumne L, De Baere E, Beysen D, Usha K, Sundaresan P, Veitia RA. A novel polyalanine expansion in FOXL2: the first evidence for a recessive form of the blepharophimosis syndrome (BPES) associated with ovarian dysfunction. Hum Genet. 121(1):107-12.

Batista F, Vaiman D, Dausset J, Fellous M, Veitia RA. Potential targets of FOXL2, a transcription factor involved in craniofacial and follicular development, identified by transcriptomics. Proc Natnl Acad Sci. USA. 104(9):3330-5.

Birchler JA and Veitia RA. The gene balance hypothesis: from classical genetics to modern genomics. Plant Cell. 19(2):395-402.

Mularoni L, Veitia RA, Alba M. Highly constrained proteins contain an unexpectedly large number of amino acid tandem repeats. Genomics 89(3):316-25.

Ettwiller L and Veitia RA.  Protein co-evolution and iso-expression in yeast macromolecular complexes. Comparative Functional Genomics. 58721.

Laissue P, Christin-Maitre S, Bouchard P, Fellous M, Veitia RA. Mutations in the NOG gene are not a common cause of nonsyndromic premature ovarian failure. Clin Endocrinol (Oxf). 66(6):900.

Nallathambi J, Moumne L, De Baere E, Beysen D, Usha K, Sundaresan P, Veitia RA. A novel polyalanine expansion in FOXL2: the first evidence for a recessive form of the blepharophimosis syndrome (BPES) associated with ovarian dysfunction. Hum. Genet. 121(1):107-12.


Laissue P, Copelli S, Bergada I, Bergada C, Barrio G, Karaboga S, Wurtz JM, Fellous M, Lalli E, Veitia RA.  Partial defects in transcriptional activity of two novel DAX-1 mutations in childhood-onset adrenal hypoplasia congenita. Clin. Endocrinol. (Oxf). 65: 681-6.

Pannetier M, Fabre S, Batista F, Kocer A, Renault L, Jolivet G, Mandon-Pepin B, Cotinot C, Veitia R, Pailhoux E. FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development. J. Mol. Endocrinol. 36:399-413.

Laissue L, Christin-Maitre SC, Touraine P, …, Fellous M and Veitia RA. Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure. Eur. J. Endo. 154:739-44.

Veitia RA and Nijhout HF. Exploring the robustness of the transcriptional response to dosage alterations in morphogenetic gradients. Bioessays. 28:282-9.

Moumné L and Veitia RA. Reprise traductionnelle en aval d'un codon stop prématuré et agrégation protéique. [Translational restart downstream of a premature stop codon and protein aggregation.] Med. Sci. (Paris). 22:232-234.

Cocquet J, Chong A, Zhang G, Veitia RA. Reverse transcriptase template switching and false alternative transcripts. Genomics. 88: 127-31


Moumne L, Fellous M, Veitia RA. Deletions in the polyAlanine-containing transcription factor FOXL2 lead to intranuclear aggregation. Hum. Mol. Genet. 14(23):3557-64.

Beysen D, Raes J,…,Veitia RA, DePaepe A, De Baere E. Deletions Involving Long-Range Conserved Nongenic Sequences Upstream and Downstream of FOXL2 as a Novel Disease-Causing Mechanism in Blepharophimosis Syndrome. Am. J. Hum. Genet. 77:205-18

Caburet S, Cocquet J, Vaiman D, Veitia RA. Coding repeats and evolutionary “agility”. Bioessays. 27:581-7.

Veitia RA. Gene deletions, duplications and dominance. Trends in Genetics. 21(1):33-5

Veitia RA. Paralogs in polyploid plants : one for all and all for one ? Plant Cell. 17: 4-11

Cocquet J, Pannetier M, Fellous M et Veitia RA. Sense and antisense FOXL2 transcripts in mouse. Genomics. 85: 531-541

Veitia RA. Stochasticity or the fatal imperfection of cloning. J. Biosciences. 30: 101-110

Birchler JA, Riddle N, Auger D, Veitia RA. Dosage balance in gene regulation : biological implications. Trends in Genetics. 21: 219-226

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