Epigenome and Paleogenome

Program: Genomes and Epigenomes

Group Leader: Thierry GRANGE

Tel.: +33 (0)157278129
grange.thierry@ijm.univ-paris-diderot.fr
Floor 5

Co-group Leader: Eva-Maria GEIGL


Tel.: 33 (0)157278132
geigl.eva-mariaATijm.univ-paris-diderot.fr


We are studying the mechanisms of transcriptional activation and of reprogramming of epigenetic memory in mammals, using as a model regulator, the glucocorticoid receptor. We are particularly interested in the mechanisms of DNA demethylation, of chromatin remodelling and of the replacement of canonical nucleosomal histones by variant histones and of the enhancer-promoter communication. Using transgenic mice, we are also studying how these different mechanisms contribute to the diverse physiological responses to glucocorticoids.

souris us 39433

 

Copyright : CNRS/IJM Th. Grange


The members of the team led by Eva-Maria Geigl are studying genetic evolution using paleogenetics.

  • First, they are studying the molecular mechanisms that lead to the preservation of DNA in mammalian bones during their fossilisation.
  • Secondly, they are putting major effort into the development of new methods to study the DNA that is preserved in fossils.
  • Thirdly, they are using the methods thus developed and the insight gained from the fossilisation and diagenetic processes to study the domestication of animals from the Neolithic period to the present day.

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Copyright : CNRS/IJM E. M. Geigl

Selection of publications

Pruvost, M., T. Grange and E. M. Geigl (2005). "Minimizing DNA contamination by using UNG-coupled quantitative real-time PCR on degraded DNA samples: application to ancient DNA studies." Biotechniques 38(4): 569-75.
abstract

Thomassin, H., C. Kress and T. Grange (2004). "MethylQuant: a sensitive method for quantifying methylation of specific cytosines within the genome." Nucleic Acids Res 32(21).
abstract

Flavin, M., L. Cappabianca, C. Kress, H. Thomassin and T. Grange (2004). "Nature of the accessible chromatin at a glucocorticoid-responsive enhancer." Mol Cell Biol 24(18): 7891-901.
abstract

Thomassin, H., M. Flavin, M. L. Espinas and T. Grange (2001). "Glucocorticoid-induced DNA demethylation and gene memory during development." Embo J 20(8): 1974-83.
abstract

Geigl, E. M. (2001). "Inadequate use of molecular hybridization to analyze DNA in Neanderthal fossils." Am J Hum Genet 68(1): 287-91.
abstract

Last modified 09/ 9/2011

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